| Year |
Citation |
Score |
| 2022 |
Bora-Singhal N, Saha B, Mohankumar D, Padmanabhan J, Coppola D, Chellappan S. A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis. Cancer Research Communications. 2: 624-638. PMID 35937460 DOI: 10.1158/2767-9764.crc-21-0084 |
0.417 |
|
| 2022 |
Sriramareddy SN, Faião-Flores F, Emmons MF, Saha B, Chellappan S, Wyatt C, Smalley I, Licht JD, Durante MA, Harbour JW, Smalley KSM. HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma. Cancer Gene Therapy. PMID 35332245 DOI: 10.1038/s41417-022-00452-7 |
0.31 |
|
| 2021 |
Padmanabhan J, Saha B, Powell C, Mo Q, Perez BA, Chellappan S. Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells. Cancers. 13. PMID 34359807 DOI: 10.3390/cancers13153906 |
0.374 |
|
| 2021 |
Rivera-Rivera Y, Marina M, Jusino S, Lee M, Velázquez JV, Chardón-Colón C, Vargas G, Padmanabhan J, Chellappan SP, Saavedra HI. The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells. Scientific Reports. 11: 9016. PMID 33907253 DOI: 10.1038/s41598-021-88512-0 |
0.328 |
|
| 2020 |
Maan M, Agrawal NJ, Padmanabhan J, Leitzinger CC, Rivera-Rivera Y, Saavedra HI, Chellappan SP. Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells. Biochimica Et Biophysica Acta. Molecular Cell Research. 118929. PMID 33310066 DOI: 10.1016/j.bbamcr.2020.118929 |
0.376 |
|
| 2020 |
Bora-Singhal N, Mohankumar D, Saha B, Colin CM, Lee JY, Martin MW, Zheng X, Coppola D, Chellappan S. Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2. Scientific Reports. 10: 4722. PMID 32170113 DOI: 10.1038/S41598-020-61295-6 |
0.45 |
|
| 2020 |
Jusino S, Chellappan SP, Saavedra HI. Role of E2F3 and shugoshin I in epithelial-to-mesenchymal transition and cell invasion in breast cancer. Journal of Clinical Oncology. 38: e13100-e13100. DOI: 10.1200/Jco.2020.38.15_Suppl.E13100 |
0.445 |
|
| 2020 |
Maan M, Dutta M, Jaiswal N, Saavedra H, Chellappan S. Abstract 1523: Novel role of TBK1 in breast cancer EMT Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1523 |
0.319 |
|
| 2020 |
Khambati F, Padmanabhan J, Chellappan S. Abstract 1011: Tank binding kinase (TBK1) inhibitor BX795 impairs anti-tumor efficacy of T cells by abrogating granzyme and perforin mobilization Immunology. 80: 1011-1011. DOI: 10.1158/1538-7445.Am2020-1011 |
0.512 |
|
| 2019 |
Sikder S, Kumari S, Kumar M, Sen S, Singhal NB, Chellappan S, Godbole M, Chandrani P, Dutt A, Gopinath KS, Kundu TK. Chromatin protein PC4 is downregulated in breast cancer to promote disease progression: Implications of miR-29a. Oncotarget. 10: 6855-6869. PMID 31839879 DOI: 10.18632/Oncotarget.27325 |
0.399 |
|
| 2019 |
Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S. Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Cell Reports. 28: 2824-2836.e8. PMID 31509745 DOI: 10.1016/J.Celrep.2019.08.011 |
0.316 |
|
| 2019 |
Alhothali M, Mathew M, Iyer G, Lawrence HR, Yang S, Chellappan S, Padmanabhan J. Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC. International Journal of Molecular Sciences. 20. PMID 31100813 DOI: 10.3390/Ijms20102423 |
0.445 |
|
| 2019 |
Andey T, Bora-Singhal N, Chellappan S, Singh M. Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 30831275 DOI: 10.1016/J.Nano.2019.02.007 |
0.438 |
|
| 2019 |
Saha B, Jaiswal N, Bora-Singhal N, Chellappan S. Abstract 4394: Molecular interplay between Tank-binding kinase (TBK1) and Yes-associated protein (YAP1) in KRAS mutant NSCLC Cancer Research. 79: 4394-4394. DOI: 10.1158/1538-7445.Sabcs18-4394 |
0.513 |
|
| 2019 |
Faiao-Flores F, Emmons M, Durante M, Saha B, Fang B, Koomen J, Chellappan S, Maria-Engler S, Licht J, Harbour W, Smalley K. Abstract 378: HDAC inhibition enhances MEK antagonist therapy in uveal melanoma through combined blockade of YAP, AKT and RTK signaling Cancer Research. 79: 378-378. DOI: 10.1158/1538-7445.Sabcs18-378 |
0.454 |
|
| 2019 |
Raj MKD, Bora-Singhal N, Chellappan S. Abstract 5063: Beta-arrestin-1 function in CAFs is necessary for enhancement of self-renewal of NSCLC stem-like cells Cancer Research. 78: 5063-5063. DOI: 10.1158/1538-7445.Am2018-5063 |
0.51 |
|
| 2018 |
Schaal CM, Bora-Singhal N, Kumar DM, Chellappan SP. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer. Molecular Cancer. 17: 149. PMID 30322398 DOI: 10.1186/S12943-018-0901-2 |
0.511 |
|
| 2018 |
Khambati F, Jaiswal N, Chellappan S, Soliman H. Abstract 4701: Verteporfin inhibits surface PD-L1 expression in triple-negative breast cancer (TNBC) cells Immunology. 78: 4701-4701. DOI: 10.1158/1538-7445.Am2018-4701 |
0.353 |
|
| 2018 |
Bhutada I, Chellappan S, Padmanabhan J. Abstract 2310: Targeting transcription-associated CDKs is an effective way to combat glioblastoma and medulloblastoma with minimal effect on primary neurons Cancer Research. 78: 2310-2310. DOI: 10.1158/1538-7445.Am2018-2310 |
0.464 |
|
| 2018 |
Singhal NB, Saha B, Chellappan S. Abstract 2052: A novel PHD2/VHL- mediated regulation of YAP1 and its role in vascular mimicry and tumor angiogenesis Cancer Research. 78: 2052-2052. DOI: 10.1158/1538-7445.Am2018-2052 |
0.493 |
|
| 2017 |
Jaiswal N, Pillai S, BoraSinghal N, Chellappan S. Abstract 3460: TBK1 regulates mitotic progression by modulating spindle assembly checkpoint in cancer cells Cancer Research. 77: 3460-3460. DOI: 10.1158/1538-7445.Am2017-3460 |
0.513 |
|
| 2017 |
Singhal NB, Chellappan S. Abstract 2145: Regulation of YAP1 during hypoxia and its novel role in vascular mimicry and angiogenesis Cancer Research. 77: 2145-2145. DOI: 10.1158/1538-7445.Am2017-2145 |
0.488 |
|
| 2016 |
Schaal C, Chellappan S. Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. Plos One. 11: e0156451. PMID 27228072 DOI: 10.1371/Journal.Pone.0156451 |
0.492 |
|
| 2016 |
Singhal NB, Chellappan S. Abstract 2496: Novel role of YAP1 in tumor angiogenesis and vascular mimicry Cancer Research. 76: 2496-2496. DOI: 10.1158/1538-7445.Am2016-2496 |
0.513 |
|
| 2016 |
Schaal C, Chellappan S. Abstract 2487: Nicotine-mediated regulation of Sox2 and stemness in non-small cell lung cancer Cancer Research. 76: 2487-2487. DOI: 10.1158/1538-7445.Am2016-2487 |
0.549 |
|
| 2015 |
Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nature Communications. 6: 10072. PMID 26656453 DOI: 10.1038/Ncomms10072 |
0.374 |
|
| 2015 |
Woods N, Trevino J, Coppola D, Chellappan S, Yang S, Padmanabhan J. Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling. Oncotarget. PMID 26440150 DOI: 10.18632/Oncotarget.5933 |
0.487 |
|
| 2015 |
Bora-Singhal N, Perumal D, Nguyen J, Chellappan S. Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non-Small Cell Lung Cancer. Neoplasia (New York, N.Y.). 17: 538-51. PMID 26297432 DOI: 10.1016/J.Neo.2015.07.001 |
0.459 |
|
| 2015 |
Schaal C, Padmanabhan J, Chellappan S. The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression. Cancers. 7: 1447-71. PMID 26264026 DOI: 10.3390/Cancers7030845 |
0.442 |
|
| 2015 |
Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells. Stem Cells (Dayton, Ohio). 33: 1705-18. PMID 25754111 DOI: 10.1002/Stem.1993 |
0.455 |
|
| 2015 |
Pillai S, Trevino J, Rawal B, Singh S, Kovacs M, Li X, Schell M, Haura E, Bepler G, Chellappan S. β-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. Cancer Research. 75: 1009-20. PMID 25600647 DOI: 10.1158/0008-5472.Can-14-0681 |
0.471 |
|
| 2015 |
Pillai SR, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Abstract 3771: Tank-binding kinase 1 associates with centrosomes and regulates microtubule dynamics and mitosis Cancer Research. 75: 3771-3771. DOI: 10.1158/1538-7445.Am2015-3771 |
0.474 |
|
| 2015 |
Schaal C, Singhal NB, Pillai S, Nguyen J, Chellappan S. Abstract 2085: Nicotine-mediated regulation of Sox2 and its implications in the biology of non-small cell lung adenocarcinoma stem-like cells Cancer Research. 75: 2085-2085. DOI: 10.1158/1538-7445.Am2015-2085 |
0.442 |
|
| 2015 |
Singhal NB, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D, Chellappan S. Abstract 1516: YAP1 regulates Oct4 activity and Sox2 expression, facilitating self-renewal and vascular mimicry of stem-like cells Cancer Research. 75: 1516-1516. DOI: 10.1158/1538-7445.Am2015-1516 |
0.337 |
|
| 2014 |
Perumal D, Pillai S, Nguyen J, Schaal C, Coppola D, Chellappan SP. Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC. Oncotarget. 5: 10486-502. PMID 25401222 DOI: 10.18632/Oncotarget.2395 |
0.541 |
|
| 2014 |
Rizwani W, Schaal C, Kunigal S, Coppola D, Chellappan S. Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells. Plos One. 9: e100888. PMID 25029110 DOI: 10.1371/Journal.Pone.0100888 |
0.42 |
|
| 2014 |
Nair S, Bora-Singhal N, Perumal D, Chellappan S. Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner. Molecular Cancer. 13: 173. PMID 25028095 DOI: 10.1186/1476-4598-13-173 |
0.525 |
|
| 2014 |
Schaal C, Pillai S, Chellappan SP. The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis. Advances in Cancer Research. 121: 147-82. PMID 24889531 DOI: 10.1016/B978-0-12-800249-0.00004-4 |
0.493 |
|
| 2014 |
Andey T, Marepally S, Patel A, Jackson T, Sarkar S, O'Connell M, Reddy RC, Chellappan S, Singh P, Singh M. Cationic lipid guided short-hairpin RNA interference of annexin A2 attenuates tumor growth and metastasis in a mouse lung cancer stem cell model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 184: 67-78. PMID 24727000 DOI: 10.1016/J.Jconrel.2014.03.049 |
0.44 |
|
| 2014 |
Schaal C, Chellappan SP. Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Molecular Cancer Research : McR. 12: 14-23. PMID 24398389 DOI: 10.1158/1541-7786.Mcr-13-0541 |
0.556 |
|
| 2014 |
Singh S, Chellappan S. Lung cancer stem cells: Molecular features and therapeutic targets. Molecular Aspects of Medicine. 39: 50-60. PMID 24016594 DOI: 10.1016/J.Mam.2013.08.003 |
0.419 |
|
| 2014 |
Sun J, He H, Pillai S, Chellappan S, Yang S. Abstract 5001: GATA3 abrogates TGFbeta-mediated breast cancer invasion and metastasis Cancer Research. 74: 5001-5001. DOI: 10.1158/1538-7445.Am2014-5001 |
0.465 |
|
| 2014 |
Singh S, Chellappan SP. The biology of lung cancer stem cells Stem Cells and Human Diseases. 509-532. DOI: 10.1007/978-94-007-2801-1_24 |
0.322 |
|
| 2014 |
Perumal D, Pillai S, Nguyen J, Schaal C, Coppola D, Chellappan SP. Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/β-arrestin-1 dependent manner in NSCLC Oncotarget. 5: 10486-10502. |
0.45 |
|
| 2013 |
Sun J, He H, Pillai S, Xiong Y, Challa S, Xu L, Chellappan S, Yang S. GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion. The Journal of Biological Chemistry. 288: 36971-82. PMID 24235142 DOI: 10.1074/Jbc.M113.506535 |
0.485 |
|
| 2013 |
Treviño JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP. Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity. Molecular Cancer Therapeutics. 12: 2722-34. PMID 24107447 DOI: 10.1158/1535-7163.Mct-12-0719 |
0.466 |
|
| 2013 |
Singh S, Bora-Singhal N, Kroeger J, Laklai H, Chellappan SP. βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancer. Plos One. 8: e55982. PMID 23418490 DOI: 10.1371/Journal.Pone.0055982 |
0.471 |
|
| 2013 |
Pillai S, Szekeres K, Lawrence NJ, Chellappan SP, Blanck G. Regulation of interlocking gene regulatory network subcircuits by a small molecule inhibitor of retinoblastoma protein (RB) phosphorylation: cancer cell expression of HLA-DR. Gene. 512: 403-7. PMID 23041127 DOI: 10.1016/J.Gene.2012.09.092 |
0.38 |
|
| 2013 |
Momi N, Ponnusamy MP, Kaur S, Rachagani S, Kunigal SS, Chellappan S, Ouellette MM, Batra SK. Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation. Oncogene. 32: 1384-95. PMID 22614008 DOI: 10.1038/Onc.2012.163 |
0.466 |
|
| 2013 |
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ. IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene. 32: 151-9. PMID 22330135 DOI: 10.1038/onc.2012.39 |
0.435 |
|
| 2013 |
Pillai S, Nguyen J, Haura E, Coppola D, Chellappan S. Abstract 5446: Nicotinic acetylcholine receptors activate TBK1 in a β-arrestin-1 dependent manner to promote NSCLC growth. Cancer Research. 73: 5446-5446. DOI: 10.1158/1538-7445.Am2013-5446 |
0.538 |
|
| 2013 |
Perumal D, Pillai S, Chellappan S. Abstract 5271: Nicotinic acetylcholine receptors and EGF induce c-Kit ligand/Stem Cell Factor (SCF) in a β-arrestin-1 and E2F1 dependent manner in NSCLC . Cancer Research. 73: 5271-5271. DOI: 10.1158/1538-7445.Am2013-5271 |
0.529 |
|
| 2013 |
Singhal NB, Perumal D, Chellappan S. Abstract 2655: Inhibitor of Differentiation/DNA binding (ID) proteins modulate the stem-like features of NSCLC cells by regulating the expression ofOct4, Sox2andNanog. Cancer Research. 73: 2655-2655. DOI: 10.1158/1538-7445.Am2013-2655 |
0.509 |
|
| 2013 |
Schaal CM, Pillai S, Johnson JL, Chellappan S. Abstract 1803: Transcriptional regulation of nicotinic acetylcholine receptors (nAChRs) by E2F family transcription factors in non-small cell lung cancer. Cancer Research. 73: 1803-1803. DOI: 10.1158/1538-7445.Am2013-1803 |
0.499 |
|
| 2012 |
Treviño JG, Pillai S, Kunigal S, Singh S, Fulp WJ, Centeno BA, Chellappan SP. Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia (New York, N.Y.). 14: 1102-14. PMID 23308043 DOI: 10.1593/Neo.121044 |
0.517 |
|
| 2012 |
Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP. EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Molecular Cancer. 11: 73. PMID 23009336 DOI: 10.1186/1476-4598-11-73 |
0.455 |
|
| 2012 |
Perumal D, Singh S, Yoder SJ, Bloom GC, Chellappan SP. A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC. Plos One. 7: e43589. PMID 22952714 DOI: 10.1371/Journal.Pone.0043589 |
0.404 |
|
| 2012 |
Johnson JL, Pillai S, Chellappan SP. Genetic and biochemical alterations in non-small cell lung cancer. Biochemistry Research International. 2012: 940405. PMID 22928112 DOI: 10.1155/2012/940405 |
0.337 |
|
| 2012 |
Kunigal S, Ponnusamy MP, Momi N, Batra SK, Chellappan SP. Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. Molecular Cancer. 11: 24. PMID 22537161 DOI: 10.1186/1476-4598-11-24 |
0.549 |
|
| 2012 |
Pillai S, Chellappan S. α7 nicotinic acetylcholine receptor subunit in angiogenesis and epithelial to mesenchymal transition. Current Drug Targets. 13: 671-9. PMID 22300034 DOI: 10.2174/138945012800398847 |
0.414 |
|
| 2012 |
Alamanda V, Singh S, Lawrence NJ, Chellappan SP. Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity. Biochemical and Biophysical Research Communications. 418: 56-61. PMID 22240023 DOI: 10.1016/J.Bbrc.2011.12.127 |
0.458 |
|
| 2012 |
Davis R, Pillai S, Lawrence N, Sebti S, Chellappan SP. TNF-α-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes. Cell Cycle (Georgetown, Tex.). 11: 109-18. PMID 22185776 DOI: 10.4161/cc.11.1.18473 |
0.343 |
|
| 2012 |
Johnson JL, Pillai S, Pernazza D, Sebti SM, Lawrence NJ, Chellappan SP. Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. Cancer Research. 72: 516-26. PMID 22086850 DOI: 10.1158/0008-5472.Can-11-2647 |
0.4 |
|
| 2012 |
Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan SP. TNF-α response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death and Differentiation. 19: 274-83. PMID 21738216 DOI: 10.1038/Cdd.2011.93 |
0.394 |
|
| 2012 |
Treviño JG, Kunigal S, Hughes SJ, Centeno BA, Chellappan SP. Abstract 798: Id1 (Inhibitor of differentiation-1) expression demonstrates important translational implications for pancreatic adenocarcinoma Cancer Research. 72: 798-798. DOI: 10.1158/1538-7445.Am2012-798 |
0.478 |
|
| 2012 |
Tortelli TC, Chammas R, Chellappan S. Abstract 5598: Interaction between BRAF inhibitor PLX-4720 and CDK inhibitors can sensitize melanoma cells with BRAF V600E mutation Cancer Research. 72: 5598-5598. DOI: 10.1158/1538-7445.Am2012-5598 |
0.418 |
|
| 2012 |
Singh M, Andey T, Singh S, Patel AR, Godugu C, Safe S, Chellappan S. Abstract 3361: Sensitization of chemoresistant H1650 lung cancer stem cells to chemotherapy by combination treatment with novel diindolylmethane compounds Cancer Research. 72: 3361-3361. DOI: 10.1158/1538-7445.Am2012-3361 |
0.428 |
|
| 2012 |
Trevino JG, George SA, Hughes SJ, Chellappan SP. Inhibitor of Differentiation-1 (Id1) Regulates Tumor Growth and Metastases in An Orthotopic Nude Mouse Model Journal of Surgical Research. 172: 242. DOI: 10.1016/J.Jss.2011.11.378 |
0.372 |
|
| 2011 |
Trevino JG, Pillai SR, Chellappan SP. Effect of nicotine on chemoresistant phenotype as mediated through Src-dependent Id1 expression in pancreatic adenocarcinoma cells. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 216. PMID 27985943 DOI: 10.1200/Jco.2011.29.4_Suppl.216 |
0.509 |
|
| 2011 |
Pillai S, Rizwani W, Li X, Rawal B, Nair S, Schell MJ, Bepler G, Haura E, Coppola D, Chellappan S. ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling. Molecular and Cellular Biology. 31: 3052-67. PMID 21606196 DOI: 10.1128/Mcb.01311-10 |
0.506 |
|
| 2011 |
Singh S, Pillai S, Chellappan S. Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. Journal of Oncology. 2011: 456743. PMID 21541211 DOI: 10.1155/2011/456743 |
0.453 |
|
| 2011 |
Dasgupta P, Rizwani W, Pillai S, Davis R, Banerjee S, Hug K, Lloyd M, Coppola D, Haura E, Chellappan SP. ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. Journal of the National Cancer Institute. 103: 317-33. PMID 21212384 DOI: 10.1093/Jnci/Djq541 |
0.495 |
|
| 2011 |
Kreahling JM, Gemmer JY, Ma Y, Cress D, Johnson J, Chellappan SP, Altiok S. Abstract 5048: Targeting regulators of Chk1 to enhance cytotoxic efficacy of HDAC inhibitors Cancer Research. 71: 5048-5048. DOI: 10.1158/1538-7445.Am2011-5048 |
0.477 |
|
| 2011 |
Nair SG, Chellappan S. Abstract 4994: Downstream targets of Id1 transcription factor in non-small cell lung cancer Cancer Research. 71: 4994-4994. DOI: 10.1158/1538-7445.Am2011-4994 |
0.549 |
|
| 2011 |
Pillai S, Trevino J, Rawal B, Singh S, Li X, Schell M, Haura E, Bepler G, Chellappan S. Abstract 4993: Nicotine induced EMT and metastasis of human NSCLC : Role of beta-arrestin-1 Cancer Research. 71: 4993-4993. DOI: 10.1158/1538-7445.Am2011-4993 |
0.495 |
|
| 2011 |
Singh S, Trevino J, Laklai H, Kroeger J, Gemmer J, Coppola D, Altiok S, Chellappan S. Abstract 4381: EGFR-Src signaling regulates self-renewal of cancer stem like cells from NSCLC through Sox2 Cancer Research. 71: 4381-4381. DOI: 10.1158/1538-7445.Am2011-4381 |
0.487 |
|
| 2011 |
Johnson J, Pillai S, Chellappan S. Abstract 268: Differential regulation of MMP promoters by E2F transcription factors: Potential role of c-MYC and Id1 Cancer Research. 71: 268-268. DOI: 10.1158/1538-7445.Am2011-268 |
0.358 |
|
| 2011 |
Treviño JG, Verma M, Singh S, Pireddu R, Sebti S, Lawrence N, Chellappan SP. Abstract 2590: Selective disruption of Rb-Raf-1 kinase interaction is a suitable therapeutic option for pancreatic adenocarcinoma Cancer Research. 71: 2590-2590. DOI: 10.1158/1538-7445.Am2011-2590 |
0.303 |
|
| 2011 |
Verma M, Johnson J, Kovacs M, Singh S, Wu X, Lawrence N, Sebti S, Chellappan S. Abstract 2108: New analogues of benzyl-isothiourea showed Rb-Raf disruption and anti-cancer activity Cancer Research. 71: 2108-2108. DOI: 10.1158/1538-7445.Am2011-2108 |
0.494 |
|
| 2011 |
Treviño JG, Pillai SR, Kunigal SS, Chellappan SP. Abstract 1972: Nicotine regulates DNA-binding protein inhibitor (Id1) through a Src-dependent pathway promoting tumorigenic properties and chemoresistance in pancreatic adenocarcinoma Cancer Research. 71: 1972-1972. DOI: 10.1158/1538-7445.Am2011-1972 |
0.568 |
|
| 2011 |
Trevino JG, Pillai SR, Chellappan SP. Src Regulates Nicotine Induced Inhibitor of DNA-binding Protein Id1 Expression In Pancreatic Adenocarcinoma Cells Journal of Surgical Research. 165: 225-226. DOI: 10.1016/J.Jss.2010.11.536 |
0.435 |
|
| 2010 |
Singh S, Davis R, Alamanda V, Pireddu R, Pernazza D, Sebti S, Lawrence N, Chellappan S. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Molecular Cancer Therapeutics. 9: 3330-41. PMID 21139044 DOI: 10.1158/1535-7163.Mct-10-0442 |
0.484 |
|
| 2010 |
Singh S, Johnson J, Chellappan S. Small molecule regulators of Rb-E2F pathway as modulators of transcription. Biochimica Et Biophysica Acta. 1799: 788-94. PMID 20637913 DOI: 10.1016/J.Bbagrm.2010.07.004 |
0.481 |
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| 2010 |
Pillai S, Kovacs M, Chellappan S. Regulation of vascular endothelial growth factor receptors by Rb and E2F1: role of acetylation. Cancer Research. 70: 4931-40. PMID 20516113 DOI: 10.1158/0008-5472.Can-10-0501 |
0.36 |
|
| 2010 |
Ma Y, Chen L, Wright GM, Pillai SR, Chellappan SP, Cress WD. CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. The Journal of Biological Chemistry. 285: 9813-22. PMID 20106982 DOI: 10.1074/Jbc.M109.091496 |
0.35 |
|
| 2010 |
Johnson JL, Pillai S, Chellappan S. Abstract 4369: MMP9, MMP14, and MMP15 genes are induced by nicotine in an E2F-dependent manner Cancer Research. 70: 4369-4369. DOI: 10.1158/1538-7445.Am10-4369 |
0.448 |
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| 2010 |
Singh S, Chellappan S. Abstract 4309: Isolation, expansion and molecular characterization of lung cancer stem cells from NSCLC cell lines Cancer Research. 70: 4309-4309. DOI: 10.1158/1538-7445.Am10-4309 |
0.47 |
|
| 2010 |
Pillai SR, Damit M, Chellappan S. Abstract 2951: Nicotine induced EMT involves β-arrestin-1 mediated regulation of E2F1 target genes Cancer Research. 70: 2951-2951. DOI: 10.1158/1538-7445.Am10-2951 |
0.493 |
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| 2010 |
Kunigal SS, Batra SK, Chellappan SP. Abstract 2948: Nicotine-induced expression of MUC4 in pancreatic cancer cells is mediated by E2F1 and STAT-1 upregulation: Relevance to smoking and pancreatic cancer Cancer Research. 70: 2948-2948. DOI: 10.1158/1538-7445.Am10-2948 |
0.543 |
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| 2009 |
Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S. Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. Plos One. 4: e7524. PMID 19841737 DOI: 10.1371/Journal.Pone.0007524 |
0.455 |
|
| 2009 |
Rizwani W, Alexandrow M, Chellappan S. Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication. Cell Cycle (Georgetown, Tex.). 8: 1621-9. PMID 19377303 DOI: 10.4161/Cc.8.10.8578 |
0.446 |
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| 2009 |
Dasgupta P, Rizwani W, Pillai S, Kinkade R, Kovacs M, Rastogi S, Banerjee S, Carless M, Kim E, Coppola D, Haura E, Chellappan S. Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. International Journal of Cancer. Journal International Du Cancer. 124: 36-45. PMID 18844224 DOI: 10.1002/Ijc.23894 |
0.773 |
|
| 2008 |
Davis RK, Chellappan S. Disrupting the Rb-Raf-1 interaction: a potential therapeutic target for cancer. Drug News & Perspectives. 21: 331-5. PMID 18836591 DOI: 10.1358/Dnp.2008.21.6.1246832 |
0.5 |
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| 2008 |
Kinkade R, Dasgupta P, Carie A, Pernazza D, Carless M, Pillai S, Lawrence N, Sebti SM, Chellappan S. A small molecule disruptor of Rb/Raf-1 interaction inhibits cell proliferation, angiogenesis, and growth of human tumor xenografts in nude mice. Cancer Research. 68: 3810-8. PMID 18483265 DOI: 10.1158/0008-5472.Can-07-6672 |
0.766 |
|
| 2007 |
Rastogi S, Banerjee S, Chellappan S, Simon GR. Glut-1 antibodies induce growth arrest and apoptosis in human cancer cell lines. Cancer Letters. 257: 244-51. PMID 17910902 DOI: 10.1016/J.Canlet.2007.07.021 |
0.431 |
|
| 2007 |
Joshi B, Rastogi S, Morris M, Carastro LM, DeCook C, Seto E, Chellappan SP. Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites. The Biochemical Journal. 401: 155-66. PMID 16918502 DOI: 10.1042/Bj20060364 |
0.412 |
|
| 2006 |
Dasgupta P, Chellappan SP. Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle (Georgetown, Tex.). 5: 2324-8. PMID 17102610 DOI: 10.4161/Cc.5.20.3366 |
0.481 |
|
| 2006 |
Dasgupta P, Padmanabhan J, Chellappan S. Rb function in the apoptosis and senescence of non-neuronal and neuronal cells: role in oncogenesis. Current Molecular Medicine. 6: 719-29. PMID 17100598 DOI: 10.2174/1566524010606070719 |
0.395 |
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| 2006 |
Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S. Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. The Journal of Clinical Investigation. 116: 2208-2217. PMID 16862215 DOI: 10.1172/Jci28164 |
0.526 |
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| 2006 |
Peng X, Mehta R, Wang S, Chellappan S, Mehta RG. Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells. Cancer Research. 66: 7361-9. PMID 16849588 DOI: 10.1158/0008-5472.Can-06-1004 |
0.363 |
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| 2006 |
Rastogi S, Joshi B, Dasgupta P, Morris M, Wright K, Chellappan S. Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Molecular and Cellular Biology. 26: 4161-71. PMID 16705168 DOI: 10.1128/Mcb.02142-05 |
0.451 |
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| 2006 |
Dasgupta P, Kinkade R, Joshi B, Decook C, Haura E, Chellappan S. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences of the United States of America. 103: 6332-7. PMID 16601104 DOI: 10.1073/Pnas.0509313103 |
0.762 |
|
| 2006 |
Rastogi S, Joshi B, Fusaro G, Chellappan S. Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism. The Journal of Biological Chemistry. 281: 2951-9. PMID 16319068 DOI: 10.1074/Jbc.M508669200 |
0.434 |
|
| 2006 |
Kinkade R, Dasgupta P, Chellappan S. The ABCs of targeting Raf: Novel approaches to cancer therapy Current Cancer Therapy Reviews. 2: 305-314. DOI: 10.2174/157339406778699204 |
0.752 |
|
| 2004 |
Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, Sebti SM, Chellappan SP. Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Molecular and Cellular Biology. 24: 9527-41. PMID 15485920 DOI: 10.1128/Mcb.24.21.9527-9541.2004 |
0.471 |
|
| 2004 |
Haura EB, Cress WD, Chellappan S, Zheng Z, Bepler G. Antiapoptotic signaling pathways in non-small-cell lung cancer: biology and therapeutic strategies. Clinical Lung Cancer. 6: 113-22. PMID 15476597 DOI: 10.3816/Clc.2004.N.025 |
0.44 |
|
| 2004 |
Dasgupta P, Betts V, Rastogi S, Joshi B, Morris M, Brennan B, Ordonez-Ercan D, Chellappan S. Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery. The Journal of Biological Chemistry. 279: 38762-9. PMID 15210709 DOI: 10.1074/Jbc.M312273200 |
0.47 |
|
| 2003 |
Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP. A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis. Biochemical and Biophysical Research Communications. 312: 459-66. PMID 14637159 DOI: 10.1016/J.Bbrc.2003.10.148 |
0.385 |
|
| 2003 |
Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. The Journal of Biological Chemistry. 278: 47853-61. PMID 14500729 DOI: 10.1074/Jbc.M305171200 |
0.416 |
|
| 2003 |
Nath N, Wang S, Betts V, Knudsen E, Chellappan S. Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases. Oncogene. 22: 5986-94. PMID 12955077 DOI: 10.1038/Sj.Onc.1206843 |
0.374 |
|
| 2002 |
Wang S, Fusaro G, Padmanabhan J, Chellappan SP. Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene. 21: 8388-96. PMID 12466959 DOI: 10.1038/Sj.Onc.1205944 |
0.43 |
|
| 2002 |
Fusaro G, Wang S, Chellappan S. Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis. Oncogene. 21: 4539-48. PMID 12085232 DOI: 10.1038/Sj.Onc.1205551 |
0.457 |
|
| 2001 |
Gewirtz DA, Di YM, Randolph JK, Jain PT, Valerie K, Bullock S, Nath N, Chellappan SP. Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol. Archives of Biochemistry and Biophysics. 388: 243-52. PMID 11368161 DOI: 10.1006/Abbi.2000.2278 |
0.421 |
|
| 2001 |
Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala HM, Dent P, Grant S. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells. Cancer Research. 61: 2583-91. PMID 11289135 |
0.346 |
|
| 1999 |
Wang S, Nath N, Fusaro G, Chellappan S. Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Molecular and Cellular Biology. 19: 7447-60. PMID 10523633 DOI: 10.1128/Mcb.19.11.7447 |
0.482 |
|
| 1999 |
Wang S, Nath N, Adlam M, Chellappan S. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. Oncogene. 18: 3501-10. PMID 10376528 DOI: 10.1038/Sj.Onc.1202684 |
0.445 |
|
| 1999 |
Wang S, Nath N, Minden A, Chellappan S. Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. The Embo Journal. 18: 1559-70. PMID 10075927 DOI: 10.1093/Emboj/18.6.1559 |
0.436 |
|
| 1998 |
Wang S, Ghosh RN, Chellappan SP. Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Molecular and Cellular Biology. 18: 7487-98. PMID 9819434 DOI: 10.1128/Mcb.18.12.7487 |
0.461 |
|
| 1998 |
Vrana JA, Saunders AM, Chellappan SP, Grant S. Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937). Differentiation; Research in Biological Diversity. 63: 33-42. PMID 9615391 DOI: 10.1046/J.1432-0436.1998.6310033.X |
0.464 |
|
| 1997 |
Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Chellappan SP, Fisher PB, Grant S. Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia. 11: 504-13. PMID 9096690 DOI: 10.1038/Sj.Leu.2400625 |
0.434 |
|
| 1997 |
Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP. Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family. Genomics. 39: 95-8. PMID 9027491 DOI: 10.1006/Geno.1996.4473 |
0.345 |
|
| 1996 |
Zhang Y, Chellappan SP. Transcriptional activation and expression of DP transcription factors during cell cycle and TPA-induced U937 differentiation Molecular and Cellular Differentiation. 4: 297-316. |
0.336 |
|
| 1995 |
Wong KK, Zou X, Merrell KT, Patel AJ, Marcu KB, Chellappan S, Calame K. v-Abl activates c-myc transcription through the E2F site. Molecular and Cellular Biology. 15: 6535-44. PMID 8524218 DOI: 10.1128/Mcb.15.12.6535 |
0.348 |
|
| 1993 |
Schwarz JK, Devoto SH, Smith EJ, Chellappan SP, Jakoi L, Nevins JR. Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. The Embo Journal. 12: 1013-20. PMID 8458319 DOI: 10.1002/J.1460-2075.1993.Tb05742.X |
0.361 |
|
| 1992 |
Hiebert SW, Chellappan SP, Horowitz JM, Nevins JR. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F Genes and Development. 6: 177-185. PMID 1531329 DOI: 10.1101/Gad.6.2.177 |
0.363 |
|
| 1992 |
Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, Nevins JR. Adeno virus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product Proceedings of the National Academy of Sciences of the United States of America. 89: 4549-4553. PMID 1316611 DOI: 10.1073/Pnas.89.10.4549 |
0.346 |
|
| 1991 |
Nevins JR, Chellappan SP, Mudryj M, Hiebert S, Devoto S, Horowitz J, Hunter T, Pines J. E2F transcription factor is a target for the RB protein and the cyclin A protein Cold Spring Harbor Symposia On Quantitative Biology. 56: 157-162. PMID 1840249 DOI: 10.1101/Sqb.1991.056.01.020 |
0.306 |
|
| 1991 |
Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR. The E2F transcription factor is a cellular target for the RB protein Cell. 65: 1053-1061. PMID 1828392 DOI: 10.1016/0092-8674(91)90557-F |
0.376 |
|
| 1990 |
Chellappan SP, Nevins JR. DNA octamer element can confer E1A trans-activation, and adenovirus infection results in a stimulation of the DNA-binding activity of OTF-1/NFIII factor Proceedings of the National Academy of Sciences of the United States of America. 87: 5878-5882. PMID 2143023 DOI: 10.1073/Pnas.87.15.5878 |
0.318 |
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