Jennifer R. Molina, Ph.D.

Affiliations: 
2009 The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Molecular Biology, Biochemistry
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Parents

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Maria-Magdalena Georgescu grad student 2009 The University of Texas Graduate School of Biomedical Sciences at Houston
 (NHERF1 recruits the tumor suppressors PTEN and PHLPP to synergistically inhibit the PI-3K pathway.)
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Publications

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Gozgit JM, Vasbinder MM, Abo RP, et al. (2021) PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell
Schenkel L, Molina J, Swinger K, et al. (2020) Abstract 1038: A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants Cancer Research. 80: 1038-1038
Molina JR, Sun Y, Protopopova M, et al. (2018) An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nature Medicine
Marszalek JR, Seth S, Corti D, et al. (2018) Abstract 2856: Targeting OXPHOS with IACS-010759 to eliminate standard of care resistant tumor cells Cancer Research. 78: 2856-2856
Francesco MED, Marszalek JR, McAfoos T, et al. (2018) Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors Cancer Research. 78: 1655-1655
Baran N, Han L, Sweeney SR, et al. (2017) Inhibition of Oxphos with Iacs-010759 Depletes AML Leukemia Initiating Cells (LIC) in Vitro and Improves Survival in Pre-Clinical AML Models Blood. 130: 1350-1350
Molina J, Bandi M, Bardenhagen J, et al. (2017) Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors Cancer Research. 77: 4971-4971
Baran N, Han L, Herbrich S, et al. (2017) Novel Complex I inhibitor IACS-010759 Targets Leukemia Initiating Cells (LICs) in AML Patients Clinical Lymphoma Myeloma and Leukemia. 17: S297
Jinesh GG, Molina JR, Huang L, et al. (2016) Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis. Cell Death Discovery. 2: 16003
Molina JR, Protopopova M, Bandi M, et al. (2016) Abstract 335: Title: IACS-010759 is a novel clinical candidate that targets AML cells by inducing a metabolic catastrophe through inhibition of oxidative phosphorylation Cancer Research. 76: 335-335
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