| Year |
Citation |
Score |
| 2023 |
Nakazawa K, Shaw T, Song YK, Kouassi-Brou M, Molotkova A, Tiwari PB, Chou HC, Wen X, Wei JS, Deniz E, Toretsky J, Keller C, Barr FG, Khan J, Üren A. Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity. Cancer Research Communications. PMID 37732905 DOI: 10.1158/2767-9764.CRC-23-0119 |
0.354 |
|
| 2023 |
Selvanesan BC, Varghese S, Andrys-Olek J, Arriaza RH, Prakash R, Tiwari PB, Hupalo D, Gusev Y, Patel MN, Contente S, Sanda M, Uren A, Wilkerson MD, Dalgard CL, Shimizu LS, et al. Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction. Cancer Letters. 558: 216094. PMID 36805500 DOI: 10.1016/j.canlet.2023.216094 |
0.346 |
|
| 2021 |
Pällmann N, Deng K, Livgård M, Tesikova M, Jin Y, Frengen NS, Kahraman N, Mokhlis H, Ozpolat B, Kildal W, Danielsen HE, Fazli L, Rennie PS, Banerjee PP, Üren A, et al. Stress mediated reprogramming of prostate cancer one-carbon cycle drives disease progression. Cancer Research. PMID 34183356 DOI: 10.1158/0008-5472.CAN-20-3956 |
0.301 |
|
| 2021 |
Bierbaumer L, Katschnig AM, Radic-Sarikas B, Kauer MO, Petro JA, Högler S, Gurnhofer E, Pedot G, Schäfer BW, Schwentner R, Mühlbacher K, Kromp F, Aryee DNT, Kenner L, Uren A, et al. YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells. Oncogenesis. 10: 2. PMID 33419969 DOI: 10.1038/s41389-020-00294-8 |
0.364 |
|
| 2020 |
Benti S, Tiwari PB, Goodlett DW, Daneshian L, Kern GB, Smith MD, Uren A, Chruszcz M, Shimizu LS, Upadhyay G. Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. Cancers. 12. PMID 32098321 DOI: 10.3390/Cancers12020509 |
0.443 |
|
| 2020 |
Conn E, Hour S, Allegakoen D, Graham G, Petro J, Kouassi-Brou M, Hong SH, Selvanathan S, Çelik H, Toretsky J, Üren A. Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279. Molecular Medicine Reports. PMID 32016454 DOI: 10.3892/Mmr.2020.10948 |
0.36 |
|
| 2019 |
Lin X, Ammosova T, Choy MS, Pietzsch CA, Ivanov A, Ahmad A, Saygideğer Y, Kumari N, Kovalskyy D, Üren A, Peti W, Bukreyev A, Nekhai S. Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition. Frontiers in Microbiology. 10: 2145. PMID 31572348 DOI: 10.3389/Fmicb.2019.02145 |
0.374 |
|
| 2019 |
Selvanathan SP, Graham GT, Grego AR, Baker TM, Hogg JR, Simpson M, Batish M, Crompton B, Stegmaier K, Tomazou EM, Kovar H, Üren A, Toretsky JA. EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex. Nucleic Acids Research. PMID 31392992 DOI: 10.1093/Nar/Gkz699 |
0.365 |
|
| 2019 |
Pällmann N, Livgård M, Tesikova M, Zeynep Nenseth H, Akkus E, Sikkeland J, Jin Y, Koc D, Kuzu OF, Pradhan M, Danielsen HE, Kahraman N, Mokhlis HM, Ozpolat B, Banerjee PP, ... Uren A, et al. Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene. PMID 31312022 DOI: 10.1038/S41388-019-0879-2 |
0.454 |
|
| 2019 |
Penchev VR, Chang YT, Begum A, Ewachiw T, Gocke C, Li J, McMillan RH, Wang Q, Anders R, Marchionni L, Maitra A, Uren A, Rasheed Z, Matsui W. Ezrin promotes stem cell properties in pancreatic ductal adenocarcinoma. Molecular Cancer Research : McR. PMID 30655325 DOI: 10.1158/1541-7786.Mcr-18-0367 |
0.419 |
|
| 2019 |
Bierbaumer L, Katschnig AM, Radic-Sarikas B, Petro JR, Mühlbacher K, Aryee DN, Pötsch AR, Högler S, Kenner L, Uren A, Kovar H. Abstract 1049: Targeting YAP/TAZ pathway inhibits Ewing sarcoma metastasis Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1049 |
0.352 |
|
| 2018 |
Ammosova T, Pietzsch CA, Saygideger Y, Ilatovsky A, Lin X, Ivanov A, Kumari N, Jerebtsova M, Kulkarni A, Petukhov M, Üren A, Bukreyev A, Nekhai S. Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication. The Journal of Infectious Diseases. PMID 30169869 DOI: 10.1093/Infdis/Jiy422 |
0.352 |
|
| 2018 |
Munguía-Moreno JA, Díaz-Chavéz J, García-Villa E, Albino-Sanchez ME, Mendoza-Villanueva D, Ocadiz-Delgado R, Bonilla-Delgado J, Marín-Flores A, Cortés-Malagón EM, Alvarez-Rios E, Hidalgo-Miranda A, Üren A, Çelik H, Lambert PF, Gariglio P. Early synergistic interactions between the HPV16‑E7 oncoprotein and 17β-oestradiol for repressing the expression of Granzyme B in a cervical cancer model. International Journal of Oncology. PMID 29901186 DOI: 10.3892/Ijo.2018.4432 |
0.367 |
|
| 2018 |
Fernandez HR, Gadre SM, Tan M, Graham GT, Mosaoa R, Ongkeko MS, Kim KA, Riggins RB, Parasido E, Petrini I, Pacini S, Cheema A, Varghese R, Ressom HW, Zhang Y, et al. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death and Differentiation. PMID 29651165 DOI: 10.1038/S41418-018-0101-Z |
0.387 |
|
| 2017 |
Lin X, Kumari N, DeMarino C, Kont YS, Ammosova T, Kulkarni A, Jerebtsova M, Vazquez-Meves G, Ivanov A, Dmytro K, Üren A, Kashanchi F, Nekhai S. Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03. Oncotarget. 8: 76749-76769. PMID 29100346 DOI: 10.18632/Oncotarget.19999 |
0.303 |
|
| 2017 |
Zöllner SK, Selvanathan SP, Graham GT, Commins RMT, Hong SH, Moseley E, Parks S, Haladyna JN, Erkizan HV, Dirksen U, Hogarty MD, Üren A, Toretsky JA. Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma. Science Signaling. 10. PMID 28974650 DOI: 10.1126/Scisignal.Aam8429 |
0.452 |
|
| 2017 |
Winters B, Brown L, Coleman I, Nguyen H, Minas TZ, Kollath L, Vasioukhin V, Nelson P, Corey E, Üren A, Morrissey C. Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279. Anticancer Research. 37: 3385-3396. PMID 28668826 DOI: 10.21873/Anticanres.11705 |
0.369 |
|
| 2017 |
Selvanathan SP, Moseley E, Graham GT, Jessen K, Lannutti B, Üren A, Toretsky JA. Abstract 694: TK-216: a novel, first-in-class, small molecule inhibitor of EWS-FLI1 in early clinical development, for the treatment of Ewing Sarcoma Cancer Research. 77: 694-694. DOI: 10.1158/1538-7445.Am2017-694 |
0.453 |
|
| 2017 |
Celik H, Sciandra M, Flashner B, Gelmez E, Kayraklıoğlu N, Allegakoen DV, Petro JR, Conn EJ, Hour S, Han J, Oktay L, Tiwari PB, Hayran M, Manara MC, Toretsky JA, ... ... Uren A, et al. Abstract 1933: Discovery of first-in-class small molecule CD99 inhibitors for targeted therapy of Ewing sarcoma Cancer Research. 77: 1933-1933. DOI: 10.1158/1538-7445.Am2017-1933 |
0.393 |
|
| 2016 |
Javaheri T, Kazemi Z, Pencik J, Pham HT, Kauer M, Noorizadeh R, Sax B, Nivarthi H, Schlederer M, Maurer B, Hofbauer M, Aryee DN, Wiedner M, Tomazou EM, Logan M, et al. Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell Death & Disease. 7: e2419. PMID 27735950 DOI: 10.1038/Cddis.2016.268 |
0.432 |
|
| 2016 |
Heckler MM, Zeleke TZ, Divekar SD, Fernandez AI, Tiek DM, Woodrick J, Farzanegan A, Roy R, Üren A, Mueller SC, Riggins RB. Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget. PMID 27363015 DOI: 10.18632/Oncotarget.9719 |
0.369 |
|
| 2016 |
Kont YS, Dutta A, Mallisetty A, Mathew J, Minas T, Kraus C, Dhopeshwarkar P, Kallakury B, Mitra S, Üren A, Adhikari S. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing. Dna Repair. 43: 38-47. PMID 27235629 DOI: 10.1016/J.Dnarep.2016.04.009 |
0.362 |
|
| 2016 |
Minas TZ, Surdez D, Javaheri T, Tanaka M, Howarth M, Kang HJ, Han J, Han ZY, Sax B, Kream BE, Hong SH, Çelik H, Tirode F, Tuckermann J, Toretsky JA, et al. Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model. Oncotarget. PMID 27191748 DOI: 10.18632/Oncotarget.9388 |
0.369 |
|
| 2016 |
Celik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, Özdemirli M, Ayhan A, Rudek MA, Toretsky JA, Üren A. Ezrin Inhibition Upregulates Stress Response Gene Expression. The Journal of Biological Chemistry. PMID 27137931 DOI: 10.1074/Jbc.M116.718189 |
0.366 |
|
| 2016 |
Roudier MP, Winters BR, Coleman I, Lam HM, Zhang X, Coleman R, Chéry L, True LD, Higano CS, Montgomery B, Lange PH, Snyder LA, Srivastava S, Corey E, Vessella RL, et al. Characterizing the molecular features of ERG-positive tumors in primary and castration resistant prostate cancer. The Prostate. PMID 26990456 DOI: 10.1002/Pros.23171 |
0.377 |
|
| 2016 |
Saygideğer-Kont Y, Minas TZ, Jones H, Hour S, Çelik H, Temel I, Han J, Atabey N, Erkizan HV, Toretsky JA, Üren A. Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small Cell Lung Cancer Cells. Neoplasia (New York, N.Y.). 18: 111-20. PMID 26936397 DOI: 10.1016/J.Neo.2016.01.002 |
0.369 |
|
| 2016 |
Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, et al. The second European interdisciplinary Ewing sarcoma research summit - A joint effort to deconstructing the multiple layers of a complex disease. Oncotarget. PMID 26802024 DOI: 10.18632/Oncotarget.6937 |
0.35 |
|
| 2016 |
Toretsky J, Graham G, Dirksen U, Erkizan HV, Lawlor E, Uren A, Selvanathan S. Abstract A39: Alternative splicing in Ewing sarcoma may be driven by phase separation of spliceosome proteins Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-A39 |
0.433 |
|
| 2016 |
Çelik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong S, Pauly GT, Hayran M, Li X, Özdemirli M, Ayhan A, Rudek MA, Toretsky JA, Üren A. Abstract 2446: Ezrin inhibition up-regulates stress response gene expression and blocks osteosarcoma metastasis Cancer Research. 76: 2446-2446. DOI: 10.1158/1538-7445.Am2016-2446 |
0.464 |
|
| 2015 |
Lu P, Hontecillas R, Abedi V, Kale S, Leber A, Heltzel C, Langowski M, Godfrey V, Philipson C, Tubau-Juni N, Carbo A, Girardin S, Uren A, Bassaganya-Riera J. Modeling-Enabled Characterization of Novel NLRX1 Ligands. Plos One. 10: e0145420. PMID 26714018 DOI: 10.1371/Journal.Pone.0145420 |
0.33 |
|
| 2015 |
Minas TZ, Han J, Javaheri T, Hong SH, Schlederer M, Saygideğer-Kont Y, Çelik H, Mueller KM, Temel I, Özdemirli M, Kovar H, Erkizan HV, Toretsky J, Kenner L, Moriggl R, et al. YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. Oncotarget. PMID 26462019 DOI: 10.18632/Oncotarget.5520 |
0.397 |
|
| 2015 |
Celik H, Hong SH, Colón-López DD, Han J, Saygideger Kont Y, Minas TZ, Swift M, Paige M, Glasgow E, Toretsky JA, Bosch J, Uren A. Identification of novel ezrin inhibitors targeting metastatic osteosarcoma by screening open access malaria box. Molecular Cancer Therapeutics. PMID 26358752 DOI: 10.1158/1535-7163.Mct-15-0511 |
0.397 |
|
| 2015 |
Gutiérrez J, García-Villa E, Ocadiz-Delgado R, Cortés-Malagón EM, Vázquez J, Roman-Rosales A, Alvarez-Rios E, Celik H, Romano MC, Üren A, Lambert PF, Gariglio P. Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice. Molecular and Cellular Biochemistry. 408: 261-72. PMID 26173416 DOI: 10.1007/S11010-015-2504-1 |
0.38 |
|
| 2015 |
Çelik H, Sajwan KP, Selvanathan SP, Marsh BJ, Pai AV, Kont YS, Han J, Minas TZ, Rahim S, Erkizan HV, Toretsky JA, Üren A. Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. Molecular and Cellular Biology. 35: 3145-62. PMID 26149384 DOI: 10.1128/Mcb.00332-15 |
0.611 |
|
| 2015 |
Simbulan-Rosenthal CM, Gaur A, Sanabria VA, Dussan LJ, Saxena R, Schmidt J, Kitani T, Chen YS, Rahim S, Uren A, Crooke E, Rosenthal DS. Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes. Experimental Dermatology. PMID 25869331 DOI: 10.1111/Exd.12729 |
0.525 |
|
| 2015 |
Erkizan HV, Schneider JA, Sajwan K, Graham GT, Griffin B, Chasovskikh S, Youbi SE, Kallarakal A, Chruszcz M, Padmanabhan R, Casey JL, Üren A, Toretsky JA. RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1. Nucleic Acids Research. 43: 1069-80. PMID 25564528 DOI: 10.1093/Nar/Gku1328 |
0.362 |
|
| 2015 |
Adhikari S, Chetram MA, Woodrick J, Mitra PS, Manthena PV, Khatkar P, Dakshanamurthy S, Dixon M, Karmahapatra SK, Nuthalapati NK, Gupta S, Narasimhan G, Mazumder R, Loffredo CA, Üren A, et al. Germ line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-ethenoadenine-induced mutations. The Journal of Biological Chemistry. 290: 4966-80. PMID 25538240 DOI: 10.1074/Jbc.M114.627000 |
0.312 |
|
| 2015 |
Bulut G, Üren A. Generation of K14-E7/∆N87βcat double transgenic mice as a model of cervical cancer. Methods in Molecular Biology (Clifton, N.J.). 1249: 393-406. PMID 25348322 DOI: 10.1007/978-1-4939-2013-6_29 |
0.331 |
|
| 2015 |
Kont YS, Celik H, Erkizan HV, Minas T, Han J, Toretsky J, Uren A. Abstract 54: Ezrin enhances signaling and nuclear translocation of the epidermal growth factor receptor in non-small cell lung cancer cells Cancer Research. 75: 54-54. DOI: 10.1158/1538-7445.Am2015-54 |
0.405 |
|
| 2015 |
Minas TZ, Han J, Hong S, Javaheri T, Schlederer M, Kenner L, Moriggl R, Toretsky J, Uren A. Abstract 3284: Unfavorable outcomes of EWS-FLI1 expression in different tissues of a transgenic mouse model Cancer Research. 75: 3284-3284. DOI: 10.1158/1538-7445.Am2015-3284 |
0.332 |
|
| 2015 |
Celik H, Sajwan KP, Pai AV, Marsh BJ, Kont YS, Rahim S, Han J, Minas T, Toretsky JA, Uren A. Abstract 3269: Ezrin binds to DEAD-box RNA helicase DDX3 and regulates its function and protein level Cancer Research. 75: 3269-3269. DOI: 10.1158/1538-7445.Am2015-3269 |
0.547 |
|
| 2015 |
Winters B, Brown L, Coleman I, Minas T, Zhang X, Kollath L, Nguyen H, Nelson P, Corey E, Uren A, Morrissey C. MP66-15 INHIBITION OF ERG ACTIVITY IN PATIENT DERIVED PROSTATE CANCER XENOGRAFTS USING THE SMALL MOLECULE INHIBITOR YK-4-279 Journal of Urology. 193. DOI: 10.1016/J.Juro.2015.02.2368 |
0.475 |
|
| 2014 |
Rahim S, Minas T, Hong SH, Justvig S, Çelik H, Kont YS, Han J, Kallarakal AT, Kong Y, Rudek MA, Brown ML, Kallakury B, Toretsky JA, Üren A. A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model. Plos One. 9: e114260. PMID 25479232 DOI: 10.1371/Journal.Pone.0114260 |
0.629 |
|
| 2014 |
Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S. 1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription. British Journal of Pharmacology. 171: 5059-75. PMID 25073485 DOI: 10.1111/Bph.12863 |
0.306 |
|
| 2014 |
Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW. Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Oncotarget. 5: 1458-74. PMID 24681547 DOI: 10.18632/Oncotarget.1538 |
0.396 |
|
| 2014 |
Paige M, Kosturko G, Bulut G, Miessau M, Rahim S, Toretsky JA, Brown ML, Üren A. Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma. Bioorganic & Medicinal Chemistry. 22: 478-87. PMID 24326277 DOI: 10.1016/J.Bmc.2013.11.003 |
0.62 |
|
| 2014 |
Xavier CP, Melikova M, Chuman Y, Üren A, Baljinnyam B, Rubin JS. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cellular Signalling. 26: 94-101. PMID 24080158 DOI: 10.1016/J.Cellsig.2013.09.016 |
0.367 |
|
| 2014 |
Minas TZ, Han J, Hong S, Toretsky J, Uren A. Abstract LB-197: YK-4-279 is effective in treating EWS-FLI1 induced myeloid/erythroid leukemia in a transgenic mouse model Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-197 |
0.382 |
|
| 2014 |
Celik H, Kallarakal A, Colon-Lopez D, Toretsky J, Bosch J, Uren A. Abstract 3987: Evaluation of anti–malarial compounds as inhibitors of ezrin in osteosarcoma cells Cancer Research. 74: 3987-3987. DOI: 10.1158/1538-7445.Am2014-3987 |
0.437 |
|
| 2014 |
Celik H, Han J, Hong S, Bulut G, Toretsky J, Uren A. Abstract 3979: NSC305787 inhibits specific protein–protein interactions involving ezrin in osteosarcoma cells Cancer Research. 74: 3979-3979. DOI: 10.1158/1538-7445.Am2014-3979 |
0.446 |
|
| 2014 |
Rahim S, Justvig S, Hong S, Tosso P, Celik H, Sayedigar-Kont Y, Brown M, Morrissey C, Toretsky J, Üren A. Abstract 2949: YK-4-279 is a small molecule inhibitor of ETV1 and inhibits metastasis in a mouse model Cancer Research. 74: 2949-2949. DOI: 10.1158/1538-7445.Am2014-2949 |
0.662 |
|
| 2013 |
Cortés-Malagón EM, Bonilla-Delgado J, Díaz-Chávez J, Hidalgo-Miranda A, Romero-Cordoba S, Uren A, Celik H, McCormick M, Munguía-Moreno JA, Ibarra-Sierra E, Escobar-Herrera J, Lambert PF, Mendoza-Villanueva D, Bermudez-Cruz RM, Gariglio P. Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue. Virology. 447: 155-65. PMID 24210110 DOI: 10.1016/J.Virol.2013.08.036 |
0.308 |
|
| 2013 |
Rahim S, Uren A. Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer. American Journal of Translational Research. 5: 254-68. PMID 23634237 |
0.572 |
|
| 2013 |
O'Neill A, Shah N, Zitomersky N, Ladanyi M, Shukla N, Uren A, Loeb D, Toretsky J. Insulin-like growth factor 1 receptor as a therapeutic target in ewing sarcoma: lack of consistent upregulation or recurrent mutation and a review of the clinical trial literature. Sarcoma. 2013: 450478. PMID 23431249 DOI: 10.1155/2013/450478 |
0.322 |
|
| 2013 |
Abaan OD, Hendriks W, Uren A, Toretsky JA, Erkizan HV. Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1. Experimental Cell Research. 319: 1-11. PMID 23018179 DOI: 10.1016/J.Yexcr.2012.09.003 |
0.413 |
|
| 2013 |
Toretsky J, Gamble SE, Monroe PJ, Hong SP, Summer SJ, Uren A, Hong S. Effect of a novel small molecule yk-4-279 on the "undruggable" target EWS-FLI1. Journal of Clinical Oncology. 31: 10042-10042. DOI: 10.1200/Jco.2013.31.15_Suppl.10042 |
0.413 |
|
| 2013 |
Assefnia S, Dakshanamurthy S, Auvil JMG, Hampel C, Anastasiadis P, Kallakury B, Uren A, Foley DW, Brown M, Shapiro L, Brenner M, Haigh D, Byers SW. Abstract A045: Cadherin-11, a common therapeutic target in poor prognosis malignancies and rheumatoid arthritis Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-A045 |
0.402 |
|
| 2013 |
Rahim S, Justvig S, Hong S, Kong Y, Brown ML, Morrissey C, Toretsky JA, Uren A. Abstract 5453: YK-4-279 inhibits ETS-positive prostate cancer cell metastasis in a mouse xenograft model. Cancer Research. 73: 5453-5453. DOI: 10.1158/1538-7445.Am2013-5453 |
0.638 |
|
| 2013 |
Roudier M, Coleman I, Zhang X, Coleman R, Chéry L, Brown L, Lakely B, Higano C, True LD, Lange PH, Srivistava S, Üren A, Corey E, Vessella RL, Nelson PS, et al. Abstract 5122: Characterizing the molecular features of ERG positive tumors in primary and castration resistant prostate cancer. Cancer Research. 73: 5122-5122. DOI: 10.1158/1538-7445.Am2013-5122 |
0.387 |
|
| 2013 |
Erkizan HV, Sajwan K, Chruszcz M, Schneider J, Gamble SE, Uren A, Minor W, Padmanabhan R, Toretsky J. Abstract 2747: EWS-FLI1 reduces RNA Helicase A activity. Cancer Research. 73: 2747-2747. DOI: 10.1158/1538-7445.Am2013-2747 |
0.388 |
|
| 2012 |
Sirajuddin P, Das S, Ringer L, Rodriguez OC, Sivakumar A, Lee YC, Üren A, Fricke ST, Rood B, Ozcan A, Wang SS, Karam S, Yenugonda V, Salinas P, Petricoin E, et al. Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. Cell Cycle (Georgetown, Tex.). 11: 3801-9. PMID 22983062 DOI: 10.4161/Cc.21988 |
0.362 |
|
| 2012 |
Schlottmann S, Erkizan HV, Barber-Rotenberg JS, Knights C, Cheema A, Uren A, Avantaggiati ML, Toretsky JA. Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity. Frontiers in Oncology. 2: 107. PMID 22973553 DOI: 10.3389/Fonc.2012.00107 |
0.399 |
|
| 2012 |
Ozen E, Gozukizil A, Erdal E, Uren A, Bottaro DP, Atabey N. Heparin inhibits Hepatocyte Growth Factor induced motility and invasion of hepatocellular carcinoma cells through early growth response protein 1. Plos One. 7: e42717. PMID 22912725 DOI: 10.1371/Journal.Pone.0042717 |
0.36 |
|
| 2012 |
Cecchi F, Pajalunga D, Fowler CA, Uren A, Rabe DC, Peruzzi B, Macdonald NJ, Blackman DK, Stahl SJ, Byrd RA, Bottaro DP. Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell. 22: 250-62. PMID 22897854 DOI: 10.1016/J.Ccr.2012.06.029 |
0.36 |
|
| 2012 |
Briggs JW, Ren L, Nguyen R, Chakrabarti K, Cassavaugh J, Rahim S, Bulut G, Zhou M, Veenstra TD, Chen Q, Wei JS, Khan J, Uren A, Khanna C. The ezrin metastatic phenotype is associated with the initiation of protein translation. Neoplasia (New York, N.Y.). 14: 297-310. PMID 22577345 DOI: 10.1593/Neo.11518 |
0.647 |
|
| 2012 |
Beauchamp EM, Uren A. A new era for an ancient drug: arsenic trioxide and Hedgehog signaling. Vitamins and Hormones. 88: 333-54. PMID 22391311 DOI: 10.1016/B978-0-12-394622-5.00015-8 |
0.719 |
|
| 2012 |
Barber-Rotenberg JS, Selvanathan SP, Kong Y, Erkizan HV, Snyder TM, Hong SP, Kobs CL, South NL, Summer S, Monroe PJ, Chruszcz M, Dobrev V, Tosso PN, Scher LJ, Minor W, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 3: 172-82. PMID 22383402 DOI: 10.18632/Oncotarget.454 |
0.391 |
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| 2012 |
Bonilla-Delgado J, Bulut G, Liu X, Cortés-Malagón EM, Schlegel R, Flores-Maldonado C, Contreras RG, Chung SH, Lambert PF, Uren A, Gariglio P. The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo. Molecular Cancer Research : McR. 10: 250-8. PMID 22160870 DOI: 10.1158/1541-7786.Mcr-11-0287 |
0.327 |
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| 2012 |
Adhikari S, Manthena PV, Kota KK, Karmahapatra SK, Roy G, Saxena R, Uren A, Roy R. A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease. Molecular and Cellular Biochemistry. 362: 195-201. PMID 22042551 DOI: 10.1007/S11010-011-1142-5 |
0.374 |
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| 2012 |
Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I, Toretsky JA, Khanna C, Uren A. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 31: 269-81. PMID 21706056 DOI: 10.1038/Onc.2011.245 |
0.758 |
|
| 2012 |
Toretsky J, Hong SP, Gamble SE, Hong S, Kobs CL, Elsass KE, South NL, Summer SJ, Monroe PJ, Uren A. Use of pharmacokinetic modeling to optimize direct inhibition of the "undruggable" target EWS-FLI1 of Ewing sarcoma. Journal of Clinical Oncology. 30: 9575-9575. DOI: 10.1200/Jco.2012.30.15_Suppl.9575 |
0.386 |
|
| 2012 |
Hong SP, Gamble SE, Hong S, Kobs CL, Elsass KE, South NL, Monroe PJ, Üren A, Toretsky JA. Abstract LB-316: Pharmacokinetic modeling optimizes direct inhibition of the ‘undruggable’ target EWS-FLI1 of Ewing Sarcoma Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-316 |
0.407 |
|
| 2012 |
Murdoch JT, Hong S, Bulut G, Kosturko GW, Drebing LE, Toretsky JA, Uren A. Abstract 4874: Small molecule inhibitor of ezrin inhibits metastasis in a transgenic mouse model of osteosarcoma Cancer Research. 72: 4874-4874. DOI: 10.1158/1538-7445.Am2012-4874 |
0.35 |
|
| 2012 |
Kosturko GW, Bulut G, Hong S, Rodriguez V, Brown M, Toretsky J, Khanna C, Paige M, Uren A. Abstract 3906: Design, synthesis and biological evaluation of 2nd generation ezrin inhibitors for metastatic osteosarcoma Cancer Research. 72: 3906-3906. DOI: 10.1158/1538-7445.Am2012-3906 |
0.439 |
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| 2011 |
Bulut G, Fallen S, Beauchamp EM, Drebing LE, Sun J, Berry DL, Kallakury B, Crum CP, Toretsky JA, Schlegel R, Üren A. Beta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic mice. Plos One. 6: e27243. PMID 22087269 DOI: 10.1371/Journal.Pone.0027243 |
0.674 |
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| 2011 |
Erkizan HV, Scher LJ, Gamble SE, Barber-Rotenberg JS, Sajwan KP, Üren A, Toretsky JA. Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors. Cell Cycle (Georgetown, Tex.). 10: 3397-408. PMID 21926473 DOI: 10.4161/Cc.10.19.17734 |
0.388 |
|
| 2011 |
Ringer L, Sirajuddin P, Heckler M, Ghosh A, Suprynowicz F, Yenugonda VM, Brown ML, Toretsky JA, Uren A, Lee Y, MacDonald TJ, Rodriguez O, Glazer RI, Schlegel R, Albanese C. VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. Cancer Biology & Therapy. 12: 818-26. PMID 21885916 DOI: 10.4161/Cbt.12.9.17682 |
0.395 |
|
| 2011 |
Adhikari S, Karmahapatra SK, Elias H, Dhopeshwarkar P, Williams RS, Byers S, Uren A, Roy R. Development of a novel assay for human tyrosyl DNA phosphodiesterase 2. Analytical Biochemistry. 416: 112-6. PMID 21620793 DOI: 10.1016/J.Ab.2011.05.008 |
0.306 |
|
| 2011 |
Rahim S, Beauchamp EM, Kong Y, Brown ML, Toretsky JA, Üren A. YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. Plos One. 6: e19343. PMID 21559405 DOI: 10.1371/Journal.Pone.0019343 |
0.743 |
|
| 2011 |
Rahim S, Üren A. A real-time electrical impedance based technique to measure invasion of endothelial cell monolayer by cancer cells. Journal of Visualized Experiments : Jove. PMID 21490581 DOI: 10.3791/2792 |
0.584 |
|
| 2011 |
Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, Peaceman D, Ozdemirli M, Rodriguez O, Macdonald TJ, Albanese C, Toretsky JA, Uren A. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. The Journal of Clinical Investigation. 121: 148-60. PMID 21183792 DOI: 10.1172/Jci42874 |
0.723 |
|
| 2011 |
Rahim S, Beauchamp EM, Kong Y, Brown ML, Toretsky JA, Üren A. Abstract 663: YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion Cancer Research. 71: 663-663. DOI: 10.1158/1538-7445.Am2011-663 |
0.764 |
|
| 2011 |
Bulut G, Hong S, Chen K, Rahim S, Kosturko GW, Beauchamp EM, Glasgow E, Toretsky JA, Khanna C, Uren A. Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents Cancer Research. 71: 4505-4505. DOI: 10.1158/1538-7445.Am2011-4505 |
0.778 |
|
| 2011 |
Bulut G, Fallen S, Beauchamp EM, Drebing LE, Sun J, Berry DL, Kallakury B, Crum CP, Toretsky JA, Schlegel R, Üren A. Abstract 4328: Beta-catenin accelerates human papillomavirus type16 -E7 mediated cervical carcinogenesis in transgenic mice Cancer Research. 71: 4328-4328. DOI: 10.1158/1538-7445.Am2011-4328 |
0.676 |
|
| 2011 |
Erkizan HV, Scher LM, Gamble E, Barber-Rotenberg J, Uren A, Toretsky J. Abstract 259: Novel peptide directed targeting of EWS-FLI1 impairs tumor cell growth Cancer Research. 71: 259-259. DOI: 10.1158/1538-7445.Am2011-259 |
0.324 |
|
| 2010 |
Schlottmann S, Erkizan HV, Barber-Rotenberg J, Uren A, Avantaggiati ML, Toretsky JA. Abstract 3897: EWS-FLI1 is regulated by acetylation Cancer Research. 70: 3897-3897. DOI: 10.1158/1538-7445.Am10-3897 |
0.447 |
|
| 2010 |
Jacobwitz LM, Erkizan HV, Üren A, Toretsky JA. Abstract 3412: Phage display identifies novel toxic binding peptides for the disordered oncoprotein EWS-FLI1 Cancer Research. 70: 3412-3412. DOI: 10.1158/1538-7445.Am10-3412 |
0.359 |
|
| 2010 |
Toretsky JA, Erkizan HV, Kong Y, Merchant M, Barber-Rotenberg JS, Brown ML, Üren A. Abstract 3411: Targeting of EWS-FLI1 with small molecule YK-4-279 reduces xenograft growth by disruption of disordered protein-protein interactions Cancer Research. 70: 3411-3411. DOI: 10.1158/1538-7445.Am10-3411 |
0.429 |
|
| 2010 |
Beauchamp EM, Rodriguez O, Albanese C, Toretsky JA, Üren A. Abstract 3409: Arsenic trioxide inhibits Ewing sarcoma growth by blocking Hedgehog/GLI pathway Cancer Research. 70: 3409-3409. DOI: 10.1158/1538-7445.Am10-3409 |
0.732 |
|
| 2010 |
Barber-Rotenberg JS, Kong Y, Schnure N, Dakshanamurthy S, Frazier P, Erkizan HV, Brown ML, Uren A, Toretsky JA. Abstract 2681: EWS-FLI1 as a molecular target: Small molecule inhibitors for a disordered protein Cancer Research. 70: 2681-2681. DOI: 10.1158/1538-7445.Am10-2681 |
0.376 |
|
| 2010 |
Bulut G, Chen K, Glasgow E, Hong S, Lee H, Kosturko G, Toretsky JA, Daar I, Khanna C, Uren A. Abstract 1550: Small molecule inhibitors of ezrin as anti-metastatic agents in osteosarcoma Cancer Research. 70: 1550-1550. DOI: 10.1158/1538-7445.Am10-1550 |
0.461 |
|
| 2009 |
Jorgensen TJ, Chen K, Chasovskikh S, Roy R, Dritschilo A, Uren A. Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates. Journal of Molecular Recognition : Jmr. 22: 446-52. PMID 19585541 DOI: 10.1002/Jmr.962 |
0.308 |
|
| 2009 |
Erkizan HV, Kong Y, Merchant M, Schlottmann S, Barber-Rotenberg JS, Yuan L, Abaan OD, Chou TH, Dakshanamurthy S, Brown ML, Uren A, Toretsky JA. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nature Medicine. 15: 750-6. PMID 19584866 DOI: 10.1038/Nm.1983 |
0.349 |
|
| 2009 |
Golestaneh N, Beauchamp E, Fallen S, Kokkinaki M, Uren A, Dym M. Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells. Reproduction (Cambridge, England). 138: 151-62. PMID 19419993 DOI: 10.1530/Rep-08-0510 |
0.673 |
|
| 2009 |
Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. The Journal of Biological Chemistry. 284: 9074-82. PMID 19189974 DOI: 10.1074/Jbc.M806233200 |
0.71 |
|
| 2009 |
Barber‐Rotenberg JS, Kong Y, Schnure N, Dakshanamurthy S, Frazier P, Erkizan HV, Brown ML, Üren A, Toretsky JA. Abstract B181: EWS‐FLI1 as a molecular target: Identification of inhibitors for a disordered protein Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B181 |
0.367 |
|
| 2008 |
Chen K, Fallen S, Abaan HO, Hayran M, Gonzalez C, Wodajo F, MacDonald T, Toretsky JA, Uren A. Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. Pediatric Blood & Cancer. 51: 349-55. PMID 18465804 DOI: 10.1002/Pbc.21595 |
0.316 |
|
| 2008 |
Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Molecular and Cellular Biology. 28: 2368-79. PMID 18212053 DOI: 10.1128/Mcb.01780-07 |
0.683 |
|
| 2006 |
Aryee DN, Kreppel M, Bachmaier R, Uren A, Muehlbacher K, Wagner S, Breiteneder H, Ban J, Toretsky JA, Kovar H. Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo. Cancer Research. 66: 9862-9. PMID 17047047 DOI: 10.1158/0008-5472.Can-05-4042 |
0.366 |
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| 2006 |
Toretsky JA, Erkizan V, Levenson A, Abaan OD, Parvin JD, Cripe TP, Rice AM, Lee SB, Uren A. Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. Cancer Research. 66: 5574-81. PMID 16740692 DOI: 10.1158/0008-5472.Can-05-3293 |
0.31 |
|
| 2005 |
Uren A, Toretsky JA. Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent. Future Oncology (London, England). 1: 521-8. PMID 16556028 DOI: 10.2217/14796694.1.4.521 |
0.392 |
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| 2005 |
Abaan OD, Levenson A, Khan O, Furth PA, Uren A, Toretsky JA. PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis. Oncogene. 24: 2715-22. PMID 15782144 DOI: 10.1038/Sj.Onc.1208247 |
0.345 |
|
| 2005 |
Uren A, Toretsky JA. Pediatric malignancies provide unique cancer therapy targets. Current Opinion in Pediatrics. 17: 14-9. PMID 15659957 DOI: 10.1097/01.Mop.0000147904.84978.Ae |
0.399 |
|
| 2004 |
Chuman Y, Uren A, Cahill J, Regan C, Wolf V, Kay BK, Rubin JS. Identification of a peptide binding motif for secreted frizzled-related protein-1. Peptides. 25: 1831-8. PMID 15501513 DOI: 10.1016/J.Peptides.2004.07.010 |
0.301 |
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| 2004 |
Uren A, Tcherkasskaya O, Toretsky JA. Recombinant EWS-FLI1 oncoprotein activates transcription. Biochemistry. 43: 13579-89. PMID 15491164 DOI: 10.1021/Bi048776Q |
0.397 |
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| 2004 |
Uren A, Wolf V, Sun YF, Azari A, Rubin JS, Toretsky JA. Wnt/Frizzled signaling in Ewing sarcoma. Pediatric Blood & Cancer. 43: 243-9. PMID 15266408 DOI: 10.1002/Pbc.20124 |
0.325 |
|
| 1997 |
De Mora JF, Uren A, Heidaran M, Santos E. Biological activity of p27(kip1) and its amino- and carboxy-terminal domains in G2/M transition of Xenopus oocytes Oncogene. 15: 2541-2551. PMID 9399642 DOI: 10.1038/Sj.Onc.1201420 |
0.302 |
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