Jeffrey A. Heibein, Ph.D.
Affiliations: | 2001 | University of Alberta, Edmonton, Alberta, Canada |
Area:
Biochemistry, Cell BiologyGoogle:
"Jeffrey Heibein"Parents
Sign in to add mentor| R C. Bleackley | grad student | 2001 | University of Alberta | |
| (Caspase -independent CTL-mediated killing.) | ||||
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Publications
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| Bleackley RC, Heibein JA. (2001) Enzymatic control of apoptosis. Natural Product Reports. 18: 431-40 |
| Pinkoski MJ, Waterhouse NJ, Heibein JA, et al. (2001) Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway. The Journal of Biological Chemistry. 276: 12060-7 |
| Heibein JA, Goping IS, Barry M, et al. (2000) Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. The Journal of Experimental Medicine. 192: 1391-402 |
| Motyka B, Korbutt G, Pinkoski MJ, et al. (2000) Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell. 103: 491-500 |
| Barry M, Heibein J, Pinkoski M, et al. (2000) Quantitative measurement of apoptosis induced by cytotoxic T lymphocytes. Methods in Enzymology. 322: 40-6 |
| Barry M, Heibein JA, Pinkoski MJ, et al. (2000) Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Molecular and Cellular Biology. 20: 3781-94 |
| Pinkoski MJ, Heibein JA, Barry M, et al. (2000) Nuclear translocation of granzyme B in target cell apoptosis. Cell Death and Differentiation. 7: 17-24 |
| Heibein JA, Barry M, Motyka B, et al. (1999) Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent. Journal of Immunology (Baltimore, Md. : 1950). 163: 4683-93 |
| Pinkoski MJ, Hobman M, Heibein JA, et al. (1998) Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood. 92: 1044-54 |