Marko Skrtic, Ph.D.

Affiliations: 
2012 Medical Science University of Toronto, Toronto, ON, Canada 
Area:
Oncology, Molecular Biology, Cell Biology
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"Marko Skrtic"
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Aaron Schimmer grad student 2012 University of Toronto
 (Inhibition of mitochondrial translation as a therpeutic strategy for acute myeloid leukemia.)
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Publications

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Sriskanthadevan S, Jeyaraju DV, Chung TE, et al. (2015) AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 125: 2120-30
Jhas B, Sriskanthadevan S, Skrtic M, et al. (2013) Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells. Plos One. 8: e58367
Sukhai MA, Prabha S, Hurren R, et al. (2013) Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors Journal of Clinical Investigation. 123: 315-328
Schimmer AD, Skrtić M. (2012) Therapeutic potential of mitochondrial translation inhibition for treatment of acute myeloid leukemia. Expert Review of Hematology. 5: 117-9
Sriskanthadevan S, Chung TE, Skrtic M, et al. (2012) AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress. Blood. 120: 2581-2581
Bozhena J, Sriskanthadevan S, Skrtic M, et al. (2012) Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML Blood. 120: 1364-1364
Sriskanthadevan S, Skrtic M, Jhas B, et al. (2012) Abstract 1123: AML cells have low reserve capacity in their respiratory chain complexes leading to increased sensitivity to palmitate-induced cell death Cancer Research. 72: 1123-1123
Sukhai MA, Hurren R, Rutledge A, et al. (2011) Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production Blood. 118: 61-61
Skrtic M, Sriskanthadevan S, Livak B, et al. (2011) Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML) Blood. 118: 233-233
Sharmeen S, Skrtic M, Sukhai MA, et al. (2010) The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells. Blood. 116: 3593-603
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