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Yvan H. Chanthery, Ph.D.

Affiliations: 
2011 Biomedical Sciences University of California, San Francisco, San Francisco, CA 
Area:
role of the cellular microenvironment and intercellular communication in breast development and cancer
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"Yvan Chanthery"
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William A. Weiss grad student UCSF (GenetiTree)
Zena Werb grad student 2011 UCSF
 (PI3K/mTOR, microRNAs, and feed forward loops all stabilize MYCN protein in neuroblastoma; Paracrine signaling by MYCN subsequently drives angiogenesis.)

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Publications

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Vaughan L, Clarke PA, Barker K, et al. (2016) Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors. Oncotarget
Cage TA, Chanthery Y, Chesler L, et al. (2015) Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Frontiers in Oncology. 5: 111
Li N, Maly DJ, Chanthery YH, et al. (2015) Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Molecular Cancer Therapeutics. 14: 419-28
Gustafson WC, Meyerowitz JG, Nekritz EA, et al. (2014) Abstract 2688: Drugging MYCN through an allosteric transition in Aurora A kinase Cancer Research. 74: 2688-2688
Puissant A, Frumm SM, Alexe G, et al. (2013) Targeting MYCN in neuroblastoma by BET bromodomain inhibition Cancer Discovery. 3: 309-323
Chanthery YH, Gustafson WC, Itsara M, et al. (2012) Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Science Translational Medicine. 4: 115ra3
Chanthery YH, Gustafson WC, Weiss WA. (2011) Abstract 1558: Paracrine signaling through Mycn enhances tumor-vascular microenvironment in neuroblastoma Cancer Research. 71: 1558-1558
Swarbrick A, Woods SL, Shaw A, et al. (2010) miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nature Medicine. 16: 1134-40
Ridgway J, Zhang G, Wu Y, et al. (2006) Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature. 444: 1083-7
Yao VJ, Ozawa MG, Varner AS, et al. (2006) Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels. Cancer Research. 66: 2639-49
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