Thomas J. Hoffmann, Ph.D. - Publications

Affiliations: 
2009 Harvard University, Cambridge, MA, United States 
Area:
Biostatistics Biology, Genetics

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Choquet H, Melles RB, Anand D, Yin J, Cuellar-Partida G, Wang W, Hoffmann TJ, Nair KS, Hysi PG, Lachke SA, Jorgenson E. A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Nature Communications. 12: 3595. PMID 34127677 DOI: 10.1038/s41467-021-23873-8  0.305
2020 Emami NC, Cavazos TB, Rashkin SR, Graff RE, Tai CG, Mefford JA, Kachuri L, Cario CL, Wan E, Wong S, Aaronson D, Presti J, Habel LA, Shan J, Ranatunga DK, ... ... Hoffmann TJ, et al. A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility. Cancer Research. PMID 33293427 DOI: 10.1158/0008-5472.CAN-20-2635  0.331
2020 Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, ... ... Hoffmann TJ, et al. Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Nature Communications. 11: 4423. PMID 32887889 DOI: 10.1038/S41467-020-18246-6  0.406
2020 Brenowitz WD, Filshtein TJ, Yaffe K, Walter S, Ackley SF, Hoffmann TJ, Jorgenson E, Whitmer RA, Glymour MM. Association of genetic risk for Alzheimer disease and hearing impairment. Neurology. PMID 32878991 DOI: 10.1212/Wnl.0000000000010709  0.31
2020 Nandakumar P, Lee D, Hoffmann TJ, Ehret GB, Arking D, Ranatunga D, Li M, Grove ML, Boerwinkle E, Schaefer C, Kwok PY, Iribarren C, Risch N, Chakravarti A. Analysis of putative cis-regulatory elements regulating blood pressure variation. Human Molecular Genetics. PMID 32436959 DOI: 10.1093/Hmg/Ddaa098  0.353
2020 Oni-Orisan A, Haldar T, Ranatunga DK, Medina MW, Schaefer C, Krauss RM, Iribarren C, Risch N, Hoffmann TJ. The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. Npj Genomic Medicine. 5: 1. PMID 31969989 DOI: 10.1038/S41525-019-0109-4  0.374
2019 Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-Amero KK, Anderson MG, Akafo S, Alhassan MB, ... ... Hoffmann TJ, et al. Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. Jama. 322: 1682-1691. PMID 31688885 DOI: 10.1001/Jama.2019.16161  0.356
2019 Emami NC, Kachuri L, Meyers TJ, Das R, Hoffman JD, Hoffmann TJ, Hu D, Shan J, Feng FY, Ziv E, Van Den Eeden SK, Witte JS. Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms. Nature Communications. 10: 3107. PMID 31308362 DOI: 10.1038/S41467-019-10808-7  0.363
2019 Ley B, Torgerson DG, Oldham JM, Adegunsoye A, Liu S, Li J, Elicker BM, Henry TS, Golden JA, Jones KD, Dressen A, Yaspan BL, Arron JR, Noth I, Hoffmann TJ, et al. Rare Protein-altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. American Journal of Respiratory and Critical Care Medicine. PMID 31268371 DOI: 10.1164/Rccm.201902-0360Oc  0.321
2019 Du Z, Hopp H, Ingles SA, Huff C, Sheng X, Weaver B, Stern M, Hoffmann TJ, John EM, Van Den Eeden SK, Strom S, Leach RJ, Thompson IM, Witte JS, Conti DV, et al. A Genome-wide Association Study of Prostate Cancer in Latinos. International Journal of Cancer. PMID 31226226 DOI: 10.1002/Ijc.32525  0.375
2019 Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK. Reply to Liu et al.: Tissue specificity of gene expression and erectile dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 30755537 DOI: 10.1073/Pnas.1900162116  0.357
2019 Brenowitz WD, Filshtein TJ, Yaffe K, Walter S, Hoffmann T, Jorgenson E, Whitmer RA, Glymour M. O3-08-06: Using Genetic Information To Identify The Earliest Manifestations Of Alzheimer'S Disease: Genetic Risk Score For Alzheimer'S Disease Predicts Lower Bmi By Age 58 Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4671  0.316
2019 Schaefer C, Thai K, Jorgenson E, Banda Y, Hoffmann T, Kvale M, Risch N. ASSOCIATIONS OF POLYGENIC RISK OF SCHIZOPHRENIA AND MAJOR DEPRESSION IN STUDIES OF BIPOLAR DISORDER AND MAJOR DEPRESSION European Neuropsychopharmacology. 29: S899-S900. DOI: 10.1016/J.Euroneuro.2017.08.212  0.36
2018 Jorgenson E, Matharu N, Palmer MR, Yin J, Shan J, Hoffmann TJ, Thai KK, Zhou X, Hotaling JM, Jarvik GP, Ahituv N, Wessells H, Van Den Eeden SK. Genetic variation in the locus is associated with erectile dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 30297428 DOI: 10.1073/Pnas.1809872115  0.402
2018 Hoffmann TJ, Choquet H, Yin J, Banda Y, Kvale MN, Glymour M, Schaefer C, Risch N, Jorgenson E. A Large Multi-ethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. Genetics. PMID 30108127 DOI: 10.1534/Genetics.118.301479  0.392
2018 Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, et al. A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci. Nature Communications. 9: 2278. PMID 29891935 DOI: 10.1038/S41467-018-04555-4  0.4
2018 Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N. A large electronic-health-record-based genome-wide study of serum lipids. Nature Genetics. PMID 29507422 DOI: 10.1038/S41588-018-0064-5  0.376
2017 Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E. A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. Nature Communications. 8: 2108. PMID 29235454 DOI: 10.1038/S41467-017-01913-6  0.394
2017 Wu YH, Graff RE, Passarelli MN, Hoffman JD, Ziv E, Hoffmann TJ, Witte JS. Identification of pleiotropic cancer susceptibility variants from genome-wide association studies reveals functional characteristics. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 29150481 DOI: 10.1158/1055-9965.Epi-17-0516  0.387
2017 Wade M, Prime H, Hoffmann TJ, Schmidt LA, O'Connor TG, Jenkins JM. Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children. Development and Psychopathology. 1-9. PMID 28511728 DOI: 10.1017/S0954579417000578  0.356
2017 Jorgenson E, Thai KK, Hoffmann TJ, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Mertens J, Weisner C, Choquet H. Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Molecular Psychiatry. 22: 1359-1367. PMID 28485404 DOI: 10.1038/Mp.2017.101  0.302
2017 Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, et al. Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer. Nature Communications. 8: 14248. PMID 28139693 DOI: 10.1038/Ncomms14248  0.369
2017 Wu Y, Graff RE, Passarelli MN, Hoffmann TJ, Ziv E, Witte JS. Abstract 1310: Identification of pleiotropic cancer susceptibility variants from genome-wide association studies reveals functional characteristics Epidemiology. 77: 1310-1310. DOI: 10.1158/1538-7445.Am2017-1310  0.363
2016 Hoffmann TJ, Ehret GB, Nandakumar P, Ranatunga D, Schaefer C, Kwok PY, Iribarren C, Chakravarti A, Risch N. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. Nature Genetics. PMID 27841878 DOI: 10.1038/Ng.3715  0.33
2016 Hoffmann TJ, Keats BJ, Yoshikawa N, Schaefer C, Risch N, Lustig LR. A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records. Plos Genetics. 12: e1006371. PMID 27764096 DOI: 10.1371/Journal.Pgen.1006371  0.364
2016 Roberts JD, Dewland TA, Glidden DV, Hoffmann TJ, Arking DE, Chen LY, Psaty BM, Olgin JE, Alonso A, Heckbert SR, Marcus GM. Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation. American Heart Journal. 175: 9-17. PMID 27179719 DOI: 10.1016/J.Ahj.2016.02.002  0.316
2016 Wade M, Hoffmann TJ, Knafo-Noam A, O'Connor TG, Jenkins JM. Oxytocin and vasopressin hormone genes in children's externalizing problems: A cognitive endophenotype approach. Hormones and Behavior. PMID 27155104 DOI: 10.1016/J.Yhbeh.2016.05.002  0.318
2016 Domingue BW, Wedow R, Conley D, McQueen M, Hoffmann TJ, Boardman JD. Genome-Wide Estimates of Heritability for Social Demographic Outcomes. Biodemography and Social Biology. 62: 1-18. PMID 27050030 DOI: 10.1080/19485565.2015.1068106  0.35
2016 Asgari MM, Wang W, Ioannidis NM, Itnyre J, Hoffmann T, Jorgenson E, Whittemore AS. Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. The Journal of Investigative Dermatology. PMID 26829030 DOI: 10.1016/J.Jid.2016.01.013  0.36
2016 Jorgenson E, Melles RB, Hoffmann TJ, Jia X, Sakoda LC, Kvale MN, Banda Y, Schaefer C, Risch N, Shen L. Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration. European Journal of Human Genetics : Ejhg. PMID 26733291 DOI: 10.1038/Ejhg.2015.247  0.363
2015 Hoffmann TJ, Witte JS. Strategies for Imputing and Analyzing Rare Variants in Association Studies. Trends in Genetics : Tig. 31: 556-63. PMID 26450338 DOI: 10.1016/J.Tig.2015.07.006  0.376
2015 Kvale MN, Hesselson S, Hoffmann TJ, Cao Y, Chan D, Connell S, Croen LA, Dispensa BP, Eshragh J, Finn A, Gollub J, Iribarren C, Jorgenson E, Kushi LH, Lao R, et al. Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. PMID 26092718 DOI: 10.1534/Genetics.115.178905  0.376
2015 Banda Y, Kvale MN, Hoffmann TJ, Hesselson SE, Ranatunga D, Tang H, Sabatti C, Croen LA, Dispensa BP, Henderson M, Iribarren C, Jorgenson E, Kushi LH, Ludwig D, Olberg D, et al. Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort. Genetics. PMID 26092716 DOI: 10.1534/Genetics.115.178616  0.356
2015 Hoffmann TJ, Van Den Eeden SK, Sakoda LC, Jorgenson E, Habel LA, Graff RE, Passarelli MN, Cario CL, Emami NC, Chao CR, Ghai NR, Shan J, Ranatunga DK, Quesenberry CP, Aaronson D, et al. A Large Multiethnic Genome-Wide Association Study of Prostate Cancer Identifies Novel Risk Variants and Substantial Ethnic Differences. Cancer Discovery. PMID 26034056 DOI: 10.1158/2159-8290.Cd-15-0315  0.371
2015 Wade M, Hoffmann TJ, Jenkins JM. Gene-environment interaction between the oxytocin receptor (OXTR) gene and parenting behaviour on children's theory of mind. Social Cognitive and Affective Neuroscience. 10: 1749-57. PMID 25977357 DOI: 10.1093/Scan/Nsv064  0.333
2015 Virlogeux V, Graff RE, Hoffmann TJ, Witte JS. Replication and heritability of prostate cancer risk variants: impact of population-specific factors. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 938-43. PMID 25809866 DOI: 10.1158/1055-9965.Epi-14-1372  0.36
2015 Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clinical Pharmacology and Therapeutics. 97: 518-25. PMID 25676789 DOI: 10.1002/Cpt.89  0.374
2015 Hoffmann TJ, Sakoda LC, Shen L, Jorgenson E, Habel LA, Liu J, Kvale MN, Asgari MM, Banda Y, Corley D, Kushi LH, Quesenberry CP, Schaefer C, Van Den Eeden SK, Risch N, et al. Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort. Plos Genetics. 11: e1004930. PMID 25629170 DOI: 10.1371/Journal.Pgen.1004930  0.357
2014 Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Genome-wide discovery of drug-dependent human liver regulatory elements. Plos Genetics. 10: e1004648. PMID 25275310 DOI: 10.1371/Journal.Pgen.1004648  0.3
2014 Hoffmann TJ, Tang H, Thornton TA, Caan B, Haan M, Millen AE, Thomas F, Risch N. Genome-wide association and admixture analysis of glaucoma in the Women's Health Initiative. Human Molecular Genetics. 23: 6634-43. PMID 25027321 DOI: 10.1093/Hmg/Ddu364  0.345
2014 Wade M, Hoffmann TJ, Jenkins JM. Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers' executive functioning. Brain and Cognition. 90: 116-23. PMID 25016245 DOI: 10.1016/J.Bandc.2014.06.002  0.351
2014 Risch N, Hoffmann TJ, Anderson M, Croen LA, Grether JK, Windham GC. Familial recurrence of autism spectrum disorder: evaluating genetic and environmental contributions. The American Journal of Psychiatry. 171: 1206-13. PMID 24969362 DOI: 10.1176/Appi.Ajp.2014.13101359  0.316
2013 Wang H, St Julien KR, Stevenson DK, Hoffmann TJ, Witte JS, Lazzeroni LC, Krasnow MA, Quaintance CC, Oehlert JW, Jelliffe-Pawlowski LL, Gould JB, Shaw GM, O'Brodovich HM. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Pediatrics. 132: 290-7. PMID 23897914 DOI: 10.1542/Peds.2013-0533  0.402
2013 Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, et al. Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. American Journal of Human Genetics. 92: 904-16. PMID 23726366 DOI: 10.1016/J.Ajhg.2013.04.025  0.369
2013 Kaklamani VG, Hoffmann TJ, Thornton TA, Hayes G, Chlebowski R, Van Horn L, Mantzoros C. Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative. Breast Cancer Research and Treatment. 139: 461-8. PMID 23624817 DOI: 10.1007/S10549-013-2546-6  0.323
2013 Lindquist KJ, Jorgenson E, Hoffmann TJ, Witte JS. The impact of improved microarray coverage and larger sample sizes on future genome-wide association studies. Genetic Epidemiology. 37: 383-92. PMID 23529720 DOI: 10.1002/Gepi.21724  0.362
2013 Shen L, Hoffmann T, Kvale M, Sakoda L, Banda Y, Kwok P, Risch N, Jorgenson E, Schaefer C. PS3-15: Genome-Wide Association Study of Anxiety Disorders: Early Results from Kaiser Permanente's Research Program on Genes, Environment, and Health (RPGEH) Clinical Medicine & Research. 11: 149-149. DOI: 10.3121/Cmr.2013.1176.Ps3-15  0.335
2013 Jorgenson E, Sciortino S, Shen L, Ranatunga D, Hoffmann T, Kvale M, Banda Y, Kwok P, Walter L, Risch N, Schaefer C. B4-4: Genome-Wide Association Study of Macular Degeneration: Early Results from the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) Clinical Medicine & Research. 11: 146-147. DOI: 10.3121/Cmr.2013.1176.B4-4  0.386
2012 Thornton T, Tang H, Hoffmann TJ, Ochs-Balcom HM, Caan BJ, Risch N. Estimating kinship in admixed populations. American Journal of Human Genetics. 91: 122-38. PMID 22748210 DOI: 10.1016/J.Ajhg.2012.05.024  0.317
2011 Kazma R, Hoffmann TJ, Witte JS. Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates. Bmc Proceedings. 5: S29. PMID 22373382 DOI: 10.1186/1753-6561-5-S9-S29  0.352
2011 Marini NJ, Hoffmann TJ, Lammer EJ, Hardin J, Lazaruk K, Stein JB, Gilbert DA, Wright C, Lipzen A, Pennacchio LA, Carmichael SL, Witte JS, Shaw GM, Rine J. A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis. Plos One. 6: e28408. PMID 22140583 DOI: 10.1371/Journal.Pone.0028408  0.392
2011 Hoffmann TJ, Zhan Y, Kvale MN, Hesselson SE, Gollub J, Iribarren C, Lu Y, Mei G, Purdy MM, Quesenberry C, Rowell S, Shapero MH, Smethurst D, Somkin CP, Van den Eeden SK, et al. Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm. Genomics. 98: 422-30. PMID 21903159 DOI: 10.1016/J.Ygeno.2011.08.007  0.337
2011 Hoffmann TJ, Kvale MN, Hesselson SE, Zhan Y, Aquino C, Cao Y, Cawley S, Chung E, Connell S, Eshragh J, Ewing M, Gollub J, Henderson M, Hubbell E, Iribarren C, et al. Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics. 98: 79-89. PMID 21565264 DOI: 10.1016/J.Ygeno.2011.04.005  0.366
2011 Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 67: 1260-70. PMID 21401569 DOI: 10.1111/J.1541-0420.2011.01581.X  0.521
2011 Witte JS, Hoffmann TJ. Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer. Omics : a Journal of Integrative Biology. 15: 393-8. PMID 21348634 DOI: 10.1089/Omi.2010.0090  0.348
2010 Hoffmann TJ, Marini NJ, Witte JS. Comprehensive approach to analyzing rare genetic variants. Plos One. 5: e13584. PMID 21072163 DOI: 10.1371/Journal.Pone.0013584  0.331
2010 Cho MH, Washko GR, Hoffmann TJ, Criner GJ, Hoffman EA, Martinez FJ, Laird N, Reilly JJ, Silverman EK. Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation. Respiratory Research. 11: 30. PMID 20233420 DOI: 10.1186/1465-9921-11-30  0.519
2010 Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM. Parsing the effects of individual SNPs in candidate genes with family data. Human Heredity. 69: 91-103. PMID 19996607 DOI: 10.1159/000264447  0.528
2009 Hoffmann TJ, Laird NM. fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages. Journal of Statistical Software. 30. PMID 21625291 DOI: 10.18637/Jss.V030.I02  0.442
2009 Hoffmann TJ, Lange C, Vansteelandt S, Laird NM. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genetic Epidemiology. 33: 691-9. PMID 19365860 DOI: 10.1002/Gepi.20421  0.523
2006 Hoffmann T, Lange C. P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R Bioinformatics. 22: 3103-3105. PMID 17021156 DOI: 10.1093/Bioinformatics/Btl507  0.335
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