| Year |
Citation |
Score |
| 2020 |
Yoo DY, Hauser AD, Joy ST, Bar-Sagi D, Arora PS. Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics. Acs Chemical Biology. PMID 32378881 DOI: 10.1021/Acschembio.0C00204 |
0.406 |
|
| 2020 |
Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnacion-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, ... Bar-Sagi D, et al. Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer. Cancer Discovery. PMID 32341021 DOI: 10.1158/2159-8290.Cd-19-0959 |
0.316 |
|
| 2020 |
Das S, Shapiro B, Vucic EA, Vogt S, Bar-Sagi D. Tumor Cell-Derived IL-1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer. Cancer Research. PMID 31915130 DOI: 10.1158/0008-5472.Can-19-2080 |
0.337 |
|
| 2020 |
LaRue MM, Cullis J, Bar-Sagi D. Abstract PR22: Collagen scavenging alters macrophage phenotype in pancreatic cancer Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-Pr22 |
0.329 |
|
| 2019 |
Ramirez C, Hauser AD, Vucic EA, Bar-Sagi D. Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis. Nature. 576: 477-481. PMID 31827278 DOI: 10.1038/S41586-019-1831-X |
0.46 |
|
| 2019 |
Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, et al. ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes & Development. PMID 31048544 DOI: 10.1101/Gad.323303.118 |
0.326 |
|
| 2019 |
Das S, Bar-Sagi D. BTK signaling drives CD1dCD5 regulatory B-cell differentiation to promote pancreatic carcinogenesis. Oncogene. PMID 30635655 DOI: 10.1038/S41388-018-0668-3 |
0.344 |
|
| 2019 |
Siolas D, Vucic E, Cullis J, Choi M, Bar-Sagi D. Abstract 2797: Accumulation of neutrophils in the tumor microenvironment promotes resistance to immunotherapy in pancreatic cancer Cancer Research. 79: 2797-2797. DOI: 10.1158/1538-7445.Am2019-2797 |
0.324 |
|
| 2018 |
Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ. EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Developmental Cell. 45: 681-695.e4. PMID 29920274 DOI: 10.1016/J.Devcel.2018.05.027 |
0.316 |
|
| 2017 |
Cullis J, Das S, Bar-Sagi D. Kras and Tumor Immunity: Friend or Foe? Cold Spring Harbor Perspectives in Medicine. PMID 29229670 DOI: 10.1101/Cshperspect.A031849 |
0.317 |
|
| 2017 |
Jang JE, Hajdu CH, Liot C, Miller G, Dustin ML, Bar-Sagi D. Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer. Cell Reports. 20: 558-571. PMID 28723561 DOI: 10.1016/J.Celrep.2017.06.062 |
0.347 |
|
| 2017 |
Fehrenbacher N, Tojal da Silva I, Ramirez C, Zhou Y, Cho KJ, Kuchay S, Shi J, Thomas S, Pagano M, Hancock JF, Bar-Sagi D, Philips MR. The G protein-coupled receptor GPR31 promotes membrane association of KRAS. The Journal of Cell Biology. PMID 28619714 DOI: 10.1083/Jcb.201609096 |
0.325 |
|
| 2017 |
Cohen DJ, Grabocka E, Bar-Sagi D, Godin R, Leichman LP. A phase Ib study combining irinotecan with AZD1775, a selective WEE 1 kinase inhibitor, in RAS/RAF mutated metastatic colorectal cancer patients who progressed on first line therapy. Journal of Clinical Oncology. 35: TPS3627-TPS3627. DOI: 10.1200/Jco.2017.35.15_Suppl.Tps3627 |
0.352 |
|
| 2016 |
Sundstrom A, Bar-Sagi D, Mishra B. Simulating Heterogeneous Tumor Cell Populations. Plos One. 11: e0168984. PMID 28030620 DOI: 10.1371/Journal.Pone.0168984 |
0.712 |
|
| 2016 |
Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, ... Bar-Sagi D, et al. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nature Medicine. PMID 28024083 DOI: 10.1038/Nm.4256 |
0.346 |
|
| 2016 |
Grabocka E, Bar-Sagi D. Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. Cell. 167: 1803-1813.e12. PMID 27984728 DOI: 10.1016/J.Cell.2016.11.035 |
0.333 |
|
| 2016 |
Daley D, Zambirinis CP, Seifert L, Akkad N, Mohan N, Werba G, Barilla R, Torres-Hernandez A, Hundeyin M, Mani VR, Avanzi A, Tippens D, Narayanan R, Jang JE, Newman E, ... ... Bar-Sagi D, et al. γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation. Cell. PMID 27569912 DOI: 10.1016/J.Cell.2016.07.046 |
0.359 |
|
| 2016 |
Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT. One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nature Structural & Molecular Biology. PMID 27501536 DOI: 10.1038/Nsmb.3275 |
0.632 |
|
| 2016 |
Sundstrom A, Grabocka E, Bar-Sagi D, Mishra B. Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia. Plos One. 11: e0153623. PMID 27093539 DOI: 10.1371/Journal.Pone.0153623 |
0.702 |
|
| 2016 |
Jang J, Hajdu CH, Miller G, Dustin ML, Bar-Sagi D. Abstract A100: Crosstalk between regulatory T cells and tumor-associated dendritic cells controls antitumor immunity in pancreatic cancer Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A100 |
0.347 |
|
| 2016 |
Bar-Sagi D. Abstract IA21: Ras oncogene in cancer pathogenesis and therapy Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Ia21 |
0.465 |
|
| 2016 |
Cullis JE, Taylor L, Low S, Bar-Sagi D. Abstract 3001: Accurins are endocytosed by KRAS-mutant cells via macropinocytosis Cancer Research. 76: 3001-3001. DOI: 10.1158/1538-7445.Am2016-3001 |
0.384 |
|
| 2015 |
Fennell M, Commisso C, Ramirez C, Garippa R, Bar-Sagi D. High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis. Assay and Drug Development Technologies. 13: 347-55. PMID 26267765 DOI: 10.1089/Adt.2015.660 |
0.427 |
|
| 2015 |
Grabocka E, Commisso C, Bar-Sagi D. Molecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1243-7. PMID 25424849 DOI: 10.1158/1078-0432.Ccr-14-0650 |
0.453 |
|
| 2015 |
Siolas D, Aristizabal O, Byrne K, Leichman LP, Vonderheide RH, Bar-Sagi D. Preclinical immunotherapy studies using an orthotopic pancreatic cancer mouse model. Journal of Clinical Oncology. 33: 324-324. DOI: 10.1200/Jco.2015.33.3_Suppl.324 |
0.322 |
|
| 2015 |
Grabocka E, Choi M, Cohen DJ, Godin R, Leichman LP, Bar-Sagi D. Selective sensitization of Ras-mutant (Ras-m) cancer cells to DNA-damaging chemotherapy by Wee1 inhibition with AZD1775. Journal of Clinical Oncology. 33: e13517-e13517. DOI: 10.1200/Jco.2015.33.15_Suppl.E13517 |
0.425 |
|
| 2015 |
Commisso C, Ramirez C, Soydaner-Azeloglu R, Bajor DL, Vonderheide RH, Bar-Sagi D. Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Pr08 |
0.428 |
|
| 2015 |
Pylayeva-Gupta Y, Handler JS, Hajdu C, Bar-Sagi D. Abstract B62: The role of B regulatory cells in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B62 |
0.31 |
|
| 2015 |
Handler J, Bar-Sagi D. Abstract A12: Establishing in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDA) utilizing both acinar and ductal lineages Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A12 |
0.329 |
|
| 2015 |
Cullis JE, Siolas D, Maitra A, Bar-Sagi D. Abstract LB-224: Nab-paclitaxel and agonist CD40 mAb combination therapy induces tumor-associated macrophage polarization switching in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-224 |
0.314 |
|
| 2014 |
Lubkov V, Bar-Sagi D. E-cadherin-mediated cell coupling is required for apoptotic cell extrusion. Current Biology : Cb. 24: 868-74. PMID 24704076 DOI: 10.1016/J.Cub.2014.02.057 |
0.762 |
|
| 2014 |
Grabocka E, Pylayeva-Gupta Y, Jones MJ, Lubkov V, Yemanaberhan E, Taylor L, Jeng HH, Bar-Sagi D. Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell. 25: 243-56. PMID 24525237 DOI: 10.1016/J.Ccr.2014.01.005 |
0.793 |
|
| 2014 |
Commisso C, Flinn RJ, Bar-Sagi D. Determining the macropinocytic index of cells through a quantitative image-based assay. Nature Protocols. 9: 182-92. PMID 24385148 DOI: 10.1038/Nprot.2014.004 |
0.366 |
|
| 2014 |
Nickerson S, Joy ST, Arora PS, Bar-Sagi D. Abstract B46: Stabilized helices targeting the RAS-SOS interaction as inhibitors of RAS-dependent cancer cell growth Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B46 |
0.489 |
|
| 2014 |
Court H, Philips MR, Bar-Sagi D. The biology of K-Ras signaling pathways in pancreatic cancer Molecular Genetics of Pancreatic Cancer. 83-115. DOI: 10.1007/978-1-4614-6549-2_5 |
0.358 |
|
| 2013 |
Nickerson S, Joy ST, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the RAS-SOS interaction. The Enzymes. 34: 25-39. PMID 25034099 DOI: 10.1016/B978-0-12-420146-0.00002-0 |
0.483 |
|
| 2013 |
Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR. Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. The Journal of Clinical Investigation. 123: 4681-94. PMID 24216479 DOI: 10.1172/Jci65764 |
0.462 |
|
| 2013 |
Dultz LA, Dhar S, Ogilvie JB, Heller KS, Bar-Sagi D, Patel KN. Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. Surgery. 154: 1239-44; discussion . PMID 24094449 DOI: 10.1016/J.Surg.2013.06.024 |
0.311 |
|
| 2013 |
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, Rabinowitz JD, Metallo CM, Vander Heiden MG, Bar-Sagi D. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 497: 633-7. PMID 23665962 DOI: 10.1038/Nature12138 |
0.453 |
|
| 2013 |
Commisso C, Chenna V, Grabocka E, Ramirez C, Anirban M, Bar-Sagi D. Abstract PR12: Bringing the outside in: Macropinocytosis and cancer therapeutics Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Pr12 |
0.487 |
|
| 2013 |
Grabocka E, Pylayeva-Gupta Y, Yemanaberhan E, Lubkov V, Taylor L, Bar-Sagi D. Abstract PR03: Selective sensitization of mutant K-Ras cancer cells to DNA damage based therapies by targeting wild type H- and N-Ras. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pr03 |
0.804 |
|
| 2012 |
Jeng HH, Taylor LJ, Bar-Sagi D. Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis Nature Communications. 3. PMID 23132018 DOI: 10.1038/Ncomms2173 |
0.727 |
|
| 2012 |
Zheng ZY, Xu L, Bar-Sagi D, Chang EC. Escorting Ras. Small Gtpases. 3: 236-9. PMID 22735486 DOI: 10.4161/sgtp.20460 |
0.357 |
|
| 2012 |
Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10843-8. PMID 22711838 DOI: 10.1073/Pnas.1201487109 |
0.487 |
|
| 2012 |
Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell. 21: 836-47. PMID 22698407 DOI: 10.1016/J.Ccr.2012.04.024 |
0.335 |
|
| 2012 |
Cao Y, E G, Wang E, Pal K, Dutta SK, Bar-Sagi D, Mukhopadhyay D. VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. Cancer Research. 72: 3912-8. PMID 22693250 DOI: 10.1158/0008-5472.Can-11-4058 |
0.38 |
|
| 2012 |
Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 31: 4630-8. PMID 22231449 DOI: 10.1038/Onc.2011.607 |
0.473 |
|
| 2012 |
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the regulator: post-translational modification of RAS. Nature Reviews. Molecular Cell Biology. 13: 39-51. PMID 22189424 DOI: 10.1038/Nrm3255 |
0.467 |
|
| 2012 |
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Metallo CM, Heiden MGV, Bar-Sagi D. Abstract PR5: Macropinocytosis as a mechanism of amino acid supply. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Pr5 |
0.474 |
|
| 2012 |
Pylayeva-Gupta Y, Lee KE, Miller G, Bar-Sagi D. Abstract A66: KRas-mediated modulation of the immune response in pancreatic neoplasia. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A66 |
0.311 |
|
| 2012 |
Commisso C, Soydaner-Azeloglu RG, Bar-Sagi D. Abstract 5147: Glutamine addiction: Recognizing and harnessing the pathometabolic potential of Ras-mediated macropinocytosis Cancer Research. 72: 5147-5147. DOI: 10.1158/1538-7445.Am2012-5147 |
0.44 |
|
| 2011 |
Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D. RAS oncogenes: weaving a tumorigenic web. Nature Reviews. Cancer. 11: 761-74. PMID 21993244 DOI: 10.1038/Nrc3106 |
0.478 |
|
| 2011 |
Patgiri A, Yadav KK, Arora PS, Bar-Sagi D. An orthosteric inhibitor of the Ras-Sos interaction. Nature Chemical Biology. 7: 585-7. PMID 21765406 DOI: 10.1038/Nchembio.612 |
0.648 |
|
| 2010 |
Nimnual AS, Taylor LJ, Nyako M, Jeng HH, Bar-Sagi D. Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b. Small Gtpases. 1: 89-97. PMID 21686260 DOI: 10.4161/Sgtp.1.2.14427 |
0.684 |
|
| 2010 |
Xu L, Zhou JL, Cohen M, Bar-Sagi D, Patel KN. Spry2 expression correlates with BRAF mutation in thyroid cancer. Surgery. 148: 1282-7; discussion 1. PMID 21134562 DOI: 10.1016/J.Surg.2010.09.028 |
0.323 |
|
| 2010 |
Lee KE, Bar-Sagi D. Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. Cancer Cell. 18: 448-58. PMID 21075310 DOI: 10.1016/J.Ccr.2010.10.020 |
0.357 |
|
| 2010 |
Xu L, Lubkov V, Taylor LJ, Bar-Sagi D. Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Current Biology : Cb. 20: 1372-7. PMID 20655225 DOI: 10.1016/J.Cub.2010.06.051 |
0.809 |
|
| 2010 |
Miaczynska M, Bar-Sagi D. Signaling endosomes: seeing is believing. Current Opinion in Cell Biology. 22: 535-40. PMID 20538448 DOI: 10.1016/J.Ceb.2010.05.007 |
0.326 |
|
| 2010 |
Yadav KK, Bar-Sagi D. Allosteric gating of Son of sevenless activity by the histone domain. Proceedings of the National Academy of Sciences of the United States of America. 107: 3436-40. PMID 20133694 DOI: 10.1073/Pnas.0914315107 |
0.642 |
|
| 2010 |
Gureasko J, Kuchment O, Makino DL, Sondermann H, Bar-Sagi D, Kuriyan J. Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless Proceedings of the National Academy of Sciences of the United States of America. 107: 3430-3435. PMID 20133692 DOI: 10.1073/Pnas.0913915107 |
0.596 |
|
| 2010 |
Connolly MK, Mallen-St Clair J, Bedrosian AS, Malhotra A, Vera V, Ibrahim J, Henning J, Pachter HL, Bar-Sagi D, Frey AB, Miller G. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. Journal of Leukocyte Biology. 87: 713-25. PMID 20042467 DOI: 10.1189/Jlb.0909607 |
0.329 |
|
| 2009 |
Ford B, Boykevisch S, Zhao C, Kunzelmann S, Bar-Sagi D, Herrmann C, Nassar N. Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry. 48: 11449-57. PMID 19883123 DOI: 10.1021/Bi901479B |
0.416 |
|
| 2009 |
Fehrenbacher N, Bar-Sagi D, Philips M. Ras/MAPK signaling from endomembranes. Molecular Oncology. 3: 297-307. PMID 19615955 DOI: 10.1016/J.Molonc.2009.06.004 |
0.447 |
|
| 2009 |
Frank MJ, Dawson DW, Bensinger SJ, Hong JS, Knosp WM, Xu L, Balatoni CE, Allen EL, Shen RR, Bar-Sagi D, Martin GR, Teitell MA. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 113: 2478-87. PMID 19147787 DOI: 10.1182/Blood-2008-05-156943 |
0.339 |
|
| 2008 |
Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z. The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 16713-8. PMID 18946040 DOI: 10.1073/Pnas.0804063105 |
0.369 |
|
| 2008 |
Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4267-74. PMID 18594009 DOI: 10.1158/1078-0432.Ccr-08-0102 |
0.446 |
|
| 2008 |
Gureasko J, Galush WJ, Boykevisch S, Sondermann H, Bar-Sagi D, Groves JT, Kuriyan J. Membrane-dependent signal integration by the Ras activator Son of sevenless. Nature Structural & Molecular Biology. 15: 452-61. PMID 18454158 DOI: 10.1038/Nsmb.1418 |
0.611 |
|
| 2008 |
Terrillon S, Bar-Sagi D. Biochemical and biophysical analyses of Ras modification by ubiquitin. Methods in Enzymology. 438: 259-76. PMID 18413254 DOI: 10.1016/S0076-6879(07)38018-X |
0.365 |
|
| 2008 |
Gureasko J, Galush WJ, Boykevisch S, Sondermann H, Bar-Sagi D, Groves JT, Kuriyan J. Erratum: Membrane-dependent signal integration by the Ras activator Son of sevenless Nature Structural & Molecular Biology. 15: 651-651. DOI: 10.1038/nsmb0608-651a |
0.557 |
|
| 2007 |
Yeh BJ, Rutigliano RJ, Deb A, Bar-Sagi D, Lim WA. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature. 447: 596-600. PMID 17515921 DOI: 10.1038/Nature05851 |
0.353 |
|
| 2007 |
Zhao C, Du G, Skowronek K, Frohman MA, Bar-Sagi D. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nature Cell Biology. 9: 706-12. PMID 17486115 DOI: 10.1038/Ncb1594 |
0.448 |
|
| 2007 |
Kim HJ, Taylor LJ, Bar-Sagi D. Spatial regulation of EGFR signaling by Sprouty2. Current Biology : Cb. 17: 455-61. PMID 17320394 DOI: 10.1016/J.Cub.2007.01.059 |
0.315 |
|
| 2007 |
Tartaglia M, Pennacchio LA, Zhao C, Yadav KK, Fodale V, Sarkozy A, Pandit B, Oishi K, Martinelli S, Schackwitz W, Ustaszewska A, Martin J, Bristow J, Carta C, Lepri F, ... ... Bar-Sagi D, et al. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nature Genetics. 39: 75-9. PMID 17143282 DOI: 10.1038/Ng1939 |
0.627 |
|
| 2007 |
Tartaglia M, Pennacchio LA, Zhao C, Yadav KK, Fodale V, Sarkozy A, Pandit B, Oishi K, Martinelli S, Schackwitz W, Ustaszewska A, Martin J, Bristow J, Carta C, Lepri F, ... ... Bar-Sagi D, et al. Erratum: Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome Nature Genetics. 39: 276-276. DOI: 10.1038/Ng0207-276A |
0.531 |
|
| 2006 |
Jura N, Bar-Sagi D. Mapping cellular routes of Ras: a ubiquitin trail. Cell Cycle (Georgetown, Tex.). 5: 2744-7. PMID 17172849 DOI: 10.4161/Cc.5.23.3532 |
0.723 |
|
| 2006 |
Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D. A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology. 131: 1844-55. PMID 17087933 DOI: 10.1053/J.Gastro.2006.09.049 |
0.575 |
|
| 2006 |
Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J, Bar-Sagi D. Regulation of Ras Signaling Dynamics by Sos-Mediated Positive Feedback Current Biology. 16: 2173-2179. PMID 17084704 DOI: 10.1016/J.Cub.2006.09.033 |
0.647 |
|
| 2006 |
Freedman TS, Sondermann H, Friedland GD, Kortemme T, Bar-Sagi D, Marqusee S, Kuriyan J. A Ras-induced conformational switch in the Ras activator Son of sevenless. Proceedings of the National Academy of Sciences of the United States of America. 103: 16692-7. PMID 17075039 DOI: 10.1073/Pnas.0608127103 |
0.625 |
|
| 2006 |
Jura N, Scotto-Lavino E, Sobczyk A, Bar-Sagi D. Differential modification of Ras proteins by ubiquitination. Molecular Cell. 21: 679-87. PMID 16507365 DOI: 10.1016/J.Molcel.2006.02.011 |
0.71 |
|
| 2005 |
Sondermann H, Zhao C, Bar-Sagi D. Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering. Methods (San Diego, Calif.). 37: 197-202. PMID 16288886 DOI: 10.1016/J.Ymeth.2005.05.016 |
0.357 |
|
| 2005 |
Sondermann H, Nagar B, Bar-Sagi D, Kuriyan J. Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless Proceedings of the National Academy of Sciences of the United States of America. 102: 16632-16637. PMID 16267129 DOI: 10.1073/Pnas.0508315102 |
0.561 |
|
| 2005 |
Sparmann A, Bar-Sagi D. Ras oncogene and inflammation: partners in crime. Cell Cycle (Georgetown, Tex.). 4: 735-6. PMID 15908805 DOI: 10.4161/Cc.4.6.1714 |
0.502 |
|
| 2005 |
Ford B, Skowronek K, Boykevisch S, Bar-Sagi D, Nassar N. Structure of the G60A mutant of Ras: implications for the dominant negative effect. The Journal of Biological Chemistry. 280: 25697-705. PMID 15878843 DOI: 10.1074/Jbc.M502240200 |
0.439 |
|
| 2005 |
Jura N, Archer H, Bar-Sagi D. Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between. Cell Research. 15: 72-7. PMID 15686632 DOI: 10.1038/Sj.Cr.7290269 |
0.604 |
|
| 2004 |
Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell. 6: 447-58. PMID 15542429 DOI: 10.1016/J.Ccr.2004.09.028 |
0.504 |
|
| 2004 |
Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J. Structural analysis of autoinhibition in the Ras activator son of sevenless Cell. 119: 393-405. PMID 15507210 DOI: 10.1016/J.Cell.2004.10.005 |
0.633 |
|
| 2004 |
Agbunag C, Bar-Sagi D. Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Research. 64: 5659-63. PMID 15313904 DOI: 10.1158/0008-5472.Can-04-0807 |
0.437 |
|
| 2004 |
Kim HJ, Bar-Sagi D. Modulation of signalling by Sprouty: a developing story. Nature Reviews. Molecular Cell Biology. 5: 441-50. PMID 15173823 DOI: 10.1038/Nrm1400 |
0.303 |
|
| 2003 |
Sondermann H, Soisson SM, Bar-Sagi D, Kuriyan J. Tandem Histone Folds in the Structure of the N-Terminal Segment of the Ras Activator Son of Sevenless Structure. 11: 1583-1593. PMID 14656442 DOI: 10.1016/J.Str.2003.10.015 |
0.53 |
|
| 2003 |
Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes & Development. 17: 629-37. PMID 12629045 DOI: 10.1101/Gad.1062903 |
0.443 |
|
| 2003 |
Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell. 112: 685-95. PMID 12628188 DOI: 10.1016/S0092-8674(03)00149-1 |
0.638 |
|
| 2003 |
Nimnual AS, Taylor LJ, Bar-Sagi D. Redox-dependent downregulation of Rho by Rac. Nature Cell Biology. 5: 236-41. PMID 12598902 DOI: 10.1038/Ncb938 |
0.335 |
|
| 2003 |
Hall AB, Jura N, DaSilva J, Jang YJ, Gong D, Bar-Sagi D. hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Current Biology : Cb. 13: 308-14. PMID 12593796 DOI: 10.1016/S0960-9822(03)00086-1 |
0.626 |
|
| 2002 |
Hall BE, Bar-Sagi D, Nassar N. The structural basis for the transition from Ras-GTP to Ras-GDP. Proceedings of the National Academy of Sciences of the United States of America. 99: 12138-42. PMID 12213964 DOI: 10.1073/Pnas.192453199 |
0.45 |
|
| 2002 |
Nimnual A, Bar-Sagi D. The two hats of SOS. Science's Stke : Signal Transduction Knowledge Environment. 2002: pe36. PMID 12177507 DOI: 10.1126/Stke.2002.145.Pe36 |
0.407 |
|
| 2002 |
Archer H, Bar-Sagi D. Ras and Rac as activators of reactive oxygen species (ROS). Methods in Molecular Biology (Clifton, N.J.). 189: 67-73. PMID 12094595 DOI: 10.1385/1-59259-281-3:067 |
0.363 |
|
| 2002 |
Egan JE, Hall AB, Yatsula BA, Bar-Sagi D. The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Proceedings of the National Academy of Sciences of the United States of America. 99: 6041-6. PMID 11983899 DOI: 10.1073/Pnas.052090899 |
0.331 |
|
| 2002 |
Hall BE, Yang SS, Bar-Sagi D. Autoinhibition of Sos by intramolecular interactions. Frontiers in Bioscience : a Journal and Virtual Library. 7: d288-94. PMID 11779695 DOI: 10.2741/Hall |
0.447 |
|
| 2001 |
Lu W, Gong D, Bar-Sagi D, Cole PA. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling Molecular Cell. 8: 759-769. PMID 11684012 DOI: 10.1016/S1097-2765(01)00369-0 |
0.314 |
|
| 2001 |
Hall BE, Yang SS, Boriack-Sjodin PA, Kuriyan J, Bar-Sagi D. Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. The Journal of Biological Chemistry. 276: 27629-37. PMID 11333268 DOI: 10.1074/Jbc.M101727200 |
0.627 |
|
| 2001 |
Walsh AB, Bar-Sagi D. Differential Activation of the Rac Pathway by Ha-Ras and K-Ras Journal of Biological Chemistry. 276: 15609-15615. PMID 11278702 DOI: 10.1074/Jbc.M010573200 |
0.465 |
|
| 2001 |
Bar-Sagi D. A ras by any other name Molecular and Cellular Biology. 21: 1441-1443. PMID 11238880 DOI: 10.1128/Mcb.21.5.1441-1443.2001 |
0.462 |
|
| 2000 |
Bar-Sagi D, Hall A. Ras and Rho GTPases: A family reunion Cell. 103: 227-238. PMID 11057896 DOI: 10.1016/S0092-8674(00)00115-X |
0.484 |
|
| 2000 |
Taylor LJ, Walsh AB, Hearing P, Bar-Sagi D. Single cell assays for Rac activity Methods in Enzymology. 325: 327-334. PMID 11036615 DOI: 10.1016/S0076-6879(00)25454-2 |
0.334 |
|
| 2000 |
Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c- mediated death pathway Science. 288: 870-874. PMID 10797012 DOI: 10.1126/Science.288.5467.870 |
0.309 |
|
| 1999 |
Kumar CC, Ohashi K, Nagata K, Walsh A, Bar-Sagi D, Mizuno K. SCH 51334, an inhibitor of RAS/RAC-mediated cell morphology pathway Annals of the New York Academy of Sciences. 886: 122-131. PMID 10667210 DOI: 10.1111/J.1749-6632.1999.Tb09407.X |
0.493 |
|
| 1999 |
Joneson T, Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPpase Molecular and Cellular Biology. 19: 5892-5901. PMID 10454536 DOI: 10.1128/Mcb.19.9.5892 |
0.476 |
|
| 1998 |
Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell. 95: 259-68. PMID 9790532 DOI: 10.1016/S0092-8674(00)81756-0 |
0.504 |
|
| 1998 |
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J. The structural basis of the activation of Ras by Sos. Nature. 394: 337-43. PMID 9690470 DOI: 10.1038/28548 |
0.618 |
|
| 1998 |
Joneson T, Bar-Sagi D. A Rac1 effector site controlling mitogenesis through superoxide production Journal of Biological Chemistry. 273: 17991-17994. PMID 9660749 DOI: 10.1074/Jbc.273.29.17991 |
0.36 |
|
| 1998 |
Joneson T, Fulton JA, Volle DJ, Chaika OV, Bar-Sagi D, Lewis RE. Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. The Journal of Biological Chemistry. 273: 7743-8. PMID 9516483 DOI: 10.1074/Jbc.273.13.7743 |
0.458 |
|
| 1998 |
Corbalan-Garcia S, Margarit SM, Galron D, Yang SS, Bar-Sagi D. Regulation of Sos activity by intramolecular interactions. Molecular and Cellular Biology. 18: 880-6. PMID 9447984 DOI: 10.1128/Mcb.18.2.880 |
0.381 |
|
| 1998 |
Nimnual AS, Yatsula BA, Bar-Sagi D. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos Science. 279: 560-563. PMID 9438849 DOI: 10.1126/Science.279.5350.560 |
0.454 |
|
| 1997 |
Walsh AB, Dhanasekaran M, Bar-Sagi D, Kumar CC. SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene. 15: 2553-60. PMID 9399643 DOI: 10.1038/Sj.Onc.1201424 |
0.482 |
|
| 1997 |
Colley WC, Sung TC, Roll R, Jenco J, Hammondt SM, Altshuller Y, Bar-Sagi D, Morris AJ, Frohman MA. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization Current Biology. 7: 191-201. PMID 9395408 DOI: 10.1016/S0960-9822(97)70090-3 |
0.356 |
|
| 1997 |
Joneson T, Bar-Sagi D. Ras effectors and their role in mitogenesis and oncogenesis Journal of Molecular Medicine. 75: 587-593. PMID 9297626 DOI: 10.1007/S001090050143 |
0.478 |
|
| 1997 |
Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 89: 693-702. PMID 9182757 DOI: 10.1016/S0092-8674(00)80252-4 |
0.406 |
|
| 1997 |
Joneson T, Bar-Sagi D. Small gtpase cascades and growth control Faseb Journal. 11. |
0.388 |
|
| 1996 |
Joneson T, McDonough M, Bar-Sagi D, Van Aelst L. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science (New York, N.Y.). 274: 1374-6. PMID 8910277 DOI: 10.1126/Science.274.5291.1374 |
0.355 |
|
| 1996 |
Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D. Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2 Molecular and Cellular Biology. 16: 5674-5682. PMID 8816480 DOI: 10.1128/Mcb.16.10.5674 |
0.305 |
|
| 1996 |
Van Aelst L, Joneson T, Bar-Sagi D. Identification of a novel Rac1-interacting protein involved in membrane ruffling. The Embo Journal. 15: 3778-86. PMID 8670882 DOI: 10.1002/J.1460-2075.1996.Tb00751.X |
0.365 |
|
| 1996 |
Joneson T, White MA, Wigler MH, Bar-Sagi D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (New York, N.Y.). 271: 810-2. PMID 8628998 DOI: 10.1126/Science.271.5250.810 |
0.421 |
|
| 1996 |
Macara IG, Lounsbury KM, Richards SA, Mckiernan C, Bar-Sagi D. The Ras superfamily of GTPases Faseb Journal. 10: 625-630. PMID 8621061 DOI: 10.1096/fasebj.10.5.8621061 |
0.332 |
|
| 1995 |
Serrano M, Gómez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D. Inhibition of ras-induced proliferation and cellular transformation by p16INK4 Science. 267: 249-252. PMID 7809631 DOI: 10.1126/Science.7809631 |
0.449 |
|
| 1995 |
Yang SS, Van Aelst L, Bar-Sagi D. Differential interactions of human Sos1 and Sos2 with Grb2. The Journal of Biological Chemistry. 270: 18212-5. PMID 7629138 DOI: 10.1074/Jbc.270.31.18212 |
0.386 |
|
| 1994 |
Boyer MJ, Gutmann DH, Collins FS, Bar-Sagi D. Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP Oncogene. 9: 349-357. PMID 8290249 |
0.327 |
|
| 1994 |
Sun H, Tonks NK, Bar-Sagi D. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1 Science. 266: 285-288. PMID 7939666 DOI: 10.1126/Science.7939666 |
0.382 |
|
| 1994 |
Schlessinger J, Bar-Sagi D. Activation of Ras and other signaling pathways by receptor tyrosine kinases. Cold Spring Harbor Symposia On Quantitative Biology. 59: 173-9. PMID 7587067 DOI: 10.1101/Sqb.1994.059.01.021 |
0.404 |
|
| 1994 |
Bar-Sagi D. The Sos (Son of sevenless) protein Trends in Endocrinology and Metabolism. 5: 165-169. DOI: 10.1016/1043-2760(94)90014-0 |
0.435 |
|
| 1993 |
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (New York, N.Y.). 260: 1338-43. PMID 8493579 DOI: 10.1126/Science.8493579 |
0.447 |
|
| 1993 |
Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363: 85-8. PMID 8479541 DOI: 10.1038/363085A0 |
0.43 |
|
| 1993 |
Gale NW, Kaplan S, Lowenstein EJ, Schlessinger J, Bar-Sagi D. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature. 363: 88-92. PMID 8386805 DOI: 10.1038/363088A0 |
0.449 |
|
| 1993 |
Simon M, Dodson G, Rubin G, Olivier J, Egan S, Giddings B, Brooks M, Buday L, Sizeland A, Weinberg R, Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D, ... ... Bar-Sagi D, et al. Tyrosine kinases to Ras Trends in Cell Biology. 3: 228. DOI: 10.1016/0962-8924(93)90117-J |
0.4 |
|
| 1992 |
Bar-Sagi D. Mechanisms of signal transduction by Ras Seminars in Cell Biology. 3: 93-98. PMID 1611045 DOI: 10.1016/S1043-4682(10)80018-2 |
0.474 |
|
| 1992 |
Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 70: 431-42. PMID 1322798 DOI: 10.1016/0092-8674(92)90167-B |
0.436 |
|
| 1991 |
Graziadei L, Burfeind P, Bar-Sagi D. Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake Analytical Biochemistry. 194: 198-203. PMID 1714252 DOI: 10.1016/0003-2697(91)90168-S |
0.306 |
|
| 1990 |
Cockcroft S, Bar-Sagi D. Effects of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes Cellular Signalling. 2: 227-234. PMID 2169290 DOI: 10.1016/0898-6568(90)90050-K |
0.305 |
|
| 1990 |
Graziadei L, Riabowol K, Bar-Sagi D. Co-capping of ras proteins with surface immunoglobulins in B lymphocytes. Nature. 347: 396-400. PMID 2120590 DOI: 10.1038/347396A0 |
0.383 |
|
| 1989 |
Bar-Sagi D. Ras proteins: Biological effects and biochemical targets (Review) Anticancer Research. 9: 1427-1438. PMID 2686537 |
0.386 |
|
| 1988 |
Bar-Sagi D, Suhan JP, McCormick F, Feramisco JR. Localization of phospholipase A2 in normal and ras-transformed cells Journal of Cell Biology. 106: 1649-1658. PMID 3286660 DOI: 10.1083/Jcb.106.5.1649 |
0.435 |
|
| 1988 |
Bar-Sagi D, Gomperts BD. Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells Oncogene. 3: 463-469. PMID 3078954 |
0.37 |
|
| 1987 |
Bar-Sagi D, McCormick F, Milley RJ, Feramisco JR. Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells Journal of Cellular Physiology. 133: 69-73. PMID 3316255 DOI: 10.1002/Jcp.1041330414 |
0.452 |
|
| 1987 |
Bar-Sagi D, Fernandez A, Feramisco JR. Regulation of membrane turnover by ras proteins Bioscience Reports. 7: 427-434. PMID 3315033 DOI: 10.1007/Bf01362505 |
0.456 |
|
| 1986 |
Bar-Sagi D, Feramisco JR. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins Science. 233: 1061-1068. PMID 3090687 DOI: 10.1126/Science.3090687 |
0.454 |
|
| 1985 |
Bar-Sagi D, Feramisco JR. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation Cell. 42: 841-848. PMID 2996779 DOI: 10.1016/0092-8674(85)90280-6 |
0.442 |
|
| Show low-probability matches. |