Juan Carlos Lacal

Affiliations: 
Instituto de Investigaciones Biomédicas "Alberto Sols" 
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"Juan Lacal"
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Publications

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Zimmerman T, Lacal JC, Ibrahim SA. (2019) Choline Kinase Emerges as a Promising Drug Target in Gram-Positive Bacteria. Frontiers in Microbiology. 6: 2146
Valdés-Mora F, Locke WJ, Bandrés E, et al. (2017) Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer. Oncotarget. 8: 26755-26770
Marien E, Meister M, Muley T, et al. (2016) Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma. Oncotarget
Lacal JC, Andera L. (2016) Choline kinase inhibitors synergize with TRAIL in the treatment of colorectal tumors and overcomes TRAIL resistance Cancer Translational Medicine. 2: 163
Estévez-Braun A, Ravelo AG, Pérez-Sacau E, et al. (2015) A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products. Clinical & Translational Oncology. 17: 74-84
Zimmerman T, Moneriz C, Diez A, et al. (2013) Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase. Antimicrobial Agents and Chemotherapy. 57: 5878-88
Cueva Adl, Molina ARd, Álvarez-Ayerza N, et al. (2013) Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts Plos One. 8
Casado-Vela J, Lacal JC, Elortza F. (2013) Protein chimerism: novel source of protein diversity in humans adds complexity to bottom-up proteomics. Proteomics. 13: 5-11
Pintzas A, Zhivotovsky B, Workman P, et al. (2012) Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium. Cancer Biology & Therapy. 13: 458-66
Gallego-Ortega D, Pulgar TGd, Valdés-Mora F, et al. (2011) Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions. Advances in Enzyme Regulation. 51: 183-194
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