| Year |
Citation |
Score |
| 2016 |
Liu X, Zheng H, Li X, Wang S, Meyerson HJ, Yang W, Neel BG, Qu CK. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proceedings of the National Academy of Sciences of the United States of America. PMID 26755576 DOI: 10.1073/pnas.1508535113 |
0.303 |
|
| 2015 |
Cordeddu V, Yin JC, Gunnarsson C, Virtanen C, Drunat S, Lepri F, De Luca A, Rossi C, Ciolfi A, Pugh TJ, Bruselles A, Priest JR, Pennacchio LA, Lu Z, Danesh A, ... ... Neel BG, et al. Activating mutations affecting the Dbl homology domain of SOS2 cause Noonan syndrome. Human Mutation. PMID 26173643 DOI: 10.1002/Humu.22834 |
0.301 |
|
| 2015 |
St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF. Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics. 15: 419-33. PMID 25311528 DOI: 10.1002/Pmic.201400259 |
0.422 |
|
| 2014 |
Goodwin CB, Li XJ, Mali RS, Chan G, Kang M, Liu Z, Vanhaesebroeck B, Neel BG, Loh ML, Lannutti BJ, Kapur R, Chan RJ. PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. Blood. 123: 2838-42. PMID 24553178 DOI: 10.1182/Blood-2013-10-535104 |
0.443 |
|
| 2013 |
Yang W, Wang J, Moore DC, Liang H, Dooner M, Wu Q, Terek R, Chen Q, Ehrlich MG, Quesenberry PJ, Neel BG. Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling. Nature. 499: 491-5. PMID 23863940 DOI: 10.1038/nature12396 |
0.405 |
|
| 2013 |
Abram CL, Roberge GL, Pao LI, Neel BG, Lowell CA. Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice. Immunity. 38: 489-501. PMID 23521885 DOI: 10.1016/J.Immuni.2013.02.018 |
0.305 |
|
| 2012 |
Mori J, Wang YJ, Ellison S, Heising S, Neel BG, Tremblay ML, Watson SP, Senis YA. Dominant role of the protein-tyrosine phosphatase CD148 in regulating platelet activation relative to protein-tyrosine phosphatase-1B. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2956-65. PMID 23065825 DOI: 10.1161/ATVBAHA.112.300447 |
0.311 |
|
| 2012 |
Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Molecular Cell. 47: 469-83. PMID 22883624 DOI: 10.1016/J.Molcel.2012.06.037 |
0.316 |
|
| 2012 |
Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T. Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Molecular and Cellular Biology. 32: 3872-90. PMID 22826437 DOI: 10.1128/Mcb.00751-12 |
0.428 |
|
| 2012 |
Haj FG, Sabet O, Kinkhabwala A, Wimmer-Kleikamp S, Roukos V, Han HM, Grabenbauer M, Bierbaum M, Antony C, Neel BG, Bastiaens PI. Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B. Plos One. 7: e36633. PMID 22655028 DOI: 10.1371/journal.pone.0036633 |
0.309 |
|
| 2011 |
Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes & Development. 25: 2069-78. PMID 21979919 DOI: 10.1101/Gad.17224711 |
0.422 |
|
| 2011 |
Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG. Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell. 146: 826-40. PMID 21884940 DOI: 10.1016/j.cell.2011.07.020 |
0.321 |
|
| 2011 |
Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood. 118: 1077-86. PMID 21636860 DOI: 10.1182/Blood-2009-12-261636 |
0.362 |
|
| 2011 |
Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, ... ... Neel BG, et al. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood. 117: 4253-61. PMID 21398220 DOI: 10.1182/Blood-2010-11-319517 |
0.307 |
|
| 2011 |
Marin TM, Keith K, Davies B, Conner DA, Guha P, Kalaitzidis D, Wu X, Lauriol J, Wang B, Bauer M, Bronson R, Franchini KG, Neel BG, Kontaridis MI. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. The Journal of Clinical Investigation. 121: 1026-43. PMID 21339643 DOI: 10.1172/Jci44972 |
0.304 |
|
| 2010 |
Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. The Journal of Cell Biology. 191: 1189-203. PMID 21135139 DOI: 10.1083/Jcb.201005035 |
0.338 |
|
| 2010 |
Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman C, Bronson R, Neel B, Seidman JG, Kucherlapati R. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. The Journal of Clinical Investigation. 120: 4353-65. PMID 21041952 DOI: 10.1172/Jci43910 |
0.302 |
|
| 2010 |
Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Research. 70: 3843-50. PMID 20406974 DOI: 10.1158/0008-5472.Can-09-3421 |
0.387 |
|
| 2010 |
Rajala RV, Tanito M, Neel BG, Rajala A. Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. The Journal of Biological Chemistry. 285: 8894-904. PMID 20061388 DOI: 10.1074/jbc.M109.070854 |
0.354 |
|
| 2010 |
Neel BG, Chan G, Dhanji S. SH2 domain-containing protein-tyrosine phosphatases Handbook of Cell Signaling, 2/E. 2: 771-809. DOI: 10.1016/B978-0-12-374145-5.00098-X |
0.313 |
|
| 2008 |
Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation. 117: 1423-35. PMID 18316486 DOI: 10.1161/Circulationaha.107.728865 |
0.418 |
|
| 2008 |
Chan G, Kalaitzidis D, Neel BG. The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metastasis Reviews. 27: 179-92. PMID 18286234 DOI: 10.1007/s10555-008-9126-y |
0.353 |
|
| 2007 |
Pao LI, Badour K, Siminovitch KA, Neel BG. Nonreceptor protein-tyrosine phosphatases in immune cell signaling. Annual Review of Immunology. 25: 473-523. PMID 17291189 DOI: 10.1146/Annurev.Immunol.23.021704.115647 |
0.35 |
|
| 2007 |
Yudushkin IA, Schleifenbaum A, Kinkhabwala A, Neel BG, Schultz C, Bastiaens PI. Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B. Science (New York, N.Y.). 315: 115-9. PMID 17204654 DOI: 10.1126/science.1134966 |
0.373 |
|
| 2007 |
Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F, Shuai K, Ng T, Neel BG, Chernoff J. Regulation of protein tyrosine phosphatase 1B by sumoylation Nature Cell Biology. 9: 80-85. PMID 17159996 DOI: 10.1038/Ncb1522 |
0.406 |
|
| 2006 |
Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H. The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. The Journal of Biological Chemistry. 281: 28615-26. PMID 16873377 DOI: 10.1074/Jbc.M603742200 |
0.391 |
|
| 2006 |
Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, Neel BG. An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival Developmental Cell. 10: 317-327. PMID 16516835 DOI: 10.1016/J.Devcel.2006.01.002 |
0.374 |
|
| 2005 |
Ren SY, Bolton E, Mohi MG, Morrione A, Neel BG, Skorski T. Phosphatidylinositol 3-kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: Molecular mechanisms and biological consequences Molecular and Cellular Biology. 25: 8001-8008. PMID 16135792 DOI: 10.1128/Mcb.25.18.8001-8008.2005 |
0.401 |
|
| 2005 |
Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10238-43. PMID 16006513 DOI: 10.1073/Pnas.0504378102 |
0.329 |
|
| 2005 |
Du Z, Shen Y, Yang W, Mecklenbrauker I, Neel BG, Ivashkiv LB. Inhibition of IFN-α signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway Proceedings of the National Academy of Sciences of the United States of America. 102: 10267-10272. PMID 16000408 DOI: 10.1073/Pnas.0408854102 |
0.31 |
|
| 2005 |
Keilhack H, David FS, McGregor M, Cantley LC, Neel BG. Diverse biochemical properties of Shp2 mutants: Implications for disease phenotypes Journal of Biological Chemistry. 280: 30984-30993. PMID 15987685 DOI: 10.1074/Jbc.M504699200 |
0.332 |
|
| 2005 |
Haider UGB, Roos TU, Kontaridis MI, Neel BG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM. Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: Role of Gab1 and Shp2 Molecular Pharmacology. 68: 41-48. PMID 15849355 DOI: 10.1124/Mol.104.005421 |
0.38 |
|
| 2005 |
Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell. 7: 179-91. PMID 15710330 DOI: 10.1016/j.ccr.2005.01.010 |
0.35 |
|
| 2005 |
Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP Molecular and Cellular Biology. 25: 819-829. PMID 15632081 DOI: 10.1128/Mcb.25.2.819-829.2005 |
0.395 |
|
| 2004 |
Mohi MG, Boulton C, Gu TL, Sternberg DW, Neuberg D, Griffin JD, Gilliland DG, Neel BG. Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs Proceedings of the National Academy of Sciences of the United States of America. 101: 3130-3135. PMID 14976243 DOI: 10.1073/pnas.0400063101 |
0.33 |
|
| 2004 |
Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T, Luo J, Thompson JA, Schraven BL, Philips MR, Neel BG. Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Molecular Cell. 13: 341-55. PMID 14967142 DOI: 10.1016/S1097-2765(04)00050-4 |
0.428 |
|
| 2004 |
Persson C, Sävenhed C, Bourdeau A, Tremblay ML, Markova B, Böhmer FD, Haj FG, Neel BG, Elson A, Heldin CH, Rönnstrand L, Östman A, Hellberg C. Site-Selective Regulation of Platelet-Derived Growth Factor β Receptor Tyrosine Phosphorylation by T-Cell Protein Tyrosine Phosphatase Molecular and Cellular Biology. 24: 2190-2201. PMID 14966296 DOI: 10.1128/Mcb.24.5.2190-2201.2004 |
0.362 |
|
| 2003 |
Araki T, Nawa H, Neel BG. Tyrosyl Phosphorylation of Shp2 Is Required for Normal ERK Activation in Response to Some, but Not All, Growth Factors Journal of Biological Chemistry. 278: 41677-41684. PMID 12923167 DOI: 10.1074/jbc.M306461200 |
0.381 |
|
| 2003 |
Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling Trends in Biochemical Sciences. 28: 284-293. PMID 12826400 DOI: 10.1016/S0968-0004(03)00091-4 |
0.328 |
|
| 2003 |
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG. Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis Journal of Cell Biology. 161: 1151-1161. PMID 12821647 DOI: 10.1083/Jcb.200212158 |
0.442 |
|
| 2003 |
Habib AA, Chun SJ, Neel BG, Vartanian T. Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal growth factor-mediated signal transduction pathways Molecular Cancer Research. 1: 219-233. PMID 12556561 |
0.392 |
|
| 2003 |
Haj FG, Markova B, Klaman LD, Bohmer FD, Neel BG. Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B Journal of Biological Chemistry. 278: 739-744. PMID 12424235 DOI: 10.1074/jbc.M210194200 |
0.409 |
|
| 2003 |
Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. The Journal of Biological Chemistry. 278: 661-71. PMID 12403768 DOI: 10.1074/jbc.M210552200 |
0.314 |
|
| 2003 |
Neel BG, Gu H, Pao L. SH2-Domain-Containing Protein-Tyrosine Phosphatases Handbook of Cell Signaling. 1: 707-728. DOI: 10.1016/B978-012124546-7/50479-4 |
0.313 |
|
| 2002 |
Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG. Direct identification of PTEN phosphorylation sites Febs Letters. 528: 145-153. PMID 12297295 DOI: 10.1016/S0014-5793(02)03274-X |
0.328 |
|
| 2002 |
Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, Gesbert F, Iwasaki H, Li S, Van Etten RA, Gu H, Griffin JD, Neel BG. Critical role for Gab2 in transformation by BCR/ABL Cancer Cell. 1: 479-492. PMID 12124177 DOI: 10.1016/S1535-6108(02)00074-0 |
0.404 |
|
| 2002 |
Heinrich R, Neel BG, Rapoport TA. Mathematical models of protein kinase signal transduction. Molecular Cell. 9: 957-70. PMID 12049733 DOI: 10.1016/S1097-2765(02)00528-2 |
0.353 |
|
| 2002 |
Zhang SQ, Tsiaras WG, Araki T, Wen G, Minichiello L, Klein R, Neel BG. Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2. Molecular and Cellular Biology. 22: 4062-72. PMID 12024020 DOI: 10.1128/Mcb.22.12.4062-4072.2002 |
0.538 |
|
| 2001 |
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG. Essential role for Gab2 in the allergic response Nature. 412: 186-190. PMID 11449275 DOI: 10.1038/35084076 |
0.354 |
|
| 2001 |
Barber DL, Beattie BK, Mason JM, Nguyen MHH, Yoakim M, Neel BG, D'Andrea AD, Frank DA. A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: Implications for the docking model of STAT activation Blood. 97: 2230-2237. PMID 11290583 DOI: 10.1182/Blood.V97.8.2230 |
0.387 |
|
| 2001 |
Tonks NK, Neel BG. Combinatorial control of the specificity of protein tyrosine phosphatases Current Opinion in Cell Biology. 13: 182-195. PMID 11248552 DOI: 10.1016/S0955-0674(00)00196-4 |
0.332 |
|
| 2001 |
Bjørbæk C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers MG, Flier JS. Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors Journal of Biological Chemistry. 276: 4747-4755. PMID 11085989 DOI: 10.1074/jbc.M007439200 |
0.52 |
|
| 2000 |
Pratt JC, Igras VE, Maeda H, Baksh S, Gelfand EW, Burakoff SJ, Neel BG, Gu H. Cutting edge: Gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling Journal of Immunology. 165: 4158-4163. PMID 11035047 DOI: 10.4049/Jimmunol.165.8.4158 |
0.363 |
|
| 2000 |
O'Reilly AM, Pluskey S, Shoelson SE, Neel BG. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Molecular and Cellular Biology. 20: 299-311. PMID 10594032 DOI: 10.1128/Mcb.20.1.299-311.2000 |
0.595 |
|
| 1998 |
Van Vactor D, O'Reilly AM, Neel BG. Genetic analysis of protein tyrosine phosphatases. Current Opinion in Genetics & Development. 8: 112-26. PMID 9529614 DOI: 10.1016/S0959-437X(98)80070-1 |
0.594 |
|
| 1998 |
O'Reilly AM, Neel BG. Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction. Molecular and Cellular Biology. 18: 161-77. PMID 9418864 |
0.559 |
|
| 1996 |
Bennett AM, Hausdorff SF, O'Reilly AM, Freeman RM, Neel BG. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Molecular and Cellular Biology. 16: 1189-202. PMID 8622663 DOI: 10.1128/Mcb.16.3.1189 |
0.589 |
|
| 1995 |
Tang TL, Freeman RM, O'Reilly AM, Neel BG, Sokol SY. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell. 80: 473-83. PMID 7859288 |
0.62 |
|
| Show low-probability matches. |