Carolyn A. Goard, Ph.D.
Affiliations: | 2013 | Medical Biophysics | University of Toronto, Toronto, ON, Canada |
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Molecular Biology, PharmacyGoogle:
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Parents
Sign in to add mentorLinda Z. Penn | grad student | 2013 | University of Toronto | |
(Molecular Markers of Sensitivity to the Anticancer Effects of Different Statins in Human Tumour Cell Lines.) |
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Publications
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Leeuwen Jv, Pandyra A, Goard C, et al. (2017) Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents Cancer Research. 77: 3543-3543 |
Pandyra AA, Mullen PJ, Goard CA, et al. (2015) Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget |
Sriskanthadevan S, Jeyaraju DV, Chung TE, et al. (2015) AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 125: 2120-30 |
Xu GW, Toth JI, da Silva SR, et al. (2014) Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells. Plos One. 9: e93530 |
Goard CA, Chan-Seng-Yue M, Mullen PJ, et al. (2014) Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells. Breast Cancer Research and Treatment. 143: 301-12 |
Goard CA, Schimmer AD. (2014) Mitochondrial matrix proteases as novel therapeutic targets in malignancy Oncogene. 33: 2690-2699 |
Goard CA, Schimmer AD. (2013) An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies. Core Evidence. 8: 15-26 |
Wang Z, Dove P, Wang X, et al. (2013) FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo Blood. 122: 1988-1988 |
Mullen PJ, Goard CA, Wasylishen AR, et al. (2011) Abstract C165: Breast cancer, statins, and 3-D cell culture. Molecular Cancer Therapeutics. 10 |
Goard CA, Mather RG, Vinepal B, et al. (2010) Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents. International Journal of Cancer. 127: 2936-48 |