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Kevin J. Gaffney, Ph.D.

Affiliations: 
2013 Chemistry University of Southern California, Los Angeles, CA, United States 
Area:
synthetic organic chemistry
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"Kevin Gaffney"
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Nicos A. Petasis grad student 2013 USC
 (Adventures in medicinal chemistry: Design and synthesis of small molecule biological modulators.)

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Publications

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Gaffney K, Weinberg M, Soto M, et al. (2018) Development of angiotensin II (1-7) analog as an oral therapeutic for the treatment of chemotherapy-induced myelosuppression. Haematologica. 103: e567-e570
Glynn SJ, Gaffney KJ, Sainz MA, et al. (2015) Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols. Organic & Biomolecular Chemistry. 13: 3887-99
Huang YJE, Gaffney KJ, Gerdts E, et al. (2014) Abstract 1811: Evaluation of anti-CXCR2 small molecule inhibitors as novel chemotherapy targeting the Interleukin-8 pathway in colorectal cancer Cancer Research. 74: 1811-1811
Thomas S, Sharma N, Golden EB, et al. (2012) Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Letters. 325: 63-71
Jayathilaka N, Han A, Gaffney KJ, et al. (2012) Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Research. 40: 5378-88
Ferrario A, Lim S, Xu F, et al. (2011) Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib Cancer Letters. 304: 33-40
Virrey JJ, Liu Z, Cho HY, et al. (2010) Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature. Molecular Cancer Therapeutics. 9: 631-41
Chen ST, Thomas S, Gaffney KJ, et al. (2010) Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2. Leukemia Research. 34: 250-3
Cho HY, Thomas S, Golden EB, et al. (2009) Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Letters. 282: 87-97
Golden EB, Lam PY, Kardosh A, et al. (2009) Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood. 113: 5927-37
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