Yu Zhan, Ph.D.

Affiliations: 
2011 Biology (Cell-Molecular Biology) The University of Toledo 
Area:
Molecular Biology, Cell Biology, Oncology
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"Yu Zhan"

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Deborah N. Chadee grad student 2011 The University of Toledo
 (Mixed Lineage Kinase 3 Signaling in Ovarian Cancer and Neurofibromatosis-2.)
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Publications

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Wu R, Zhang Z, Xu Q, et al. (2024) Integration of network pharmacology and experimental verifications reveals the Bian-Se-Tong mixture can alleviate constipation in STC rats by reducing apoptosis of Cajal cells via activating PI3K-Akt signaling pathway. Heliyon. 10: e28022
Ran L, Murphy D, Sher J, et al. (2018) Abstract A15: Modeling sporadic gastrointestinal stromal tumor with BRAFV600E mutation Clinical Cancer Research. 24
Shukla S, Cyrta J, Murphy DA, et al. (2017) Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell
Ran L, Murphy D, Sher J, et al. (2017) ETV1-positive cells give rise to BRAFV600E mutant gastrointestinal stromal tumors. Cancer Research
Zhan Y, Seregin SS, Chen J, et al. (2016) Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production. Journal of Immunology (Baltimore, Md. : 1950)
Liu S, Sun X, Wang M, et al. (2014) A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 147: 847-859.e11
Zhan Y, Abi Saab WF, Modi N, et al. (2012) Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells. Experimental Cell Research. 318: 1641-8
Zhan Y, Modi N, Stewart AM, et al. (2011) Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. Oncogene. 30: 781-9
Zhan Y, Chadee DN. (2010) Inhibition of Cdc42-mediated activation of mixed lineage kinase 3 by the tumor suppressor protein merlin. Small Gtpases. 1: 183-186
Cole ET, Zhan Y, Abi Saab WF, et al. (2009) Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. Biochimica Et Biophysica Acta. 1793: 1811-8
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