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Kenneth M. Humphries, Ph.D. - Publications

Affiliations: 
2000 Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Area:
Biochemistry, General Biophysics, Molecular Biology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mendez Garcia MF, Matsuzaki S, Batushansky A, Newhardt R, Kinter C, Jin Y, Mann SN, Stout MB, Gu H, Chiao YA, Kinter M, Humphries KM. Increased cardiac PFK-2 protects against high-fat diet-induced cardiomyopathy and mediates beneficial systemic metabolic effects. Iscience. 26: 107131. PMID 37534142 DOI: 10.1016/j.isci.2023.107131  0.366
2022 Li P, Newhardt MF, Matsuzaki S, Eyster C, Pranay A, Peelor FF, Batushansky A, Kinter C, Subramani K, Subrahmanian S, Ahamed J, Yu P, Kinter M, Miller BF, Humphries KM. The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner. Geroscience. PMID 36460774 DOI: 10.1007/s11357-022-00695-0  0.301
2020 Eyster CA, Matsuzaki S, Newhardt MF, Giorgione JR, Humphries KM. Diabetes induced decreases in PKA signaling in cardiomyocytes: The role of insulin. Plos One. 15: e0231806. PMID 32817622 DOI: 10.1371/Journal.Pone.0231806  0.308
2020 Yap ZY, Strucinska K, Matsuzaki S, Lee S, Si Y, Humphries K, Tarnopolsky MA, Yoon WH. A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease. Journal of Inherited Metabolic Disease. PMID 32383294 DOI: 10.1002/Jimd.12248  0.37
2019 Newhardt MF, Batushansky A, Matsuzaki S, Young ZT, West M, Chin NC, Szweda LI, Kinter M, Humphries KM. Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short term high fat diet. The Journal of Biological Chemistry. PMID 31562244 DOI: 10.1074/Jbc.Ra119.010371  0.654
2019 Batushansky A, Matsuzaki S, Newhardt MF, West MS, Griffin TM, Humphries KM. GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting. Metabolomics : Official Journal of the Metabolomic Society. 15: 18. PMID 30830475 DOI: 10.1007/S11306-019-1478-5  0.383
2019 Pearsall EA, Cheng R, Matsuzaki S, Zhou K, Ding L, Ahn B, Kinter M, Humphries KM, Quiambao AB, Farjo RA, Ma JX. Neuroprotective effects of PPARα in retinopathy of type 1 diabetes. Plos One. 14: e0208399. PMID 30716067 DOI: 10.1371/Journal.Pone.0208399  0.403
2019 Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, et al. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. Journal of Cachexia, Sarcopenia and Muscle. PMID 30706998 DOI: 10.1002/Jcsm.12375  0.342
2018 Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS. Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. Embo Reports. PMID 29420235 DOI: 10.15252/Embr.201745009  0.392
2018 Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, et al. Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Molecular Metabolism. PMID 29398615 DOI: 10.1016/J.Molmet.2018.01.013  0.603
2017 Bockus LB, Matsuzaki S, Vadvalkar SS, Young ZT, Giorgione JR, Newhardt MF, Kinter M, Humphries KM. Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity. Journal of the American Heart Association. 6. PMID 29203581 DOI: 10.1161/Jaha.117.007159  0.367
2017 Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, et al. PPARα is essential for retinal lipid metabolism and neuronal survival. Bmc Biology. 15: 113. PMID 29183319 DOI: 10.1186/S12915-017-0451-X  0.567
2017 Vadvalkar SS, Matsuzaki S, Eyster CA, Giorgione JR, Bockus LB, Kinter CS, Kinter M, Humphries KM. Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: Role of MPC2 Acetylation. The Journal of Biological Chemistry. PMID 28154187 DOI: 10.1074/Jbc.M116.753509  0.454
2017 Ahn B, Ranjit R, Matsuzaki S, Premkumar P, Pharaoh G, Riddle K, Wronowski B, Kinter M, Humphries K, Freeman W, Richardson A, Remmen HV. MnSod deficiency causes significant mitochondrial abnormalities and contractile dysfunction in skeletal muscle, but does not decrease muscle mass Free Radical Biology and Medicine. 112: 48. DOI: 10.1016/J.Freeradbiomed.2017.10.062  0.381
2016 Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA. AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Letters. PMID 27939695 DOI: 10.1016/J.Canlet.2016.11.040  0.409
2016 Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL. Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes. PMID 27679559 DOI: 10.2337/Db16-0709  0.371
2016 Bastian A, Matsuzaki S, Humphries KM, Bailey-Downs LC, Gangjee A, Ihnat MA. Abstract 3776: Mechanistic evaluation of AG311 - an OXPHOS inhibitor - as a potential treatment for breast cancer Cancer Research. 76: 3776-3776. DOI: 10.1158/1538-7445.Am2016-3776  0.318
2015 Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie. PMID 26476002 DOI: 10.1016/J.Biochi.2015.10.013  0.595
2015 Bockus LB, Humphries KM. cAMP-dependent Protein Kinase (PKA) Signaling Is Impaired in the Diabetic Heart. The Journal of Biological Chemistry. 290: 29250-8. PMID 26468277 DOI: 10.1074/Jbc.M115.681767  0.307
2015 Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M. Lysine Acetylation Activates Mitochondrial Aconitase in the Heart. Biochemistry. 54: 4008-18. PMID 26061789 DOI: 10.1021/Acs.Biochem.5B00375  0.646
2015 Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM. Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Research & Therapy. 17: 54. PMID 25889867 DOI: 10.1186/S13075-015-0566-9  0.474
2015 Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. The Journal of Pharmacology and Experimental Therapeutics. 353: 392-404. PMID 25720766 DOI: 10.1124/Jpet.114.220335  0.353
2015 Matsuzaki S, Humphries KM. Selective inhibition of deactivated mitochondrial complex I by biguanides. Biochemistry. 54: 2011-21. PMID 25719498 DOI: 10.1021/Bi501473H  0.433
2015 Bastian A, Bailey-Downs LC, Thorpe JE, Devambatla RKV, Gangjee A, Humphries KM, Ihnat MA. Abstract 4451: Novel small molecule AG311 induces tumor cell death through inhibition of mitochondrial electron transport Cancer Research. 75: 4451-4451. DOI: 10.1158/1538-7445.Am2015-4451  0.35
2015 Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M. Lysine Acetylation Activates Mitochondrial Aconitase in the Heart Biochemistry. 54: 4008-4018. DOI: 10.1021/acs.biochem.5b00375  0.602
2014 Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina. The American Journal of Pathology. 184: 2709-20. PMID 25108226 DOI: 10.1016/J.Ajpath.2014.06.021  0.308
2013 Vadvalkar SS, Baily CN, Matsuzaki S, West M, Tesiram YA, Humphries KM. Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of type 1 diabetes. The Biochemical Journal. 449: 253-61. PMID 23030792 DOI: 10.1042/Bj20121038  0.462
2013 Matsuzaki S, Humphries KM. PSS159 - Mechanisms and Consequences of Mitochondrial Complex I Inactivation during Cardiac Ischemia Free Radical Biology and Medicine. 65. DOI: 10.1016/J.Freeradbiomed.2013.10.578  0.418
2011 Matsuzaki S, Kotake Y, Humphries KM. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry. 50: 10792-803. PMID 22091587 DOI: 10.1021/Bi201714W  0.413
2011 Baily CN, Cason RW, Vadvalkar SS, Matsuzaki S, Humphries KM. Inhibition of mitochondrial respiration by phosphoenolpyruvate. Archives of Biochemistry and Biophysics. 514: 68-74. PMID 21867675 DOI: 10.1016/J.Abb.2011.08.003  0.485
2011 McLain AL, Humphries KM, Stofan D, Kinter MT, Szweda LI. Inactivation of α-Ketoglutarate Dehydrogenase by 4Hydroxy-2-nonenal; Modification and Metabolic Fate of the Cofactor Lipoic Acid Free Radical Biology and Medicine. 51. DOI: 10.1016/J.Freeradbiomed.2011.10.073  0.573
2010 Griesel BA, Weems J, Russell RA, Dale Abel E, Humphries K, Olson AL. Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through Liver X Receptor (LXR) signaling Diabetes. 59: 800-807. PMID 20103707 DOI: 10.2337/Db09-1542  0.31
2010 Humphries KM, Matsuzaki S. Identification of Carboncentered Radical Formation from Mitochondrial Electron Transport Chain by EPRspin Trapping Techniques Free Radical Biology and Medicine. 49. DOI: 10.1016/J.Freeradbiomed.2010.10.254  0.381
2010 Humphries KM, Vadvalkar SS, Baily CN. Phosphoenolpyruvate Inhibits Mitochondrial Respiration and Increases Free Radical Production Free Radical Biology and Medicine. 49. DOI: 10.1016/J.Freeradbiomed.2010.10.246  0.46
2009 Matsuzaki S, Szweda PA, Szweda LI, Humphries KM. Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning. Advanced Drug Delivery Reviews. 61: 1324-31. PMID 19716389 DOI: 10.1016/J.Addr.2009.05.008  0.651
2009 Moser MD, Matsuzaki S, Humphries KM. Inhibition of succinate-linked respiration and complex II activity by hydrogen peroxide. Archives of Biochemistry and Biophysics. 488: 69-75. PMID 19540189 DOI: 10.1016/J.Abb.2009.06.009  0.353
2009 Matsuzaki S, Szweda LI, Humphries KM. Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration. Archives of Biochemistry and Biophysics. 484: 87-93. PMID 19467633 DOI: 10.1016/J.Abb.2009.01.006  0.643
2008 Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, Olson EN. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice Journal of Clinical Investigation. 118: 3588-3597. PMID 18830415 DOI: 10.1172/Jci35847  0.376
2008 Applegate MA, Humphries KM, Szweda LI. Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. Biochemistry. 47: 473-8. PMID 18081316 DOI: 10.1021/Bi7017464  0.627
2007 Humphries KM, Pennypacker JK, Taylor SS. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. The Journal of Biological Chemistry. 282: 22072-9. PMID 17548350 DOI: 10.1074/Jbc.M702582200  0.345
2006 Humphries KM, Szweda PA, Szweda LI. Aging: a shift from redox regulation to oxidative damage. Free Radical Research. 40: 1239-43. PMID 17090412 DOI: 10.1080/10715760600913184  0.612
2002 Sadek HA, Humphries KM, Szweda PA, Szweda LI. Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Archives of Biochemistry and Biophysics. 406: 222-8. PMID 12361710 DOI: 10.1016/S0003-9861(02)00446-0  0.672
2002 Humphries KM, Juliano C, Taylor SS. Regulation of cAMP-dependent protein kinase activity by glutathionylation. The Journal of Biological Chemistry. 277: 43505-11. PMID 12189155 DOI: 10.1074/Jbc.M207088200  0.344
2001 Bulteau AL, Lundberg KC, Humphries KM, Sadek HA, Szweda PA, Friguet B, Szweda LI. Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. The Journal of Biological Chemistry. 276: 30057-63. PMID 11375979 DOI: 10.1074/Jbc.M100142200  0.62
2000 Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, Bach JF, Gershwin ME. Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic. Journal of Autoimmunity. 15: 51-60. PMID 10936028 DOI: 10.1006/Jaut.2000.0390  0.492
1998 Humphries KM, Szweda LI. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry. 37: 15835-41. PMID 9843389 DOI: 10.1021/Bi981512H  0.678
1998 Humphries KM, Yoo Y, Szweda LI. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry. 37: 552-7. PMID 9425076 DOI: 10.1021/Bi971958I  0.684
1997 Humphries KM, Szweda LI. 4-hydroxy-2-nonenal mediated declines in mitochondrial respiration Faseb Journal. 11.  0.656
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