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Jung-Mi Hah, Ph.D. - Publications

Affiliations: 
2002 Northwestern University, Evanston, IL 
Area:
Organic, Synthetic, Bio-Organic, Medicinal Chemistry, Chemical Biology
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Baek J, Jun J, Kim H, Bae H, Park H, Cho H, Han S, Shin HC, Hah JM. Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. Journal of Medicinal Chemistry. PMID 38530425 DOI: 10.1021/acs.jmedchem.3c02366  0.306
2022 Jun J, Baek J, Kang D, Moon H, Kim H, Cho H, Hah JM. Novel 1,4,5,6-tetrahydrocyclopenta[d]imidazole-5-carboxamide-based JNK3 inhibitors: Design, synthesis, molecular docking, and therapeutic potential in neurodegenerative diseases. European Journal of Medicinal Chemistry. 245: 114917. PMID 36395646 DOI: 10.1016/j.ejmech.2022.114917  0.35
2022 Jun J, Yang S, Lee J, Moon H, Kim J, Jung H, Im D, Oh Y, Jang M, Cho H, Baek J, Kim H, Kang D, Bae H, Tak C, ... ... Hah JM, et al. Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 245: 114894. PMID 36343411 DOI: 10.1016/j.ejmech.2022.114894  0.33
2022 Bhujbal SP, Kim H, Bae H, Hah JM. Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking. Pharmaceuticals (Basel, Switzerland). 15. PMID 36297281 DOI: 10.3390/ph15101170  0.377
2022 Bhujbal SP, He W, Hah JM. Design of Novel IRAK4 Inhibitors Using Molecular Docking, Dynamics Simulation and 3D-QSAR Studies. Molecules (Basel, Switzerland). 27. PMID 36234844 DOI: 10.3390/molecules27196307  0.354
2022 Im D, Jun J, Baek J, Kim H, Kang D, Bae H, Cho H, Hah JM. Rational design and synthesis of 2-(1-indazol-6-yl)-1-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants. Journal of Enzyme Inhibition and Medicinal Chemistry. 37: 472-486. PMID 35067150 DOI: 10.1080/14756366.2021.2020772  0.403
2021 Jun J, Baek J, Yang S, Moon H, Kim H, Cho H, Hah JM. Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons. International Journal of Molecular Sciences. 22. PMID 34681742 DOI: 10.3390/ijms222011084  0.367
2021 Cho H, Hah JM. A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer's Disease: Investigating Structure through Docking Studies. Biomedicines. 9. PMID 34680547 DOI: 10.3390/biomedicines9101431  0.321
2021 Oh Y, Jung H, Kim H, Baek J, Jun J, Cho H, Im D, Hah JM. Design and Synthesis of a Novel PLK1 Inhibitor Scaffold Using a Hybridized 3D-QSAR Model. International Journal of Molecular Sciences. 22. PMID 33917995 DOI: 10.3390/ijms22083865  0.342
2020 Im D, Moon H, Kim J, Oh Y, Jang M, Hah JM. Discovery of 5-methyl--(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1110-1115. PMID 32338093 DOI: 10.1080/14756366.2020.1758689  0.465
2020 Jang M, Oh Y, Cho H, Yang S, Moon H, Im D, Hah JM. Discovery of 1-Pyrimidinyl-2-Aryl-4,6-Dihydropyrrolo [3,4-d]Imidazole-5(1)-Carboxamide as a Novel JNK Inhibitor. International Journal of Molecular Sciences. 21. PMID 32131443 DOI: 10.3390/Ijms21051698  0.468
2020 Oh Y, Jang M, Cho H, Yang S, Im D, Moon H, Hah JM. Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1pyrazole derivatives as a novel selective inhibitor scaffold of JNK3. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 372-376. PMID 31856610 DOI: 10.1080/14756366.2019.1705294  0.493
2019 Im D, Moon H, Kim J, Oh Y, Jang M, Hah JM. Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl--(2-aryl-1-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 1716-1721. PMID 31571509 DOI: 10.1080/14756366.2019.1671837  0.481
2019 Kim J, Choi B, Im D, Jung H, Moon H, Aman W, Hah JM. Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 1314-1320. PMID 31307243 DOI: 10.1080/14756366.2019.1599366  0.46
2019 Jung H, Kim J, Im D, Moon H, Hah JM. Design, synthesis, and in vitro evaluation of N-(3-(3-alkyl-1H-pyrazol-5-yl) phenyl)-aryl amide for selective RAF inhibition. Bioorganic & Medicinal Chemistry Letters. PMID 30630714 DOI: 10.1016/J.Bmcl.2019.01.003  0.418
2018 Venkanna A, Cho KH, Dhorma LP, Kumar DN, Hah JM, Park HG, Kim SY, Kim MH. Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone. European Journal of Medicinal Chemistry. 163: 453-480. PMID 30530196 DOI: 10.1016/j.ejmech.2018.11.037  0.356
2018 Lee J, Jung H, Kim M, Lee E, Im D, Aman W, Hah JM. Discovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents. Bioorganic & Medicinal Chemistry. PMID 29459144 DOI: 10.1016/J.Bmc.2018.02.009  0.397
2017 Jung H, Aman W, Hah JM. Novel scaffold evolution through combinatorial 3D-QSAR model studies of two types of JNK3 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28372912 DOI: 10.1016/J.Bmcl.2017.03.063  0.392
2016 Aman W, Lee J, Kim M, Yang S, Jung H, Hah JM. Discovery of highly selective CRAF inhibitors, 3-carboxamido-2H-indazole-6-arylamide: In silico FBLD design, synthesis and evaluation. Bioorganic & Medicinal Chemistry Letters. PMID 26810260 DOI: 10.1016/J.Bmcl.2016.01.037  0.511
2015 Park Y, Bae SY, Hah JM, Lee SK, Ryu JS. Synthesis of stereochemically diverse cyclic analogs of tubulysins. Bioorganic & Medicinal Chemistry. PMID 26474666 DOI: 10.1016/J.Bmc.2015.10.003  0.313
2015 Im D, Jung K, Yang S, Aman W, Hah JM. Discovery of 4-arylamido 3-methyl isoxazole derivatives as novel FMS kinase inhibitors. European Journal of Medicinal Chemistry. 102: 600-610. PMID 26318067 DOI: 10.1016/J.Ejmech.2015.08.031  0.399
2015 Kim MH, Lee J, Hah JM. De Novo Design and Synthesis of a γ-Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand. Chemistry, An Asian Journal. 10: 1318-26. PMID 25712695 DOI: 10.1002/Asia.201403417  0.328
2014 Song D, Park Y, Yoon J, Aman W, Hah JM, Ryu JS. Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors. Bioorganic & Medicinal Chemistry. 22: 4855-66. PMID 25042560 DOI: 10.1016/J.Bmc.2014.06.047  0.447
2014 Kim M, Lee J, Jung K, Kim H, Aman W, Ryu JS, Hah JM. Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 3600-4. PMID 24878193 DOI: 10.1016/J.Bmcl.2014.05.030  0.441
2013 Kim MH, Lee J, Jung K, Kim M, Park YJ, Ahn H, Kwon YH, Hah JM. Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects. Bioorganic & Medicinal Chemistry. 21: 2271-85. PMID 23498914 DOI: 10.1016/J.Bmc.2013.02.021  0.431
2013 Kim MH, Ryu JS, Hah JM. 3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells. Bioorganic & Medicinal Chemistry Letters. 23: 1639-42. PMID 23416008 DOI: 10.1016/J.Bmcl.2013.01.082  0.457
2013 Li F, Park Y, Hah JM, Ryu JS. Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 1083-6. PMID 23294702 DOI: 10.1016/J.Bmcl.2012.12.008  0.405
2012 Kim HJ, Cho HJ, Kim H, El-Gamal MI, Oh CH, Lee SH, Sim T, Hah JM, Yoo KH. New diarylureas and diarylamides possessing acet(benz)amidophenyl scaffold: design, synthesis, and antiproliferative activity against melanoma cell line. Bioorganic & Medicinal Chemistry Letters. 22: 3269-73. PMID 22460030 DOI: 10.1016/J.Bmcl.2012.03.020  0.327
2012 Ham YJ, Yu H, Kim ND, Hah JM, Selim KB, Choi HG, Sim T. Rhodium-catalyzed reductive cyclization of 1,6-enynes and stereoselective synthesis of the putative structure of lucentamycin A and its stereoisomers Tetrahedron. 68: 1918-1925. DOI: 10.1016/J.Tet.2011.12.075  0.309
2011 Kim H, Kim M, Lee J, Yu H, Hah JM. Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells. Bioorganic & Medicinal Chemistry. 19: 6760-7. PMID 22014755 DOI: 10.1016/J.Bmc.2011.09.042  0.415
2011 Kim MH, Chung JY, Ryu JS, Hah JM. Structure tuning of pyrazolylpyrrole derivatives as ERK inhibitors utilizing dual tools; 3D-QSAR and side-chain hopping. Bioorganic & Medicinal Chemistry Letters. 21: 4900-4. PMID 21775139 DOI: 10.1016/J.Bmcl.2011.06.016  0.422
2011 Kim MH, Kim M, Yu H, Kim H, Yoo KH, Sim T, Hah JM. Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells. Bioorganic & Medicinal Chemistry. 19: 1915-23. PMID 21353571 DOI: 10.1016/j.bmc.2011.01.067  0.355
2010 Lee J, Nam BS, Kim H, Oh CH, Lee SH, Cho SJ, Sim TB, Hah JM, Kim DJ, Tae J, Yoo KH. Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line. Bioorganic & Medicinal Chemistry Letters. 20: 5722-5. PMID 20797858 DOI: 10.1016/J.Bmcl.2010.08.010  0.341
2010 Chung JY, Chung HW, Cho SJ, Hah JM, Cho AE. QM/MM based 3D QSAR models for potent B-Raf inhibitors. Journal of Computer-Aided Molecular Design. 24: 385-97. PMID 20358258 DOI: 10.1007/S10822-010-9337-5  0.396
2010 Choi HG, Son JB, Park DS, Ham YJ, Hah JM, Sim T. An efficient and enantioselective total synthesis of naturally occurring L-783277 Tetrahedron Letters. 51: 4942-4946. DOI: 10.1016/J.Tetlet.2010.07.122  0.355
2009 Chung JY, Cho AE, Hah JM. Hologram and receptor-guided 3D QSAR analysis of anilinobipyridine JNK3 inhibitors Bulletin of the Korean Chemical Society. 30: 2739-2748. DOI: 10.5012/Bkcs.2009.30.11.2739  0.401
2009 Neaz MM, Pasha FA, Muddassar M, Lee SH, Sim T, Hah JM, Cho SJ. Pharmacophore based 3D-QSAR study of VEGFR-2 inhibitors Medicinal Chemistry Research. 18: 127-142. DOI: 10.1007/S00044-008-9113-4  0.362
2008 Li H, Hah JM, Lawrence DS. Light-mediated liberation of enzymatic activity: "small molecule" caged protein equivalents. Journal of the American Chemical Society. 130: 10474-5. PMID 18642802 DOI: 10.1021/Ja803395D  0.419
2006 Hah JM, Sharma V, Li H, Lawrence DS. Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy. Journal of the American Chemical Society. 128: 5996-7. PMID 16669643 DOI: 10.1021/Ja060136I  0.514
2004 Flinspach ML, Li H, Jamal J, Yang W, Huang H, Hah JM, Gómez-Vidal JA, Litzinger EA, Silverman RB, Poulos TL. Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nature Structural & Molecular Biology. 11: 54-9. PMID 14718923 DOI: 10.1038/Nsmb704  0.569
2003 Hah JM, Martásek P, Roman LJ, Silverman RB. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 46: 1661-9. PMID 12699384 DOI: 10.1021/Jm0202932  0.623
2001 Hah JM, Roman LJ, Martásek P, Silverman RB. Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. Journal of Medicinal Chemistry. 44: 2667-70. PMID 11472219 DOI: 10.1021/Jm0101491  0.634
2001 Huang H, Hah JM, Silverman RB. Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism. Journal of the American Chemical Society. 123: 2674-6. PMID 11456942 DOI: 10.1021/Ja005900U  0.511
2000 Hah JM, Roman LJ, Silverman RB. Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase. Bioorganic & Medicinal Chemistry. 8: 1931-6. PMID 11003138 DOI: 10.1016/S0968-0896(00)00154-1  0.476
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