Klaus P. Hoeflich, Ph.D.
Affiliations: | 2001 | University of Toronto, Toronto, ON, Canada |
Area:
Molecular BiologyGoogle:
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Parents
Sign in to add mentor| James R. Woodgett | grad student | 2001 | University of Toronto | |
| (Physiological roles of protein kinases involved in TNF signal transduction.) | ||||
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Publications
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| Dogan T, Gnad F, Chan J, et al. (2017) Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling to the cell cycle. The Journal of Biological Chemistry |
| Kirkpatrick DS, Bustos DJ, Dogan T, et al. (2013) Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition. Proceedings of the National Academy of Sciences of the United States of America. 110: 19426-31 |
| Ong CC, Jubb AM, Zhou W, et al. (2011) p21-activated kinase 1: PAK'ed with potential. Oncotarget. 2: 491-6 |
| Ong CC, Jubb AM, Haverty PM, et al. (2011) Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 7177-82 |
| Hatzivassiliou G, Song K, Yen I, et al. (2010) RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 464: 431-5 |
| Hoeflich K, Ong C, Jubb A, et al. (2010) 343 Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of squamous NSCLC cells European Journal of Cancer Supplements. 8: 109 |
| Hoeflich KP, Herter S, Tien J, et al. (2009) Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Research. 69: 3042-51 |
| Degtyarev M, De Mazière A, Orr C, et al. (2008) Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. The Journal of Cell Biology. 183: 101-16 |
| Hoeflich KP, Eby MT, Forrest WF, et al. (2006) Regulation of ERK3/MAPK6 expression by BRAF. International Journal of Oncology. 29: 839-49 |
| Hoeflich KP, Ikura M. (2004) Radixin: cytoskeletal adopter and signaling protein. The International Journal of Biochemistry & Cell Biology. 36: 2131-6 |