Brooke E. Sylvester, Ph.D.

Affiliations: 
2011 Cancer Biology University of Chicago, Chicago, IL 
Area:
Genetics, Molecular Biology, Oncology
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"Brooke Sylvester"

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Olufunmilayo I. Olopade grad student 2011 Chicago
 (Molecular genetics of colorectal cancer progression in a diverse hospital-based study.)
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Publications

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Zhang Y, Doran C, Le TK, et al. (2023) Adverse events and clinical outcomes in patients treated with PD-(L)1 blockade for advanced non-small-cell lung cancer. Future Oncology (London, England)
Alatise OI, Knapp GC, Sharma A, et al. (2021) Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nature Communications. 12: 6821
Hanrahan AJ, Sylvester BE, Chang MT, et al. (2020) Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer. Cancer Research
Gao J, Chang MT, Johnsen HC, et al. (2017) 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets. Genome Medicine. 9: 4
Gao J, Chang MT, Sylvester BE, et al. (2016) Abstract 3606: Identification of oncogenic mutation hotspots via three-dimensional proximity Cancer Research. 76: 3606-3606
Sylvester BE, Vakiani E. (2015) Tumor evolution and intratumor heterogeneity in colorectal carcinoma: insights from comparative genomic profiling of primary tumors and matched metastases. Journal of Gastrointestinal Oncology. 6: 668-75
Diamond EL, Durham BH, Haroche J, et al. (2015) Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms. Cancer Discovery
Grisham RN, Sylvester BE, Won H, et al. (2015) Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Grimm WA, Messer JS, Murphy SF, et al. (2015) The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut
Arcila ME, Drilon A, Sylvester BE, et al. (2015) MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1935-43
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