| Year |
Citation |
Score |
| 2020 |
Stahl E, Nott R, Koessel K, Cance W, Marlowe T. Computational-based discovery of FAK FERM domain chemical probes that inhibit HER2-FAK cancer signaling. Chemical Biology & Drug Design. 95: 584-599. PMID 32080977 DOI: 10.1111/cbdd.13671 |
0.329 |
|
| 2019 |
Marlowe T, Alvarado C, Rivera A, Lenzo F, Nott R, Bondugji D, Montoya J, Hurley A, Kaplan M, Capaldi A, Cance W. Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK-Paxillin Interaction. Slas Discovery : Advancing Life Sciences R & D. 2472555219874313. PMID 31513463 DOI: 10.1177/2472555219874313 |
0.303 |
|
| 2019 |
Marlowe T, Dementiev A, Figel S, Rivera A, Flavin M, Cance W. High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site. Bmc Molecular and Cell Biology. 20: 10. PMID 31109284 DOI: 10.1186/s12860-019-0193-4 |
0.326 |
|
| 2017 |
Lenzo FL, Cance WG. From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein. Translational Cancer Research. 6: S957-S960. PMID 30740315 DOI: 10.21037/Tcr.2017.06.05 |
0.538 |
|
| 2016 |
Marlowe TA, Lenzo FL, Figel SA, Grapes AT, Cance WG. Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-kinase Inhibitors. Molecular Cancer Therapeutics. PMID 27638858 DOI: 10.1158/1535-7163.Mct-16-0366 |
0.507 |
|
| 2016 |
Zhang H, Shao H, Golubovskaya VM, Chen H, Cance W, Adjei AA, Dy GK. Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways. British Journal of Cancer. PMID 27336608 DOI: 10.1038/Bjc.2016.190 |
0.477 |
|
| 2016 |
Wilton J, Kurenova E, Pitzonka L, Gaudy A, Curtin L, Sexton S, Cance W, Fetterly G. Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs. European Journal of Drug Metabolism and Pharmacokinetics. 41: 55-67. PMID 25377246 DOI: 10.1007/S13318-014-0233-6 |
0.353 |
|
| 2015 |
Li Z, Lebedyeva IO, Golubovskaya VM, Cance WG, Alamry KA, Faidallah HM, Dennis Hall C, Katritzky AR. Synthesis and bioactivity of a Goralatide analog with antileukemic activity. Bioorganic & Medicinal Chemistry. 23: 5056-60. PMID 26048023 DOI: 10.1016/J.Bmc.2015.04.061 |
0.362 |
|
| 2015 |
Golubovskaya V, O'Brien S, Ho B, Heffler M, Conroy J, Hu Q, Wang D, Liu S, Cance WG. Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15. Journal of Cancer Research and Clinical Oncology. PMID 25656374 DOI: 10.1007/S00432-015-1924-3 |
0.443 |
|
| 2015 |
Golubovskaya V, Curtin L, Groman A, Sexton S, Cance WG. In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride). Archives of Toxicology. 89: 1095-101. PMID 24915938 DOI: 10.1007/S00204-014-1290-Y |
0.305 |
|
| 2015 |
Stewart JE, Ma X, Megison M, Nabers H, Cance WG, Kurenova EV, Beierle EA. Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma. Molecular Carcinogenesis. 54: 9-23. PMID 23868727 DOI: 10.1002/Mc.22070 |
0.563 |
|
| 2015 |
Figel S, Lenzo F, Marlowe T, Cance W. Abstract C77: Oncogenic drivers reactivate kinase-inhibited focal adhesion kinase (FAK) through phosphorylation of effector residues Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C77 |
0.503 |
|
| 2015 |
Marlowe T, Figel S, Lenzo F, Golubovskaya V, Kurenova E, Tropsha A, Cance W. Abstract A64: Human epidermal growth factor receptor 2 (HER2) directly binds and activates focal adhesion kinase (FAK) to promote oncogenesis Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-A64 |
0.519 |
|
| 2014 |
Kurenova E, Ucar D, Liao J, Yemma M, Gogate P, Bshara W, Sunar U, Seshadri M, Hochwald SN, Cance WG. A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells. Cell Cycle (Georgetown, Tex.). 13: 2542-53. PMID 25486195 DOI: 10.4161/15384101.2015.941760 |
0.75 |
|
| 2014 |
Golubovskaya VM, Ylagan L, Miller A, Hughes M, Wilson J, Wang D, Brese E, Bshara W, Edge S, Morrison C, Cance WG. High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype. Bmc Cancer. 14: 769. PMID 25326692 DOI: 10.1186/1471-2407-14-769 |
0.474 |
|
| 2014 |
O'Brien S, Golubovskaya VM, Conroy J, Liu S, Wang D, Liu B, Cance WG. FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Oncotarget. 5: 7945-59. PMID 25277206 DOI: 10.18632/Oncotarget.2381 |
0.428 |
|
| 2014 |
O'Brien S, Golubovskaya VM, Conroy J, Liu S, Wang D, Liu B, Cance WG. FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Oncotarget. PMID 25210005 |
0.358 |
|
| 2014 |
Dy GK, Ylagan L, Pokharel S, Miller A, Brese E, Bshara W, Morrison C, Cance WG, Golubovskaya VM. The prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 1278-84. PMID 25122425 DOI: 10.1097/Jto.0000000000000248 |
0.381 |
|
| 2014 |
Gogate PN, Kurenova EV, Ethirajan M, Liao J, Yemma M, Sen A, Pandey RK, Cance WG. Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer. Cancer Letters. 353: 281-9. PMID 25067788 DOI: 10.1016/J.Canlet.2014.07.032 |
0.756 |
|
| 2014 |
Gogate PN, Ethirajan M, Kurenova EV, Magis AT, Pandey RK, Cance WG. Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction. European Journal of Medicinal Chemistry. 80: 154-66. PMID 24780592 DOI: 10.1016/J.Ejmech.2014.04.041 |
0.751 |
|
| 2014 |
Golubovskaya VM, Ho B, Conroy J, Liu S, Wang D, Cance WG. Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex. Cancers. 6: 166-78. PMID 24452144 DOI: 10.3390/Cancers6010166 |
0.367 |
|
| 2014 |
Beierle EA, Ma X, Stewart JE, Megison M, Cance WG, Kurenova EV. Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines. Molecular Carcinogenesis. 53: 230-42. PMID 23065847 DOI: 10.1002/Mc.21969 |
0.561 |
|
| 2013 |
Kurenova E, Liao J, He DH, Hunt D, Yemma M, Bshara W, Seshadri M, Cance WG. The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget. 4: 1632-46. PMID 24142503 DOI: 10.18632/Oncotarget.1365 |
0.586 |
|
| 2013 |
Golubovskaya VM, Cance WG. Targeting the p53 pathway. Surgical Oncology Clinics of North America. 22: 747-64. PMID 24012397 DOI: 10.1016/J.Soc.2013.06.003 |
0.362 |
|
| 2013 |
Golubovskaya VM, Ho B, Zheng M, Magis A, Ostrov D, Morrison C, Cance WG. Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth. Bmc Cancer. 13: 342. PMID 23841915 DOI: 10.1186/1471-2407-13-342 |
0.51 |
|
| 2013 |
Heffler M, Golubovskaya VM, Dunn KMB, Cance W. Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer Biology & Therapy. 14: 761-772. PMID 23792569 DOI: 10.4161/Cbt.25185 |
0.543 |
|
| 2013 |
Cance WG, Kurenova E, Marlowe T, Golubovskaya V. Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics. Science Signaling. 6: pe10. PMID 23532331 DOI: 10.1126/Scisignal.2004021 |
0.551 |
|
| 2013 |
Golubovskaya VM, Huang G, Ho B, Yemma M, Morrison CD, Lee J, Eliceiri BP, Cance WG. Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Molecular Cancer Therapeutics. 12: 162-72. PMID 23243059 DOI: 10.1158/1535-7163.Mct-12-0701 |
0.516 |
|
| 2013 |
Heffler M, Golubovskaya VM, Conroy J, Liu S, Wang D, Cance WG, Dunn KB. FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes. Anti-Cancer Agents in Medicinal Chemistry. 13: 584-94. PMID 22934709 DOI: 10.2174/1871520611313040008 |
0.475 |
|
| 2013 |
Golubovskaya VM, Ho B, Zheng M, Magis A, Ostrov D, Cance WG. Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities. Anti-Cancer Agents in Medicinal Chemistry. 13: 546-54. PMID 22292772 DOI: 10.2174/1871520611313040003 |
0.523 |
|
| 2013 |
Golubovskaya VM, Palma NL, Zheng M, Ho B, Magis A, Ostrov D, Cance WG. A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo. Anti-Cancer Agents in Medicinal Chemistry. 13: 532-45. PMID 22292771 DOI: 10.2174/1871520611313040002 |
0.488 |
|
| 2013 |
Kurenova EV, Sanghera SS, Liao J, Yemma M, Cance WG. Demonstration of the efficacy of compound CFAK-C4 targeting FAK-VEGFR3 protein-protein interaction in gastric cancer. Journal of Clinical Oncology. 31. DOI: 10.1200/Jco.2013.31.15_Suppl.E22143 |
0.479 |
|
| 2013 |
Cance WG, Curtin L, Buitrago S, Golubovskaya V. Preclinical toxicology studies with Y15, a novel focal adhesion kinase (FAK) inhibitor. Journal of Clinical Oncology. 31. DOI: 10.1200/Jco.2013.31.15_Suppl.E13561 |
0.477 |
|
| 2013 |
O'Brien S, Golubovskaya V, Zajac-Kaye M, Hochwald SN, Cance WG. Focal adhesion kinase inhibition as a therapeutic strategy in differentiated thyroid cancer. Journal of Clinical Oncology. 31: e13556-e13556. DOI: 10.1200/Jco.2013.31.15_Suppl.E13556 |
0.51 |
|
| 2013 |
Golubovskaya V, Ho B, Stright A, Zajac-Kaye M, Hochwald SN, Cance WG. Targeting Y397 FAK scaffolding compared with FAK kinase inhibition: Efficacy and specificity for tumor cells. Journal of Clinical Oncology. 31: e13547-e13547. DOI: 10.1200/Jco.2013.31.15_Suppl.E13547 |
0.545 |
|
| 2013 |
O'Brien SB, Golubovskaya VM, Cance WG. Abstract 4096: FAK inhibition with small molecule inhibitor Y15 decreases viability in thyroid cancer cell lines. Cancer Research. 73: 4096-4096. DOI: 10.1158/1538-7445.Am2013-4096 |
0.466 |
|
| 2013 |
Agharkar PA, Ethirajan M, Magis A, Liao J, Yemma M, Cance W, Pandey R, Kurenova E. Abstract 3247: Novel small molecule inhibitors C9 and C10 specifically disrupt the FAK-VEGFR3 signaling axis in cancer cells. Cancer Research. 73: 3247-3247. DOI: 10.1158/1538-7445.Am2013-3247 |
0.579 |
|
| 2013 |
Kurenova E, Sanghera S, Liao J, Yemma M, Cance W. Abstract C211: Demonstration of the efficacy of compound CFAK-C4, Targeting FAK-VEGFR-3 protein-protein interaction in animal models of gastric cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C211 |
0.559 |
|
| 2013 |
Agharkar PA, Ethirajan M, Liao J, Yemma M, Buckley B, Chernov M, Cance W, Pandey R, Kurenova E. Abstract B3: Anti-angiogenic properties of FAK-VEGFR3 scaffold inhibitors, C9 and C10. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B3 |
0.55 |
|
| 2013 |
Ho B, Heffler M, Conroy J, Song L, Wang D, Cance WG, Golubovskaya VM. Abstract A51: Cancer stem cell marker ALDH1A3 is associated with increased resistance of Lovo-1 colon cancer cells to autophosphorylation inhibitor of FAK. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A51 |
0.476 |
|
| 2013 |
Golubovskaya VM, Lebedyeva I, Ho B, Yemma M, Singh N, Arcara M, Ostrov D, Katritzky A, Cance W. Abstract A293: Novel allosteric small molecule FAK inhibitors effectively inhibit cancer cell viability and clonogenicity. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A293 |
0.544 |
|
| 2012 |
Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle (Georgetown, Tex.). 11: 3250-9. PMID 22894899 DOI: 10.1093/Carcin/Bgr115 |
0.472 |
|
| 2012 |
Ho B, Olson G, Figel S, Gelman I, Cance WG, Golubovskaya VM. Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. The Journal of Biological Chemistry. 287: 18656-73. PMID 22493428 DOI: 10.1074/Jbc.M111.322883 |
0.459 |
|
| 2012 |
Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov DA, Gelman IH, Cance WG. A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo. Carcinogenesis. 33: 1004-13. PMID 22402131 DOI: 10.1093/Carcin/Bgs120 |
0.567 |
|
| 2012 |
Liu B, Kurenova E, Cance WG, Burns S, Fetterly G. Abstract 3786: Physiologically based pharmacokinetic model of CFAK-C4 disposition in mice for understanding its anti-tumor efficacy Cancer Research. 72: 3786-3786. DOI: 10.1158/1538-7445.Am2012-3786 |
0.314 |
|
| 2012 |
Agharkar PA, Ethirajan M, Liao J, Yemma M, Cance W, Pandey R, Kurenova E. Abstract 3756: Structure activity relationship studies of novel FAK inhibitor C4 Cancer Research. 72: 3756-3756. DOI: 10.1158/1538-7445.Am2012-3756 |
0.559 |
|
| 2012 |
Heffler MD, Golubovskaya VM, Cance WG, Dunn KMB. Dual FAK-Hsp70 Inhibition Synergistically Inhibits Colon Cancer Cell Viability and Improves the Efficacy of Chemotherapy Journal of Surgical Research. 172: 192. DOI: 10.1016/J.Jss.2011.11.115 |
0.415 |
|
| 2011 |
Kurenova EV, Liao J, He D, Hunt DL, Chekhau A, Hochwald SN, Ostrov DA, Cance WG. Effect of a novel FAK inhibitor targeted to the binding site of VEGFR3 on pancreatic cancer proliferation in vitro and in vivo. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 214. PMID 27985935 DOI: 10.1200/Jco.2011.29.4_Suppl.214 |
0.487 |
|
| 2011 |
Golubovskaya VM, Cance WG. FAK and p53 protein interactions. Anti-Cancer Agents in Medicinal Chemistry. 11: 617-9. PMID 21355845 DOI: 10.2174/187152011796817619 |
0.361 |
|
| 2011 |
Dy GK, Shao H, Ho B, Yemma M, Adjei A, Golubovskaya V, Cance W. Abstract C191: Preclinical investigation of the antitumor efficacy in lung cancer of Y15, a novel focal adhesion kinase inhibitor. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C191 |
0.521 |
|
| 2011 |
Melissa H, Golubovskaya VM, Cance WG, Dunn KMB. Abstract C184: A small molecule FAK inhibitor increases the cytotoxicity of 5-fluorouracil. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C184 |
0.543 |
|
| 2011 |
Agharkar PA, Ethirajan M, Liao J, Yemma M, Magis A, Cance W, Pandey R, Kurenova E. Abstract C124: Development of novel FAK inhibitors targeting the FAK-VEGFR3 protein-protein interaction site. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-C124 |
0.554 |
|
| 2011 |
Golubovskaya VM, Grace H, Ho B, Yemma M, Morrison C, Song L, Hu Q, Cance W. Abstract B244: The small molecule focal adhesion kinase inhibitor Y15 decreases human glioblastoma cell viability, clonogenicity, and tumor growth. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B244 |
0.532 |
|
| 2011 |
Heffler MD, Zhao Y, Johnson C, Golubovskaya VM, Cance WG, Dunn KMB. Hyaluronan And Hyaluronan Synthase-3 Mediate FAK Expression And Activation In Colon Cancer Cells Journal of Surgical Research. 165: 298. DOI: 10.1016/J.Jss.2010.11.363 |
0.414 |
|
| 2011 |
Beierle E, Ma X, Cance W, Kurenova E. Disruption Of FAK And VEGFR-3 Binding Results In Upregulation Of Downstream Cell Survival Signals In Neuroblastoma Journal of Surgical Research. 165: 339. DOI: 10.1016/J.Jss.2010.11.135 |
0.354 |
|
| 2010 |
Golubovskaya VM, Cance W. Focal adhesion kinase and p53 signal transduction pathways in cancer. Frontiers in Bioscience. 15: 901-912. PMID 20515733 DOI: 10.2741/3653 |
0.509 |
|
| 2010 |
Beierle EA, Ma X, Stewart J, Nyberg C, Trujillo A, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma. Cell Cycle (Georgetown, Tex.). 9: 1005-15. PMID 20160475 DOI: 10.4161/Cc.9.5.10936 |
0.519 |
|
| 2010 |
Beierle EA, Ma X, Trujillo A, Kurenova EV, Cance WG, Golubovskaya VM. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Molecular Carcinogenesis. 49: 224-34. PMID 19885861 DOI: 10.1002/Mc.20592 |
0.487 |
|
| 2010 |
Zheng D, Golubovskaya V, Kurenova E, Wood C, Massoll NA, Ostrov D, Cance WG, Hochwald SN. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Molecular Carcinogenesis. 49: 200-9. PMID 19885860 DOI: 10.1002/Mc.20590 |
0.441 |
|
| 2010 |
Heffler M, Zhao Y, Cance WG, Golubovskaya V, Dunn KB. The effect of a novel small molecule inhibitor of FAK on viability of human colon cancer cells. Journal of Clinical Oncology. 28. DOI: 10.1200/Jco.2010.28.15_Suppl.E13635 |
0.501 |
|
| 2010 |
Golubovskaya VM, Beierle EA, Hochwald SN, Kurenova EV, Cance WG. Focal adhesion kinase with the interacting proteins and signaling in cancer Cell-Extracellular Matrix Interactions in Cancer. 275-305. DOI: 10.1007/978-1-4419-0814-8_12 |
0.448 |
|
| 2009 |
Golubovskaya VM, Zheng M, Zhang L, Li JL, Cance WG. The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. Bmc Cancer. 9: 280. PMID 19671193 DOI: 10.1186/1471-2407-9-280 |
0.492 |
|
| 2009 |
Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN. Targeting of the protein interaction site between FAK and IGF-1R. Biochemical and Biophysical Research Communications. 388: 301-5. PMID 19664602 DOI: 10.1016/J.Bbrc.2009.07.156 |
0.381 |
|
| 2009 |
Kurenova EV, Hunt DL, He D, Magis AT, Ostrov DA, Cance WG. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. Journal of Medicinal Chemistry. 52: 4716-24. PMID 19610651 DOI: 10.1021/Jm900159G |
0.576 |
|
| 2009 |
Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG, Golubovskaya VM. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle (Georgetown, Tex.). 8: 2435-43. PMID 19571674 DOI: 10.4161/Cc.8.15.9145 |
0.552 |
|
| 2009 |
Kurenova EV, Hunt DL, He D, Fu AD, Massoll NA, Golubovskaya VM, Garces CA, Cance WG. Vascular endothelial growth factor receptor-3 promotes breast cancer cell proliferation, motility and survival in vitro and tumor formation in vivo. Cell Cycle (Georgetown, Tex.). 8: 2266-80. PMID 19556880 DOI: 10.4161/Cc.8.14.9101 |
0.471 |
|
| 2009 |
Golubovskaya VM, Conway-Dorsey K, Edmiston SN, Tse CK, Lark AA, Livasy CA, Moore D, Millikan RC, Cance WG. FAK overexpression and p53 mutations are highly correlated in human breast cancer. International Journal of Cancer. Journal International Du Cancer. 125: 1735-8. PMID 19521985 DOI: 10.1002/Ijc.24486 |
0.384 |
|
| 2009 |
Kweh F, Zheng M, Kurenova E, Wallace M, Golubovskaya V, Cance WG. Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Molecular Carcinogenesis. 48: 1005-17. PMID 19479903 DOI: 10.1002/Mc.20552 |
0.468 |
|
| 2009 |
Oh MA, Choi S, Lee MJ, Choi MC, Lee SA, Ko W, Cance WG, Oh ES, Buday L, Kim SH, Lee JW. Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes. Biochimica Et Biophysica Acta. 1793: 781-91. PMID 19339212 DOI: 10.1016/J.Bbamcr.2009.01.015 |
0.459 |
|
| 2009 |
Golubovskaya VM, Kweh FA, Cance WG. Focal adhesion kinase and cancer. Histology and Histopathology. 24: 503-10. PMID 19224453 DOI: 10.14670/Hh-24.503 |
0.535 |
|
| 2009 |
Kurenova EV, Hunt D, Ucar D, He D, Nyberg C, Hochwald S, Magis A, Ostrov D, Cance WG. Abstract C137: Pinpointing a protein‐protein interaction site of focal adhesion kinase and VEGFR‐3 suppresses cancer growth in vivo Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C137 |
0.597 |
|
| 2009 |
Trujillo A, Ma X, Golubovskaya V, Ostrov D, Cance W, Beierle E. 74. Targeting FAK Autophosphorylation Inhibits Viability of MYCN Amplified Neuroblastoma Cells Journal of Surgical Research. 151: 204-205. DOI: 10.1016/J.Jss.2008.11.088 |
0.404 |
|
| 2009 |
Hochwald SN, Nyberg C, Zheng M, Zheng D, Magis A, Ostrov D, Cance WG, Golubovskaya V. 41: A Novel Small Molecule Inhibitor of FAK Decreases Growth of Human Pancreatic Cancer Journal of Surgical Research. 151: 190. DOI: 10.1016/J.Jss.2008.11.068 |
0.41 |
|
| 2008 |
Golubovskaya VM, Nyberg C, Zheng M, Kweh F, Magis A, Ostrov D, Cance WG. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. Journal of Medicinal Chemistry. 51: 7405-16. PMID 18989950 DOI: 10.1021/Jm800483V |
0.524 |
|
| 2008 |
Magis AT, Bailey KM, Kurenova EV, Hernández Prada JA, Cance WG, Ostrov DA. Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 564-6. PMID 18540077 DOI: 10.1107/S1744309108011421 |
0.353 |
|
| 2008 |
Beierle EA, Massoll NA, Hartwich J, Kurenova EV, Golubovskaya VM, Cance WG, McGrady P, London WB. Focal adhesion kinase expression in human neuroblastoma: immunohistochemical and real-time PCR analyses. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3299-305. PMID 18519756 DOI: 10.1158/1078-0432.Ccr-07-1511 |
0.446 |
|
| 2008 |
Cance WG, Golubovskaya VM. Focal adhesion kinase versus p53: apoptosis or survival? Science Signaling. 1: pe22. PMID 18493017 DOI: 10.1126/Stke.120Pe22 |
0.472 |
|
| 2008 |
Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. 29: 1096-107. PMID 18263593 DOI: 10.1093/Carcin/Bgn026 |
0.498 |
|
| 2008 |
Beierle EA, Trujillo A, Nagaram A, Golubovskaya VM, Cance WG, Kurenova EV. TAE226 inhibits human neuroblastoma cell survival. Cancer Investigation. 26: 145-51. PMID 18259944 DOI: 10.1080/07357900701577475 |
0.447 |
|
| 2008 |
Golubovskaya VM, Finch R, Zheng M, Kurenova EV, Cance WG. The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. The Biochemical Journal. 411: 151-60. PMID 18215142 DOI: 10.1042/Bj20071657 |
0.322 |
|
| 2008 |
Golubovskaya VM, Finch R, Kweh F, Massoll NA, Campbell-Thompson M, Wallace MR, Cance WG. p53 regulates FAK expression in human tumor cells. Molecular Carcinogenesis. 47: 373-82. PMID 17999388 DOI: 10.1002/Mc.20395 |
0.423 |
|
| 2008 |
Funa NS, Reddy K, Bhandarkar S, Kurenova EV, Yang L, Cance WG, Welsh M, Arbiser JL. Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo Journal of Investigative Dermatology. 128: 710-716. PMID 17914455 DOI: 10.1038/Sj.Jid.5701057 |
0.535 |
|
| 2008 |
Golubovskaya VM, Virnig C, Cance WG. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular Carcinogenesis. 47: 222-34. PMID 17849451 DOI: 10.1002/Mc.20380 |
0.473 |
|
| 2008 |
Meyers MO, Klauber-Demore N, Ollila DW, Dees EC, Calvo BF, Moore DT, Cance WG, Sartor CI, Carey LA. Locoregional control in locally advanced breast cancer using neoadjuvant chemotherapy followed by breast conservation Journal of Clinical Oncology. 26: 539-539. DOI: 10.1200/Jco.2008.26.15_Suppl.539 |
0.303 |
|
| 2007 |
Golubovskaya VM, Cance WG. Focal adhesion kinase and p53 signaling in cancer cells. International Review of Cytology. 263: 103-53. PMID 17725966 DOI: 10.1016/S0074-7696(07)63003-4 |
0.527 |
|
| 2007 |
Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM. N-MYC regulates focal adhesion kinase expression in human neuroblastoma. The Journal of Biological Chemistry. 282: 12503-16. PMID 17327229 DOI: 10.1074/Jbc.M701450200 |
0.324 |
|
| 2006 |
Garces CA, McAuliffe PF, Hochwald SN, Cance WG. Neoadjuvant therapy in the treatment of solid tumors. Current Problems in Surgery. 43: 457-551. PMID 16860653 DOI: 10.1067/J.Cpsurg.2006.04.003 |
0.313 |
|
| 2006 |
Garces CA, Kurenova EV, Golubovskaya VM, Cance WG. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. Cancer Research. 66: 1446-54. PMID 16452200 DOI: 10.1158/0008-5472.Can-05-1661 |
0.522 |
|
| 2006 |
Beierle E, Nagaram A, Garces C, Golubovskaya V, Cance W, Kurenova E. Inhibition of VEGFR-3 binding to FAK induces apoptosis in human neuroblastoma cells Journal of Surgical Research. 130: 179-180. DOI: 10.1016/J.Jss.2005.11.054 |
0.345 |
|
| 2005 |
Smith CS, Golubovskaya VM, Peck E, Xu LH, Monia BP, Yang X, Cance WG. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines. Melanoma Research. 15: 357-62. PMID 16179862 DOI: 10.1097/00008390-200510000-00003 |
0.455 |
|
| 2005 |
Lark AL, Livasy CA, Dressler L, Moore DT, Millikan RC, Geradts J, Iacocca M, Cowan D, Little D, Craven RJ, Cance W. High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype Modern Pathology. 18: 1289-1294. PMID 15861214 DOI: 10.1038/Modpathol.3800424 |
0.405 |
|
| 2005 |
Golubovskaya VM, Finch R, Cance WG. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. The Journal of Biological Chemistry. 280: 25008-21. PMID 15855171 DOI: 10.1074/Jbc.M414172200 |
0.39 |
|
| 2005 |
Bauer TW, Fan F, Liu W, Johnson M, Parikh NU, Parry GC, Callahan J, Mazar AP, Gallick GE, Ellis LM, Cance WG, Slingluff CL, Smythe WR, Townsend CM. Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor Annals of Surgery. 241: 748-758. PMID 15849510 DOI: 10.1097/01.Sla.0000160699.59061.92 |
0.389 |
|
| 2004 |
Lightfoot HM, Lark A, Livasy CA, Moore DT, Cowan D, Dressler L, Craven RJ, Cance WG. Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis Breast Cancer Research and Treatment. 88: 109-116. PMID 15564794 DOI: 10.1007/S10549-004-1022-8 |
0.445 |
|
| 2004 |
Livasy CA, Moore D, Cance WG, Lininger RA. Focal adhesion kinase overexpression in endometrial neoplasia. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 12: 342-5. PMID 15536334 DOI: 10.1097/00129039-200412000-00009 |
0.494 |
|
| 2004 |
Golubovskaya V, Kaur A, Cance W. Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites. Biochimica Et Biophysica Acta. 1678: 111-125. PMID 15157737 DOI: 10.1016/J.Bbaexp.2004.03.002 |
0.344 |
|
| 2004 |
Kurenova E, Xu LH, Yang X, Baldwin AS, Craven RJ, Hanks SK, Liu ZG, Cance WG. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Molecular and Cellular Biology. 24: 4361-71. PMID 15121855 DOI: 10.1128/Mcb.24.10.4361-4371.2004 |
0.446 |
|
| 2004 |
Rhoads JM, Chen W, Gookin J, Wu GY, Fu Q, Blikslager AT, Rippe RA, Argenzio RA, Cance WG, Weaver EM, Romer LH. Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism Gut. 53: 514-522. PMID 15016745 DOI: 10.1136/Gut.2003.027540 |
0.426 |
|
| 2004 |
Park HB, Golubovskaya V, Xu L, Yang X, Lee JW, Scully S, Craven RJ, Cance WG. Activated Src increases adhesion, survival and alpha2-integrin expression in human breast cancer cells. The Biochemical Journal. 378: 559-67. PMID 14629195 DOI: 10.1042/Bj20031392 |
0.478 |
|
| 2004 |
Garces CA, Chang J, Wilson RI, Kurenova EV, Golubovskaya VM, Cance WG. Focal adhesion kinase inhibitory peptides induce apoptosis in human breast cancer cells Annals of Surgical Oncology. 11. DOI: 10.1007/Bf02524026 |
0.414 |
|
| 2003 |
Lee JW, Hee Kim Y, Boong Park H, Xu LH, Cance WG, Block JA, Scully SP. The C-terminal domain of focal adhesion kinase reduces the tumor cell invasiveness in chondrosarcoma cell lines. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 21: 1071-80. PMID 14554221 DOI: 10.1016/S0736-0266(03)00101-3 |
0.515 |
|
| 2003 |
Golubovskaya VM, Gross S, Kaur AS, Wilson RI, Xu LH, Yang XH, Cance WG. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular Cancer Research : McR. 1: 755-64. PMID 12939401 |
0.33 |
|
| 2003 |
Yang XH, Hand RA, Livasy CA, Cance WG, Craven RJ. Overexpression of the receptor tyrosine kinase Tie-1 intracellular domain in breast cancer. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. 24: 61-9. PMID 12853700 DOI: 10.1159/000071078 |
0.498 |
|
| 2003 |
Craven RJ, Lightfoot H, Cance WG. A decade of tyrosine kinases: from gene discovery to therapeutics. Surgical Oncology. 12: 39-49. PMID 12689669 DOI: 10.1016/S0960-7404(03)00004-5 |
0.479 |
|
| 2003 |
Beviglia L, Golubovskaya V, Xu L, Yang X, Craven RJ, Cance WG. Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis. The Biochemical Journal. 373: 201-10. PMID 12659633 DOI: 10.1042/Bj20021846 |
0.463 |
|
| 2003 |
Lotz M, Wang HH-, Cance W, Matthews TJ, Pories S. Epidermal growth factor stimulation can substitute for c-Src overexpression in promoting breast carcinoma invasion Journal of Surgical Research. 109: 123-129. PMID 12643853 DOI: 10.1016/S0022-4804(02)00100-2 |
0.462 |
|
| 2003 |
Meyer T, Xu L, Chang J, Liu ET, Craven RJ, Cance WG. Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase. International Journal of Cancer. 104: 139-46. PMID 12569567 DOI: 10.1002/Ijc.10925 |
0.513 |
|
| 2003 |
Lark AL, Livasy CA, Calvo B, Caskey L, Moore DT, Yang X, Cance WG. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 215-22. PMID 12538472 |
0.376 |
|
| 2003 |
Beierle E, Dai W, Cance W, Langham M, Chen M. FAK expression in neuroblastoma Journal of Surgical Research. 114: 309. DOI: 10.1016/J.Jss.2003.08.126 |
0.419 |
|
| 2002 |
Golubovskaya V, Beviglia L, Xu LH, Earp HS, Craven R, Cance W. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. The Journal of Biological Chemistry. 277: 38978-87. PMID 12167618 DOI: 10.1074/Jbc.M205002200 |
0.468 |
|
| 2001 |
Owens LV, Xu L, Marston WA, Yang X, Farber MA, Iacocca MV, Cance WG, Keagy BA. Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia Journal of Vascular Surgery. 34: 344-349. PMID 11496289 DOI: 10.1067/Mva.2001.114814 |
0.404 |
|
| 2000 |
Xu LH, Yang X, Bradham CA, Brenner DA, Baldwin AS, Craven RJ, Cance WG. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. The Journal of Biological Chemistry. 275: 30597-604. PMID 10899173 DOI: 10.1074/Jbc.M910027199 |
0.453 |
|
| 2000 |
Cance WG, Harris JE, Iacocca MV, Roche E, Yang XH, Chang J, Simkins S, Xu LH. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: Correlation with preinvasive and invasive phenotypes Clinical Cancer Research. 6: 2417-2423. PMID 10873094 |
0.307 |
|
| 2000 |
Cance WG, Stewart AK, Menck HR. The National Cancer Data Base report on treatment patterns for hepatocellular carcinomas: Improved Survival of Surgically Resected Patients, 1985-1996 Cancer. 88: 912-920. PMID 10679662 DOI: 10.1002/(Sici)1097-0142(20000215)88:4<912::Aid-Cncr23>3.0.Co;2-T |
0.32 |
|
| 1999 |
Judson PL, He X, Cance WG, Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma Cancer. 86: 1551-1556. PMID 10526262 DOI: 10.1002/(SICI)1097-0142(19991015)86:6<1551::AID-CNCR23>3.0.CO;2-P |
0.326 |
|
| 1999 |
Li X, Dy RC, Cance WG, Graves LM, Earp HS. Interactions between two cytoskeleton-associated tyrosine kinases: Calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase Journal of Biological Chemistry. 274: 8917-8924. PMID 10085136 DOI: 10.1074/Jbc.274.13.8917 |
0.406 |
|
| 1998 |
Xu LH, Yang X, Craven RJ, Cance WG. The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells Cell Growth and Differentiation. 9: 999-1005. PMID 9869300 |
0.387 |
|
| 1996 |
Xu LH, Owens LV, Sturge GC, Yang X, Liu ET, Craven RJ, Cance WG. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells Cell Growth and Differentiation. 7: 413-418. PMID 9052982 |
0.415 |
|
| 1996 |
Owens LV, Xu L, Dent GA, Yang X, Sturge GC, Craven RJ, Cance WG. Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Annals of Surgical Oncology. 3: 100-5. PMID 8770310 DOI: 10.1007/Bf02409059 |
0.415 |
|
| 1995 |
Craven RJ, Xu LH, Weiner TM, Fridell YW, Dent GA, Srivastava S, Varnum B, Liu ET, Cance WG. Receptor tyrosine kinases expressed in metastatic colon cancer. International Journal of Cancer. Journal International Du Cancer. 60: 791-7. PMID 7896447 DOI: 10.1002/Ijc.2910600611 |
0.451 |
|
| 1995 |
Owens LV, Xu L, Craven RJ, Dent GA, Weiner TM, Kornberg L, Liu ET, Cance WG. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Research. 55: 2752-5. PMID 7796399 |
0.363 |
|
| 1995 |
Craven RJ, Cance WG, Liu ET. The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb Cancer Research. 55: 3969-3972. PMID 7664264 |
0.366 |
|
| 1995 |
Cance WG, Liu ET. Protein kinases in human breast cancer Breast Cancer Research and Treatment. 35: 105-114. PMID 7612897 DOI: 10.1007/Bf00694751 |
0.437 |
|
| 1994 |
Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene. 9: 1977-88. PMID 8208544 |
0.307 |
|
| 1994 |
Weiner T, Cance WG. Molecular mechanisms involved in tumorigenesis and their surgical implications. American Journal of Surgery. 167: 428-34. PMID 8179089 DOI: 10.1016/0002-9610(94)90129-5 |
0.327 |
|
| 1994 |
Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors. Annals of Surgical Oncology. 1: 18-27. PMID 7834423 DOI: 10.1007/Bf02303537 |
0.449 |
|
| 1994 |
Cance WG, Craven RJ, Bergman M, Xu L, Alitalo K, Liu ET. Rak, a novel nuclear tyrosine kinase expressed in epithelial cells Cell Growth and Differentiation. 5: 1347-1355. PMID 7696183 |
0.389 |
|
| 1993 |
Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase gene and invasive cancer. Lancet (London, England). 342: 1024-5. PMID 8105266 DOI: 10.1016/0140-6736(93)92881-S |
0.438 |
|
| 1993 |
Cance WG, Craven RJ, Weiner TM, Liu ET. Novel protein kinases expressed in human breast cancer. International Journal of Cancer. Journal International Du Cancer. 54: 571-7. PMID 8099900 DOI: 10.1002/Ijc.2910540409 |
0.451 |
|
| 1990 |
Cance WG, Brennan MF, Dudas ME, Huang CM, Cordon-Cardo C. Altered expression of the retinoblastoma gene product in human sarcomas New England Journal of Medicine. 323: 1457-1462. PMID 2233918 DOI: 10.1056/Nejm199011223232105 |
0.372 |
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