Timothy P. Heffernan, Ph.D.
Affiliations: | 2005 | University of North Carolina, Chapel Hill, Chapel Hill, NC |
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Cell BiologyGoogle:
"Timothy Heffernan"Parents
Sign in to add mentorWilliam K. Kaufmann | grad student | 2005 | UNC Chapel Hill | |
(Mechanisms of S checkpoint function in human cells.) |
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Publications
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Ho IL, Li CY, Wang F, et al. (2024) Clonal dominance defines metastatic dissemination in pancreatic cancer. Science Advances. 10: eadd9342 |
Pilie PG, Giuliani V, Wang WL, et al. (2024) Ataxia-Telangiectasia Mutated (ATM) loss of function displays variant and tissue-specific differences across tumor types. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
Perelli L, Zhang L, Mangiameli S, et al. (2023) Evolutionary fingerprints of EMT in pancreatic cancers. Biorxiv : the Preprint Server For Biology |
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) KRAS inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 T cells. Cancer Cell |
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) Oncogenic Kras specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 T cells dependent manner. Biorxiv : the Preprint Server For Biology |
Thatikonda V, Lu H, Jurado S, et al. (2023) Combined KRAS and SOS1 inhibition enhances and extends the anti-tumor response in KRAS -driven cancers by addressing intrinsic and acquired resistance. Biorxiv : the Preprint Server For Biology |
Redwood AB, Zhang X, Seth SB, et al. (2021) The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors. Npj Breast Cancer. 7: 152 |
Evans KW, Yuca E, Scott SS, et al. (2021) Oxidative phosphorylation is a metabolic vulnerability in chemotherapy-resistant triple negative breast cancer. Cancer Research |
Giuliani V, Miller MA, Liu CY, et al. (2021) PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nature Communications. 12: 4626 |
Yan L, Tu B, Yao J, et al. (2021) Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition. Cancer Research |