Jaime E. Symowicz, Ph.D.

Affiliations: 
2007 Northwestern University, Evanston, IL 
Area:
molecular mechanisms of metastasis
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M. Sharon Stack grad student 2007 Northwestern
 (Microenvironment regulation of proteinase expression and E-cadherin ectodomain generation in ovarian cancer.)
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Publications

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Liu Y, Burkhalter R, Symowicz J, et al. (2012) Lysophosphatidic Acid disrupts junctional integrity and epithelial cohesion in ovarian cancer cells. Journal of Oncology. 2012: 501492
Burkhalter RJ, Symowicz J, Hudson LG, et al. (2011) Integrin regulation of beta-catenin signaling in ovarian carcinoma. The Journal of Biological Chemistry. 286: 23467-75
Woo MM, Salamanca CM, Symowicz J, et al. (2008) SV40 early genes induce neoplastic properties in serous borderline ovarian tumor cells. Gynecologic Oncology. 111: 125-31
Cowden Dahl KD, Symowicz J, Ning Y, et al. (2008) Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells. Cancer Research. 68: 4606-13
Woo MMM, Salamanca CM, Miller M, et al. (2008) Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas. International Journal of Gynecological Cancer. 18: 1234-1247
Symowicz J, Adley BP, Gleason KJ, et al. (2007) Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Research. 67: 2030-9
Symowicz J, Adley BP, Woo MM, et al. (2005) Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. Cancer Research. 65: 2234-42
Schroeder MD, Symowicz J, Schuler LA. (2002) PRL modulates cell cycle regulators in mammary tumor epithelial cells. Molecular Endocrinology (Baltimore, Md.). 16: 45-57
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