Carolyn A. Goard, Ph.D.

Affiliations: 
2013 Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology, Pharmacy
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"Carolyn Goard"
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Parents

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Linda Z. Penn grad student 2013 University of Toronto
 (Molecular Markers of Sensitivity to the Anticancer Effects of Different Statins in Human Tumour Cell Lines.)
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Publications

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Leeuwen Jv, Pandyra A, Goard C, et al. (2017) Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents Cancer Research. 77: 3543-3543
Pandyra AA, Mullen PJ, Goard CA, et al. (2015) Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget
Sriskanthadevan S, Jeyaraju DV, Chung TE, et al. (2015) AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 125: 2120-30
Xu GW, Toth JI, da Silva SR, et al. (2014) Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. Plos One. 9: e93530
Goard CA, Chan-Seng-Yue M, Mullen PJ, et al. (2014) Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells. Breast Cancer Research and Treatment. 143: 301-12
Goard CA, Schimmer AD. (2014) Mitochondrial matrix proteases as novel therapeutic targets in malignancy Oncogene. 33: 2690-2699
Goard CA, Schimmer AD. (2013) An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies. Core Evidence. 8: 15-26
Wang Z, Dove P, Wang X, et al. (2013) FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo Blood. 122: 1988-1988
Mullen PJ, Goard CA, Wasylishen AR, et al. (2011) Abstract C165: Breast cancer, statins, and 3-D cell culture. Molecular Cancer Therapeutics. 10
Goard CA, Mather RG, Vinepal B, et al. (2010) Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. International Journal of Cancer. 127: 2936-48
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