| Year |
Citation |
Score |
| 2023 |
Palomino-Antolín A, Decouty-Pérez C, Farré-Alins V, Narros-Fernández P, Lopez-Rodriguez AB, Álvarez-Rubal M, Valencia I, López-Muñoz F, Ramos E, Cuadrado A, Casas AI, Romero A, Egea J. Redox Regulation of Microglial Inflammatory Response: Fine Control of NLRP3 Inflammasome through Nrf2 and NOX4. Antioxidants (Basel, Switzerland). 12. PMID 37760032 DOI: 10.3390/antiox12091729 |
0.522 |
|
| 2020 |
Casas AI, Nogales C, Mucke HAM, Petraina A, Cuadrado A, Rojo AI, Ghezzi P, Jaquet V, Augsburger F, Dufrasne F, Soubhye J, Deshwal S, Di Sante M, Kaludercic N, Di Lisa F, et al. On the Clinical Pharmacology of Reactive Oxygen Species. Pharmacological Reviews. 72: 801-828. PMID 32859763 DOI: 10.1124/Pr.120.019422 |
0.329 |
|
| 2020 |
Duarte P, Cuadrado A, León R. Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches. Handbook of Experimental Pharmacology. PMID 32852645 DOI: 10.1007/164_2020_384 |
0.318 |
|
| 2020 |
Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, ... Cuadrado A, et al. Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 32831200 DOI: 10.3233/Jad-200208 |
0.317 |
|
| 2020 |
Escoll M, Lastra D, Robledinos-Antón N, Wandosell F, Antón IM, Cuadrado A. WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Antioxidants (Basel, Switzerland). 9. PMID 32825452 DOI: 10.3390/Antiox9090773 |
0.382 |
|
| 2020 |
Lastra D, Fernández-Ginés R, Manda G, Cuadrado A. Perspectives on the Clinical Development of NRF2-Targeting Drugs. Handbook of Experimental Pharmacology. PMID 32776282 DOI: 10.1007/164_2020_381 |
0.412 |
|
| 2020 |
Cuadrado A, Pajares M, Benito C, Jiménez-Villegas J, Escoll M, Fernández-Ginés R, Garcia Yagüe AJ, Lastra D, Manda G, Rojo AI, Dinkova-Kostova AT. Can Activation of NRF2 Be a Strategy against COVID-19? Trends in Pharmacological Sciences. PMID 32711925 DOI: 10.1016/J.Tips.2020.07.003 |
0.333 |
|
| 2020 |
Martin-Hurtado A, Lastres-Becker I, Cuadrado A, Garcia-Gonzalo FR. NRF2 and Primary Cilia: An Emerging Partnership. Antioxidants (Basel, Switzerland). 9. PMID 32498260 DOI: 10.3390/Antiox9060475 |
0.357 |
|
| 2020 |
Manda G, Rojo AI, Martínez-Klimova E, Pedraza-Chaverri J, Cuadrado A. Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases. Frontiers in Pharmacology. 11: 151. PMID 32184727 DOI: 10.3389/Fphar.2020.00151 |
0.353 |
|
| 2020 |
Herrera-Arozamena C, Estrada-Valencia M, Pérez C, Lagartera L, Morales-García JA, Pérez-Castillo A, Franco-Gonzalez JF, Michalska P, Duarte P, León R, López MG, Mills A, Gago F, García-Yagüe ÁJ, Fernández-Ginés R, ... Cuadrado A, et al. Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. European Journal of Medicinal Chemistry. 190: 112090. PMID 32018096 DOI: 10.1016/J.Ejmech.2020.112090 |
0.311 |
|
| 2020 |
Escoll M, Lastra D, Pajares M, Robledinos-Antón N, Rojo AI, Fernández-Ginés R, Mendiola M, Martínez-Marín V, Esteban I, López-Larrubia P, Gargini R, Cuadrado A. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Redox Biology. 30: 101425. PMID 31918259 DOI: 10.1016/J.Redox.2019.101425 |
0.363 |
|
| 2019 |
Michalska P, Buendia I, Duarte P, FernandezMendivil C, Negredo P, Cuadrado A, López MG, Leon R. Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization. Pharmacological Research. 104597. PMID 31838078 DOI: 10.1016/J.Phrs.2019.104597 |
0.366 |
|
| 2019 |
Martin-Hurtado A, Martin-Morales R, Robledinos-Antón N, Blanco R, Palacios-Blanco I, Lastres-Becker I, Cuadrado A, Garcia-Gonzalo FR. NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. Scientific Reports. 9: 13896. PMID 31554934 DOI: 10.1038/S41598-019-50356-0 |
0.395 |
|
| 2019 |
Robledinos-Antón N, Fernández-Ginés R, Manda G, Cuadrado A. Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development. Oxidative Medicine and Cellular Longevity. 2019: 9372182. PMID 31396308 DOI: 10.1155/2019/9372182 |
0.379 |
|
| 2019 |
Elbatreek MH, Pachado MP, Cuadrado A, Jandeleit-Dahm K, Schmidt HHHW. Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage. Trends in Endocrinology and Metabolism: Tem. PMID 30928357 DOI: 10.1016/J.Tem.2019.02.006 |
0.323 |
|
| 2019 |
Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nature Reviews. Drug Discovery. PMID 30610225 DOI: 10.1038/S41573-018-0008-X |
0.36 |
|
| 2018 |
Rojo AI, Pajares M, García-Yagüe AJ, Buendia I, Van Leuven F, Yamamoto M, López MG, Cuadrado A. Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy. Redox Biology. 18: 173-180. PMID 30029164 DOI: 10.1016/J.Redox.2018.07.006 |
0.351 |
|
| 2018 |
Pajares M, Rojo AI, Arias E, Díaz-Carretero A, Cuervo AM, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. PMID 29950142 DOI: 10.1080/15548627.2018.1474992 |
0.425 |
|
| 2018 |
Pajares M, Cuadrado A, Engedal N, Jirsova Z, Cahova M. The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Oxidative Medicine and Cellular Longevity. 2018: 2450748. PMID 29682156 DOI: 10.1155/2018/2450748 |
0.332 |
|
| 2018 |
Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, Ghezzi P, León R, López MG, Oliva B, Pajares M, Rojo AI, Robledinos-Antón N, Valverde AM, Guney E, et al. Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacological Reviews. 70: 348-383. PMID 29507103 DOI: 10.1124/Pr.117.014753 |
0.352 |
|
| 2018 |
Rius-Pérez S, Pérez S, Martí-Andrés P, Finamor I, Taléns-Visconti R, Cuadrado A, Toledano MB, Sastre J. Time-course of thiol oxidation of protein phosphatases during cerulein-induced acute pancreatitis Free Radical Biology and Medicine. 120: S143. DOI: 10.1016/J.Freeradbiomed.2018.04.471 |
0.348 |
|
| 2018 |
González R, Rodriguez-Hernández A, Ranguelova K, Rossin A, Padillo J, Cuadrado A, Bárcena JA, Hueber AO, Padilla CA, Muntané J. Thioredoxin 1 plays a key role in S-nitrosylation of cell death receptors and apoptosis in Sorafenib-treated hepatocarcinoma cells Free Radical Biology and Medicine. 120. DOI: 10.1016/J.Freeradbiomed.2018.04.363 |
0.364 |
|
| 2018 |
Pajares M, Rojo AI, Arias E, Diaz-Carretero A, Cuervo AM, Cuadrado A. Transcription factor NRF2 modulates chaperone mediated autophagy through the regulation of LAMP2A Free Radical Biology and Medicine. 120: S28. DOI: 10.1016/J.Freeradbiomed.2018.04.098 |
0.417 |
|
| 2017 |
Cuadrado A, Kügler S, Lastres-Becker I. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biology. 14: 522-534. PMID 29121589 DOI: 10.1016/J.Redox.2017.10.010 |
0.409 |
|
| 2017 |
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, ... ... Cuadrado A, et al. Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. Redox Biology. PMID 29107648 DOI: 10.1016/J.Redox.2017.10.001 |
0.487 |
|
| 2017 |
Tobón-Velasco JC, Limón-Pacheco JH, Orozco-Ibarra M, Macías-Silva M, Vázquez-Victorio G, Cuevas E, Ali SF, Cuadrado A, Pedraza-Chaverrí J, Santamaría A. Retraction notice to "RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors" [Toxicology (2013) 109 - 119]. Toxicology. 390: 167. PMID 28991642 DOI: 10.1016/J.Tox.2017.10.001 |
0.32 |
|
| 2017 |
Rojo AI, Pajares M, Rada P, Nuñez A, Nevado-Holgado AJ, Killik R, Van Leuven F, Ribe E, Lovestone S, Yamamoto M, Cuadrado A. NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Redox Biology. 13: 444-451. PMID 28704727 DOI: 10.1016/J.Redox.2017.07.006 |
0.377 |
|
| 2017 |
Robledinos-Antón N, Rojo AI, Ferreiro E, Núñez Á, Krause KH, Jaquet V, Cuadrado A. Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus. Redox Biology. 13: 393-401. PMID 28667908 DOI: 10.1016/J.Redox.2017.06.010 |
0.359 |
|
| 2017 |
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, ... ... Cuadrado A, et al. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology. 13: 94-162. PMID 28577489 DOI: 10.1016/J.Redox.2017.05.007 |
0.567 |
|
| 2017 |
Nayernia Z, Colaianna M, Robledinos-Antón N, Gutzwiller E, Sloan-Béna F, Stathaki E, Hibaoui Y, Cuadrado A, Hescheler J, José Stasia M, Saric T, Jaquet V, Krause KH. Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC. Redox Biology. 13: 82-93. PMID 28575744 DOI: 10.1016/J.Redox.2017.04.026 |
0.336 |
|
| 2017 |
Ghezzi P, Floridi L, Boraschi D, Cuadrado A, Manda G, Levic S, D'Acquisto F, Hamilton AL, Athersuch T, Selley L. Oxidative stress and inflammation induced by environmental and psychological stressors: a biomarker perspective. Antioxidants & Redox Signaling. PMID 28494612 DOI: 10.1089/Ars.2017.7147 |
0.339 |
|
| 2017 |
Gameiro I, Michalska P, Tenti G, Cores Á, Buendia I, Rojo AI, Georgakopoulos ND, Hernández-Guijo JM, Teresa Ramos M, Wells G, López MG, Cuadrado A, Menéndez JC, León R. Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer's disease. Scientific Reports. 7: 45701. PMID 28361919 DOI: 10.1038/Srep45701 |
0.375 |
|
| 2017 |
Tobón-Velasco JC, Vázquez-Victorio G, Macías-Silva M, Cuevas E, Ali SF, Maldonado PD, González-Trujano ME, Cuadrado A, José Pedraza-Chaverrí, Santamaría A. Retraction notice to S-Allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades [FRB 53/5 (2012) 1024 - 1040]. Free Radical Biology & Medicine. 104: 382. PMID 28237391 DOI: 10.1016/J.Freeradbiomed.2016.12.044 |
0.347 |
|
| 2017 |
Escoll M, Gargini R, Cuadrado A, Anton IM, Wandosell F. Mutant p53 oncogenic functions in cancer stem cells are regulated by WIP through YAP/TAZ Oncogene. 36: 3515-3527. PMID 28166194 DOI: 10.1038/Onc.2016.518 |
0.318 |
|
| 2017 |
Pajares M, Cuadrado A, Rojo AI. Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases. Redox Biology. 11: 543-553. PMID 28104575 DOI: 10.1016/J.Redox.2017.01.006 |
0.37 |
|
| 2017 |
González R, Rodríguez-Hernández MA, López-Grueso MJ, Rojo AI, Navarro-Villarán E, Padillo J, Bárcena JA, Cuadrado A, Padilla CA, Muntane J. Regulation of Nrf2 signaling during the antitumoral activity of Sorafenib in hepatoma cells Free Radical Biology and Medicine. 108. DOI: 10.1016/J.Freeradbiomed.2017.04.307 |
0.398 |
|
| 2017 |
Pajares M, Rojo AI, Cuadrado A. NRF2 controls proteostasis through the transcriptional regulation of autophagy Free Radical Biology and Medicine. 108. DOI: 10.1016/J.Freeradbiomed.2017.04.172 |
0.381 |
|
| 2016 |
Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 0. PMID 27427974 DOI: 10.1080/15548627.2016.1208889 |
0.367 |
|
| 2016 |
Lastres Becker I, Garcia-Yague AJ, Scannevin RH, Casarejos MJ, Kügler S, Rábano A, Cuadrado A. Repurposing the NRF2 activator dimethyl fumarate as therapy against synucleinopathy in Parkinson's disease. Antioxidants & Redox Signaling. PMID 27009601 DOI: 10.1089/Ars.2015.6549 |
0.364 |
|
| 2016 |
Cuadrado A. NRF2 in neurodegenerative diseases Current Opinion in Toxicology. 1: 46-53. DOI: 10.1016/J.Cotox.2016.09.004 |
0.362 |
|
| 2015 |
Cuadrado A. Transcription Factor Nrf2: a novel target to modulate inflammatory and neuroprotective responses in Parkinson's disease. Springerplus. 4: L43. PMID 27386205 DOI: 10.1186/2193-1801-4-S1-L43 |
0.363 |
|
| 2015 |
Casas AI, Dao VT, Daiber A, Maghzal GJ, Di Lisa F, Kaludercic N, Leach S, Cuadrado A, Jaquet V, Seredenina T, Krause KH, López MG, Stocker R, Ghezzi P, Schmidt HH. Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxidants & Redox Signaling. 23: 1171-85. PMID 26583264 DOI: 10.1089/Ars.2015.6433 |
0.368 |
|
| 2015 |
Prieto P, Rosales-Mendoza CE, Terrón V, Toledano V, Cuadrado A, López-Collazo E, Bannenberg G, Martín-Sanz P, Fernández-Velasco M, Boscá L. Activation of autophagy in macrophages by pro-resolving lipid mediators. Autophagy. 11: 1729-44. PMID 26506892 DOI: 10.1080/15548627.2015.1078958 |
0.329 |
|
| 2015 |
Frijhoff J, Winyard PG, Zarkovic N, Davies S, Stocker R, Cheng D, Knight A, Taylor EL, Oettrich J, Ruskovska T, Cipak Gasparovic A, Cuadrado A, Weber D, Poulsen HE, Grune T, et al. Clinical relevance of biomarkers of oxidative stress. Antioxidants & Redox Signaling. PMID 26415143 DOI: 10.1089/Ars.2015.6317 |
0.322 |
|
| 2015 |
Dao VT, Casas AI, Maghzal GJ, Seredenina T, Kaludercic N, Robledinos-Anton N, Di Lisa F, Stocker R, Ghezzi P, Jaquet V, Cuadrado A, Schmidt HH. Pharmacology and Clinical Drug Candidates in Redox Medicine. Antioxidants & Redox Signaling. PMID 26415051 DOI: 10.1089/Ars.2015.6430 |
0.329 |
|
| 2015 |
Pajares M, Jiménez-Moreno N, Dias IH, Debelec B, Vucetic M, Fladmark KE, Basaga H, Ribaric S, Milisav I, Cuadrado A. Redox control of protein degradation. Redox Biology. 6: 409-420. PMID 26381917 DOI: 10.1016/J.Redox.2015.07.003 |
0.332 |
|
| 2015 |
Schmidt HH, Stocker R, Vollbracht C, Paulsen G, Riley D, Daiber A, Cuadrado A. Antioxidants in Translational Medicine. Antioxidants & Redox Signaling. PMID 26154592 DOI: 10.1089/Ars.2015.6393 |
0.346 |
|
| 2015 |
Freitas AE, Egea J, Buendia I, Gómez-Rangel V, Parada E, Navarro E, Casas AI, Wojnicz A, Ortiz JA, Cuadrado A, Ruiz-Nuño A, Rodrigues AL, Lopez MG. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. Molecular Neurobiology. PMID 25966970 DOI: 10.1007/S12035-015-9182-6 |
0.546 |
|
| 2015 |
Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, Módol T, Santamaría B, Weber M, Herrero L, Serra D, Muntané J, Cuadrado A, Moreno-Aliaga MJ, Alfredo Martínez J, Valverde ÁM. Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. Free Radical Biology & Medicine. 84: 263-78. PMID 25841776 DOI: 10.1016/J.Freeradbiomed.2015.03.019 |
0.361 |
|
| 2015 |
Egea J, Buendia I, Parada E, Navarro E, Rada P, Cuadrado A, López MG, García AG, León R. Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action. British Journal of Pharmacology. 172: 1807-21. PMID 25425158 DOI: 10.1111/Bph.13025 |
0.572 |
|
| 2015 |
Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martín JP, González-Sancho JM, Valverde ÁM, Dale T, Regadera J, Cuadrado A. WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxidants & Redox Signaling. 22: 555-71. PMID 25336178 DOI: 10.1089/Ars.2014.6040 |
0.317 |
|
| 2015 |
Freitas AE, Egea J, Buendía I, Navarro E, Rada P, Cuadrado A, Rodrigues AL, López MG. Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line. Molecular Neurobiology. 51: 1504-19. PMID 25084759 DOI: 10.1007/S12035-014-8827-1 |
0.59 |
|
| 2015 |
Delgado-Buenrostro NL, Medina-Reyes EI, Lastres-Becker I, Freyre-Fonseca V, Ji Z, Hernández-Pando R, Marquina B, Pedraza-Chaverri J, Espada S, Cuadrado A, Chirino YI. Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release. Environmental Toxicology. 30: 782-92. PMID 24615891 DOI: 10.1002/Tox.21957 |
0.315 |
|
| 2015 |
Pajares M, Rojo AI, Jiménez N, Cuadrado A. Impact of the transcription factor NRF2 in the modulation of autophagy on TAU and β-amyloid pathology in a combined mouse model of Alzheimer’s disease Free Radical Biology and Medicine. 86. DOI: 10.1016/J.Freeradbiomed.2015.07.030 |
0.34 |
|
| 2015 |
Freitas AE, Egea J, Buendia I, Gómez-Rangel V, Parada E, Navarro E, Casas AI, Wojnicz A, Ortiz JA, Cuadrado A, Ruiz-Nuño A, Rodrigues ALS, Lopez MG. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice Molecular Neurobiology. DOI: 10.1007/s12035-015-9182-6 |
0.476 |
|
| 2014 |
Rojo AI, Rada P, Mendiola M, Ortega-Molina A, Wojdyla K, Rogowska-Wrzesinska A, Hardisson D, Serrano M, Cuadrado A. The PTEN/NRF2 axis promotes human carcinogenesis. Antioxidants & Redox Signaling. 21: 2498-514. PMID 24892215 DOI: 10.1089/Ars.2014.5843 |
0.325 |
|
| 2014 |
Cuadrado A, MartÃn-Moldes Z, Ye J, Lastres-Becker I. Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation. The Journal of Biological Chemistry. 289: 15244-58. PMID 24759106 DOI: 10.1074/Jbc.M113.540633 |
0.376 |
|
| 2014 |
Rojo AI, McBean G, Cindric M, Egea J, López MG, Rada P, Zarkovic N, Cuadrado A. Redox control of microglial function: molecular mechanisms and functional significance. Antioxidants & Redox Signaling. 21: 1766-801. PMID 24597893 DOI: 10.1089/Ars.2013.5745 |
0.603 |
|
| 2014 |
Parada E, Buendia I, León R, Negredo P, Romero A, Cuadrado A, López MG, Egea J. Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. Journal of Pineal Research. 56: 204-12. PMID 24350834 DOI: 10.1111/Jpi.12113 |
0.547 |
|
| 2014 |
Lastres-Becker I, Innamorato NG, Jaworski T, Rábano A, Kügler S, Van Leuven F, Cuadrado A. Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain : a Journal of Neurology. 137: 78-91. PMID 24277722 DOI: 10.1093/Brain/Awt323 |
0.392 |
|
| 2014 |
Simon D, Herva ME, Benitez MJ, Garrido JJ, Rojo AI, Cuadrado A, Torres JM, Wandosell F. Dysfunction of the PI3K-Akt-GSK-3 pathway is a common feature in cell culture and in vivo models of prion disease. Neuropathology and Applied Neurobiology. 40: 311-26. PMID 23741998 DOI: 10.1111/Nan.12066 |
0.37 |
|
| 2013 |
Mobasher MA, González-Rodriguez A, SantamarÃa B, Ramos S, MartÃn MÃ, Goya L, Rada P, Letzig L, James LP, Cuadrado A, MartÃn-Pérez J, Simpson KJ, Muntané J, Valverde AM. Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death & Disease. 4: e626. PMID 23661004 DOI: 10.1038/Cddis.2013.150 |
0.394 |
|
| 2013 |
GarcÃa-Yagüe ÃJ, Rada P, Rojo AI, Lastres-Becker I, Cuadrado A. Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. The Journal of Biological Chemistry. 288: 5506-17. PMID 23283970 DOI: 10.1074/Jbc.M112.439190 |
0.354 |
|
| 2013 |
Tobón-Velasco JC, Limón-Pacheco JH, Orozco-Ibarra M, MacÃas-Silva M, Vázquez-Victorio G, Cuevas E, Ali SF, Cuadrado A, Pedraza-Chaverrà J, SantamarÃa A. 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors. Toxicology. 304: 109-19. PMID 23274087 DOI: 10.1016/J.Tox.2012.12.011 |
0.378 |
|
| 2013 |
Chowdhry S, Zhang Y, McMahon M, Sutherland C, Cuadrado A, Hayes JD. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene. 32: 3765-81. PMID 22964642 DOI: 10.1038/Onc.2012.388 |
0.353 |
|
| 2013 |
Zuntilde A, iga-Toala, Medina-Campos ON, Espada r, Cuadrado A, Pedraza-Chaverri J. Nordihydroguaiaretic acid induces heme oxygenase-1 (HO-1) and cytoprotection in a phosphatidyl inositol 3 kinase (PI3K)-dependent way in renal epithelial (LLC-PK1) cells Journal of Medicinal Plants Research. 7: 186-190. DOI: 10.5897/Jmpr.9000935 |
0.348 |
|
| 2012 |
Tobón-Velasco JC, Vázquez-Victorio G, MacÃas-Silva M, Cuevas E, Ali SF, Maldonado PD, González-Trujano ME, Cuadrado A, Pedraza-Chaverrà J, SantamarÃa A. S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Free Radical Biology & Medicine. 53: 1024-40. PMID 22781654 DOI: 10.1016/J.Freeradbiomed.2012.06.040 |
0.41 |
|
| 2012 |
Rada P, Rojo AI, Evrard-Todeschi N, Innamorato NG, Cotte A, Jaworski T, Tobón-Velasco JC, Devijver H, GarcÃa-Mayoral MF, Van Leuven F, Hayes JD, Bertho G, Cuadrado A. Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Molecular and Cellular Biology. 32: 3486-99. PMID 22751928 DOI: 10.1128/Mcb.00180-12 |
0.367 |
|
| 2012 |
Lastres-Becker I, Ulusoy A, Innamorato NG, Sahin G, Rábano A, Kirik D, Cuadrado A. α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease. Human Molecular Genetics. 21: 3173-92. PMID 22513881 DOI: 10.1093/Hmg/Dds143 |
0.359 |
|
| 2012 |
MartÃn-Moreno AM, Brera B, Spuch C, Carro E, GarcÃa-GarcÃa L, Delgado M, Pozo MA, Innamorato NG, Cuadrado A, de Ceballos ML. Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice. Journal of Neuroinflammation. 9: 8. PMID 22248049 DOI: 10.1186/1742-2094-9-8 |
0.321 |
|
| 2012 |
Rojo AI, Medina-Campos ON, Rada P, Zúñiga-Toalá A, López-Gazcón A, Espada S, Pedraza-Chaverri J, Cuadrado A. Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3. Free Radical Biology & Medicine. 52: 473-87. PMID 22142471 DOI: 10.1016/J.Freeradbiomed.2011.11.003 |
0.409 |
|
| 2011 |
Granado N, Lastres-Becker I, Ares-Santos S, Oliva I, Martin E, Cuadrado A, Moratalla R. Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia. 59: 1850-63. PMID 21882243 DOI: 10.1002/Glia.21229 |
0.381 |
|
| 2011 |
Maicas N, Ferrándiz ML, Brines R, Ibáñez L, Cuadrado A, Koenders MI, van den Berg WB, Alcaraz MJ. Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease. Antioxidants & Redox Signaling. 15: 889-901. PMID 21406003 DOI: 10.1089/Ars.2010.3835 |
0.366 |
|
| 2011 |
MartÃn-Moreno AM, Reigada D, RamÃrez BG, Mechoulam R, Innamorato N, Cuadrado A, de Ceballos ML. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Molecular Pharmacology. 79: 964-73. PMID 21350020 DOI: 10.1124/Mol.111.071290 |
0.359 |
|
| 2011 |
Jazwa A, Rojo AI, Innamorato NG, Hesse M, Fernández-Ruiz J, Cuadrado A. Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. Antioxidants & Redox Signaling. 14: 2347-60. PMID 21254817 DOI: 10.1089/Ars.2010.3731 |
0.383 |
|
| 2011 |
Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Molecular and Cellular Biology. 31: 1121-33. PMID 21245377 DOI: 10.1128/Mcb.01204-10 |
0.344 |
|
| 2010 |
Jazwa A, Cuadrado A. Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases. Current Drug Targets. 11: 1517-31. PMID 20704549 DOI: 10.2174/1389450111009011517 |
0.369 |
|
| 2010 |
Innamorato NG, Jazwa A, Rojo AI, García C, Fernández-Ruiz J, Grochot-Przeczek A, Stachurska A, Jozkowicz A, Dulak J, Cuadrado A. Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. Plos One. 5: e11838. PMID 20676377 DOI: 10.1371/Journal.Pone.0011838 |
0.364 |
|
| 2010 |
Espada S, Ortega F, Molina-Jijón E, Rojo AI, Pérez-Sen R, Pedraza-Chaverri J, Miras-Portugal MT, Cuadrado A. The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. Free Radical Biology & Medicine. 49: 416-26. PMID 20447456 DOI: 10.1016/J.Freeradbiomed.2010.04.031 |
0.395 |
|
| 2010 |
Niso-Santano M, González-Polo RA, Bravo-San Pedro JM, Gómez-Sánchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Morán JM, Cuadrado A, Fuentes JM. Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. Free Radical Biology & Medicine. 48: 1370-81. PMID 20202476 DOI: 10.1016/J.Freeradbiomed.2010.02.024 |
0.423 |
|
| 2010 |
Rojo AI, Innamorato NG, MartÃn-Moreno AM, De Ceballos ML, Yamamoto M, Cuadrado A. Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Glia. 58: 588-98. PMID 19908287 DOI: 10.1002/Glia.20947 |
0.401 |
|
| 2009 |
Egea J, Rosa AO, Lorrio S, del Barrio L, Cuadrado A, López MG. Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test. Pain. 146: 75-83. PMID 19660867 DOI: 10.1016/J.Pain.2009.07.007 |
0.573 |
|
| 2009 |
Espada S, Rojo AI, Salinas M, Cuadrado A. The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection. Journal of Neurochemistry. 110: 1107-19. PMID 19558456 DOI: 10.1111/J.1471-4159.2009.06208.X |
0.332 |
|
| 2009 |
MegÃas J, Guillén MI, Clérigues V, Rojo AI, Cuadrado A, Castejón MA, Gomar F, Alcaraz MJ. Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes. Biochemical Pharmacology. 77: 1806-13. PMID 19428335 DOI: 10.1016/J.Bcp.2009.03.009 |
0.356 |
|
| 2009 |
Innamorato NG, Lastres-Becker I, Cuadrado A. Role of microglial redox balance in modulation of neuroinflammation. Current Opinion in Neurology. 22: 308-14. PMID 19359988 DOI: 10.1097/Wco.0B013E32832A3225 |
0.387 |
|
| 2009 |
Cuadrado A, Moreno-Murciano P, Pedraza-Chaverri J. The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease. Expert Opinion On Therapeutic Targets. 13: 319-29. PMID 19236154 DOI: 10.1517/13543780802716501 |
0.386 |
|
| 2008 |
Guzmán-Beltrán S, Espada S, Orozco-Ibarra M, Pedraza-Chaverri J, Cuadrado A. Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress. Neuroscience Letters. 447: 167-71. PMID 18852027 DOI: 10.1016/J.Neulet.2008.09.079 |
0.37 |
|
| 2008 |
Rojo AI, Rada P, Egea J, Rosa AO, López MG, Cuadrado A. Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Molecular and Cellular Neurosciences. 39: 125-32. PMID 18619545 DOI: 10.1016/J.Mcn.2008.06.007 |
0.596 |
|
| 2008 |
Innamorato NG, Rojo AI, GarcÃa-Yagüe AJ, Yamamoto M, de Ceballos ML, Cuadrado A. The transcription factor Nrf2 is a therapeutic target against brain inflammation. Journal of Immunology (Baltimore, Md. : 1950). 181: 680-9. PMID 18566435 DOI: 10.4049/Jimmunol.181.1.680 |
0.393 |
|
| 2008 |
Cuadrado A, Rojo AI. Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Current Pharmaceutical Design. 14: 429-42. PMID 18289070 DOI: 10.2174/138161208783597407 |
0.35 |
|
| 2008 |
Rojo AI, Sagarra MR, Cuadrado A. GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress. Journal of Neurochemistry. 105: 192-202. PMID 18005231 DOI: 10.1111/J.1471-4159.2007.05124.X |
0.375 |
|
| 2008 |
Rosa AO, Egea J, Lorrio S, Rojo AI, Cuadrado A, López MG. Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice. Pain. 137: 332-9. PMID 17964723 DOI: 10.1016/J.Pain.2007.09.015 |
0.583 |
|
| 2007 |
Rojo AI, Cavada C, de Sagarra MR, Cuadrado A. Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Experimental Neurology. 208: 120-6. PMID 17880941 DOI: 10.1016/J.Expneurol.2007.07.022 |
0.309 |
|
| 2007 |
Egea J, Rosa AO, Cuadrado A, GarcÃa AG, López MG. Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress. Journal of Neurochemistry. 102: 1842-52. PMID 17540012 DOI: 10.1111/J.1471-4159.2007.04665.X |
0.591 |
|
| 2007 |
Matesanz N, Lafuente N, Azcutia V, MartÃn D, Cuadrado A, Nevado J, RodrÃguez-Mañas L, Sánchez-Ferrer CF, Peiró C. Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-Jun N-terminal kinase and p38 mitogen-activated protein kinases. Journal of Hypertension. 25: 609-18. PMID 17278978 DOI: 10.1097/Hjh.0B013E328013E7C4 |
0.324 |
|
| 2006 |
Rojo AI, Salina M, Salazar M, Takahashi S, Suske G, Calvo V, de Sagarra MR, Cuadrado A. Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1. Free Radical Biology & Medicine. 41: 247-61. PMID 16814105 DOI: 10.1016/J.Freeradbiomed.2006.04.002 |
0.346 |
|
| 2006 |
Salazar M, Rojo AI, Velasco D, de Sagarra RM, Cuadrado A. Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2. The Journal of Biological Chemistry. 281: 14841-51. PMID 16551619 DOI: 10.1074/Jbc.M513737200 |
0.371 |
|
| 2006 |
Marinissen MJ, Tanos T, Bolós M, de Sagarra MR, Coso OA, Cuadrado A. Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor. The Journal of Biological Chemistry. 281: 11332-46. PMID 16476737 DOI: 10.1074/Jbc.M512199200 |
0.359 |
|
| 2004 |
Salinas M, Wang J, Rosa de Sagarra M, MartÃn D, Rojo AI, Martin-Perez J, Ortiz de Montellano PR, Cuadrado A. Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. Febs Letters. 578: 90-4. PMID 15581622 DOI: 10.1016/J.Febslet.2004.10.077 |
0.358 |
|
| 2004 |
Rojo AI, Salinas M, MartÃn D, Perona R, Cuadrado A. Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7324-34. PMID 15317858 DOI: 10.1523/Jneurosci.2111-04.2004 |
0.37 |
|
| 2004 |
Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, Puig-Kröger A, GarcÃa-Bordas J, MartÃn D, Longo N, Cuadrado A, Cabañas C, Corbà AL, Sánchez-Mateos P, RodrÃguez-Fernández JL. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood. 104: 619-25. PMID 15059845 DOI: 10.1182/Blood-2003-11-3943 |
0.351 |
|
| 2004 |
Sánchez-MartÃn L, Sánchez-Sánchez N, Gutiérrez-López MD, Rojo AI, Vicente-Manzanares M, Pérez-Alvarez MJ, Sánchez-Mateos P, Bustelo XR, Cuadrado A, Sánchez-Madrid F, RodrÃguez-Fernández JL, Cabañas C. Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1. The Journal of Biological Chemistry. 279: 16194-205. PMID 14960575 DOI: 10.1074/Jbc.M400905200 |
0.347 |
|
| 2004 |
Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. The Journal of Biological Chemistry. 279: 8919-29. PMID 14688281 DOI: 10.1074/Jbc.M309660200 |
0.414 |
|
| 2003 |
Salinas M, Diaz R, Abraham NG, Ruiz de Galarreta CM, Cuadrado A. Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner. The Journal of Biological Chemistry. 278: 13898-904. PMID 12578834 DOI: 10.1074/Jbc.M209164200 |
0.409 |
|
| 2002 |
Martin D, Salinas M, Fujita N, Tsuruo T, Cuadrado A. Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. The Journal of Biological Chemistry. 277: 42943-52. PMID 12213802 DOI: 10.1074/Jbc.M201070200 |
0.375 |
|
| 2002 |
Conejo R, de Alvaro C, Benito M, Cuadrado A, Lorenzo M. Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. Oncogene. 21: 3739-53. PMID 12032842 DOI: 10.1038/Sj.Onc.1205469 |
0.318 |
|
| 2001 |
MartÃn D, Salinas M, López-Valdaliso R, Serrano E, Recuero M, Cuadrado A. Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells. Journal of Neurochemistry. 78: 1000-8. PMID 11553674 DOI: 10.1046/J.1471-4159.2001.00472.X |
0.335 |
|
| 2001 |
Salinas M, MartÃn D, Alvarez A, Cuadrado A. Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Molecular and Cellular Neurosciences. 17: 67-77. PMID 11161470 DOI: 10.1006/Mcne.2000.0921 |
0.4 |
|
| 2000 |
Salinas M, López-Valdaliso R, MartÃn D, Alvarez A, Cuadrado A. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Molecular and Cellular Neurosciences. 15: 156-69. PMID 10673324 DOI: 10.1006/Mcne.1999.0813 |
0.343 |
|
| 1998 |
Murga C, Laguinge L, Wetzker R, Cuadrado A, Gutkind JS. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. The Journal of Biological Chemistry. 273: 19080-5. PMID 9668091 DOI: 10.1074/Jbc.273.30.19080 |
0.327 |
|
| 1992 |
Molloy CJ, Fleming TP, Bottaro DP, Cuadrado A, Aaronson SA. Platelet-derived growth factor stimulation of GTPase-activating protein tyrosine phosphorylation in control and c-H-ras-expressing NIH 3T3 cells correlates with p21ras activation. Molecular and Cellular Biology. 12: 3903-9. PMID 1508192 DOI: 10.1128/Mcb.12.9.3903 |
0.304 |
|
| 1990 |
Cuadrado A, Molloy CJ, Pech M. Expression of protein kinase CI in NIH 3T3 cells increases its growth response to specific activators. Febs Letters. 260: 281-4. PMID 2298303 DOI: 10.1016/0014-5793(90)80123-Z |
0.307 |
|
| 1990 |
Lacal JC, Cuadrado A, Jones JE, Trotta R, Burstein DE, Thomson T, Pellicer A. Regulation of protein kinase C activity in neuronal differentiation induced by the N-ras oncogene in PC-12 cells. Molecular and Cellular Biology. 10: 2983-90. PMID 2188105 DOI: 10.1128/mcb.10.6.2983-2990.1990 |
0.303 |
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