Jeffrey A. Toretsky
Affiliations: | Tumor Biology | Georgetown University, Washington, DC |
Area:
Oncology, BiochemistryGoogle:
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Publications
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| Nakazawa K, Shaw T, Song YK, et al. (2023) Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity. Cancer Research Communications |
| Ko K, Kitani T, Harris BT, et al. (2020) A novel PARD3B-NUTM1 fusion in an aggressive primary CNS embryonal tumor in a young adult. Acta Neuropathologica Communications. 8: 112 |
| Conn E, Hour S, Allegakoen D, et al. (2020) Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279. Molecular Medicine Reports |
| Selvanathan SP, Graham GT, Grego AR, et al. (2019) EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex. Nucleic Acids Research |
| Spriano F, Chung EYL, Gaudio E, et al. (2019) The ETS inhibitors YK-4-279 and TK-216 are novel anti-lymphoma agents. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
| Ma Y, Baltezor M, Rajewski L, et al. (2019) Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis. Journal of Molecular Medicine (Berlin, Germany) |
| Anderson ND, de Borja R, Young MD, et al. (2018) Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors. Science (New York, N.Y.). 361 |
| Tsafou K, Katschnig AM, Radic-Sarikas B, et al. (2018) Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers. Oncotarget. 9: 31018-31031 |
| Tsafou K, Tiwari PB, Forman-Kay JD, et al. (2018) Targeting intrinsically disordered transcription factors: Changing the paradigm. Journal of Molecular Biology |
| Gorthi A, Romero JC, Loranc E, et al. (2018) EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature |