Keefe T. Chan, Ph.D.
Affiliations: | 2010 | University of Wisconsin, Madison, Madison, WI |
Area:
Cell BiologyGoogle:
"Keefe Chan"Parents
Sign in to add mentor| Anna Huttenlocher | grad student | 2010 | UW Madison | |
| (The roles of FAK and calpain 2 in regulating adhesion dynamics during cell migration and invasion.) | ||||
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Publications
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| Dietrich C, Trub A, Ahn A, et al. (2023) INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors. Cancer Discovery |
| Zhu H, Chan KT, Huang X, et al. (2022) Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. Elife. 11 |
| Kusnadi EP, Trigos AS, Cullinane C, et al. (2020) Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis. The Embo Journal. e105111 |
| Zhu H, Blake S, Kusuma FK, et al. (2020) Oncogene-Induced Senescence: from Biology to Therapy. Mechanisms of Ageing and Development. 111229 |
| AbuHammad S, Cullinane C, Martin C, et al. (2019) Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma. Proceedings of the National Academy of Sciences of the United States of America |
| Chan KT, Blake S, Zhu H, et al. (2019) A functional genetic screen defines the AKT-induced senescence signaling network. Cell Death and Differentiation |
| Zhu H, Blake S, Chan KT, et al. (2018) Cystathionine -Synthase in Physiology and Cancer. Biomed Research International. 2018: 3205125 |
| Yan S, Frank D, Son J, et al. (2017) The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer. International Journal of Molecular Sciences. 18 |
| Yan S, Chan KT, Simpson KJ, et al. (2017) Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer Molecular Cancer Research. 15 |
| Chan KT, Paavolainen L, Hannan KM, et al. (2016) Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence. Assay and Drug Development Technologies. 14: 416-428 |