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Ben Barthel, Ph.D. - Publications

Affiliations: 
2008 Chemistry University of Colorado, Boulder, Boulder, CO, United States 
Area:
Pharmaceutical Chemistry, Organic Chemistry, Biochemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ganesh AN, Aman A, Logie J, Barthel BL, Cogan P, Al-Awar R, Koch TH, Shoichet BK, Shoichet MS. Colloidal drug aggregate stability in high serum conditions and pharmacokinetic consequence. Acs Chemical Biology. PMID 30840432 DOI: 10.1021/Acschembio.9B00032  0.528
2017 Ganesh AN, Logie J, McLaughlin CK, Barthel BL, Koch TH, Shoichet BK, Shoichet MS. Leveraging colloidal aggregation for drug-rich nanoparticle formulations. Molecular Pharmaceutics. PMID 28502177 DOI: 10.1021/Acs.Molpharmaceut.6B01015  0.529
2016 Barthel BL, Mooz EL, Wiener LE, Koch GG, Koch TH. Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde. Journal of Medicinal Chemistry. 59: 2205-21. PMID 26881291 DOI: 10.1021/Acs.Jmedchem.5B01956  0.677
2013 Xiao D, Shi D, Yang D, Barthel B, Koch TH, Yan B. Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs. Biochemical Pharmacology. 85: 439-47. PMID 23228697 DOI: 10.1016/J.Bcp.2012.11.026  0.657
2012 Barthel BL, Rudnicki DL, Kirby TP, Colvin SM, Burkhart DJ, Koch TH. Synthesis and biological characterization of protease-activated prodrugs of doxazolidine. Journal of Medicinal Chemistry. 55: 6595-607. PMID 22742660 DOI: 10.1021/Jm300714P  0.64
2009 Barthel BL, Zhang Z, Rudnicki DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC, Koch TH. Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine. Journal of Medicinal Chemistry. 52: 7678-88. PMID 19634903 DOI: 10.1021/Jm900694Z  0.752
2008 Koch TH, Barthel BL, Kalet BT, Rudnicki DL, Post GC, Burkhart DJ. Anthracycline-formaldehyde conjugates and their targeted prodrugs. Topics in Current Chemistry. 283: 141-70. PMID 23605631 DOI: 10.1007/128_2007_4  0.619
2008 Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH. Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug Journal of Medicinal Chemistry. 51: 298-304. PMID 18173233 DOI: 10.1021/Jm7011479  0.653
2006 Burkhart DJ, Barthel BL, Post GC, Kalet BT, Nafie JW, Shoemaker RK, Koch TH. Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases. Journal of Medicinal Chemistry. 49: 7002-12. PMID 17125253 DOI: 10.1021/Jm060597E  0.723
2005 Post GC, Barthel BL, Burkhart DJ, Hagadorn JR, Koch TH. Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA. Journal of Medicinal Chemistry. 48: 7648-57. PMID 16302805 DOI: 10.1021/Jm050678V  0.79
2003 Sutter AP, Maaser K, Barthel B, Scherübl H. Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: Involvement of the p38MAPK signalling pathway British Journal of Cancer. 89: 564-572. PMID 12888831 DOI: 10.1038/sj.bjc.6601125  0.344
2002 Sutter AP, Maaser K, Höpfner M, Barthel B, Grabowski P, Faiss S, Carayon P, Zeitz M, Scherübl H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells. International Journal of Cancer. Journal International Du Cancer. 102: 318-27. PMID 12402299 DOI: 10.1002/ijc.10724  0.409
2002 Höpfner M, Sutter AP, Beck NI, Barthel B, Maaser K, Jockers-Scherübl MC, Zeitz M, Scherübl H. Meta-iodobenzylguanidine induces growth inhibition and apoptosis of neuroendocrine gastrointestinal tumor cells. International Journal of Cancer. Journal International Du Cancer. 101: 210-6. PMID 12209970 DOI: 10.1002/ijc.10553  0.368
2002 Maaser K, Höpfner M, Kap H, Sutter AP, Barthel B, Von Lampe B, Zeitz M, Scherübl H. Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2-receptors British Journal of Cancer. 86: 636-644. PMID 11870549 DOI: 10.1038/sj.bjc.6600100  0.335
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