Jeremy A. Hengst, Ph.D.
Affiliations: | Pennsylvania State University, State College, PA, United States |
Area:
metalloproteinasesGoogle:
"Jeremy Hengst"Mean distance: 9.8 | S | N | B | C | P |
Parents
Sign in to add mentor| Judith S. Bond | grad student | 2002 | Penn State | |
| (The roles of the EFG-like, transmembrane and cytoplasmic domains of meprin in the secretory pathway.) | ||||
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Publications
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| Hengst JA, Dick TE, Smith CD, et al. (2020) Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA). Cancer Biology & Therapy. 1-12 |
| Hengst JA, Hegde S, Paulson RF, et al. (2020) Development of SKI-349, a Dual-Targeted Inhibitor of Sphingosine Kinase and Microtubule Polymerization. Bioorganic & Medicinal Chemistry Letters. 127453 |
| Hengst JA, Dick TE, Sharma A, et al. (2017) SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models. Cancer Translational Medicine. 3: 109-121 |
| Desai DH, Kale VP, Hengst JA, et al. (2016) Abstract 4805: In vitro characterization of novel inhibitors of ROCK and MRCK kinases as anticancer agents Cancer Research. 76: 4805-4805 |
| Lee S, Hengst J. (2016) DDIS-15. SPECIFIC SPHINGOSINE KINASE 1 INHIBITORS FOR MALIGNANT GLIOMA TREATMENT Neuro-Oncology. 18: vi50-vi50 |
| LeBlanc FR, Liu X, Hengst J, et al. (2015) Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. Cancer Biology & Therapy. 0 |
| Kale VP, Hengst JA, Desai DH, et al. (2015) The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration. Cancer Letters. 361: 185-96 |
| Dick TE, Hengst JA, Fox TE, et al. (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. The Journal of Pharmacology and Experimental Therapeutics. 352: 494-508 |
| Dick TE, Hengst J, Kale V, et al. (2015) Abstract 2933: The apoptotic mechanism of action of SKI-178, a novel Sphingosine kinase 1 selective inhibitor Cancer Research. 75: 2933-2933 |
| Kale VP, Hengst JA, Desai DH, et al. (2014) A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Letters. 354: 299-310 |