Alexandra R. Grassian, Ph.D.

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
Cell Biology, Oncology
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"Alexandra Grassian"

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Joan S. Brugge grad student 2011 Harvard
 (Extracellular Matrix and Oncogene Regulation of Growth Factor Signaling and Cellular Metabolism.)
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Publications

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Thomenius MJ, Totman J, Harvey D, et al. (2018) Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. Plos One. 13: e0197372
Chan-Penebre E, Armstrong K, Drew A, et al. (2017) Selective killing of SMARCA2- and SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type cells by inhibition of EZH2: In vitro and in vivo preclinical models. Molecular Cancer Therapeutics
Grassian AR, Harvey D, Fowler J, et al. (2017) Abstract 406: CRISPR pooled screening of hundreds of cancer cell lines identifies differential dependencies on epigenetic pathways and synthetic lethal relationships Cancer Research. 77: 406-406
Kawano S, Grassian AR, Tsuda M, et al. (2016) Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. Plos One. 11: e0158888
Grassian AR, Scales TM, Knutson SK, et al. (2015) A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality. Biological Procedures Online. 17: 15
Grassian AR, Scales T, Knutson SK, et al. (2015) Abstract C162: A medium-throughput single cell CRISPR-Cas9 assay to assess gene essentiality Molecular Cancer Therapeutics. 14
Grassian AR, Fowler J, Feldman I, et al. (2015) Abstract B78: CRISPR pooled screening identifies differential dependencies on epigenetic pathways Molecular Cancer Therapeutics. 14
Grassian AR, Parker SJ, Davidson SM, et al. (2014) IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. Cancer Research. 74: 3317-31
Grassian AR, Pagliarini R, Chiang DY. (2014) Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma. Current Opinion in Gastroenterology. 30: 295-302
Grassian AR, Parker S, Davidson S, et al. (2014) Abstract LB-139: IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism Cancer Research. 74
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