Zhaoyu Jin, Ph.D.

Affiliations: 
2005 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Pharmacology, Oncology
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"Zhaoyu Jin"
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Wafik S. El-Deiry grad student 2005 Penn
 (The regulation of death receptor -mediated apoptosis in tumor cells.)
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Publications

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Jin Z, Li Y, Pitti R, et al. (2009) Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell. 137: 721-35
Ricci MS, Kim SH, Ogi K, et al. (2007) Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell. 12: 66-80
Jin Z, El-Deiry WS. (2006) Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis. Molecular and Cellular Biology. 26: 8136-48
Dicker DT, Kim SH, Jin Z, et al. (2005) Heterogeneity in non-invasive detection of apoptosis among human tumor cell lines using annexin-V tagged with EGFP or Qdot-705. Cancer Biology & Therapy. 4: 1014-7
Jin Z, El-Deiry WS. (2005) Overview of cell death signaling pathways. Cancer Biology & Therapy. 4: 139-63
Ricci MS, Jin Z, Dews M, et al. (2004) Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Molecular and Cellular Biology. 24: 8541-55
Jin Z, McDonald ER, Dicker DT, et al. (2004) Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. The Journal of Biological Chemistry. 279: 35829-39
Jin Z, Dicker DT, El-Deiry WS. (2002) Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL. Cell Cycle (Georgetown, Tex.). 1: 82-9
Goldberg GS, Jin Z, Ichikawa H, et al. (2001) Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis. Cancer Research. 61: 1334-7
Mitchell KO, Ricci MS, Miyashita T, et al. (2000) Bax is a transcriptional target and mediator of c-myc-induced apoptosis. Cancer Research. 60: 6318-25
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