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Edward P. Chen

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Cyclooxygenase
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"Edward Chen"
Cross-listing: Neurotree - Chemistry Tree

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Emer M. Smyth grad student 2014 Penn (Neurotree)
 (Augmenting anti-tumor immunity by targeting macrophage COX-2 in breast cancer.)

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Markosyan N, Chen EP, Smyth EM. (2014) Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance. Oncoimmunology. 3: e29287
Chen EP, Markosyan N, Connolly E, et al. (2014) Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. Carcinogenesis. 35: 1788-97
Markosyan N, Chen EP, Evans RA, et al. (2013) Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. Breast Cancer Research : Bcr. 15: R75
Chen EP, Smyth EM. (2011) COX-2 and PGE2-dependent immunomodulation in breast cancer. Prostaglandins & Other Lipid Mediators. 96: 14-20
Markosyan N, Chen EP, Ndong VN, et al. (2011) Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis. 32: 1441-9
Boehme SA, Franz-Bacon K, Chen EP, et al. (2009) Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2). International Immunology. 21: 621-32
Boehme SA, Chen EP, Franz-Bacon K, et al. (2009) Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms. International Immunology. 21: 1-17
Boehme SA, Franz-Bacon K, Chen EP, et al. (2009) A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. International Immunology. 21: 81-93
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