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I-Chu Tseng, Ph.D.

Affiliations: 
2010 Biochemistry University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Biochemistry, Cell Biology, Molecular Biology
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"I-Chu Tseng"
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Chen-Yong Lin grad student 2010 University of Maryland Medical School
 (Molecular mechanisms governing matriptase.)

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Publications

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Tseng CC, Jia B, Barndt R, et al. (2017) Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity. Plos One. 12: e0183507
Wang X, Zhou Y, Wang J, et al. (2016) SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 12586-12597
Huang TY, Zhao Y, Li X, et al. (2016) SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7996-8011
Lin CY, Hsieh HY, Pitt WG, et al. (2015) Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 212: 1-9
Wang JK, Teng IJ, Lo TJ, et al. (2014) Matriptase autoactivation is tightly regulated by the cellular chemical environments. Plos One. 9: e93899
Justilien V, Regala RP, Tseng IC, et al. (2012) Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. Plos One. 7: e35040
Xu H, Xu Z, Tseng IC, et al. (2012) Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. American Journal of Physiology. Cell Physiology. 302: C453-62
Justilien V, Regala RP, Tseng I, et al. (2012) Abstract LB-204: Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential Cancer Research. 72
Tseng IC, Xu H, Chou FP, et al. (2010) Matriptase activation, an early cellular response to acidosis. The Journal of Biological Chemistry. 285: 3261-70
Wang JK, Lee MS, Tseng IC, et al. (2009) Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. American Journal of Physiology. Cell Physiology. 297: C459-70
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