Can E. Senkal, Ph.D.
Affiliations: | 2008 | Medical University of South Carolina, Charleston, SC, United States |
Area:
Biochemistry, Molecular BiologyGoogle:
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Parents
Sign in to add mentor| Besim Ogretmen | grad student | 2008 | MUSC | |
| (Role of ceramide metabolism and signaling in the regulation of head and neck cancer growth and therapy.) | ||||
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| Zhang X, Sakamoto W, Canals D, et al. (2021) Ceramide synthase 2-C -ceramide axis limits the metastatic potential of ovarian cancer cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21287 |
| Gencer S, Oleinik N, Kim J, et al. (2017) TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Science Signaling. 10 |
| Hernández-Corbacho MJ, Canals D, Adada MM, et al. (2015) Tumor Necrosis Factor alpha (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. The Journal of Biological Chemistry |
| Qin Z, Dai L, Trillo-Tinoco J, et al. (2014) Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Molecular Cancer Therapeutics. 13: 154-64 |
| El Osta M, Liu M, Adada M, et al. (2014) Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 495-505 |
| Saddoughi SA, Gencer S, Peterson YK, et al. (2013) Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. Embo Molecular Medicine. 5: 105-21 |
| Qin Z, Dai L, Plaisance-Bonstaff K, et al. (2013) Targeting Sphingosine Kinase Induces Apoptosis and Regression Of Virus-Associated Lymphoma In Vivo Blood. 122: 4414-4414 |
| Sentelle RD, Senkal CE, Jiang W, et al. (2012) Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chemical Biology. 8: 831-8 |
| Meyers-Needham M, Ponnusamy S, Gencer S, et al. (2012) Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. Embo Molecular Medicine. 4: 78-92 |
| Simon GR, Saddoughi S, Mukhopadhyay A, et al. (2011) Targeting I2PP2A by FTY720: A novel, mechanism-based treatment strategy for patients with advanced and previously treated non-small cell lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 7574 |