Timothy P. Heffernan, Ph.D.

Affiliations: 
2005 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Cell Biology
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"Timothy Heffernan"

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William K. Kaufmann grad student 2005 UNC Chapel Hill
 (Mechanisms of S checkpoint function in human cells.)
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Publications

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Ho IL, Li CY, Wang F, et al. (2024) Clonal dominance defines metastatic dissemination in pancreatic cancer. Science Advances. 10: eadd9342
Pilie PG, Giuliani V, Wang WL, et al. (2024) Ataxia-Telangiectasia Mutated (ATM) loss of function displays variant and tissue-specific differences across tumor types. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Perelli L, Zhang L, Mangiameli S, et al. (2023) Evolutionary fingerprints of EMT in pancreatic cancers. Biorxiv : the Preprint Server For Biology
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) KRAS inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 T cells. Cancer Cell
Mahadevan KK, McAndrews KM, LeBleu VS, et al. (2023) Oncogenic Kras specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 T cells dependent manner. Biorxiv : the Preprint Server For Biology
Thatikonda V, Lu H, Jurado S, et al. (2023) Combined KRAS and SOS1 inhibition enhances and extends the anti-tumor response in KRAS -driven cancers by addressing intrinsic and acquired resistance. Biorxiv : the Preprint Server For Biology
Redwood AB, Zhang X, Seth SB, et al. (2021) The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors. Npj Breast Cancer. 7: 152
Evans KW, Yuca E, Scott SS, et al. (2021) Oxidative phosphorylation is a metabolic vulnerability in chemotherapy-resistant triple negative breast cancer. Cancer Research
Giuliani V, Miller MA, Liu CY, et al. (2021) PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nature Communications. 12: 4626
Yan L, Tu B, Yao J, et al. (2021) Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition. Cancer Research
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