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Jason D. Galpin, Ph.D. - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Studies on novel enzyme mechanisms; epimerases and racemases; sugar nucleotide-modifying enzymes; isotope effects; inhibitor design; site-directed mutagenesis
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A. Backbone amides are determinants of Cl selectivity in CLC ion channels. Nature Communications. 13: 7508. PMID 36473856 DOI: 10.1038/s41467-022-35279-1  0.393
2021 Zhao C, Hong L, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions. The Journal of General Physiology. 153. PMID 34228044 DOI: 10.1085/jgp.202012832  0.35
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Divergent Cland H pathways underlie transport coupling and gating in CLC exchangers and channels. Elife. 9. PMID 32343228 DOI: 10.7554/Elife.51224  0.445
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Elife. DOI: 10.7554/Elife.51224.Sa2  0.393
2020 Zhao C, Hong L, Riahi S, Galpin JD, Ahern CA, Tobias DJ, Tombola F. Rationally Designed Proton Channel Inhibitors Reveal a Druggable Pocket in a Voltage-sensing Domain Biophysical Journal. 118: 111a. DOI: 10.1016/J.Bpj.2019.11.754  0.428
2019 Zhao C, Hong L, Galpin JD, Ahern CA, Tombola F. Two-Pronged Aromatic Arginine-Mimics as Hv1 Proton Channel Inhibitors Biophysical Journal. 116: 540a. DOI: 10.1016/J.Bpj.2018.11.2904  0.457
2018 Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI. Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor. Nature Communications. 9: 5055. PMID 30498243 DOI: 10.1038/S41467-018-07477-3  0.463
2018 Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA. Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. The Journal of General Physiology. PMID 29866793 DOI: 10.1085/Jgp.201812075  0.495
2018 Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA. Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte. Scientific Reports. 8: 5166. PMID 29581437 DOI: 10.1038/S41598-018-23201-Z  0.438
2018 Infield DT, Goodchild SJ, Galpin JD, Ahern CA. Insights into Sodium Channel Gating Enabled by Transplantation of an Aryl Sulfonamide Drug Binding Site in Combination with Genetically-Encoded Cross Linking Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.264  0.381
2018 Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA. Orthogonality of a Synthetic Pyrrolysine tRNA in the Xenopus Oocyte and its use to Encode Unnatural Amino Acids into Ion Channels Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2628  0.434
2018 Infield DT, Galpin JD, Galles GD, Ahern CA. Site-Specific Encoding of Citrulline, a Neutral Analog of Arginine, to Study the Atomic Basis for Voltage-Dependent Gating In Ion Channels Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2626  0.451
2018 Infield DT, Matulef K, Galpin JD, Ahern CA, Valiyaveetil FI. The Role of Backbone Hydrogen Bonds in the Voltage Sensor of K+ Channels Biophysical Journal. 114: 477a. DOI: 10.1016/J.Bpj.2017.11.2622  0.39
2018 Zhao C, Hong L, Galpin JD, Ahern CA, Tombola F. Exploiting Π-Stacking Interactions to Improve Inhibition of the Hv1 Channel by Aromatic Guanidine Derivatives Biophysical Journal. 114: 374a. DOI: 10.1016/J.Bpj.2017.11.2073  0.435
2017 Steinberg X, Kasimova MA, Cabezas-Bratesco D, Galpin JD, Ladron-de-Guevara E, Villa F, Carnevale V, Islas L, Ahern CA, Brauchi SE. Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid. Elife. 6. PMID 29206105 DOI: 10.7554/Elife.28626  0.454
2017 Steinberg X, Kasimova MA, Cabezas-Bratesco D, Galpin JD, Ladron-de-Guevara E, Villa F, Carnevale V, Islas L, Ahern CA, Brauchi SE. Author response: Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid Elife. DOI: 10.7554/Elife.28626.018  0.439
2016 Leisle L, Chadda R, Lueck JD, Infield DT, Galpin JD, Krishnamani V, Robertson JL, Ahern CA. Cellular encoding of Cy dyes for single-molecule imaging. Elife. 5. PMID 27938668 DOI: 10.7554/Elife.19088  0.373
2016 Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T. Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 27849612 DOI: 10.1073/Pnas.1615562113  0.494
2016 Lueck JD, Mackey AL, Infield DT, Galpin JD, Li J, Roux B, Ahern CA. Atomic mutagenesis in ion channels with engineered stoichiometry. Elife. 5. PMID 27710770 DOI: 10.7554/Elife.18976  0.485
2016 Lueck JD, Mackey AL, Infield DT, Galpin JD, Li J, Roux B, Ahern CA. Author response: Atomic mutagenesis in ion channels with engineered stoichiometry Elife. DOI: 10.7554/Elife.18976.014  0.397
2016 Lueck JD, Mackey AL, Galpin JD, Ahern CA. Engineering Subunit and Nonsense Suppression Stoichiometry in Potassium Channels Biophysical Journal. 110: 105. DOI: 10.1016/J.Bpj.2015.11.624  0.517
2016 Leisle L, Chadda R, Galpin JD, Robertson JL, Ahern CA. Genetically Encoding Single-Molecule Fluorophores into Ion Channels in Living Cells Biophysical Journal. 110: 34a. DOI: 10.1016/J.Bpj.2015.11.251  0.402
2016 Hong L, Galpin JD, Ahern CA, Tombola F. Energetic Contributions of Aromatic Residues in HV1 Block by 2-Guanidinoimidazoles and in HV1 Voltage-Dependent Activation Biophysical Journal. 110: 281a. DOI: 10.1016/J.Bpj.2015.11.1522  0.505
2015 Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT. Atomic basis for therapeutic activation of neuronal potassium channels. Nature Communications. 6: 8116. PMID 26333338 DOI: 10.1038/Ncomms9116  0.507
2015 Kim RY, Yau MC, Pless SA, Galpin JD, Ahern CA, Kurata HT. Atomic Basis for Potassium Channel Potentiation by A Novel Class of Anti-Epileptic Drugs Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.136  0.487
2014 Pless SA, Elstone FD, Niciforovic AP, Galpin JD, Yang R, Kurata HT, Ahern CA. Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains. The Journal of General Physiology. 143: 645-56. PMID 24778431 DOI: 10.1085/Jgp.201311036  0.464
2014 Pless SA, Yau M, Galpin JD, Ahern CA, Kurata HT. Unnatural Amino Acid Mutagenesis Reveals the Critical Role of Hydrogen Bonding for Binding of Retigabine in the Pore of KCNQ Channels Biophysical Journal. 106: 1-3. DOI: 10.1016/J.Bpj.2013.11.828  0.521
2014 Steinberg Acuña XP, Cabezas D, Galpin J, Sepulveda R, Goodchild S, González D, Ahern C, Brauchi S. The Functional Incorporation of Tyr-Coumarin Into Proteins Synthesized by HEK293T Cells Biophysical Journal. 106: 198a. DOI: 10.1016/J.Bpj.2013.11.1170  0.319
2013 Pless SA, Galpin JD, Niciforovic AP, Kurata HT, Ahern CA. Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels. Elife. 2: e01289. PMID 24327560 DOI: 10.7554/Elife.01289  0.507
2013 Pless SA, Niciforovic AP, Galpin JD, Nunez JJ, Kurata HT, Ahern CA. A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel. Nature Communications. 4: 1784. PMID 23653196 DOI: 10.1038/Ncomms2761  0.486
2013 Pless SA, Galpin JD, Niciforovic AP, Kurata HT, Ahern CA. Author response: Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels Elife. DOI: 10.7554/Elife.01289.023  0.448
2013 Paz Steinberg-Acuña X, Goodchild S, Villegas J, Galpin J, Ahern C, Brauchi S. TYR-Coumarin Functional Incorporation into Proteins Synthesized by HEK293T Cells Biophysical Journal. 104: 458a. DOI: 10.1016/J.Bpj.2012.11.2535  0.32
2012 Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F. Intermediate state trapping of a voltage sensor. The Journal of General Physiology. 140: 635-52. PMID 23183699 DOI: 10.1085/Jgp.201210827  0.444
2012 Lacroix JJ, Pless SA, Campos FV, Maragliano L, Galpin JD, Ahern CA, Roux B, Bezanilla F. Position of the Second Gating Charge along S4 in an Intermediate Conformation of a K+ Channel Voltage Sensor Biophysical Journal. 102: 530a. DOI: 10.1016/J.Bpj.2011.11.2899  0.449
2012 Pless SA, Galpin JD, Niciforovic AP, Ahern CA. Molecular Determinants of Slow Inactivation in Voltage-Gated Potassium Channels Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.095  0.534
2011 Pless SA, Leung AW, Galpin JD, Ahern CA. Contributions of conserved residues at the gating interface of glycine receptors. The Journal of Biological Chemistry. 286: 35129-36. PMID 21835920 DOI: 10.1074/Jbc.M111.269027  0.482
2011 Pless SA, Galpin JD, Niciforovic AP, Ahern CA. Contributions of counter-charge in a potassium channel voltage-sensor domain. Nature Chemical Biology. 7: 617-23. PMID 21785425 DOI: 10.1038/Nchembio.622  0.493
2011 Pless SA, Galpin JD, Frankel A, Ahern CA. Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels. Nature Communications. 2: 351. PMID 21673672 DOI: 10.1038/Ncomms1351  0.349
2010 Pless SA, Galpin JD, Frankel A, Ahern CA. A Cation-Pi Interaction in the Cardiac Sodium Channel Local Anesthetic Receptor Discriminates Between Antiarrythmics Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.048  0.462
1999 Galpin JD, Ellis BE, Tanner ME. The inactivation of histidine ammonia-lyase by L-cysteine and oxygen: Modification of the electrophilic center [7] Journal of the American Chemical Society. 121: 10840-10841. DOI: 10.1021/Ja992729H  0.498
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