Year |
Citation |
Score |
2017 |
Meyer D, Smeilus T, Pliatsika D, Mousavizadeh F, Giannis A. Synthesis of novel C-9 carbon substituted derivatives of artemisinin. Bioorganic & Medicinal Chemistry. PMID 28341405 DOI: 10.1016/J.Bmc.2017.03.021 |
0.343 |
|
2016 |
Antoniou A, Chatzopoulou M, Bantzi M, Athanassopoulos CM, Giannis A, Pitsinos EN. Identification of Gli-mediated transcription inhibitors through synthesis and evaluation of taepeenin D analogues Medchemcomm. 7: 2328-2331. DOI: 10.1039/C6Md00354K |
0.356 |
|
2016 |
Psarra V, Fousteris MA, Hennig L, Bantzi M, Giannis A, Nikolaropoulos SS. Identification of azepinone fused tetracyclic heterocycles as new chemotypes with protein kinase inhibitory activities Tetrahedron. 72: 2376-2385. DOI: 10.1016/J.Tet.2016.03.048 |
0.365 |
|
2015 |
Heretsch P, Giannis A. The Veratrum and Solanum alkaloids. The Alkaloids. Chemistry and Biology. 74: 201-32. PMID 25845062 DOI: 10.1016/Bs.Alkal.2014.11.002 |
0.627 |
|
2015 |
Smeilus T, Hennig L, Beyer L, Sieler J, Giannis A. The Mistake in Carl Bosch's PhD Thesis: A Contribution to "Retro-Chemistry" Synthesis (Germany). 47: 1887-1892. DOI: 10.1055/S-0034-1380495 |
0.301 |
|
2014 |
Wratil PR, Rigol S, Solecka B, Kohla G, Kannicht C, Reutter W, Giannis A, Nguyen LD. A novel approach to decrease sialic acid expression in cells by a C-3-modified N-acetylmannosamine. The Journal of Biological Chemistry. 289: 32056-63. PMID 25278018 DOI: 10.1074/Jbc.M114.608398 |
0.323 |
|
2014 |
Rabe S, Moschner J, Bantzi M, Heretsch P, Giannis A. C-H-Functionalization logic guides the synthesis of a carbacyclopamine analog. Beilstein Journal of Organic Chemistry. 10: 1564-9. PMID 25161712 DOI: 10.3762/Bjoc.10.161 |
0.629 |
|
2014 |
Heretsch P, Giannis A. Cyclopamine and Congeners Natural Products in Medicinal Chemistry. 545-564. DOI: 10.1002/9783527676545.ch15 |
0.58 |
|
2013 |
Moschner J, Chentsova A, Eilert N, Rovardi I, Heretsch P, Giannis A. Cyclopamine analogs bearing exocyclic methylenes are highly potent and acid-stable inhibitors of hedgehog signaling. Beilstein Journal of Organic Chemistry. 9: 2328-35. PMID 24367396 DOI: 10.3762/Bjoc.9.267 |
0.665 |
|
2012 |
Aurich A, Specht R, Müller RA, Stottmeister U, Yovkova V, Otto C, Holz M, Barth G, Heretsch P, Thomas FA, Sicker D, Giannis A. Microbiologically produced carboxylic acids used as building blocks in organic synthesis. Sub-Cellular Biochemistry. 64: 391-423. PMID 23080261 DOI: 10.1007/978-94-007-5055-5_19 |
0.673 |
|
2012 |
Seifert K, Büttner A, Rigol S, Eilert N, Wandel E, Giannis A. Potent small molecule Hedgehog agonists induce VEGF expression in vitro. Bioorganic & Medicinal Chemistry. 20: 6465-81. PMID 22985958 DOI: 10.1016/J.Bmc.2012.08.026 |
0.3 |
|
2011 |
Heretsch P, Büttner A, Tzagkaroulaki L, Zahn S, Kirchner B, Giannis A. Exo-cyclopamine--a stable and potent inhibitor of hedgehog-signaling. Chemical Communications (Cambridge, England). 47: 7362-4. PMID 21589966 DOI: 10.1039/C1Cc11782C |
0.662 |
|
2011 |
Vasconcelos RS, Silva LF, Giannis A. Synthesis of tetrahydrofurans by cyclization of homoallylic alcohols with iodine/iodine(III). The Journal of Organic Chemistry. 76: 1499-502. PMID 21244003 DOI: 10.1021/Jo102413U |
0.305 |
|
2010 |
Heretsch P, Tzagkaroulaki L, Giannis A. Modulators of the hedgehog signaling pathway. Bioorganic & Medicinal Chemistry. 18: 6613-24. PMID 20708941 DOI: 10.1016/J.Bmc.2010.07.038 |
0.626 |
|
2010 |
Heretsch P, Rabe S, Giannis A. A biomimetic approach to C-nor-D-homo-steroids. Journal of the American Chemical Society. 132: 9968-9. PMID 20597501 DOI: 10.1021/Ja103152K |
0.647 |
|
2010 |
Büttner A, Cottin T, Xu J, Tzagkaroulaki L, Giannis A. Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. 18: 3387-402. PMID 20456957 DOI: 10.1016/J.Bmc.2010.04.001 |
0.32 |
|
2010 |
Heretsch P, Tzagkaroulaki L, Giannis A. Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives. Angewandte Chemie (International Ed. in English). 49: 3418-27. PMID 20429080 DOI: 10.1002/Anie.200906967 |
0.61 |
|
2010 |
Wetzel S, Wilk W, Chammaa S, Sperl B, Roth AG, Yektaoglu A, Renner S, Berg T, Arenz C, Giannis A, Oprea TI, Rauh D, Kaiser M, Waldmann H. A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones. Angewandte Chemie (International Ed. in English). 49: 3666-70. PMID 20394088 DOI: 10.1002/Anie.200906555 |
0.677 |
|
2010 |
Churruca F, Fousteris M, Ishikawa Y, Rekowski Mv, Hounsou C, Surrey T, Giannis A. A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues. Organic Letters. 12: 2096-9. PMID 20387880 DOI: 10.1021/Ol100579W |
0.36 |
|
2010 |
von Wantoch Rekowski M, Pyriochou A, Papapetropoulos N, Stössel A, Papapetropoulos A, Giannis A. Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase. Bioorganic & Medicinal Chemistry. 18: 1288-96. PMID 20036129 DOI: 10.1016/J.Bmc.2009.12.027 |
0.384 |
|
2010 |
HENK T, GIANNIS A, SANDHOFF K. ChemInform Abstract: Wittig Olefination of Unprotected Carbohydrates with a Semistabilized Ylide. Cheminform. 23: no-no. DOI: 10.1002/chin.199220276 |
0.542 |
|
2010 |
Heretsch P, Tzagkaroulaki L, Giannis A. Cyclopamin und der Hedgehog-Signaltransduktionsweg: Chemie, Biologie, medizinische Perspektiven Angewandte Chemie. 122: 3492-3502. DOI: 10.1002/Ange.200906967 |
0.62 |
|
2009 |
Heretsch P, Rabe S, Giannis A. Synthesis of all diastereomers of the piperidine--alkaloid substructure of cyclopamine. Organic Letters. 11: 5410-2. PMID 19883099 DOI: 10.1021/Ol902270F |
0.692 |
|
2009 |
Giannis A, Heretsch P, Sarli V, Stössel A. Synthesis of cyclopamine using a biomimetic and diastereoselective approach. Angewandte Chemie (International Ed. in English). 48: 7911-4. PMID 19591183 DOI: 10.1002/Anie.200902520 |
0.652 |
|
2009 |
Büttner A, Seifert K, Cottin T, Sarli V, Tzagkaroulaki L, Scholz S, Giannis A. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorganic & Medicinal Chemistry. 17: 4943-54. PMID 19541490 DOI: 10.1016/J.Bmc.2009.06.008 |
0.318 |
|
2009 |
Sardon T, Cottin T, Xu J, Giannis A, Vernos I. Development and biological evaluation of a novel aurora A kinase inhibitor. Chembiochem : a European Journal of Chemical Biology. 10: 464-78. PMID 19199284 DOI: 10.1002/Cbic.200800600 |
0.325 |
|
2009 |
Giannis A, Heretsch P, Sarli V, Stößel A. Cover Picture: Synthesis of Cyclopamine Using a Biomimetic and Diastereoselective Approach (Angew. Chem. Int. Ed. 42/2009) Angewandte Chemie International Edition. 48: 7707-7707. DOI: 10.1002/Anie.200904019 |
0.652 |
|
2009 |
Giannis A, Heretsch P, Sarli V, Stößel A. Titelbild: Synthese von Cyclopamin unter Verwendung biomimetischer und diastereoselektiver Transformationen (Angew. Chem. 42/2009) Angewandte Chemie. 121: 7843-7843. DOI: 10.1002/Ange.200904019 |
0.671 |
|
2009 |
Giannis A, Heretsch P, Sarli V, Stößel A. Synthese von Cyclopamin unter Verwendung biomimetischer und diastereoselektiver Transformationen Angewandte Chemie. 121: 8052-8055. DOI: 10.1002/Ange.200902520 |
0.671 |
|
2008 |
Heretsch P, Thomas F, Aurich A, Krautscheid H, Sicker D, Giannis A. Syntheses with a chiral building block from the citric acid cycle: (2R,3S)-isocitric acid by fermentation of sunflower oil. Angewandte Chemie (International Ed. in English). 47: 1958-60. PMID 18236482 DOI: 10.1002/Anie.200705000 |
0.64 |
|
2008 |
Mann S, Sarli V, Giannis A. A convenient synthesis of functionalized furans Synthesis. 2617-2625. DOI: 10.1055/S-2008-1067183 |
0.347 |
|
2008 |
Heretsch P, Thomas F, Aurich A, Krautscheid H, Sicker D, Giannis A. Synthesen mit einem chiralen Baustein aus dem Citratzyklus: (2R,3S)-Isocitronensäure aus einer Fermentation mit Sonnenblumenöl Angewandte Chemie. 120: 1984-1986. DOI: 10.1002/Ange.200705000 |
0.607 |
|
2007 |
Batova A, Lam T, Wascholowski V, Yu AL, Giannis A, Theodorakis EA. Synthesis and evaluation of caged Garcinia xanthones. Organic & Biomolecular Chemistry. 5: 494-500. PMID 17252132 DOI: 10.1039/B612903J |
0.35 |
|
2007 |
Müller C, Gross D, Sarli V, Gartner M, Giannis A, Bernhardt G, Buschauer A. Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells. Cancer Chemotherapy and Pharmacology. 59: 157-64. PMID 16703323 DOI: 10.1007/S00280-006-0254-1 |
0.301 |
|
2007 |
Heretsch P, Giannis A. An efficient entry to amino-substituted resorcylic acid derivatives for the synthesis of platensimycin and analogues Synthesis. 2614-2616. DOI: 10.1055/S-2007-983843 |
0.681 |
|
2005 |
Sarli V, Huemmer S, Sunder-Plassmann N, Mayer TU, Giannis A. Synthesis and biological evaluation of novel EG5 inhibitors. Chembiochem : a European Journal of Chemical Biology. 6: 2005-13. PMID 16216042 DOI: 10.1002/Cbic.200500168 |
0.389 |
|
2005 |
Sunder-Plassmann N, Sarli V, Gartner M, Utz M, Seiler J, Huemmer S, Mayer TU, Surrey T, Giannis A. Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5. Bioorganic & Medicinal Chemistry. 13: 6094-111. PMID 16084101 DOI: 10.1016/J.Bmc.2005.06.027 |
0.369 |
|
2005 |
Mazitschek R, Huwe A, Giannis A. Synthesis and biological evaluation of novel fumagillin and ovalicin analogues. Organic & Biomolecular Chemistry. 3: 2150-4. PMID 15917904 DOI: 10.1039/B503163J |
0.336 |
|
2005 |
Gartner M, Sunder-Plassmann N, Seiler J, Utz M, Vernos I, Surrey T, Giannis A. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. Chembiochem : a European Journal of Chemical Biology. 6: 1173-7. PMID 15912555 DOI: 10.1002/Cbic.200500005 |
0.32 |
|
2005 |
Gartner M, Müller T, Simon JC, Giannis A, Sleeman JP. Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent. Chembiochem : a European Journal of Chemical Biology. 6: 171-7. PMID 15593112 DOI: 10.1002/Cbic.200400195 |
0.304 |
|
2004 |
Al-Rawi S, Hinderlich S, Reutter W, Giannis A. Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase. Angewandte Chemie (International Ed. in English). 43: 4366-70. PMID 15368395 DOI: 10.1002/Anie.200453863 |
0.345 |
|
2004 |
Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H. Synthesis and biological evaluation of an indomethacin library reveals a new class of angiogenesis-related kinase inhibitors. Angewandte Chemie (International Ed. in English). 43: 224-8. PMID 14695616 DOI: 10.1002/Anie.200352582 |
0.34 |
|
2004 |
Schulze A, Giannis A. IBX-mediated conversion of primary alcohols and aldehydes to N-hydroxysuccinimide esters Advanced Synthesis and Catalysis. 346: 252-256. DOI: 10.1002/Adsc.200303195 |
0.328 |
|
2003 |
Pitsinos EN, Wascholowski V, Karaliota S, Rigou C, Couladouros EA, Giannis A. Synthesis and evaluation of three novel scyphostatin analogues as neutral sphingomyelinase inhibitors. Chembiochem : a European Journal of Chemical Biology. 4: 1223-5. PMID 14613115 DOI: 10.1002/Cbic.200300667 |
0.314 |
|
2003 |
Stieber F, Grether U, Mazitschek R, Soric N, Giannis A, Waldmann H. Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 3282-91. PMID 12866072 DOI: 10.1002/Chem.200304821 |
0.314 |
|
2002 |
Stahl P, Kissau L, Mazitschek R, Giannis A, Waldmann H. Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors. Angewandte Chemie (International Ed. in English). 41: 1174-8. PMID 12491250 DOI: 10.1002/1521-3773(20020402)41:7<1174::Aid-Anie1174>3.0.Co;2-V |
0.304 |
|
2002 |
Arenz C, Thutewohl M, Block O, Waldmann H, Altenbach HJ, Giannis A. Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase. Chembiochem : a European Journal of Chemical Biology. 2: 141-3. PMID 11828438 DOI: 10.1002/1439-7633(20010202)2:2<141::Aid-Cbic141>3.0.Co;2-P |
0.718 |
|
2001 |
Stahl P, Kissau L, Mazitschek R, Huwe A, Furet P, Giannis A, Waldmann H. Total synthesis and biological evaluation of the nakijiquinones. Journal of the American Chemical Society. 123: 11586-93. PMID 11716712 DOI: 10.1021/Ja011413I |
0.367 |
|
2001 |
Arenz C, Gartner M, Wascholowski V, Giannis A. Synthesis and biochemical investigation of scyphostatin analogues as inhibitors of neutral sphingomyelinase Bioorganic and Medicinal Chemistry. 9: 2901-2904. PMID 11597471 DOI: 10.1016/S0968-0896(01)00165-1 |
0.727 |
|
2001 |
Ficht S, Mülbaier M, Giannis A. Development of new and efficient polymer-supported hypervalent iodine reagents Tetrahedron. 57: 4863-4866. DOI: 10.1016/S0040-4020(01)00424-0 |
0.304 |
|
2001 |
Mülbaier M, Giannis A. Festphasen-gebundenes IBX: Synthese und Oxidationseigenschaften Angewandte Chemie. 113: 4530-4532. DOI: 10.1002/1521-3757(20011203)113:23<4530::Aid-Ange4530>3.0.Co;2-1 |
0.354 |
|
2001 |
Arenz C, Giannis A. Synthesis of the first selective irreversible inhibitor of neutral sphingomyelinase European Journal of Organic Chemistry. 137-140. DOI: 10.1002/(Sici)1521-3773(20000417)39:8<1440::Aid-Anie1440>3.0.Co;2-R |
0.732 |
|
2000 |
Rübsam F, Mazitschek R, Giannis A. Synthesis of chiral piperazinones as versatile scaffolds for peptidomimetics Tetrahedron. 56: 8481-8487. DOI: 10.1016/S0040-4020(00)00787-0 |
0.348 |
|
2000 |
Arenz C, Giannis A. Synthese des ersten selektiven irreversiblen Inhibitors der neutralen Sphingomyelinase Angewandte Chemie. 112: 1498-1500. DOI: 10.1002/(Sici)1521-3757(20000417)112:8<1498::Aid-Ange1498>3.0.Co;2-Y |
0.725 |
|
1998 |
Van Echten-Deckert G, Giannis A, Schwarz A, Futerman AH, Sandhoff K. 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis Journal of Biological Chemistry. 273: 1184-1191. PMID 9422785 DOI: 10.1074/Jbc.273.2.1184 |
0.562 |
|
1996 |
Schick A, Kolter T, Giannis A, Sandhoff K. Synthesis of phosphoramide analogues of sphinganine-1-phosphate Tetrahedron. 52: 2945-2956. DOI: 10.1016/0040-4020(95)01119-6 |
0.635 |
|
1995 |
Schick A, Kolter T, Giannis A, Sandhoff K. Synthesis of phosphonate analogues of sphinganine-1-phosphate and sphingosine-1-phosphate Tetrahedron. 51: 11207-11218. DOI: 10.1016/0040-4020(95)00688-5 |
0.632 |
|
1993 |
Liessem B, Giannis A, Sandhoff K, Nieger M. Synthese von 2-acetamido-1,4-imino-1,2,4-tridesoxy-d- galaktitol und kompetitive Inhibition der humanen lysosomalen β-hexosaminidase A Carbohydrate Research. 250: 19-30. PMID 8143290 DOI: 10.1016/0008-6215(93)84151-U |
0.604 |
|
1992 |
Zeitler R, Giannis A, Danneschewski S, Henk E, Henk T, Bauer C, Reutter W, Sandhoff K. Inhibition of N-acetylglucosamine kinase and N-acetylmannosamine kinase by 3-O-methyl-N-acetyl-D-glucosamine in vitro European Journal of Biochemistry. 204: 1165-1168. PMID 1312935 DOI: 10.1111/J.1432-1033.1992.Tb16743.X |
0.585 |
|
1992 |
Brenner-Weiß G, Giannis A, Sandhoff K. Synthesis of potential inhibitors of the glycosphingolipid biosynthesis Tetrahedron. 48: 5855-5860. DOI: 10.1016/S0040-4020(01)90177-2 |
0.646 |
|
1992 |
Henk T, Giannis A, Sandhoff K. Wittig Olefination of Unprotected Carbohydrates with a Semistabilized Ylide Liebigs Annalen Der Chemie. 1992: 167-168. DOI: 10.1002/Jlac.199219920130 |
0.593 |
|
1991 |
Giannis A, Henk T. Synthese chiraler Bausteine ausD-glucosamin-hydrochlorid Liebigs Annalen Der Chemie. 1991: 789-793. DOI: 10.1002/Jlac.1991199101135 |
0.37 |
|
1990 |
Singh NP, Schmidt RR, Giannis A, Henk E, Kolter T, Sandhoff K. Synthesis of 2-Carboxy-Substituted Sphingosine Derivatives Journal of Carbohydrate Chemistry. 9: 543-559. DOI: 10.1080/07328309008543852 |
0.633 |
|
1990 |
Giannis A, Henk T. Chirospecific synthesis of amino acids, amino aldehydes and amino alcohols from D-glucosamine hydrochloride. A multigram synthesis of N-boc-L-serinal Tetrahedron Letters. 31: 1253-1256. DOI: 10.1016/S0040-4039(00)88778-X |
0.332 |
|
1989 |
Giannis A, Sandhoff K. LiBH4(NaBH4)/Me3SiCl, an Unusually Strong and Versatile Reducing Agent Angewandte Chemie International Edition in English. 28: 218-220. DOI: 10.1002/Anie.198902181 |
0.551 |
|
1989 |
Giannis A, Sandhoff K. LiBH4(NaBH4)/Me3SiCl, ein ungewöhnlich starkes und vielseitig einsetzbares Reduktionsmittel Angewandte Chemie. 101: 220-222. DOI: 10.1002/Ange.19891010231 |
0.565 |
|
1988 |
Giannis A, Münster P, Sandhoff K, Steglich W. Fragmentation and wittig olefination of glucosamine derivatives-a simple route to open chain amino sugars and chiral glycerols Tetrahedron. 44: 7177-7180. DOI: 10.1016/S0040-4020(01)86086-5 |
0.605 |
|
1987 |
Giannis A, Sandhoff K. Diastereoselektive synthese von funktionalisierten C-α- und -β-glykosylderivaten der 2-acetamido-2-desoxy-d-glucose Carbohydrate Research. 171: 201-210. DOI: 10.1016/S0008-6215(00)90887-5 |
0.586 |
|
1985 |
Giannis A, Sandhoff K. Stereoselective synthesis of α- C-allyl-glycopyranosides Tetrahedron Letters. 26: 1479-1482. DOI: 10.1016/S0040-4039(00)98529-0 |
0.628 |
|
1981 |
Reetz MT, Giannis A. Lewis Acid Mediated A-Thioalkylation of Ketones Synthetic Communications. 11: 315-322. DOI: 10.1080/00397918108063611 |
0.379 |
|
1981 |
Reetz MT, Giannis A. LEWIS ACID MEDIATED α‐THIOALKYLATION OF KETONES Cheminform. 12: 315-322. DOI: 10.1002/Chin.198143125 |
0.365 |
|
1981 |
REETZ MT, MAIER WF, CHATZIIOSIFIDIS I, GIANNIS A, HEIMBACH H, LOEWE U. ChemInform Abstract: LEWIS ACID MEDIATED α-ALKYLATION OF CARBONYL COMPOUNDS. VII. REGIO AND POSITION SPECIFIC α-TERT-ALKYLATION OF KETONES Chemischer Informationsdienst. 12. DOI: 10.1002/Chin.198109166 |
0.65 |
|
1981 |
REETZ MT, MAIER WF, HEIMBACH H, GIANNIS A, ANASTASSIOUS G. ChemInform Abstract: LEWIS ACID MEDIATED α-ALKYLATION OF CARBONYL COMPOUNDS. VI. OPTIMIZATION OF THE PROCEDURE FOR THE α-TERT-ALKYLATION OF KETONES AND ALDEHYDES Chemischer Informationsdienst. 12. DOI: 10.1002/Chin.198109165 |
0.648 |
|
1980 |
Reetz MT, Maier WF, Chatziiosifidis I, Giannis A, Heimbach H, Löwe U. Lewis-Säure-bedingte α-Alkylierung von Carbonylverbindungen, VII. Regio- und positionsspezifische α-tert-Alkylierung von Ketonen Chemische Berichte. 113: 3741-3757. DOI: 10.1002/Cber.19801131208 |
0.476 |
|
1980 |
Reetz MT, Maier WF, Heimbach H, Giannis A, Anastassious G. Lewis-Säure-bedingte α-Alkylierung von Carbonylverbindungen, VI. Optimierung des Verfahrens zur α-tert-Alkylierung von Ketonen und Aldehyden Chemische Berichte. 113: 3734-3740. DOI: 10.1002/Cber.19801131207 |
0.486 |
|
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