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Dale A. Ramsden

Affiliations: 
Biochemistry and Biophysics University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Biochemistry
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Stephanie A. Nick McElhinny grad student 2004 UNC Chapel Hill
Eric J. Perkins grad student 2004 UNC Chapel Hill
Natasha T. Strande grad student 2013 UNC Chapel Hill

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Publications

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Kaminski AM, Chiruvella KK, Ramsden DA, et al. (2024) DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining. Dna Repair. 136: 103645
Stroik S, Carvajal-Garcia J, Gupta D, et al. (2023) Stepwise requirements for polymerases δ and θ in theta-mediated end joining. Nature. 623: 836-841
Stroik S, Luthman AJ, Ramsden DA. (2023) Templated insertions-DNA repair gets acrobatic. Environmental and Molecular Mutagenesis
Yang F, Su W, Chung OW, et al. (2023) Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis. Nature
Luedeman ME, Stroik S, Feng W, et al. (2022) Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection. Nature Communications. 13: 4547
Kaminski AM, Chiruvella KK, Ramsden DA, et al. (2022) Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining. Nature Communications. 13: 3806
Ramsden DA, Carvajal-Garcia J, Gupta GP. (2021) Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining. Nature Reviews. Molecular Cell Biology
Feng W, Simpson DA, Cho JE, et al. (2021) Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks. Nucleic Acids Research
Carvajal-Garcia J, Crown KN, Ramsden DA, et al. (2021) DNA polymerase theta suppresses mitotic crossing over. Plos Genetics. 17: e1009267
Kumar RJ, Chao HX, Simpson DA, et al. (2020) Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency. Nar Cancer. 2: zcaa038
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