Sergey Seregin, Ph.D.

Affiliations: 
2010 Michigan State University, East Lansing, MI 
Area:
Microbiology Biology
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"Sergey Seregin"

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Andrea Amalfitano grad student 2010 Michigan State
 (Evaluating and modifying Adenovirus vector interactions with multiple arms of the innate immune system.)
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Publications

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Toubai T, Fujiwara H, Rossi C, et al. (2019) Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition. Nature Microbiology
Kady NM, Liu X, Lydic TA, et al. (2018) ELOVL4-Mediated Production of Very Long Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes
Rastall DP, Seregin SS, Aldhamen YA, et al. (2016) Long-term, high level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus. Gene Therapy
Aldhamen YA, Rastall DP, Chen W, et al. (2016) CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets. Vaccine
Alyaqoub FS, Aldhamen YA, Koestler BJ, et al. (2016) In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens. Journal of Immunology (Baltimore, Md. : 1950)
Aldhamen YA, Pepelyayeva Y, Rastall DP, et al. (2015) Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells. Journal of Innate Immunity. 7: 275-89
Koestler BJ, Seregin SS, Rastall DP, et al. (2014) Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus. Clinical and Vaccine Immunology : Cvi. 21: 1550-9
Rastall DP, Aldhamen YA, Seregin SS, et al. (2014) ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses. International Immunology. 26: 685-95
Aldhamen YA, Seregin SS, Aylsworth CF, et al. (2014) Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy. International Immunology. 26: 291-303
Zervoudi E, Saridakis E, Birtley JR, et al. (2013) Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses. Proceedings of the National Academy of Sciences of the United States of America. 110: 19890-5
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