| Year |
Citation |
Score |
| 2023 |
Buerer L, Clark N, Welch A, Duan C, Taggart A, Townley B, Wang J, Soemedi R, Rong S, Lin CL, Zeng Y, Katolik A, Staley J, Damha M, Mosammaparast N, ... Fairbrother W, et al. The debranching enzyme Dbr1 regulates lariat turnover and intron splicing. Research Square. PMID 37398028 DOI: 10.21203/rs.3.rs-2931976/v1 |
0.387 |
|
| 2023 |
Townley BA, Buerer L, Tsao N, Bacolla A, Mansoori F, Rusanov T, Clark N, Goodarzi N, Schmidt N, Srivatsan SN, Sun H, Sample RA, Brickner JR, McDonald D, Tsai MS, ... ... Fairbrother WG, et al. A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy. Molecular Cell. PMID 37369199 DOI: 10.1016/j.molcel.2023.06.011 |
0.308 |
|
| 2023 |
Rong S, Neil CR, Welch A, Duan C, Maguire S, Meremikwu IC, Meyerson M, Evans BJ, Fairbrother WG. Large-scale functional screen identifies genetic variants with splicing effects in modern and archaic humans. Proceedings of the National Academy of Sciences of the United States of America. 120: e2218308120. PMID 37192163 DOI: 10.1073/pnas.2218308120 |
0.391 |
|
| 2022 |
Fredericks AM, East KW, Shi Y, Liu J, Maschietto F, Ayala A, Cioffi WG, Cohen M, Fairbrother WG, Lefort CT, Nau GJ, Levy MM, Wang J, Batista VS, Lisi GP, et al. Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations. Frontiers in Molecular Biosciences. 9: 1080964. PMID 36589229 DOI: 10.3389/fmolb.2022.1080964 |
0.313 |
|
| 2022 |
Rhine CL, Neil C, Wang J, Maguire S, Buerer L, Salomon M, Meremikwu IC, Kim J, Strande NT, Fairbrother WG. Massively parallel reporter assays discover de novo exonic splicing mutants in paralogs of Autism genes. Plos Genetics. 18: e1009884. PMID 35051175 DOI: 10.1371/journal.pgen.1009884 |
0.331 |
|
| 2021 |
Glidden DT, Buerer JL, Saueressig CF, Fairbrother WG. Hotspot exons are common targets of splicing perturbations. Nature Communications. 12: 2756. PMID 33980843 DOI: 10.1038/s41467-021-22780-2 |
0.443 |
|
| 2020 |
Rong S, Buerer L, Rhine CL, Wang J, Cygan KJ, Fairbrother WG. Mutational bias and the protein code shape the evolution of splicing enhancers. Nature Communications. 11: 2845. PMID 32504065 DOI: 10.1038/S41467-020-16673-Z |
0.457 |
|
| 2020 |
Fredericks AM, Wang LJ, Fairbrother WG, Ayala A, Monaghan SF. Alternative RNA splicing and alternative transcription start/end in acute respiratory distress syndrome. Intensive Care Medicine. PMID 32077999 DOI: 10.1007/S00134-020-05953-3 |
0.35 |
|
| 2019 |
Neil CR, Fairbrother WG. Intronic RNA: Ad'junk' mediator of post-transcriptional gene regulation. Biochimica Et Biophysica Acta. 1862: 194439. PMID 31682938 DOI: 10.1016/J.Bbagrm.2019.194439 |
0.432 |
|
| 2019 |
Mount SM, Avsec Ž, Carmel L, Casadio R, Çelik MH, Chen K, Cheng J, Cohen NE, Fairbrother WG, Fenesh T, Gagneur J, Gotea V, Holzer T, Lin CF, Martelli PL, et al. Assessing predictions of the impact of variants on splicing in CAGI5. Human Mutation. PMID 31301154 DOI: 10.1002/Humu.23869 |
0.389 |
|
| 2019 |
Rhine CL, Neil C, Glidden DT, Cygan KJ, Fredericks AM, Wang J, Walton NA, Fairbrother WG. Future directions for high-throughput splicing assays in precision medicine. Human Mutation. PMID 31297895 DOI: 10.1002/Humu.23866 |
0.457 |
|
| 2019 |
Cheng J, Nguyen TYD, Cygan KJ, Çelik MH, Fairbrother WG, Avsec Ž, Gagneur J. MMSplice: modular modeling improves the predictions of genetic variant effects on splicing. Genome Biology. 20: 48. PMID 30823901 DOI: 10.1186/S13059-019-1653-Z |
0.378 |
|
| 2018 |
Monaghan SF, Banerjee D, Chung CS, Lomas-Neira J, Cygan KJ, Rhine CL, Fairbrother WG, Heffernan DS, Levy MM, Cioffi WG, Ayala A. Changes in the process of alternative RNA splicing results in soluble B and T lymphocyte attenuator with biological and clinical implications in critical illness. Molecular Medicine (Cambridge, Mass.). 24: 32. PMID 30134817 DOI: 10.1186/S10020-018-0036-3 |
0.326 |
|
| 2018 |
Rhine CL, Cygan KJ, Soemedi R, Maguire S, Murray MF, Monaghan SF, Fairbrother WG. Hereditary cancer genes are highly susceptible to splicing mutations. Plos Genetics. 14: e1007231. PMID 29505604 DOI: 10.1371/Journal.Pgen.1007231 |
0.458 |
|
| 2018 |
Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, ... ... Fairbrother WG, et al. Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 172: 952-965.e18. PMID 29474921 DOI: 10.1016/J.Cell.2018.02.019 |
0.343 |
|
| 2017 |
Kim SW, Taggart AJ, Heintzelman C, Cygan KJ, Hull CG, Wang J, Shrestha B, Fairbrother WG. Widespread intra-dependencies in the removal of introns from human transcripts. Nucleic Acids Research. 45: 9503-9513. PMID 28934498 DOI: 10.1093/Nar/Gkx661 |
0.458 |
|
| 2017 |
Cygan KJ, Sanford CH, Fairbrother WG. Spliceman2: a computational web server that predicts defects in pre-mRNA splicing Bioinformatics. 33: 2943-2945. PMID 28911038 DOI: 10.1093/Bioinformatics/Btx343 |
0.505 |
|
| 2017 |
Cygan KJ, Soemedi R, Rhine CL, Profeta A, Murphy EL, Murray MF, Fairbrother WG. Defective splicing of the RB1 transcript is the dominant cause of retinoblastomas. Human Genetics. PMID 28780672 DOI: 10.1007/S00439-017-1833-4 |
0.467 |
|
| 2017 |
Soemedi R, Cygan KJ, Rhine C, Glidden DT, Taggart AJ, Lin CL, Fredericks AM, Fairbrother WG. The Effects of Structure on pre-mRNA Processing and Stability. Methods (San Diego, Calif.). PMID 28595983 DOI: 10.1016/J.Ymeth.2017.06.001 |
0.434 |
|
| 2017 |
Soemedi R, Cygan KJ, Rhine CL, Wang J, Bulacan C, Yang J, Bayrak-Toydemir P, McDonald J, Fairbrother WG. Pathogenic variants that alter protein code often disrupt splicing. Nature Genetics. PMID 28416821 DOI: 10.1038/Ng.3837 |
0.473 |
|
| 2017 |
Taggart AJ, Lin CL, Shrestha B, Heintzelman C, Kim S, Fairbrother WG. Large-scale analysis of branchpoint usage across species and cell lines. Genome Research. PMID 28119336 DOI: 10.1101/Gr.202820.115 |
0.453 |
|
| 2016 |
Lin CL, Taggart AJ, Fairbrother WG. RNA Structure in Splicing: an Evolutionary Perspective. Rna Biology. 0. PMID 27454491 DOI: 10.1080/15476286.2016.1208893 |
0.441 |
|
| 2016 |
Stracquadanio G, Wang X, Wallace MD, Grawenda AM, Zhang P, Hewitt J, Zeron-Medina J, Castro-Giner F, Tomlinson IP, Goding CR, Cygan KJ, Fairbrother WG, Thomas LF, Sætrom P, Gemignani F, et al. The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nature Reviews. Cancer. 16: 251-65. PMID 27009395 DOI: 10.1038/Nrc.2016.15 |
0.334 |
|
| 2016 |
Stracquadanio G, Wallace M, Grawenda A, Zhang P, Hewitt J, Zeron-Medina J, Castro-Giner F, Tomlinson I, Goding C, Cygan K, Fairbrother W, Thomas L, Sætrom P, Gemignani F, Landi S, et al. Polymorphisms in the p53 pathway are enriched in cancer susceptibility loci and share characteristics with somatic pathway mutations European Journal of Cancer. 61: S179. DOI: 10.1016/S0959-8049(16)61634-9 |
0.316 |
|
| 2015 |
Lin CL, Taggart AJ, Lim KH, Ferraris L, Cygan KJ, Creton R, Huang YT, Fairbrother WG. RNA structure replaces the need for U2AF65 in splicing. Genome Research. PMID 26566657 DOI: 10.1101/Gr.181008.114 |
0.402 |
|
| 2014 |
Soemedi R, Vega H, Belmont JM, Ramachandran S, Fairbrother WG. Genetic variation and RNA binding proteins: tools and techniques to detect functional polymorphisms. Advances in Experimental Medicine and Biology. 825: 227-66. PMID 25201108 DOI: 10.1007/978-1-4939-1221-6_7 |
0.468 |
|
| 2014 |
Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, ... ... Fairbrother W, et al. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology. 15: R53. PMID 24667040 DOI: 10.1186/Gb-2014-15-3-R53 |
0.335 |
|
| 2013 |
Ceyhan-Birsoy O, Agrawal PB, Hidalgo C, Schmitz-Abe K, DeChene ET, Swanson LC, Soemedi R, Vasli N, Iannaccone ST, Shieh PB, Shur N, Dennison JM, Lawlor MW, Laporte J, Markianos K, ... Fairbrother WG, et al. Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology. 81: 1205-14. PMID 23975875 DOI: 10.1212/Wnl.0B013E3182A6Ca62 |
0.406 |
|
| 2012 |
Yajima M, Fairbrother WG, Wessel GM. ISWI contributes to ArsI insulator function in development of the sea urchin. Development (Cambridge, England). 139: 3613-22. PMID 22949616 DOI: 10.1242/Dev.081828 |
0.347 |
|
| 2012 |
Taggart AJ, DeSimone AM, Shih JS, Filloux ME, Fairbrother WG. Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo. Nature Structural & Molecular Biology. 19: 719-21. PMID 22705790 DOI: 10.1038/Nsmb.2327 |
0.419 |
|
| 2012 |
Lim KH, Fairbrother WG. Spliceman--a computational web server that predicts sequence variations in pre-mRNA splicing. Bioinformatics (Oxford, England). 28: 1031-2. PMID 22328782 DOI: 10.1093/Bioinformatics/Bts074 |
0.481 |
|
| 2011 |
Lim KH, Ferraris L, Filloux ME, Raphael BJ, Fairbrother WG. Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 11093-8. PMID 21685335 DOI: 10.1073/Pnas.1101135108 |
0.507 |
|
| 2011 |
Ferraris L, Stewart AP, Kang J, DeSimone AM, Gemberling M, Tantin D, Fairbrother WG. Combinatorial binding of transcription factors in the pluripotency control regions of the genome. Genome Research. 21: 1055-64. PMID 21527551 DOI: 10.1101/Gr.115824.110 |
0.332 |
|
| 2011 |
Ferraris L, Stewart AP, Gemberling MP, Reid DC, Lapadula MJ, Thompson WA, Fairbrother WG. High-throughput mapping of protein occupancy identifies functional elements without the restriction of a candidate factor approach. Nucleic Acids Research. 39: e33. PMID 21169336 DOI: 10.1093/Nar/Gkq1213 |
0.402 |
|
| 2010 |
Chang B, Levin J, Thompson WA, Fairbrother WG. High-throughput binding analysis determines the binding specificity of ASF/SF2 on alternatively spliced human pre-mRNAs. Combinatorial Chemistry & High Throughput Screening. 13: 242-52. PMID 20015017 DOI: 10.2174/138620710790980522 |
0.463 |
|
| 2009 |
Watkins KH, Stewart A, Fairbrother W. A rapid high-throughput method for mapping ribonucleoproteins (RNPs) on human pre-mRNA. Journal of Visualized Experiments : Jove. PMID 19956082 DOI: 10.3791/1622 |
0.468 |
|
| 2009 |
Reid DC, Chang BL, Gunderson SI, Alpert L, Thompson WA, Fairbrother WG. Next-generation SELEX identifies sequence and structural determinants of splicing factor binding in human pre-mRNA sequence. Rna (New York, N.Y.). 15: 2385-97. PMID 19861426 DOI: 10.1261/Rna.1821809 |
0.426 |
|
| 2009 |
Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin D. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes & Development. 23: 208-22. PMID 19171782 DOI: 10.1101/Gad.1750709 |
0.315 |
|
| 2008 |
Tantin D, Gemberling M, Callister C, Fairbrother WG, Fairbrother W. High-throughput biochemical analysis of in vivo location data reveals novel distinct classes of POU5F1(Oct4)/DNA complexes. Genome Research. 18: 631-9. PMID 18212089 DOI: 10.1101/Gr.072942.107 |
0.391 |
|
| 2005 |
Pfarr N, Prawitt D, Kirschfink M, Schroff C, Knuf M, Habermehl P, Mannhardt W, Zepp F, Fairbrother WG, Fairbrother W, Loos M, Burge CB, Pohlenz J. Linking C5 deficiency to an exonic splicing enhancer mutation. Journal of Immunology (Baltimore, Md. : 1950). 174: 4172-7. PMID 15778377 DOI: 10.4049/Jimmunol.174.7.4172 |
0.458 |
|
| 2004 |
Fairbrother WG, Holste D, Burge CB, Sharp PA. Single nucleotide polymorphism-based validation of exonic splicing enhancers. Plos Biology. 2: E268. PMID 15340491 DOI: 10.1371/Journal.Pbio.0020268 |
0.431 |
|
| 2004 |
Fairbrother WG, Yeo GW, Yeh R, Goldstein P, Mawson M, Sharp PA, Burge CB. RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Research. 32: W187-90. PMID 15215377 DOI: 10.1093/Nar/Gkh393 |
0.469 |
|
| 2002 |
Fairbrother WG, Yeh RF, Sharp PA, Burge CB. Predictive identification of exonic splicing enhancers in human genes. Science (New York, N.Y.). 297: 1007-13. PMID 12114529 DOI: 10.1126/Science.1073774 |
0.491 |
|
| 2000 |
Fairbrother WG, Chasin LA. Human genomic sequences that inhibit splicing. Molecular and Cellular Biology. 20: 6816-25. PMID 10958678 DOI: 10.1128/Mcb.20.18.6816-6825.2000 |
0.45 |
|
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