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Shennan Lu, Ph.D.

Affiliations: 
2000 University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States 
Area:
Molecular Biology, Oncology, Obstetrics and Gynecology, Pharmacology
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"Shennan Lu"
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Doris M. Benbrook grad student 2000 University of Oklahoma Health Sciences Center
 (Retinoids can inhibit cell growth through AP-1-independent pathways.)

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Publications

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Lu S, Benbrook DM. (2006) Role of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by Retinoids American Journal of Pharmacology and Toxicology. 1: 40-47
Simoni D, Roberti M, Invidiata FP, et al. (2001) Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells Journal of Medicinal Chemistry. 44: 2308-2318
Dhar A, Liu S, Klucik J, et al. (2000) Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids Journal of Medicinal Chemistry. 43: 303
Zacheis D, Dhar A, Lu S, et al. (1999) Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. Journal of Medicinal Chemistry. 42: 4434-45
Dhar A, Liu S, Klucik J, et al. (1999) Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids. Journal of Medicinal Chemistry. 42: 3602-14
Salsman S, Lu S, Benbrook DM. (1999) The mechanism of retinoic acid radiosensitization is independent of AP-1 repression in a cervical carcinoma cell line. Gynecologic Oncology. 73: 253-6
Benbrook DM, Madler MM, Spruce LW, et al. (1997) Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity. Journal of Medicinal Chemistry. 40: 3567-83
Benbrook DM, Lu S, Flanagan C, et al. (1997) Biological assay for activity and molecular mechanism of retinoids in cervical tumor cells. Gynecologic Oncology. 66: 114-21
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