Ryan Bruce Corcoran - Publications

Affiliations: 
2006 Stanford University, Palo Alto, CA 

156 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Corcoran RB, Do KT, Kim JE, Cleary JM, Parikh AR, Yeku OO, Xiong N, Weekes CD, Veneris J, Ahronian LG, Mauri G, Tian J, Norden BL, Michel AG, Van Seventer EE, et al. Phase 1/2 study of combined BCL-xL and MEK inhibition with navitoclax and trametinib in KRAS or NRAS mutant advanced solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 38456660 DOI: 10.1158/1078-0432.CCR-23-3135  0.31
2024 Balasooriya ER, Wu Q, Ellis H, Zhen Y, Norden BL, Corcoran RB, Mohan A, Martin E, Franovic A, Tyhonas J, Lardy M, Grandinetti KB, Pelham R, Soroceanu L, Silveira VS, et al. The irreversible FGFR inhibitor KIN-3248 overcomes FGFR2 kinase domain mutations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 38437671 DOI: 10.1158/1078-0432.CCR-23-3588  0.302
2024 Rubinson DA, Tanaka N, Fece de la Cruz F, Kapner KS, Rosenthal MH, Norden BL, Barnes H, Ehnstrom S, Morales-Giron AA, Brais LK, Lemke CT, Aguirre AJ, Corcoran RB. Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers. Cancer Discovery. PMID 38236605 DOI: 10.1158/2159-8290.CD-23-1138  0.359
2023 Varkaris A, Fece de la Cruz F, Martin EE, Norden BL, Chevalier N, Kehlmann AM, Leshchiner I, Barnes H, Ehnstrom S, Stavridi AM, Yuan X, Kim JS, Ellis H, Papatheodoridi A, Gunaydin H, ... ... Corcoran RB, et al. Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations. Cancer Discovery. PMID 37916958 DOI: 10.1158/2159-8290.CD-23-0704  0.343
2023 Tian J, Chen JH, Chao SX, Pelka K, Giannakis M, Hess J, Burke K, Jorgji V, Sindurakar P, Braverman J, Mehta A, Oka T, Huang M, Lieb D, Spurrell M, ... ... Corcoran RB, et al. Combined PD-1, BRAF and MEK inhibition in BRAF colorectal cancer: a phase 2 trial. Nature Medicine. PMID 36702949 DOI: 10.1038/s41591-022-02181-8  0.332
2023 Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, Fu A, Ma X, Gwee J, Tiwari P, Du PP, ... ... Corcoran RB, et al. Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature. PMID 36634707 DOI: 10.1038/s41586-023-05704-6  0.301
2021 Cleary JM, Raghavan S, Wu Q, Li YY, Spurr LF, Gupta HV, Rubinson DA, Fetter IJ, Hornick JL, Nowak JA, Siravegna G, Goyal L, Shi L, Brais LK, Loftus M, ... ... Corcoran RB, et al. FGFR2 Extracellular Domain In-Frame Deletions are Therapeutically Targetable Genomic Alterations that Function as Oncogenic Drivers in Cholangiocarcinoma. Cancer Discovery. PMID 33926920 DOI: 10.1158/2159-8290.CD-20-1669  0.3
2021 Tanaka N, Lin JJ, Li C, Ryan MB, Zhang J, Kiedrowski LA, Michel AG, Syed MU, Fella KA, Sakhi M, Baiev I, Juric D, Gainor JF, Klempner SJ, Lennerz JK, ... ... Corcoran RB, et al. Clinical acquired resistance to KRASG12C inhibition through a novel KRAS switch-II pocket mutation and polyclonal alterations converging on RAS-MAPK reactivation. Cancer Discovery. PMID 33824136 DOI: 10.1158/2159-8290.CD-21-0365  0.356
2020 Chaudhary S, Kwak EL, Hwang KL, Lennerz JK, Corcoran RB, Heist RS, Russo AL, Parikh A, Borger DR, Blaszkowsky LS, Faris JE, Murphy JE, Azzoli CG, Roeland EJ, Goyal L, et al. Revisiting MET: Clinical Characteristics and Treatment Outcomes of Patients with Locally Advanced or Metastatic, MET-Amplified Esophagogastric Cancers. The Oncologist. PMID 32820577 DOI: 10.1634/Theoncologist.2020-0274  0.408
2020 Lin JJ, Langenbucher A, Gupta P, Yoda S, Fetter IJ, Rooney M, Do A, Kem M, Chang KP, Oh AY, Chin E, Juric D, Corcoran RB, Dagogo-Jack I, Gainor JF, et al. Small cell transformation of fusion-positive lung cancer resistant to ROS1 inhibition. Npj Precision Oncology. 4: 21. PMID 32802958 DOI: 10.1038/s41698-020-0127-9  0.308
2020 Dasari A, Morris VK, Allegra CJ, Atreya C, Benson AB, Boland P, Chung K, Copur MS, Corcoran RB, Deming DA, Dwyer A, Diehn M, Eng C, George TJ, Gollub MJ, et al. ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper. Nature Reviews. Clinical Oncology. PMID 32632268 DOI: 10.1038/S41571-020-0392-0  0.401
2020 Jalili P, Bowen D, Langenbucher A, Park S, Aguirre K, Corcoran RB, Fleischman AG, Lawrence MS, Zou L, Buisson R. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nature Communications. 11: 2971. PMID 32532990 DOI: 10.1038/S41467-020-16802-8  0.406
2020 Gumusay O, Vitiello PP, Wabl C, Corcoran RB, Bardelli A, Rugo HS. Strategic Combinations to Prevent and Overcome Resistance to Targeted Therapies in Oncology. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 40: e292-e308. PMID 32453634 DOI: 10.1200/EDBK_280845  0.345
2020 Corcoran RB, Grothey A. Efficacy of Immunotherapy in Microsatellite-Stable or Mismatch Repair Proficient Colorectal Cancer-Fact or Fiction? Jama Oncology. PMID 32379270 DOI: 10.1001/Jamaoncol.2020.0504  0.396
2020 Middleton G, Yang Y, Campbell CD, André T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, ... ... Corcoran RB, et al. BRAF-mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32047001 DOI: 10.1158/1078-0432.Ccr-19-3579  0.465
2020 Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, ... ... Corcoran RB, et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nature Biotechnology. PMID 32042168 DOI: 10.1038/S41587-019-0404-8  0.355
2020 Parikh AR, Mojtahed A, Schneider JL, Kanter K, Van Seventer EE, Fetter IJ, Thabet A, Fish MG, Teshome B, Fosbenner K, Nadres B, Shahzade HA, Allen JN, Blaszkowsky LS, Ryan DP, ... ... Corcoran RB, et al. Serial ctDNA monitoring to predict response to systemic therapy in metastatic gastrointestinal cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31941831 DOI: 10.1158/1078-0432.Ccr-19-3467  0.393
2020 Parikh AR, Fish M, Van Seventer EE, Fosbenner K, Kanter K, Allen JN, Clark JW, Giantonio B, Weekes CD, Klempner SJ, Franses JW, Roeland E, Goyal L, Wo JY, Hong TS, ... ... Corcoran RB, et al. The role of circulating tumor DNA (ctDNA), tumor markers (TMs), and patient-reported outcomes (PROs) in predicting treatment response in patients with metastatic gastrointestinal (GI) cancer. Journal of Clinical Oncology. 38: 833-833. DOI: 10.1200/Jco.2020.38.4_Suppl.833  0.336
2020 Bitterman DS, Price KS, Van Seventer EE, Clark JW, Allen JN, Blaszkowsky LS, Ryan DP, Eyler CE, Wo JY, Hong TS, Nipp RD, Roeland E, Murphy JE, Corcoran RB, Weekes CD, et al. Noninvasive comprehensive genomic profiling from plasma ctDNA in pancreatic cancer patients. Journal of Clinical Oncology. 38: 753-753. DOI: 10.1200/Jco.2020.38.4_Suppl.753  0.377
2020 Hong TS, Goyal L, Parikh AR, Yeap BY, Ulysse CA, Drapek LC, Allen JN, Clark JW, Christopher B, Bolton C, Ryan DP, Corcoran RB, Meyerhardt JA, Wo JY, Zhu AX. A pilot study of durvalumab/tremelimumab (durva/treme) and radiation (XRT) for metastatic biliary tract cancer (mBTC): Preliminary safety and efficacy. Journal of Clinical Oncology. 38: 547-547. DOI: 10.1200/Jco.2020.38.4_Suppl.547  0.347
2020 Bitterman DS, Niemierko A, Van Seventer EE, Kim DW, Qadan M, Blaszkowsky LS, Clark JW, Zhu AX, Goyal L, Keane F, Eyler CE, Parikh AR, Corcoran RB, Wo JY, Hong TS. Clinical and genomic factors associated with outcome following ablative radiotherapy for oligometastatic and oligoprogressive liver tumors. Journal of Clinical Oncology. 38: 515-515. DOI: 10.1200/Jco.2020.38.4_Suppl.515  0.387
2020 Parikh AR, Rajurkar M, Van Seventer EE, Gemma AJ, Allen JN, Blaszkowsky LS, Clark JW, Goyal L, Hong TS, Wo JY, Corcoran RB, Solovyov A, Greenbaum B, Szabolcs A, Tai EC, et al. Phase II study of lamivudine in p53 mutant metastatic colorectal cancer (mCRC). Journal of Clinical Oncology. 38: 149-149. DOI: 10.1200/Jco.2020.38.4_Suppl.149  0.372
2020 Ryan MB, Cruz FFdl, Ahronian LG, Phat S, Myers DT, Shahzade HA, Hong C, Corcoran RB. Abstract B50: ERK MAPK inhibition enhances the immunogenicity of KRAS-mutant colorectal cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-B50  0.498
2020 Corcoran R, Giannakis M, Allen J, Chen J, Pelka K, Chao S, Meyerhardt J, Enzinger A, Enzinger P, McCleary N, Yugelun M, Abrams T, Kanter K, Seventer EV, Bradford W, et al. SO-26 Clinical efficacy of combined BRAF, MEK, and PD-1 inhibition in BRAFV600E colorectal cancer patients Annals of Oncology. 31. DOI: 10.1016/J.Annonc.2020.04.041  0.388
2019 Parikh A, Clark J, Wo J, Yeap B, Allen J, Blaszkowsky L, Ryan D, Giantonio B, Weekes C, Zhu A, Van Seventer E, Ly L, Matlack L, Foreman B, Drapek L, ... ... Corcoran R, et al. Proof of concept of the abscopal effect in MSS GI cancers: A phase 2 study of ipilimumab and nivolumab with radiation in metastatic pancreatic and colorectal adenocarcinoma. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 30: iv128. PMID 32085022 DOI: 10.1093/Annonc/Mdz154.007  0.348
2019 Mauri G, Kanter K, Fish M, Horick N, Allen J, Blaszkowsky L, Clark J, Ryan D, Nipp R, Giantonio B, Goyal L, Dubois J, Murphy J, Roeland E, Weekes C, ... ... Corcoran R, et al. PARP-ness in metastatic colorectal cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 30: iv117. PMID 32084989 DOI: 10.1093/Annonc/Mdz156.021  0.41
2019 Parikh A, Kanter K, Mojtahed A, Schneider J, Van Seventer E, Fish M, Allen J, Blaszkowsky L, Wo J, Clark J, Giantonio B, Goyal L, Hong T, Nipp R, Roeland E, ... ... Corcoran R, et al. Serial circulating tumor DNA (ctDNA) monitoring to predict response to treatment in metastatic gastrointestinal cancers. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 30: iv112. PMID 32084975 DOI: 10.1093/Annonc/Mdz156.007  0.393
2019 Ryan MB, Fece de la Cruz F, Phat S, Myers DT, Wong E, Shahzade HA, Hong CB, Corcoran RB. Vertical pathway inhibition overcomes adaptive feedback resistance to KRASG12C inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31776128 DOI: 10.1158/1078-0432.Ccr-19-3523  0.371
2019 Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin EE, Van Seventer EE, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, ... ... Corcoran RB, et al. Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nature Medicine. PMID 31745334 DOI: 10.1038/S41591-019-0698-6  0.381
2019 Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas V, et al. Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation-positive lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31548343 DOI: 10.1158/1078-0432.Ccr-19-1667  0.458
2019 Yaeger R, Kotani D, Mondaca S, Parikh AR, Bando H, Van Seventer EE, Taniguchi H, Zhao H, Thant CN, de Stanchina E, Rosen N, Corcoran RB, Yoshino T, Yao Z, Ebi H. Response to Anti-EGFR Therapy in Patients with BRAF non-V600-Mutant Metastatic Colorectal Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31515458 DOI: 10.1158/1078-0432.Ccr-19-2004  0.423
2019 Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin EE, Van Seventer EE, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, ... ... Corcoran RB, et al. Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers. Nature Medicine. 25: 1415-1421. PMID 31501609 DOI: 10.1038/S41591-019-0561-9  0.439
2019 Siravegna G, Mussolin B, Venesio T, Marsoni S, Seoane J, Dive C, Papadopoulos N, Kopetz S, Corcoran RB, Siu LL, Bardelli A. How liquid biopsies can change clinical practice in oncology. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 31373349 DOI: 10.1093/Annonc/Mdz227  0.355
2019 Kamran SC, Lennerz JK, Margolis CA, Liu D, Reardon B, Wankowicz SA, Van Seventer EE, Tracy A, Wo JY, Carter SL, Willers H, Corcoran RB, Hong TS, Van Allen EM. Integrative molecular characterization of resistance to neoadjuvant chemoradiation in rectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31253631 DOI: 10.1158/1078-0432.Ccr-19-0908  0.359
2019 Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, Ferrone CR, Parikh AR, Weekes CD, Nipp RD, Kwak EL, ... ... Corcoran RB, et al. Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. Jama Oncology. PMID 31145418 DOI: 10.1001/Jamaoncol.2019.0892  0.385
2019 Goyal L, Shi L, Liu LY, Fece de la Cruz F, Lennerz JK, Raghavan S, Leshchiner I, Elagina L, Siravegna G, Ng RWS, Vu P, Patra KC, Saha SK, Uppot RN, Arellano R, ... ... Corcoran RB, et al. TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma. Cancer Discovery. PMID 31109923 DOI: 10.1158/2159-8290.Cd-19-0182  0.424
2019 Lieu CH, Corcoran RB, Overman MJ. Integrating Biomarkers and Targeted Therapy Into Colorectal Cancer Management. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 39: 207-215. PMID 31099678 DOI: 10.1200/EDBK_240839  0.31
2019 Parikh AR, He Y, Hong TS, Corcoran RB, Clark JW, Ryan DP, Zou L, Ting DT, Catenacci DV, Chao J, Fakih M, Klempner SJ, Ross JS, Frampton GM, Miller VA, et al. Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. The Oncologist. PMID 31040255 DOI: 10.1634/Theoncologist.2019-0034  0.439
2019 Yaeger R, Corcoran RB. Targeting Alterations in the RAF-MEK Pathway. Cancer Discovery. PMID 30770389 DOI: 10.1158/2159-8290.Cd-18-1321  0.43
2019 Corcoran RB, Chabner BA. Cell-free DNA Analysis in Cancer. The New England Journal of Medicine. 380: 501-502. PMID 30699310 DOI: 10.1056/Nejmc1816154  0.347
2019 Fece de la Cruz F, Corcoran RB. Methylation in cell-free DNA for early cancer detection. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 29: 1351-1353. PMID 29668834 DOI: 10.1093/Annonc/Mdy134  0.321
2019 Kotani D, Mondaca S, Parikh A, Bando H, Van Seventer E, Taniguchi H, Yoshino T, Corcoran RB, Yaeger R, Ebi H. Clinicopathological features, efficacy of anti-EGFR therapy, and survival outcomes in patients with BRAF non-V600 mutated metastatic colorectal cancer. Journal of Clinical Oncology. 37: 659-659. DOI: 10.1200/Jco.2019.37.4_Suppl.659  0.395
2019 Raghav KPS, Yaeger R, Loree JM, Dasari A, Morris VK, Kee BK, Raymond VM, Nagy RJ, Lanman RB, Strickler JH, Corcoran RB, Overman MJ, Kopetz S. Comprehensive landscape of gene amplifications (amps) in tissue and circulating tumor DNA (ctDNA) in metastatic colorectal cancer (mCRC). Journal of Clinical Oncology. 37: 604-604. DOI: 10.1200/Jco.2019.37.4_Suppl.604  0.416
2019 Henry J, Loree JM, Strickler JH, Raghav KPS, Morris VK, Raymond VM, Lanman RB, Yaeger R, Corcoran RB, Overman MJ, Kopetz S. Quantifying the evolution of tumor architecture using serial circulating tumor DNA. Journal of Clinical Oncology. 37: 600-600. DOI: 10.1200/Jco.2019.37.4_Suppl.600  0.401
2019 McDuff SG, Hardiman K, Parikh AR, Ulintz P, Hazar-Rethinam M, Zheng H, Van Seventer E, Fetter I, Nadres B, Ryan DP, Weekes CD, Clark JW, Cusack JC, Goyal L, Zhu AX, ... ... Corcoran RB, et al. Using circulating tumor DNA (ctDNA) to predict surgical outcome and postoperative recurrence following neoadjuvant chemoradiation (CRT) for borderline resectable/locally advanced rectal cancer (LARC). Journal of Clinical Oncology. 37: 562-562. DOI: 10.1200/Jco.2019.37.4_Suppl.562  0.339
2019 Parikh A, Wo JY, Ryan DP, Clark JW, Nipp RD, Blaszkowsky LS, Weekes CD, Van Seventer E, Ly L, Foreman B, Corcoran RB, Hong TS. A phase II study of ipilimumab and nivolumab with radiation in metastatic pancreatic adenocarcinoma. Journal of Clinical Oncology. 37: 391-391. DOI: 10.1200/Jco.2019.37.4_Suppl.391  0.32
2019 Wo JY, Clark JW, Allen JN, Blaszkowsky LS, Keane F, Drapek LC, Ryan DP, Corcoran RB, Roeland E, Parikh AR, Khandekar MJ, Heist RS, Morse C, Yeap BY, Ulysse CA, et al. A pilot study of neoadjuvant FOLFIRINOX followed by chemoradiation for gastric and gastroesophageal cancer: Preliminary results. Journal of Clinical Oncology. 37: 4057-4057. DOI: 10.1200/Jco.2019.37.15_Suppl.4057  0.317
2019 Parikh AR, Van Seventer EE, Boland GM, Hartwig A, Jaimovich A, Raymond VM, Talasaz A, Corcoran RB. A plasma-only integrated genomic and epigenomic circulating tumor DNA (ctDNA) assay to inform recurrence risk in colorectal cancer (CRC). Journal of Clinical Oncology. 37: 3602-3602. DOI: 10.1200/Jco.2019.37.15_Suppl.3602  0.332
2019 Fish M, Kanter K, Mauri G, Horick N, Allen JN, Blaszkowsky LS, Clark JW, Ryan DP, Nipp RD, Giantonio BJ, Goyal L, Murphy JE, Roeland E, Weekes CD, Wo JY, ... ... Corcoran RB, et al. Aggressiveness of care and overall survival in young metastatic colorectal cancer patients. Journal of Clinical Oncology. 37: 3563-3563. DOI: 10.1200/Jco.2019.37.15_Suppl.3563  0.349
2019 Parikh AR, Clark JW, Wo JY, Yeap BY, Allen JN, Blaszkowsky LS, Ryan DP, Giantonio BJ, Weekes CD, Zhu AX, Van Seventer EE, Matlack L, Foreman B, Ly L, Drapek LC, ... ... Corcoran RB, et al. A phase II study of ipilimumab and nivolumab with radiation in microsatellite stable (MSS) metastatic colorectal adenocarcinoma (mCRC). Journal of Clinical Oncology. 37: 3514-3514. DOI: 10.1200/Jco.2019.37.15_Suppl.3514  0.322
2019 Hartwig A, Artieri C, Jaimovich A, Van Seventer EE, Parikh AR, Corcoran RB, Baca A, Talasaz A. Analytical validation of a tumor-agnostic integrated multianalyte circulating tumor DNA (ctDNA) assay in early-stage cancer. Journal of Clinical Oncology. 37: 3057-3057. DOI: 10.1200/Jco.2019.37.15_Suppl.3057  0.393
2019 Parikh AR, Leshchiner I, Elagina L, Goyal L, Levovitz C, Siravegna G, Livitz D, Rhrissorrakrai K, Martin L, Seventer EEV, Hanna M, Slowik K, Utro F, Pinto CJ, Wong A, ... ... Corcoran RB, et al. Abstract LB-257: Liquid biopsy versus tissue biopsy to assess acquired resistance and tumor heterogeneity in gastrointestinal cancers Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Lb-257  0.389
2019 Maruvka YE, Frazer R, Grimsby J, Cibulskis C, Adalsteinsson V, Corcoran R, Getz G. Abstract 2677: MSIClass–Identification and classification of microsatellite unstable using cell-free DNA from ultra-low-pass sequencing Cancer Research. 79: 2677-2677. DOI: 10.1158/1538-7445.Am2019-2677  0.365
2019 Ryan MB, Cruz FFdl, Phat S, Myers DT, Shahzade HA, Hong CB, Corcoran RB. Abstract A129: Vertical inhibition overcomes adaptive resistance to KRASG12C inhibition Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-A129  0.44
2019 Maruvka YE, Frazer R, Grimsby J, Seventer EEV, Cibulskis C, Adalsteinsson V, Corcoran R, Getz G. Abstract A094: MSIClass - Identification and classification of microsatellite unstable tumors using cell-free DNA from ultra low pass sequencing Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-A094  0.363
2019 Corcoran R, Do K, Cleary J, Parikh A, Yeku O, Weekes C, Veneris J, Ahronian L, Mauri G, Van Seventer E, Fetter I, Gurski J, Matulonis U, Juric D, Flaherty K, et al. Phase I/II study of combined BCL-XL and MEK inhibition with navitoclax (N) and trametinib (T) in KRAS or NRAS mutant advanced solid tumours Annals of Oncology. 30: v164. DOI: 10.1093/Annonc/Mdz244.009  0.394
2019 Parikh A, Seventer EV, Boland G, Hartwig A, Jaimovich A, Raymond V, Talasaz A, Corcoran R. Serial assessment of cell-free circulating tumor DNA (ctDNA) to assess treatment effect and minimal residual disease during neoadjuvant and adjuvant therapy in colorectal cancer Annals of Oncology. 30. DOI: 10.1093/Annonc/Mdz154.015  0.407
2019 Wo JY, Clark JW, Roeland E, Parikh AS, Corcoran R, Ryan DP, Drapek LC, Keane FK, Khandekar MJ, Baglini C, Allen JN, Heist R, Lanuti M, Morse CR, Seventer EV, et al. A Pilot Study of Neoadjuvant FOLFIRINOX followed by Chemoradiation for Gastric and Gastroesophageal Cancer: Preliminary Results and Prognostic Implications of ctDNA International Journal of Radiation Oncology Biology Physics. 105. DOI: 10.1016/J.Ijrobp.2019.06.554  0.325
2018 Parseghian CM, Loree JM, Morris VK, Liu X, Clifton KK, Napolitano S, Henry JT, Pereira AA, Vilar E, Johnson B, Kee B, Raghav K, Dasari A, Wu J, Garg N, ... ... Corcoran RB, et al. Anti-EGFR Resistant Clones Decay Exponentially After Progression: Implications for Anti-EGFR Re-challenge. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 30462160 DOI: 10.1093/Annonc/Mdy509  0.391
2018 Corcoran RB, Chabner BA. Application of Cell-free DNA Analysis to Cancer Treatment. The New England Journal of Medicine. 379: 1754-1765. PMID 30380390 DOI: 10.1097/01.Ogx.0000554379.46945.9E  0.393
2018 Mitra D, Clark JW, Shih HA, Oh KS, Brastianos PK, Wo JY, Strickland MR, Curry WT, Parikh AR, Corcoran RB, Ryan DP, Iafrate AJ, Borger DR, Lennerz JK, Hong TS. Enrichment of Amplification in Brain Metastases from Primary Gastrointestinal Malignancies. The Oncologist. PMID 30373904 DOI: 10.1634/Theoncologist.2018-0152  0.352
2018 Siravegna G, Corcoran RB. Blood-Based Prediction of Tumor Relapse: The cfDNA Forecast. Cancer Discovery. 8: 1213-1215. PMID 30279194 DOI: 10.1158/2159-8290.Cd-18-0952  0.42
2018 Ryan MB, Corcoran RB. Therapeutic strategies to target RAS-mutant cancers. Nature Reviews. Clinical Oncology. PMID 30275515 DOI: 10.1038/S41571-018-0105-0  0.342
2018 Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, ... ... Corcoran RB, et al. Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine. Cancer Discovery. PMID 29903880 DOI: 10.1158/2159-8290.Cd-18-0275  0.371
2018 Kamran SC, Clark JW, Zheng H, Borger DR, Blaszkowsky LS, Allen JN, Kwak EL, Wo JY, Parikh AR, Nipp RD, Murphy JE, Goyal L, Zhu AX, Iafrate AJ, Corcoran RB, et al. Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis. Cancer Medicine. PMID 29771009 DOI: 10.1002/Cam4.1558  0.416
2018 Mooradian MJ, Reuben A, Prieto PA, Hazar-Rethinam M, Frederick DT, Nadres B, Piris A, Juneja V, Cooper ZA, Sharpe AH, Corcoran RB, Flaherty KT, Lawrence DP, Wargo JA, Sullivan RJ. A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma. Oncoimmunology. 7: e1423172. PMID 29721378 DOI: 10.1080/2162402X.2017.1423172  0.372
2018 Corcoran RB, Andre T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Middleton G, Muro K, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, et al. Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer. Cancer Discovery. PMID 29431699 DOI: 10.1158/2159-8290.Cd-17-1226  0.449
2018 Hazar-Rethinam M, Kleyman M, Han GC, Liu D, Ahronian LG, Shahzade HA, Chen L, Parikh AR, Allen JN, Clark JW, Kwak EL, Faris JE, Murphy JE, Hong TS, Van Seventer EE, ... ... Corcoran RB, et al. Convergent therapeutic strategies to overcome the heterogeneity of acquired resistance in BRAFV600E colorectal cancer. Cancer Discovery. PMID 29431697 DOI: 10.1158/2159-8290.Cd-17-1227  0.466
2018 Hong TS, Hwang KL, Clark JW, Lennerz JK, Shui A, Zheng H, Szymonifka J, Corcoran RB, Heist RS, Russo AL, Parikh AR, Borger DR, Blaszkowsky LS, Faris JE, Murphy JE, et al. MET-amplification (MET-amp) in relation to aggressive biology in esophagogastric cancer (EGC): An analysis of clinical outcomes of MET-amp vs non-MET-amp EGC. Journal of Clinical Oncology. 36: 74-74. DOI: 10.1200/Jco.2018.36.4_Suppl.74  0.44
2018 Kamran SC, Lennerz JK, Margolis C, Liu D, Reardon B, Wankowicz SA, Wo JY, Willers H, Corcoran RB, Van Allen EM, Hong TS. Genomic evolution and acquired resistance to preoperative chemoradiation therapy (CRT) in rectal cancer. Journal of Clinical Oncology. 36: 613-613. DOI: 10.1200/Jco.2018.36.4_Suppl.613  0.445
2018 Mitra D, Shih HA, Oh K, Brastianos P, Wo JY, Curry W, Clark JW, Parikh A, Corcoran RB, Ryan DP, Lennerz JK, Hong TS. HER2 positivity in brain metastases from gastrointestinal primary malignancies. Journal of Clinical Oncology. 36: 61-61. DOI: 10.1200/Jco.2018.36.4_Suppl.61  0.431
2018 Parikh AR, He Y, Hong TS, Corcoran RB, Clark JW, Ryan DP, Catenacci DV, Chao J, Fakih M, Ross JS, Stephens PJ, Miller VA, Ali SM, Schrock AB. Analysis of DNA damage response (DDR) genes and tumor mutational burden (TMB) across 17,486 carcinomas of the tubular GI tract: Implications for therapy. Journal of Clinical Oncology. 36: 43-43. DOI: 10.1200/Jco.2018.36.4_Suppl.43  0.417
2018 McDuff S, Parikh AR, Hazar-Rethinam M, Zheng H, Van Seventer E, Nadres B, Ryan DP, Weekes CD, Clark JW, Fernandez-del Castillo C, Ferrone C, Lillemoe KD, Murphy JE, Goyal L, Zhu AX, ... ... Corcoran RB, et al. Using circulating tumor DNA (ctDNA) to predict surgical outcome after neoadjuvant chemoradiation for locally advanced pancreatic cancer (LAPC). Journal of Clinical Oncology. 36: 272-272. DOI: 10.1200/Jco.2018.36.4_Suppl.272  0.313
2018 Clifton K, Raymond VM, Dasari A, Raghav KPS, Parseghian CM, Pereira AAL, Loree JM, Yaeger R, Strickler JH, Corcoran RB, Lanman RB, Kopetz S, Morris VK. Actionable fusions in colorectal cancer using a cell-free circulating tumor DNA (ctDNA) assay. Journal of Clinical Oncology. 36: 3507-3507. DOI: 10.1200/Jco.2018.36.15_Suppl.3507  0.395
2018 Medford A, Niemierko A, Moy B, Spring L, Malvarosa G, Younger J, Lanman RB, Nagy RJ, Corcoran RB, Isakoff SJ, Ellisen LW, Juric D, Bardia A. Molecular alterations in the Ras-Raf-Erk (MAPK) pathway in metastatic hormone receptor positive (HR+)/HER2- breast cancer: Incidence and impact on clinical outcomes. Journal of Clinical Oncology. 36: 1021-1021. DOI: 10.1200/Jco.2018.36.15_Suppl.1021  0.433
2018 Shi A, Cintolo-Gonzalez JA, Chien I, Frederick DT, Alpatov R, Michaud W, Plana D, Panka D, Corcoran R, Flaherty K, Sullivan R, Kellis M, Boland G. Abstract B25: Exosomal transcriptomic signatures tracks and predicts response to checkpoint blockade immunotherapy Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-B25  0.357
2018 Corcoran RB. Abstract IA15: Overcoming drug resistance and tumor heterogeneity in gastrointestinal cancers Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Tcm17-Ia15  0.513
2018 Goyal L, Liu LY, Lennerz JK, Harding JJ, Huang J, Winkler R, Hiroshi H, Ting DT, Juric D, Corcoran RB, El-Bardeesy N, Zhu AX. Abstract LB-092: TAS120, a covalently-binding FGFR inhibitor (FGFRi), overcomes resistance to BGJ398 in patients with FGFR2 fusion positive cholangiocarcinoma Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-092  0.464
2018 Shi A, Kasumova G, Chien I, Cintolo-Gonzalez J, Frederick DT, Alpatov R, Michaud WA, Plana D, Corcoran R, Flaherty K, Sullivan R, Kellis M, Boland G. Abstract 4282: Deconvolution of plasma-derived exosomes for tracking and prediction of immunotherapy across multiple tissues Cancer Research. 78: 4282-4282. DOI: 10.1158/1538-7445.Am2018-4282  0.342
2018 Hazar-Rethinam M, Kleyman M, Han GC, Liu D, Ahronian LG, Shahzade HA, Chen L, Parikh AR, Allen JN, Clark JW, Kwak EL, Faris JE, Murphy JE, Hong TS, Seventer EEV, ... ... Corcoran RB, et al. Abstract LB-A34: Modeling convergent therapeutic strategies to overcome the heterogeneity of acquired resistance in BRAF-mutant colorectal cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-Lb-A34  0.483
2018 Goyal L, Kelley RK, Kiedrowski L, Catenacci D, Mody K, Shroff R, Parikh A, Reyes S, Maurer JR, Corcoran RB, Fanta P, Cusnir M, Nagy B, Lanman R, Morse M, et al. Abstract A183: Blood-based genomic profiling of cell-free tumor DNA (ctDNA) in patients with biliary tract cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A183  0.495
2018 McDuff S, Parikh A, Hazar-Rethinam M, Zheng H, Van Seventer E, Nadres B, Lennerz J, Ryan D, Weekes C, Clark J, Casti CF, Ferrone C, Lillemoe K, Goyal L, Zhu A, ... ... Corcoran R, et al. Circulating Tumor DNA to Predict Surgical Outcome after Neoadjuvant Chemoradiation for Borderline Resectable/Locally Advanced Pancreatic Cancer International Journal of Radiation Oncology*Biology*Physics. 102: S134. DOI: 10.1016/J.Ijrobp.2018.06.330  0.355
2017 Parikh A, Goyal L, Hazar-Rethinam M, Siravegna G, Blaszkowsky L, Russo M, Van Seventer E, Nadres B, Shahzade H, Clark J, Allen J, John IA, Ryan DP, Murphy J, Bardelli A, ... ... Corcoran R, et al. Systematic liquid biopsy identifies novel and heterogeneous mechanisms of acquired resistance in gastrointestinal (GI) cancer patients. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 28: iii137. PMID 32135760 DOI: 10.1093/Annonc/Mdx262  0.406
2017 Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, ... Corcoran RB, et al. Genomic landscape of cell-free DNA in patients with colorectal cancer. Cancer Discovery. PMID 29196463 DOI: 10.1158/2159-8290.Cd-17-1009  0.472
2017 Sade-Feldman M, Jiao YJ, Chen JH, Rooney MS, Barzily-Rokni M, Eliane JP, Bjorgaard SL, Hammond MR, Vitzthum H, Blackmon SM, Frederick DT, Hazar-Rethinam M, Nadres BA, Van Seventer EE, Shukla SA, ... ... Corcoran RB, et al. Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Nature Communications. 8: 1136. PMID 29070816 DOI: 10.1038/S41467-017-01062-W  0.396
2017 Parikh AR, Corcoran RB. Fast-TRKing Drug Development for Rare Molecular Targets. Cancer Discovery. 7: 934-936. PMID 28864638 DOI: 10.1158/2159-8290.Cd-17-0704  0.394
2017 Piotrowska Z, Stirling K, Heist R, Campo M, Rizzo C, Digumarthy SR, Lanuti M, Fintelmann FJ, Lennes I, Farago A, Gainor J, Azzoli CG, Temel J, Mino-Kenudson M, Dias-Santagata D, ... Corcoran R, et al. Heterogeneity and Variation in Resistance Mechanisms Among 223 Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer Patients With > 1 Post-Resistance Biopsy. International Journal of Radiation Oncology, Biology, Physics. 98: 220. PMID 28586967 DOI: 10.1016/J.Ijrobp.2017.01.037  0.388
2017 Ahronian LG, Corcoran RB. Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy. Genome Medicine. 9: 37. PMID 28431544 DOI: 10.1186/S13073-017-0431-3  0.46
2017 Strickler JH, Banks KC, Nagy RJ, Lanman RB, Talasaz A, Corcoran RB, Kopetz S. Blood-based genomic profiling of circulating cell-free tumor DNA (ctDNA) in 1397 patients (pts) with colorectal cancer (CRC). Journal of Clinical Oncology. 35: 584-584. DOI: 10.1200/Jco.2017.35.4_Suppl.584  0.422
2017 Corcoran RB. Abstract IA23: Overcoming drug resistance and tumor heterogeneity in gastrointestinal cancers Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-Ia23  0.513
2017 Goyal L, Saha SK, Liu LY, Siravegna G, Leshchiner I, Ahronian LG, Lennerz JK, Vu P, Mussolin B, Reyes S, Furet P, Iafrate AJ, Getz G, Porta DG, Tiedt R, ... ... Corcoran RB, et al. Abstract 4114: Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in FGFR2 fusion-positive cholangiocarcinoma patients Cancer Research. 77: 4114-4114. DOI: 10.1158/1538-7445.Am2017-4114  0.495
2017 Ahronian LG, Misale S, Godfrey JT, Nishimura K, Chen L, Engelman JA, Corcoran RB. Abstract 101: Adaptive feedback reactivates MAPK signaling in KRAS-mutant cancers with inhibition of MEK, but not ERK Cancer Research. 77: 101-101. DOI: 10.1158/1538-7445.Am2017-101  0.454
2017 Piotrowska Z, Stirling K, Heist R, Mooradian M, Rizzo C, Digumarthy S, Lanuti M, Fintelmann F, Lennes I, Farago A, Gainor J, Azzoli C, Temel J, Mino-Kenudson M, Dias-Santagata D, ... Corcoran R, et al. OA 07.05 Serial Biopsies in Patients with EGFR-Mutant NSCLC Highlight the Spatial and Temporal Heterogeneity of Resistance Mechanisms Journal of Thoracic Oncology. 12: S1762. DOI: 10.1016/J.Jtho.2017.09.364  0.346
2017 Kamran S, Lennerz J, Reardon B, Mullane S, Wo J, Willers H, Corcoran R, Van Allen E, Hong T. Genomic Evolution and Acquired Resistance to Pre-Operative Chemoradiation Therapy in Locally Advanced Rectal Cancer International Journal of Radiation Oncology*Biology*Physics. 99: S22-S23. DOI: 10.1016/J.Ijrobp.2017.06.065  0.366
2016 Goyal L, Saha SK, Liu LY, Siravegna G, Leshchiner I, Ahronian LG, Lennerz JK, Vu P, Deshpande V, Kambadakone A, Mussolin B, Reyes S, Henderson L, Sun JE, Van Seventer EE, ... ... Corcoran RB, et al. Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma. Cancer Discovery. PMID 28034880 DOI: 10.1158/2159-8290.Cd-16-1000  0.485
2016 Manchado E, Weissmueller S, Morris JP, Chen CC, Wullenkord R, Lujambio A, de Stanchina E, Poirier JT, Gainor JF, Corcoran RB, Engelman JA, Rudin CM, Rosen N, Lowe SW. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. PMID 27338794 DOI: 10.1038/Nature18600  0.468
2016 Oddo D, Sennott EM, Barault L, Valtorta E, Arena S, Cassingena A, Filiciotto G, Marzolla G, Elez E, van Geel RM, Bartolini A, Crisafulli G, Boscaro V, Godfrey JT, Buscarino M, ... ... Corcoran RB, et al. Molecular landscape of acquired resistance to targeted therapy combinations in BRAF mutant colorectal cancer. Cancer Research. PMID 27312529 DOI: 10.1158/0008-5472.Can-16-0396  0.475
2016 Ahronian LG, Corcoran RB. Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations. Molecular & Cellular Oncology. 3: e1048405. PMID 27308562 DOI: 10.1080/23723556.2015.1048405  0.507
2016 Bernstein BE, Gray N, Boyd MR, Corcoran RB, Stone RM, Armand P, Sykes DB, Gopal R, Gala MK, Liu D, Tothova Z, Nodelman O, Maus MV, Wu CJ. Chabner Colloquium: Answering the Big Questions in Cancer Research & 2016 STO Annual Meeting Oncologist. 21. DOI: 10.1634/Theoncologist.2016-Ma-1  0.328
2016 Kamran SC, Clark JW, Borger DR, Szymonifka J, Kwak EL, Blaszkowsky LS, Murphy JE, Goyal L, Allen JN, Wo JY, Zhu AX, Iafrate AJ, Corcoran RB, Ryan DP, Hong TS. Clinical correlation with codon-specific mutations in metastatic colorectal cancer. Journal of Clinical Oncology. 34: 3596-3596. DOI: 10.1200/Jco.2016.34.15_Suppl.3596  0.425
2016 Russo M, Siravegna G, Blaszkowsky LS, Corti G, Crisafulli G, Ahronian LG, Mussolin B, Kwak EL, Buscarino M, Lazzari L, Valtorta E, Truini M, Jessop NA, Robinson HE, Hong TS, ... ... Corcoran RB, et al. Abstract 878: Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer Cancer Research. 76: 878-878. DOI: 10.1158/1538-7445.Am2016-878  0.521
2016 Corcoran R, André T, Yoshino T, Bendell J, Atreya C, Schellens J, Ducreux M, McRee A, Siena S, Middleton G, Gordon M, Humblet Y, Muro K, Elez E, Yaeger R, et al. Efficacy and circulating tumor DNA (ctDNA) analysis of the BRAF inhibitor dabrafenib (D), MEK inhibitor trametinib (T), and anti-EGFR antibody panitumumab (P) in patients (pts) with BRAF V600E–mutated (BRAFm) metastatic colorectal cancer (mCRC) Annals of Oncology. 27: vi150. DOI: 10.1093/Annonc/Mdw370.04  0.438
2016 Parikh A, Kwak E, Goyal L, Blaszkowsky L, Hazar-Rethinam M, Siravegna G, Russo M, Van Seventer E, Nadres B, Shahzade H, Clark J, Allen J, Iafrate A, Bardellli A, Ryan D, ... ... Corcoran R, et al. A systematic liquid biopsy program identifies novel and heterogeneous mechanisms of acquired resistance in gastrointestinal (GI) cancer patients European Journal of Cancer. 69: S3. DOI: 10.1016/S0959-8049(16)32610-7  0.378
2015 Corcoran RB. New therapeutic strategies for BRAF mutant colorectal cancers. Journal of Gastrointestinal Oncology. 6: 650-9. PMID 26697198 DOI: 10.3978/J.Issn.2078-6891.2015.076  0.456
2015 Russo M, Siravegna G, Blaszkowsky LS, Corti G, Crisafulli G, Ahronian LG, Mussolin B, Kwak EL, Buscarino M, Lazzari L, Valtorta E, Truini M, Jessop NA, Robinson HE, Hong TS, ... ... Corcoran RB, et al. Tumor heterogeneity and lesion-specific response to targeted therapy in colorectal cancer. Cancer Discovery. PMID 26644315 DOI: 10.1158/2159-8290.Cd-15-1283  0.474
2015 Kwak EL, Ahronian LG, Siravegna G, Mussolin B, Godfrey JT, Clark JW, Blaszkowsky LS, Ryan DP, Lennerz JK, Iafrate AJ, Bardelli A, Hong TS, Corcoran RB. Molecular heterogeneity and receptor co-amplification drive resistance to targeted therapy in MET-amplified esophagogastric cancer. Cancer Discovery. PMID 26432108 DOI: 10.1158/2159-8290.Cd-15-0748  0.485
2015 Corcoran RB, Atreya CE, Falchook GS, Kwak EL, Ryan DP, Bendell JC, Hamid O, Messersmith WA, Daud A, Kurzrock R, Pierobon M, Sun P, Cunningham E, Little S, Orford K, et al. Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 26392102 DOI: 10.1200/Jco.2015.63.2471  0.446
2015 Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Ponzetti A, Cremolini C, Amatu A, Lauricella C, Lamba S, Hobor S, Avallone A, Valtorta E, Rospo G, ... ... Corcoran RB, et al. Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nature Medicine. 21: 827. PMID 26151329 DOI: 10.1038/nm0715-827b  0.325
2015 Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Ponzetti A, Cremolini C, Amatu A, Lauricella C, Lamba S, Hobor S, Avallone A, Valtorta E, Rospo G, ... ... Corcoran RB, et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nature Medicine. PMID 26030179 DOI: 10.1038/Nm.3870  0.455
2015 Ahronian LG, Sennott EM, Van Allen EM, Wagle N, Kwak EL, Faris JE, Godfrey JT, Nishimura K, Lynch KD, Mermel CH, Lockerman EL, Kalsy A, Gurski JM, Bahl S, Anderka K, ... ... Corcoran RB, et al. Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations. Cancer Discovery. 5: 358-67. PMID 25673644 DOI: 10.1158/2159-8290.Cd-14-1518  0.53
2015 Atreya CE, Corcoran RB, Kopetz S. Expanded RAS: refining the patient population. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 682-5. PMID 25584005 DOI: 10.1200/Jco.2014.58.9325  0.435
2015 Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Deshpande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes C, Engelman JA, Bardeesy N. Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 396-404. PMID 25348516 DOI: 10.1158/1078-0432.Ccr-14-1591  0.395
2015 Kwak EL, Lennerz JK, Szymonifka J, Corcoran RB, Clark JW, Russo AL, Borger DR, Blaszkowsky LS, Dias LE, Faris JE, Murphy JE, Fidias P, Lennes IT, Azzoli CG, Gainor JF, et al. Clinical characteristics and treatment outcomes of patients with metastatic, MET-amplified esophagogastric cancers. Journal of Clinical Oncology. 33: 4043-4043. DOI: 10.1200/Jco.2015.33.15_Suppl.4043  0.408
2015 Siravegna G, Mussolin B, Buscarino M, Corti G, Crisafulli G, Ponzetti A, Cremolini C, Lamba S, Avallone A, Rospo G, Veronese S, Budillon A, Montagut C, Racca P, Corcoran RB, et al. Raise and decline of KRAS mutant clones in colorectal cancers (CRCs) treated with multiple rounds of anti-EGFR antibodies. Journal of Clinical Oncology. 33: 11073-11073. DOI: 10.1200/Jco.2015.33.15_Suppl.11073  0.403
2015 Atreya CE, Van Cutsem E, Bendell JC, Andre T, Schellens JHM, Gordon MS, McRee AJ, O'Dwyer PJ, Muro K, Tabernero J, van Geel R, Sidhu R, Greger JG, Rangwala FA, Motwani M, ... ... Corcoran RB, et al. Updated efficacy of the MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitumumab (P) in patients (pts) with BRAF V600E mutated (BRAFm) metastatic colorectal cancer (mCRC). Journal of Clinical Oncology. 33: 103-103. DOI: 10.1200/Jco.2015.33.15_Suppl.103  0.444
2015 Corcoran RB, Ahronian LG, Allen EV, Coffee EM, Wagle N, Kwak EL, Faris JE, Iafrate AJ, Garraway LA, Engelman JA. Abstract NG04: Clinical acquired resistance to RAF inhibitor combinations in BRAF mutant colorectal cancer through MAPK pathway alterations Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng04  0.512
2015 Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Corcoran RB, Ponzetti A, Budillon A, Racca P, Marsoni S, Nicolantonio FD, Loupakis F, Siena S, Bianchi AS, et al. Abstract 616: Blood-based molecular landscapes of resistance to EGFR blockade in colorectal cancer patients Cancer Research. 75: 616-616. DOI: 10.1158/1538-7445.Am2015-616  0.428
2015 Siravegna G, Russo M, Blaszkowsky LS, Corti G, Crisafulli G, Ahronian LG, Mussolin B, Kwak EL, Buscarino M, Lazzari L, Valtorta E, Truini M, Jessop NA, Robinson HE, Hong TS, ... ... Corcoran RB, et al. Abstract PR01: Acquisition of resistance to anti-EGFR therapy drives genomic heterogeneity and lesion-specific responses in colorectal cancer Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Pr01  0.513
2015 Van Cutsem E, Atreya C, André T, Bendell J, Schellens J, Gordon M, McRee A, Yoshino T, Muro K, ODwyer P, Tabernero J, Middleton G, Ducreux M, van Geel R, Sidhu R, ... ... Corcoran R, et al. LBA-07 Updated Results of the MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitumumab (P) in patients (pts) with BRAF V600E mutated (BRAFm) metastatic colorectal cancer (mCRC) Annals of Oncology. 26: iv119. DOI: 10.1093/Annonc/Mdv262.07  0.428
2014 Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, ... ... Corcoran RB, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discovery. 4: 452-65. PMID 24444711 DOI: 10.1158/2159-8290.Cd-13-0646  0.41
2014 Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, ... Corcoran RB, et al. mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Cancer Discovery. 4: 42-52. PMID 24163374 DOI: 10.1158/2159-8290.Cd-13-0315  0.493
2014 Corcoran RB, Atreya CE, Falchook GS, Infante JR, Hamid O, Messersmith WA, Daud A, Kwak EL, Ryan D, Kurzrock R, Sun P, Cunningham EA, Orford KW, Motwani M, Bai Y, et al. Phase 1-2 trial of the BRAF inhibitor dabrafenib (D) plus MEK inhibitor trametinib (T) in BRAF V600 mutant colorectal cancer (CRC): Updated efficacy and biomarker analysis. Journal of Clinical Oncology. 32: 3517-3517. DOI: 10.1200/Jco.2014.32.15_Suppl.3517  0.444
2014 Bendell JC, Atreya CE, André T, Tabernero J, Gordon MS, Bernards R, Van Cutsem E, Tejpar S, Sidhu R, Go WY, Allred A, Motwani M, Suttle BB, Wu Y, Hoos A, ... ... Corcoran RB, et al. Efficacy and tolerability in an open-label phase I/II study of MEK inhibitor trametinib (T), BRAF inhibitor dabrafenib (D), and anti-EGFR antibody panitumumab (P) in combination in patients (pts) with BRAF V600E mutated colorectal cancer (CRC). Journal of Clinical Oncology. 32: 3515-3515. DOI: 10.1200/Jco.2014.32.15_Suppl.3515  0.443
2014 Coffee EM, Corcoran RB, Engelman JA. Abstract 3135: Pre-treatment p-EGFR levels in tumors from a genetically engineered mouse model of BRAFV600E colorectal cancer predict response to combined BRAF/EGFR inhibition Cancer Research. 74: 3135-3135. DOI: 10.1158/1538-7445.Am2014-3135  0.464
2014 Corcoran R, Coffee E, van Allen E, Ahronian L, Wagle N, Kwak E, Faris J, Iafrate A, Garraway L, Engelman J. 428 Clinical acquired resistance to combined RAF/EGFR or RAF/MEK inhibition in BRAF mutant colorectal cancer (CRC) patients through MAPK pathway alterations European Journal of Cancer. 50: 141. DOI: 10.1016/S0959-8049(14)70554-4  0.481
2013 Corcoran RB, Rothenberg SM, Hata AN, Faber AC, Piris A, Nazarian RM, Brown RD, Godfrey JT, Winokur D, Walsh J, Mino-Kenudson M, Maheswaran S, Settleman J, Wargo JA, Flaherty KT, et al. TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Science Translational Medicine. 5: 196ra98. PMID 23903755 DOI: 10.1126/Scitranslmed.3005753  0.412
2013 Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Hung KE, Shioda T, Dias-Santagata D, et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell. 23: 121-8. PMID 23245996 DOI: 10.1016/J.Ccr.2012.11.007  0.479
2013 Corcoran RB, Ebi H, Ryan DP, Meyerhardt JA, Engelman JA. Relationship of EGFR-independent activation of PI3K in KRAS wild-type colorectal cancers and cetuximab resistance. Journal of Clinical Oncology. 31: 385-385. DOI: 10.1200/Jco.2013.31.4_Suppl.385  0.504
2013 Corcoran RB, Falchook GS, Infante JR, Hamid O, Messersmith WA, Daud A, Kwak EL, Ryan DP, Kurzrock R, Atreya CE, Luan J, Sun P, Schaeffer M, Motwani M, Bleam MR, et al. Pharmacodynamic and efficacy analysis of the BRAF inhibitor dabrafenib (GSK436) in combination with the MEK inhibitor trametinib (GSK212) in patients with BRAFV600 mutant colorectal cancer (CRC). Journal of Clinical Oncology. 31: 3507-3507. DOI: 10.1200/Jco.2013.31.15_Suppl.3507  0.371
2013 Corcoran RB. Abstract SY10-01: Strategies to overcome resistance to MAPK inhibition. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy10-01  0.535
2013 Corcoran RB, Rothenberg SM, Hata AN, Faber AC, Winokur D, Piris A, Nazarian RM, Brown RD, Godfrey JT, Mino-Kenudson M, Settleman J, Wargo JA, Flaherty KT, Haber DA, Engelman JA. Abstract 4568: Rapid assessment of TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF mutant melanoma. Cancer Research. 73: 4568-4568. DOI: 10.1158/1538-7445.Am2013-4568  0.472
2013 Coffee EM, Faber AC, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, J E, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, ... Corcoran RB, et al. Abstract C263: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C263  0.482
2013 Corcoran RB, Rothenberg SM, Hata AN, Faber AC, Piris A, Nazarian RM, Brown RD, Godfrey JT, Winokur D, Walsh J, Mino-Kenudson M, Maheswaran S, Settleman J, Wargo JA, Flaherty KT, et al. Abstract C137: Rapid assessment of TORC1 suppression as a functional biomarker predicting responsiveness to RAF and MEK inhibitors in BRAF-mutant melanoma patients. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C137  0.492
2013 Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Shioda T, Dias-Santagata D, Singh A, et al. Abstract PR09: Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS-mutant cancer models Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Pr09  0.499
2013 Corcoran R, Godfrey J, Engelman J. Different Subsets of Braf Mutant Colorectal Cancers Exhibit Egfr-Dependent and Independent Resistance to Raf Inhibitor Therapy Annals of Oncology. 24: iv25. DOI: 10.1093/Annonc/Mdt202.3  0.472
2013 Corcoran R, Rothenberg M, Piris A, Nazarian R, Maheswaran S, Settleman J, Wargo J, Flaherty K, Haber D, Engelman J. MC13-0075 Rapid assessment of TORC1 suppression as a functional biomarker predicting responsiveness to RAF and MEK inhibitors in BRAF-mutant melanoma patients European Journal of Cancer. 49: S12. DOI: 10.1016/S0959-8049(13)70119-9  0.35
2012 Corcoran RB, Ebi H, Ryan DP, Meyerhardt JA, Engelman JA. Relationship of incomplete inhibition of PI3K pathway signaling and efficacy of cetuximab in KRAS wild-type colorectal cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 462. PMID 27983029 DOI: 10.1200/Jco.2012.30.4_Suppl.462  0.493
2012 Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, Brown RD, Della Pelle P, Dias-Santagata D, Hung KE, Flaherty KT, Piris A, Wargo JA, Settleman J, Mino-Kenudson M, et al. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discovery. 2: 227-35. PMID 22448344 DOI: 10.1158/2159-8290.Cd-11-0341  0.475
2012 Corcoran RB, Falchook GS, Infante JR, Hamid O, Messersmith WA, Kwak EL, Ryan DP, Kurzrock R, Brenner AA, Luan J, Sun P, Allred AJ, Little SM, Patel K, Kopetz S, et al. BRAF V600 mutant colorectal cancer (CRC) expansion cohort from the phase I/II clinical trial of BRAF inhibitor dabrafenib (GSK2118436) plus MEK inhibitor trametinib (GSK1120212). Journal of Clinical Oncology. 30: 3528-3528. DOI: 10.1200/Jco.2012.30.15_Suppl.3528  0.45
2012 Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, Brown RD, Dias-Santagata D, Pelle PD, Hung KE, Flaherty KT, Piris A, Wargo JA, Settleman J, Mino-Kenudson M, et al. Abstract LB-350: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition by vemurafenib Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-350  0.513
2012 Corcoran RB, Cheng KA, Wong K, Engelman JA. Abstract 875: Markedin vivoefficacy of combined BCLXL and MEK inhibition in KRAS mutant cancers revealed by a pooled shRNA-drug screen for genes that are “synthetically lethal” with MEK inhibitors Cancer Research. 72: 875-875. DOI: 10.1158/1538-7445.Am2012-875  0.508
2012 Rothenberg SM, Wargo J, Juric D, Corcoran RB, Winokur D, Flaherty KT, Baselga J, Maheswaran S, Engelman JA, Haber DA. Abstract 2446: Real-time molecular imaging of targeted therapies in patient-derived tumor cells by quantitative immunofluorescence microscopy Cancer Research. 72: 2446-2446. DOI: 10.1158/1538-7445.Am2012-2446  0.467
2012 Corcoran RB, Hung KE, Flaherty KT, Piris A, Wargo JA, Settleman J, Mino-Kenudson M, Engelman JA, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, Brown RD, Pelle PD, et al. Abstract PR8: Insensitivity to RAF inhibition by vemurafenib in BRAF mutant colorectal cancer by EGFR-mediated reactivation of MAPK signaling Clinical Cancer Research. 18: PR8-PR8. DOI: 10.1158/1078-0432.MECHRES-PR8  0.375
2012 Corcoran R, Cheng K, Hata A, Faber A, Singh A, Settleman J, Benes C, Mino-Kenudson M, Wong K, Engelman J. 149 Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS-mutant Cancer Models European Journal of Cancer. 48: 46. DOI: 10.1016/S0959-8049(12)71947-0  0.422
2011 Faber AC, Corcoran RB, Ebi H, Sequist LV, Waltman BA, Chung E, Incio J, Digumarthy SR, Pollack SF, Song Y, Muzikansky A, Lifshits E, Roberge S, Coffman EJ, Benes CH, et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. Cancer Discovery. 1: 352-65. PMID 22145099 DOI: 10.1158/2159-8290.Cd-11-0106  0.459
2011 Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Wong KK, Cantley LC, Engelman JA. Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. The Journal of Clinical Investigation. 121: 4311-21. PMID 21985784 DOI: 10.1172/Jci57909  0.483
2011 Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA, Bardeesy N. STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Research. 71: 5020-9. PMID 21586612 DOI: 10.1158/0008-5472.Can-11-0908  0.399
2011 Corcoran RB, Settleman J, Engelman JA. Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers. Oncotarget. 2: 336-46. PMID 21505228 DOI: 10.18632/Oncotarget.262  0.443
2011 Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Cantley LC, Wong K, Engelman JA. Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers Cancer Research. 71: 956-956. DOI: 10.1158/1538-7445.Am2011-956  0.5
2010 Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Science Signaling. 3: ra84. PMID 21098728 DOI: 10.1126/Scisignal.2001148  0.472
2010 Courtney KD, Corcoran RB, Engelman JA. The PI3K pathway as drug target in human cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 1075-83. PMID 20085938 DOI: 10.1200/Jco.2009.25.3641  0.478
2009 Rohatgi R, Milenkovic L, Corcoran RB, Scott MP. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proceedings of the National Academy of Sciences of the United States of America. 106: 3196-201. PMID 19218434 DOI: 10.1073/Pnas.0813373106  0.669
2009 Scott M, Rohatgi R, Milenkovic L, Lee E, Corcoran R, Barakat M, Humke E. S02-04 Communicating with Hedgehogs: Signaling in development and disease Mechanisms of Development. 126: S26-S27. DOI: 10.1016/J.Mod.2009.06.1065  0.676
2008 Corcoran RB, Bachar Raveh T, Barakat MT, Lee EY, Scott MP. Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice. Cancer Research. 68: 8788-95. PMID 18974121 DOI: 10.1158/0008-5472.Can-08-2135  0.654
2006 Corcoran RB, Scott MP. Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 8408-13. PMID 16707575 DOI: 10.1073/Pnas.0602852103  0.531
2001 Corcoran RB, Scott MP. A mouse model for medulloblastoma and basal cell nevus syndrome. Journal of Neuro-Oncology. 53: 307-18. PMID 11718263 DOI: 10.1023/A:1012260318979  0.535
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