Todd Macfarlan, Ph.D.

Affiliations: 
2005 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Cell Biology
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"Todd Macfarlan"
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Debabrata Chakravarti grad student 2005 Penn
 (Identification and initial characterization of thanatos associated protein 7 (THAP7), a putative transcriptional repressor.)
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Publications

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Du C, Jiang J, Li Y, et al. (2023) Regulation of endogenous retrovirus-derived regulatory elements by GATA2/3 and MSX2 in human trophoblast stem cells. Genome Research
Agarwal S, Bonefas KM, Garay PM, et al. (2021) KDM1A maintains genome-wide homeostasis of transcriptional enhancers. Genome Research
Bertozzi TM, Elmer JL, Macfarlan TS, et al. (2020) KRAB zinc finger protein diversification drives mammalian interindividual methylation variability. Proceedings of the National Academy of Sciences of the United States of America. 117: 31290-31300
Kumar J, Kaur G, Ren R, et al. (2020) KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. Nar Cancer. 2: zcaa007
Mahgoub M, Paiano J, Bruno M, et al. (2020) Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice. Elife. 9
Chen C, Sun MA, Warzecha C, et al. (2020) HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis. Cell Reports
Yang F, Huang X, Zang R, et al. (2020) DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell Stem Cell. 26: 234-250.e7
Seah MKY, Wang Y, Goy PV, et al. (2019) The KRAB-Zinc finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons. Development (Cambridge, England)
Patel A, Yang P, Tinkham M, et al. (2018) DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Cell
Yang P, Wang Y, Macfarlan TS. (2017) The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution. Trends in Genetics : Tig
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