Year |
Citation |
Score |
2010 |
Kong Y, Wang K, Edler MC, Hamel E, Mooberry SL, Paige MA, Brown ML. A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent. Bioorganic & Medicinal Chemistry. 18: 971-7. PMID 20006519 DOI: 10.1016/J.Bmc.2009.11.003 |
0.479 |
|
2009 |
La Regina G, Sarkar T, Bai R, Edler MC, Saletti R, Coluccia A, Piscitelli F, Minelli L, Gatti V, Mazzoccoli C, Palermo V, Mazzoni C, Falcone C, Scovassi AI, Giansanti V, et al. New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies Journal of Medicinal Chemistry. 52: 7512-7527. PMID 19601594 DOI: 10.1021/jm900016t |
0.476 |
|
2009 |
Edler MC, Yang G, Katherine Jung M, Bai R, Bornmann WG, Hamel E. Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity Archives of Biochemistry and Biophysics. 487: 98-104. PMID 19497297 DOI: 10.1016/j.abb.2009.05.014 |
0.329 |
|
2007 |
Shin Y, Fournier JH, Brückner A, Madiraju C, Balachandran R, Raccor BS, Edler MC, Hamel E, Sikorski RP, Vogt A, Day BW, Curran DP. Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers. Tetrahedron. 63: 8537-8562. PMID 18728696 DOI: 10.1016/J.Tet.2007.05.033 |
0.421 |
|
2007 |
La Regina G, Edler MC, Brancale A, Kandil S, Coluccia A, Piscitelli F, Hamel E, De Martino G, Matesanz R, Díaz JF, Scovassi AI, Prosperi E, Lavecchia A, Novellino E, Artico M, et al. Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry. 50: 2865-74. PMID 17497841 DOI: 10.1021/Jm061479U |
0.454 |
|
2007 |
Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature Chemical Biology. 3: 117-25. PMID 17206139 DOI: 10.1038/Nchembio853 |
0.405 |
|
2006 |
De Martino G, Edler MC, La Regina G, Coluccia A, Barbera MC, Barrow D, Nicholson RI, Chiosis G, Brancale A, Hamel E, Artico M, Silvestri R. New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry. 49: 947-54. PMID 16451061 DOI: 10.1021/Jm050809S |
0.453 |
|
2006 |
Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Erratum: Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site (Biochemistry (August 30, 2005) 44, 34 (11525-11538)) Biochemistry. 45. DOI: 10.1021/Bi068009M |
0.36 |
|
2005 |
Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry. 44: 15053-63. PMID 16274252 DOI: 10.1021/Bi050685L |
0.477 |
|
2005 |
Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. Biochemistry. 44: 11525-38. PMID 16114889 DOI: 10.1021/Bi050660M |
0.445 |
|
2005 |
Shin Y, Fournier JH, Balachandran R, Madiraju C, Raccor BS, Zhu G, Edler MC, Hamel E, Day BW, Curran DP. Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin. Organic Letters. 7: 2873-6. PMID 15987158 DOI: 10.1021/Ol050808U |
0.374 |
|
2004 |
De Martino G, La Regina G, Coluccia A, Edler MC, Barbera MC, Brancale A, Wilcox E, Hamel E, Artico M, Silvestri R. Arylthioindoles, potent inhibitors of tubulin polymerization. Journal of Medicinal Chemistry. 47: 6120-3. PMID 15566282 DOI: 10.1021/Jm049360D |
0.419 |
|
2004 |
Raffa D, Edler MC, Daidone G, Maggio B, Merikech M, Merickech M, Plescia S, Schillaci D, Bai R, Hamel E. Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones. European Journal of Medicinal Chemistry. 39: 299-304. PMID 15072839 DOI: 10.1016/J.Ejmech.2003.12.009 |
0.507 |
|
2004 |
Raffa D, Edler MC, Daidone G, Maggio B, Merikech M, Plescia S, Schillaci D, Bai R, Hamel E. Corrigendum to “Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones” (Eur. J. Med. Chem. 39 (2004) 299–304) European Journal of Medicinal Chemistry. 39: 647. DOI: 10.1016/J.Ejmech.2004.05.002 |
0.373 |
|
2002 |
Edler MC, Fernandez AM, Lassota P, Ireland CM, Barrows LR. Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10. Biochemical Pharmacology. 63: 707-15. PMID 11992639 DOI: 10.1016/S0006-2952(01)00898-X |
0.369 |
|
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