Bryan T. Mott, Ph.D.
Affiliations: | 2013 | Johns Hopkins University, Baltimore, MD |
Area:
Medicinal, Organic and Organometallic ChemistryGoogle:
"Bryan Mott"Mean distance: 8.28 | S | N | B | C | P |
Parents
Sign in to add mentor| Gary Herbert Posner | grad student | 2013 | Johns Hopkins | |
| (Studies in organic and medicinal chemistry: Treatment of malaria and cytomegalovirus.) | ||||
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Publications
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| Christov PP, Kim K, Jana S, et al. (2021) Optimization of ether and aniline based inhibitors of lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 127974 |
| Rai G, Urban DJ, Mott BT, et al. (2020) Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. Journal of Medicinal Chemistry |
| Oshima N, Ishida R, Kishimoto S, et al. (2020) Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy. Cell Reports. 30: 1798-1810.e4 |
| Horton JR, Woodcock CB, Chen Q, et al. (2018) Structure-based engineering of irreversible inhibitors against histone lysine demethylase KDM5A. Journal of Medicinal Chemistry |
| Horton JR, Liu X, Wu L, et al. (2018) Insights into the action of inhibitor enantiomers against histone lysine demethylase 5A. Journal of Medicinal Chemistry |
| Rai G, Brimacombe KR, Mott BT, et al. (2017) Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry |
| Varadarajan J, McWilliams MJ, Mott BT, et al. (2016) Drug resistant integrase mutants cause aberrant HIV integrations. Retrovirology. 13: 71 |
| Horton JR, Liu X, Gale M, et al. (2016) Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chemical Biology |
| Kasbekar M, Fischer G, Mott BT, et al. (2016) Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site. Proceedings of the National Academy of Sciences of the United States of America |
| Fox JM, Moynihan JR, Mott BT, et al. (2016) Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs. Oncotarget |