Charles T. Spencer, Ph.D.

Affiliations: 
2008 Saint Louis University, St. Louis, MO, United States 
Area:
Immunology, Microbiology Biology
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"Charles Spencer"

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Daniel F. Hoft grad student 2008 Saint Louis University
 (Characterization of gammadelta T cells relevant for protective tuberculosis immunity: T cell specificity, antigen identification and mechanisms of inhibition.)
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Publications

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Spencer CT, Ramos Muniz MG, Setzu NR, et al. (2021) Francisella tularensis Infection of Mice as a Model of Sepsis. Methods in Molecular Biology (Clifton, N.J.). 2321: 75-100
Kulkarni AA, Sajith AM, Duarte TT, et al. (2020) Design, synthesis, and screening of sulfonylurea-derived NLRP3 inflammasome inhibitors. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 29: 126-135
Ramos Muniz MG, Palfreeman M, Setzu N, et al. (2018) Obesity Exacerbates the Cytokine Storm Elicited by Infection of Females and Is Associated with Increased Mortality. Biomed Research International. 2018: 3412732
Xia M, Hesser DC, De P, et al. (2016) A Subset of Protective γ9δ2 T cells is Activated by Novel Mycobacterial Lipid Components. Infection and Immunity
Spencer CT, Bezbradica JS, Ramos MG, et al. (2015) Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules. Proteomics. Clinical Applications. 9: 1035-52
Abate G, Spencer CT, Hamzabegovic F, et al. (2015) Mycobacteria-specific γ9δ2 T cells mediate both pathogen inhibitory and CD40L-dependent antigen presentation effects important for TB immunity. Infection and Immunity
Gilchuk P, Spencer CT, Conant SB, et al. (2013) Discovering naturally processed antigenic determinants that confer protective T cell immunity. The Journal of Clinical Investigation. 123: 1976-87
Spencer CT, Dragovic SM, Conant SB, et al. (2013) Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. European Journal of Immunology. 43: 1162-72
Spencer CT, Abate G, Sakala IG, et al. (2013) Granzyme A produced by γ(9)δ(2) T cells induces human macrophages to inhibit growth of an intracellular pathogen. Plos Pathogens. 9: e1003119
Hoft DF, Babusis E, Worku S, et al. (2011) Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children Journal of Infectious Diseases. 204: 845-853
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