| Year |
Citation |
Score |
| 2020 |
Molokhia S, Papangkorn K, Butler C, Higuchi JW, Brar B, Ambati B, Li SK, Higuchi WI. Transscleral Iontophoresis for Noninvasive Ocular Drug Delivery of Macromolecules. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 32155098 DOI: 10.1089/Jop.2019.0081 |
0.318 |
|
| 2014 |
Hymas RV, Ho NF, Higuchi WI. Capric Acid Absorption in the Presence of Hydroxypropyl-β-Cyclodextrin in the Rat Ileum using the In Situ Single-Pass Perfusion Technique. Journal of Pharmaceutical Sciences. PMID 25393711 DOI: 10.1002/Jps.24212 |
0.312 |
|
| 2013 |
Yan G, Moribe K, Otsuka M, Papangkorn K, Higuchi WI. Quantitative determination of lattice fluoride effects on the solubility and crystallinity of carbonated apatites with incorporated fluoride. Caries Research. 47: 193-202. PMID 23235353 DOI: 10.1159/000345080 |
0.548 |
|
| 2012 |
Hymas RV, Ho NF, Higuchi WI. Transport of a lipophilic ionizable permeant (capric acid) across a lipophilic membrane (silicone polymer membrane) from aqueous buffered solutions in the presence of hydroxypropyl-β-cyclodextrin. Journal of Pharmaceutical Sciences. 101: 2340-52. PMID 22544457 DOI: 10.1002/Jps.23120 |
0.375 |
|
| 2012 |
Otsuka M, Nakagawa H, Otsuka K, Ito A, Higuchi WI. Drug Release from a Three-Dimensionally Perforated Porous Apatite/Collagen Composite Cement Bioceramics Development and Applications. 2: 1-3. DOI: 10.4303/Bda/D110189 |
0.31 |
|
| 2011 |
Liddell MR, Li SK, Higuchi WI. Transport behavior of hairless mouse skin during constant current DC iontophoresis, part 2: iontophoresis of nonionic molecules with cotransport of polystyrene sulfonate oligomers. Journal of Pharmaceutical Sciences. 100: 2816-25. PMID 21455977 DOI: 10.1002/Jps.22520 |
0.795 |
|
| 2011 |
Liddell MR, Li SK, Higuchi WI. Transport behavior of hairless mouse skin during constant current DC iontophoresis I: baseline studies. Journal of Pharmaceutical Sciences. 100: 1475-87. PMID 21259234 DOI: 10.1002/Jps.22381 |
0.789 |
|
| 2010 |
Otsuka M, Nakagawa H, Ito A, Higuchi WI. Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement. Journal of Pharmaceutical Sciences. 99: 286-92. PMID 19821491 DOI: 10.1002/Jps.21835 |
0.325 |
|
| 2010 |
Yang J, Higuchi WI, Chiang H, Liu C. A Monomer-Micelle Model for the Formation of Simple Taurocholate Micelles Journal of the Chinese Chemical Society. 57: 199-204. DOI: 10.1002/Jccs.201000031 |
0.313 |
|
| 2009 |
Chantasart D, Pongjanyakul T, Higuchi WI, Li SK. Effects of oxygen-containing terpenes as skin permeation enhancers on the lipoidal pathways of human epidermal membrane. Journal of Pharmaceutical Sciences. 98: 3617-32. PMID 19156845 DOI: 10.1002/Jps.21666 |
0.338 |
|
| 2009 |
Xu Q, Ibrahim SA, Higuchi WI, Li SK. Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir. International Journal of Pharmaceutics. 369: 105-13. PMID 19041698 DOI: 10.1016/J.Ijpharm.2008.11.001 |
0.343 |
|
| 2008 |
Suhonen M, Li SK, Higuchi WI, Herron JN. A liposome permeability model for stratum corneum lipid bilayers based on commercial lipids. Journal of Pharmaceutical Sciences. 97: 4278-93. PMID 18240299 DOI: 10.1002/Jps.21306 |
0.308 |
|
| 2008 |
Papangkorn K, Yan G, Heslop DD, Moribe K, Baig AA, Otsuka M, Higuchi WI. Influence of crystallite microstrain on surface complexes governing the metastable equilibrium solubility behavior of carbonated apatites. Journal of Colloid and Interface Science. 320: 96-109. PMID 18222463 DOI: 10.1016/J.Jcis.2007.07.084 |
0.764 |
|
| 2008 |
Tsutsumi K, Li SK, Hymas RV, Teng CL, Tillman LG, Hardee GE, Higuchi WI, Ho NF. Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer. Journal of Pharmaceutical Sciences. 97: 350-67. PMID 17847071 DOI: 10.1002/Jps.21093 |
0.348 |
|
| 2008 |
Yan G, Xu Q, Anissimov YG, Hao J, Higuchi WI, Li SK. Alternating current (AC) iontophoretic transport across human epidermal membrane: effects of AC frequency and amplitude. Pharmaceutical Research. 25: 616-24. PMID 17703345 DOI: 10.1007/S11095-007-9405-2 |
0.519 |
|
| 2008 |
Warner KS, Shaker DS, Molokhia S, Xu Q, Hao J, Higuchi WI, Li SK. Silicone elastomer uptake method for determination of free 1-alkyl-2-pyrrolidone concentration in micelle and hydroxypropyl-beta-cyclodextrin systems used in skin transport studies. Journal of Pharmaceutical Sciences. 97: 368-80. PMID 17688265 DOI: 10.1002/Jps.21094 |
0.772 |
|
| 2007 |
Longo N, Li SK, Yan G, Kochambilli RP, Papangkorn K, Berglund D, Ghanem AH, Ashurst CL, Ernst SL, Pasquali M, Higuchi WI. Noninvasive measurement of phenylalanine by iontophoretic extraction in patients with phenylketonuria. Journal of Inherited Metabolic Disease. 30: 910-5. PMID 17912613 DOI: 10.1007/S10545-007-0675-Y |
0.509 |
|
| 2007 |
Wang D, Miller SC, Shlyakhtenko LS, Portillo AM, Liu XM, Papangkorn K, Kopecková P, Lyubchenko Y, Higuchi WI, Kopecek J. Osteotropic Peptide that differentiates functional domains of the skeleton. Bioconjugate Chemistry. 18: 1375-8. PMID 17705416 DOI: 10.1021/Bc7002132 |
0.445 |
|
| 2007 |
Chantasart D, Sa-Nguandeekul P, Prakongpan S, Li SK, Higuchi WI. Comparison of the effects of chemical permeation enhancers on the lipoidal pathways of human epidermal membrane and hairless mouse skin and the mechanism of enhancer action. Journal of Pharmaceutical Sciences. 96: 2310-26. PMID 17387696 DOI: 10.1002/Jps.20865 |
0.353 |
|
| 2006 |
Li SK, Zhu H, Higuchi WI. Enhanced transscleral lontophoretic transport with ion-exchange membrane. Pharmaceutical Research. 23: 1857-67. PMID 16841198 DOI: 10.1007/S11095-006-9010-9 |
0.521 |
|
| 2005 |
Yan G, Li SK, Higuchi WI. Evaluation of constant current alternating current iontophoresis for transdermal drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 110: 141-50. PMID 16289410 DOI: 10.1016/J.Jconrel.2005.09.006 |
0.554 |
|
| 2005 |
Heslop DD, Bi Y, Baig AA, Otsuka M, Higuchi WI. A comparative study of the metastable equilibrium solubility behavior of high-crystallinity and low-crystallinity carbonated apatites using pH and solution strontium as independent variables. Journal of Colloid and Interface Science. 289: 14-25. PMID 15913637 DOI: 10.1016/J.Jcis.2004.12.050 |
0.785 |
|
| 2005 |
He N, Warner KS, Higuchi WI, Li SK. Model analysis of flux enhancement across hairless mouse skin induced by chemical permeation enhancers. International Journal of Pharmaceutics. 297: 9-21. PMID 15907593 DOI: 10.1016/J.Ijpharm.2005.01.041 |
0.778 |
|
| 2005 |
Li SK, Zhang Y, Zhu H, Higuchi WI, White HS. Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport. Journal of Pharmaceutical Sciences. 94: 847-60. PMID 15736190 DOI: 10.1002/Jps.20293 |
0.563 |
|
| 2005 |
Yan G, Peck KD, Zhu H, Higuchi WI, Li SK. Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane. Journal of Pharmaceutical Sciences. 94: 547-58. PMID 15637683 DOI: 10.1002/Jps.20247 |
0.639 |
|
| 2005 |
Kevin Li S, Zhang Y, Zhu H, Higuchi WI, White HS. Influence of asymmetric donor–receiver ion concentration upon transscleral iontophoretic transport. J. Pharm. Sci. 94, 847–860, 2005. Journal of Pharmaceutical Sciences. 94: 2344. DOI: 10.1002/Jps.20482 |
0.49 |
|
| 2004 |
Yan G, Li SK, Peck KD, Zhu H, Higuchi WI. Quantitative study of electrophoretic and electroosmotic enhancement during alternating current iontophoresis across synthetic membranes. Journal of Pharmaceutical Sciences. 93: 2895-908. PMID 15459891 DOI: 10.1002/Jps.20162 |
0.648 |
|
| 2004 |
Yan G, Higuchi WI, Szabo A, Li SK. Correlation of transdermal iontophoretic phenylalanine and mannitol transport: test of the internal standard concept under DC iontophoresis and constant resistance AC iontophoresis conditions. Journal of Controlled Release : Official Journal of the Controlled Release Society. 98: 127-38. PMID 15245895 DOI: 10.1016/J.Jconrel.2004.04.016 |
0.524 |
|
| 2004 |
He N, Warner KS, Chantasart D, Shaker DS, Higuchi WI, Li SK. Mechanistic study of chemical skin permeation enhancers with different polar and lipophilic functional groups. Journal of Pharmaceutical Sciences. 93: 1415-30. PMID 15124201 DOI: 10.1002/Jps.20030 |
0.779 |
|
| 2004 |
Li SK, Higuchi WI, Kochambilli RP, Zhu H. Mechanistic studies of flux variability of neutral and ionic permeants during constant current dc iontophoresis with human epidermal membrane. International Journal of Pharmaceutics. 273: 9-22. PMID 15010125 DOI: 10.1016/J.Ijpharm.2003.12.009 |
0.545 |
|
| 2004 |
Chantasart D, Li SK, He N, Warner KS, Prakongpan S, Higuchi WI. Mechanistic studies of branched-chain alkanols as skin permeation enhancers. Journal of Pharmaceutical Sciences. 93: 762-79. PMID 14762914 DOI: 10.1002/Jps.10550 |
0.77 |
|
| 2004 |
Heslop DD, Bi Y, Baig AA, Higuchi WI. Metastable equilibrium solubility behavior of carbonated apatite in the presence of solution strontium. Calcified Tissue International. 74: 72-85. PMID 14564430 DOI: 10.1007/S00223-002-0035-8 |
0.786 |
|
| 2003 |
Li SK, Higuchi WI, Zhu H, Kern SE, Miller DJ, Hastings MS. In vitro and in vivo comparisons of constant resistance AC iontophoresis and DC iontophoresis. Journal of Controlled Release : Official Journal of the Controlled Release Society. 91: 327-43. PMID 12932711 DOI: 10.1016/S0168-3659(03)00268-2 |
0.523 |
|
| 2003 |
Warner KS, Li SK, He N, Suhonen TM, Chantasart D, Bolikal D, Higuchi WI. Structure-activity relationship for chemical skin permeation enhancers: probing the chemical microenvironment of the site of action. Journal of Pharmaceutical Sciences. 92: 1305-22. PMID 12761819 DOI: 10.1002/Jps.10367 |
0.768 |
|
| 2003 |
Zhu H, Peck KD, Miller DJ, Liddell MR, Yan G, Higuchi WI, Li SK. Investigation of properties of human epidermal membrane under constant conductance alternating current iontophoresis. Journal of Controlled Release : Official Journal of the Controlled Release Society. 89: 31-46. PMID 12695061 DOI: 10.1016/S0168-3659(03)00032-4 |
0.779 |
|
| 2003 |
Shaker DS, Ghanem AH, Li SK, Warner KS, Hashem FM, Higuchi WI. Mechanistic studies of the effect of hydroxypropyl-beta-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin. International Journal of Pharmaceutics. 253: 1-11. PMID 12593932 DOI: 10.1016/S0378-5173(02)00625-7 |
0.785 |
|
| 2003 |
Tsutsumi K, Li SK, Ghanem AH, Ho NF, Higuchi WI. A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes. Journal of Pharmaceutical Sciences. 92: 344-59. PMID 12532384 DOI: 10.1002/Jps.10278 |
0.358 |
|
| 2003 |
He N, Li SK, Suhonen TM, Warner KS, Higuchi WI. Mechanistic study of alkyl azacycloheptanones as skin permeation enhancers by permeation and partition experiments with hairless mouse skin. Journal of Pharmaceutical Sciences. 92: 297-310. PMID 12532380 DOI: 10.1002/Jps.10269 |
0.77 |
|
| 2003 |
Barry AB, Zhuang H, Baig AA, Higuchi WI. Effect of fluoride pretreatment on the solubility of synthetic carbonated apatite Calcified Tissue International. 72: 236-242. PMID 12532280 DOI: 10.1007/S00223-001-1069-Z |
0.787 |
|
| 2002 |
Zhu H, Li SK, Peck KD, Miller DJ, Higuchi WI. Improvement on conventional constant current DC iontophoresis: a study using constant conductance AC iontophoresis. Journal of Controlled Release : Official Journal of the Controlled Release Society. 82: 249-61. PMID 12175741 DOI: 10.1016/S0168-3659(02)00107-4 |
0.543 |
|
| 2002 |
Barry AB, Baig AA, Miller SC, Higuchi WI. Effect of age on rat bone solubility and crystallinity Calcified Tissue International. 71: 167-171. PMID 12060867 DOI: 10.1007/S00223-001-1071-5 |
0.766 |
|
| 2002 |
Song Y, Li SK, Peck KD, Zhu H, Ghanem AH, Higuchi WI. Human epidermal membrane constant conductance iontophoresis: alternating current to obtain reproducible enhanced permeation and reduced lag times of a nonionic polar permeant. International Journal of Pharmaceutics. 232: 45-57. PMID 11790489 DOI: 10.1016/S0378-5173(01)00910-3 |
0.539 |
|
| 2001 |
Zhuang H, Baig AA, Zhang N, Chhettry A, Higuchi WI. Relationships involving metastable equilibrium solubility, surface complexes, and crystallite disorder with carbonated apatites. Calcified Tissue International. 69: 343-9. PMID 11800231 DOI: 10.1007/S00223-001-1038-6 |
0.792 |
|
| 2001 |
Warner KS, Li SK, Higuchi WI. Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement. Journal of Pharmaceutical Sciences. 90: 1143-53. PMID 11536219 DOI: 10.1002/Jps.1068 |
0.756 |
|
| 2001 |
Zhu H, Peck KD, Li SK, Ghanem AH, Higuchi WI. Quantification of pore induction in human epidermal membrane during iontophoresis: the importance of background electrolyte selection. Journal of Pharmaceutical Sciences. 90: 932-42. PMID 11458340 DOI: 10.1002/Jps.1044 |
0.536 |
|
| 2001 |
Li SK, Ghanem AH, Teng CL, Hardee GE, Higuchi WI. Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model. Journal of Pharmaceutical Sciences. 90: 915-31. PMID 11458339 DOI: 10.1002/Jps.1043 |
0.344 |
|
| 2000 |
Otsuka M, Matsuda Y, Baig AA, Chhettry A, Higuchi WI. Calcium-level responsive controlled drug delivery from implant dosage forms to treat osteoporosis in an animal model. Advanced Drug Delivery Reviews. 42: 249-58. PMID 10963839 DOI: 10.1016/S0169-409X(00)00065-X |
0.772 |
|
| 2000 |
Zhuang H, Baig AA, Fox JL, Wang Z, Colby SJ, Chhettry A, Higuchi WI. Metastable Equilibrium Solubility Behavior of Carbonated Apatites in the Presence of Solution Fluoride. Journal of Colloid and Interface Science. 222: 90-96. PMID 10655129 DOI: 10.1006/jcis.1999.6557 |
0.799 |
|
| 1999 |
Higuchi WI, Li SK, Ghanem AH, Zhu H, Song Y. Mechanistic aspects of iontophoresis in human epidermal membrane. Journal of Controlled Release : Official Journal of the Controlled Release Society. 62: 13-23. PMID 10518630 DOI: 10.1016/S0168-3659(99)00026-7 |
0.551 |
|
| 1999 |
Chhettry A, Wang Z, Hsu J, Fox JL, Baig AA, Barry AM, Zhuang H, Otsuka M, Higuchi WI. Metastable Equilibrium Solubility Distribution of Carbonated Apatite as a Function of Solution Composition. Journal of Colloid and Interface Science. 218: 57-67. PMID 10489279 DOI: 10.1006/jcis.1999.6384 |
0.797 |
|
| 1999 |
Chhettry A, Wang Z, Fox JL, Baig AA, Zhuang H, Higuchi WI. Use of Dicalcium Phosphate Dihydrate as a Probe in an Approach for Accurate Calculations of Solution Equilibria in Buffered Calcium Phosphate Systems. Journal of Colloid and Interface Science. 218: 47-56. PMID 10489278 DOI: 10.1006/Jcis.1999.6307 |
0.795 |
|
| 1999 |
Baig AA, Fox JL, Young RA, Wang Z, Hsu J, Higuchi WI, Chhettry A, Zhuang H, Otsuka M. Relationships among carbonated apatite solubility, crystallite size, and microstrain parameters. Calcified Tissue International. 64: 437-49. PMID 10203421 DOI: 10.1007/Pl00005826 |
0.776 |
|
| 1999 |
Li SK, Ghanem AH, Peck KD, Higuchi WI. Pore induction in human epidermal membrane during low to moderate voltage iontophoresis: A study using AC iontophoresis. Journal of Pharmaceutical Sciences. 88: 419-27. PMID 10187752 DOI: 10.1021/Js980331Y |
0.311 |
|
| 1998 |
HIGUCHI WI, ROWE EL, HIESTAND EN. Dissolution rates of finely divided drug powders. II. Micronized methyl-prednisolone. Journal of Pharmaceutical Sciences. 52: 162-4. PMID 13954439 DOI: 10.1002/Jps.2600520213 |
0.32 |
|
| 1998 |
Otsuka M, Nakahigashi Y, Matsuda Y, Fox JL, Higuchi WI, Sugiyama Y. Effect of geometrical cement size on in vitro and in vivo indomethacin release from self-setting apatite cement. Journal of Controlled Release : Official Journal of the Controlled Release Society. 52: 281-9. PMID 9743448 DOI: 10.1016/S0168-3659(97)00264-2 |
0.301 |
|
| 1998 |
Peck KD, Hsu J, Li SK, Ghanem AH, Higuchi WI. Flux enhancement effects of ionic surfactants upon passive and electroosmotic transdermal transport. Journal of Pharmaceutical Sciences. 87: 1161-9. PMID 9724571 DOI: 10.1021/Js970012R |
0.355 |
|
| 1998 |
Afouna MI, Mehta SC, Ghanem AH, Higuchi WI, Kern ER, De Clercq E, El-Shattawy HH. Assessment of correlation between skin target site free drug concentration and the in vivo topical antiviral efficacy in hairless mice for (E)-5-(2-bromovinyl)-2'-deoxyuridine and acyclovir formulations. Journal of Pharmaceutical Sciences. 87: 917-21. PMID 9687333 DOI: 10.1021/Js980052A |
0.343 |
|
| 1998 |
Yoneto K, Li SK, Higuchi WI, Shimabayashi S. Influence of the permeation enhancers 1-alkyl-2-pyrrolidones on permeant partitioning into the stratum corneum. Journal of Pharmaceutical Sciences. 87: 209-14. PMID 9519155 DOI: 10.1021/Js970190K |
0.316 |
|
| 1998 |
Li SK, Ghanem AH, Peck KD, Higuchi WI. Characterization of the transport pathways induced during low to moderate voltage iontophoresis in human epidermal membrane. Journal of Pharmaceutical Sciences. 87: 40-8. PMID 9452966 DOI: 10.1021/Js970189L |
0.322 |
|
| 1998 |
Li S, Suh W, Parikh HH, Ghanem A, Mehta SC, Peck KD, Higuchi WI. Lag time data for characterizing the pore pathway of intact and chemically pretreated human epidermal membrane International Journal of Pharmaceutics. 170: 93-108. DOI: 10.1016/S0378-5173(98)00139-2 |
0.33 |
|
| 1997 |
Mehta SC, Afouna MI, Ghanem AH, Higuchi WI, Kern ER. Relationship of skin target site free drug concentration (C*) to the in vivo efficacy: an extensive evaluation of the predictive value of the C* concept using acyclovir as a model drug. Journal of Pharmaceutical Sciences. 86: 797-801. PMID 9232519 DOI: 10.1021/Js960515H |
0.323 |
|
| 1997 |
Li SK, Ghanem AH, Peck KD, Higuchi WI. Iontophoretic transport across a synthetic membrane and human epidermal membrane: a study of the effects of permeant charge. Journal of Pharmaceutical Sciences. 86: 680-9. PMID 9188050 DOI: 10.1021/Js960479M |
0.332 |
|
| 1997 |
Peck KD, Srinivasan V, Li SK, Higuchi WI, Ghanem AH. Quantitative description of the effect of molecular size upon electroosmotic flux enhancement during iontophoresis for a synthetic membrane and human epidermal membrane. Journal of Pharmaceutical Sciences. 85: 781-8. PMID 8819006 DOI: 10.1021/Js950044J |
0.337 |
|
| 1997 |
Otsuka M, Nakahigashi Y, Matsuda Y, Fox JL, Higuchi WI, Sugiyama Y. A novel skeletal drug delivery system using self-setting calcium phosphate cement VIII: the relationship between in vitro and in vivo drug release from indomethacin-containing cement Journal of Controlled Release. 43: 115-122. DOI: 10.1016/S0168-3659(96)01493-9 |
0.329 |
|
| 1996 |
Wang Z, Fox JL, Baig AA, Otsuka M, Higuchi WI. Calculation of intercrystalline solution composition during in vitro subsurface lesion formation in dental minerals. Journal of Pharmaceutical Sciences. 85: 117-28. PMID 8926576 DOI: 10.1021/Js940685Z |
0.357 |
|
| 1996 |
Yoneto K, Li SK, Higuchi WI, Jiskoot W, Herron JN. Fluorescent probe studies of the interactions of 1-alkyl-2-pyrrolidones with stratum corneum lipid liposomes. Journal of Pharmaceutical Sciences. 85: 511-7. PMID 8742943 DOI: 10.1021/Js950471X |
0.305 |
|
| 1996 |
Peck KD, Ghanem AH, Higuchi WI. The effect of temperature upon the permeation of polar and ionic solutes through human epidermal membrane. Journal of Pharmaceutical Sciences. 84: 975-82. PMID 7500283 DOI: 10.1002/Jps.2600840813 |
0.309 |
|
| 1995 |
Otsuka M, Nakahigashi Y, Matsuda Y, Fox JL, Higuchi WI. A novel skeletal drug delivery system using self-setting calcium phosphate cement. 7. Effect of biological factors on indomethacin release from the cement loaded on bovine bone. Journal of Pharmaceutical Sciences. 83: 1569-73. PMID 7891276 DOI: 10.1002/Jps.2600831110 |
0.312 |
|
| 1995 |
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI. A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 5. Drug release behavior from a heterogeneous drug-loaded cement containing an anticancer drug. Journal of Pharmaceutical Sciences. 83: 1565-8. PMID 7891275 DOI: 10.1002/Jps.2600831109 |
0.325 |
|
| 1995 |
Yoneto K, Ghanem A, Higuchi WI, Peck KD, Li SK. Mechanistic Studies of the 1‐Alkyl‐2‐pyrrolidones as Skin Permeation Enhancers Journal of Pharmaceutical Sciences. 84: 312-317. PMID 7616370 DOI: 10.1002/Jps.2600840310 |
0.365 |
|
| 1995 |
Yoneto K, Li SK, Ghanem AH, Crommelin DJ, Higuchi WI. A mechanistic study of the effects of the 1-alkyl-2-pyrrolidones on bilayer permeability of stratum corneum lipid liposomes: a comparison with hairless mouse skin studies. Journal of Pharmaceutical Sciences. 84: 853-61. PMID 7562437 DOI: 10.1002/Jps.2600840714 |
0.374 |
|
| 1995 |
Otsuka M, Matsuda Y, Fox JL, Higuchi WI. A novel skeletal drug delivery system using self-setting calcium phosphate cement. 9: Effects of the mixing solution volume on anticancer drug release from homogeneous drug-loaded cement. Journal of Pharmaceutical Sciences. 84: 733-6. PMID 7562414 DOI: 10.1002/Jps.2600840614 |
0.347 |
|
| 1995 |
Fox JL, Bergstrom DH, Higuchi WI. Physical model for lesion formation in the presence of low levels of solution fluoride. Journal of Pharmaceutical Sciences. 84: 1005-13. PMID 7500269 DOI: 10.1002/Jps.2600840818 |
0.348 |
|
| 1994 |
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI. A novel skeletal drug-delivery system using self-setting calcium phosphate cement. 4. Effects of the mixing solution volume on the drug-release rate of heterogeneous aspirin-loaded cement. Journal of Pharmaceutical Sciences. 83: 259-63. PMID 8169801 DOI: 10.1002/Jps.2600830230 |
0.36 |
|
| 1994 |
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI. A novel skeletal drug-delivery system using self-setting calcium phosphate cement. 3. Physicochemical properties and drug-release rate of bovine insulin and bovine albumin. Journal of Pharmaceutical Sciences. 83: 255-8. PMID 8169800 DOI: 10.1002/Jps.2600830229 |
0.322 |
|
| 1994 |
Su MH, Srinivasan V, Ghanem AH, Higuchi WI. Quantitative in vivo iontophoretic studies. Journal of Pharmaceutical Sciences. 83: 12-7. PMID 8138902 DOI: 10.1002/Jps.2600830105 |
0.305 |
|
| 1994 |
Otsuka M, Matsuda Y, Suwa Y, Fox JL, Higuchi WI. A novel skeletal drug delivery system using self-setting calcium phosphate cement. 2. Physicochemical properties and drug release rate of the cement-containing indomethacin. Journal of Pharmaceutical Sciences. 83: 611-5. PMID 8071805 DOI: 10.1002/Jps.2600830502 |
0.332 |
|
| 1994 |
Imanidis G, Song WQ, Lee PH, Su MH, Kern ER, Higuchi WI. Estimation of skin target site acyclovir concentrations following controlled (trans)dermal drug delivery in topical and systemic treatment of cutaneous HSV-1 infections in hairless mice. Pharmaceutical Research. 11: 1035-41. PMID 7937545 DOI: 10.1023/A:1018995606568 |
0.32 |
|
| 1994 |
Liu P, Higuchi WI, Ghanem AH, Good WR. Transport of β-Estradiol in Freshly Excised Human Skin in Vitro: Diffusion and Metabolism in Each Skin Layer Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 11: 1777-1784. PMID 7899244 DOI: 10.1023/A:1018975602818 |
0.319 |
|
| 1994 |
Peck KD, Ghanem AH, Higuchi WI. Hindered Diffusion of Polar Molecules Through and Effective Pore Radii Estimates of Intact and Ethanol Treated Human Epidermal Membrane Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 11: 1306-1314. PMID 7816761 DOI: 10.1023/A:1018998529283 |
0.307 |
|
| 1994 |
Inamori T, Ghanem AH, Higuchi WI, Srinivasan V. Macromolecule transport in and effective pore size of ethanol pretreated human epidermal membrane International Journal of Pharmaceutics. 105: 113-123. DOI: 10.1016/0378-5173(94)90457-X |
0.315 |
|
| 1993 |
Shah VP, Behl CR, Flynn GL, Higuchi WI, Schaefer H. Principles and criteria in the development and optimization of topical therapeutic products. Skin Pharmacology : the Official Journal of the Skin Pharmacology Society. 6: 72-80. PMID 8489779 DOI: 10.1159/000211090 |
0.531 |
|
| 1993 |
Lee PH, Su M, Ghanem A, Inamori T, Kern ER, Higuchi WI. An application of the C∗ concept in predicting the topical efficacy of finite dose acyclovir in the treatment of cutaneous HSV-1 infections in hairless mice International Journal of Pharmaceutics. 93: 139-152. DOI: 10.1016/0378-5173(93)90172-C |
0.301 |
|
| 1993 |
Peck KD, Ghanem AH, Higuchi WI, Srinivasan V. Improved stability of the human epidermal membrane during successive permeability experiments International Journal of Pharmaceutics. 98: 141-147. DOI: 10.1016/0378-5173(93)90050-P |
0.302 |
|
| 1993 |
Krill SL, Knutson K, Higuchi WI. The influence of iso-propanol, n-propanol and n-butanol on stratum corneum lipid phase behavior Journal of Controlled Release. 25: 31-42. DOI: 10.1016/0168-3659(93)90092-J |
0.307 |
|
| 1993 |
Sims SM, Higuchi WI, Srinivasan V, Peck K. Ionic Partition Coefficients and Electroosmotic Flow in Cylindrical Pores: Comparison of the Predictions of the Poisson-Boltzmann Equation with Experiment Journal of Colloid and Interface Science. 155: 210-220. DOI: 10.1006/Jcis.1993.1027 |
0.329 |
|
| 1992 |
Si SM, Higuchi WI, Srinivasan V. Skin Alteration and Convective Solvent Flow Effects During Iontophoresis II. Monovalent Anion and Cation Transport Across Human Skin Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 9: 1402-1409. PMID 1475225 DOI: 10.1023/A:1015898510531 |
0.316 |
|
| 1992 |
Krill SL, Knutson K, Higuchi WI. The stratum corneum lipid thermotropic phase behavior Bba - Biomembranes. 1112: 281-286. PMID 1457460 DOI: 10.1016/0005-2736(92)90403-9 |
0.327 |
|
| 1992 |
Krill SL, Knutson K, Higuchi WI. Ethanol effects on the stratum corneum lipid phase behavior Bba - Biomembranes. 1112: 273-280. PMID 1457459 DOI: 10.1016/0005-2736(92)90402-8 |
0.307 |
|
| 1992 |
Borsadia S, Ghanem AH, Seta Y, Higuchi WI, Flynn GL, Behl CR, Shah VP. Factors to be considered in the evaluation of bioavailability and bioequivalence of topical formulations Skin Pharmacology. 5: 129-145. PMID 1445703 DOI: 10.1159/000211030 |
0.605 |
|
| 1992 |
Shah VP, Behl CR, Flynn GL, Higuchi WI, Schaefer H. Principles and criteria in the development and optimization of topical therapeutic products Journal of Pharmaceutical Sciences. 81: 1051-1054. PMID 1432620 DOI: 10.1002/Jps.2600811020 |
0.527 |
|
| 1992 |
Shah VP, Behl CR, Flynn GL, Higuchi WI, Schaefer H. Principles and criteria in the development and optimization of topical therapeutic products. Pharmaceutical Research. 9: 1107-11. PMID 1357648 DOI: 10.1023/A:1015831201020 |
0.513 |
|
| 1992 |
Liu P, Higuchi WI, Ghanem A, Kurihara-Bergstrom T, Good WR. Assessing the influence of ethanol on simultaneous diffusion and metabolism of ß-estradiol in hairless mouse skin for the ‘asymmetric’ situation in vitro International Journal of Pharmaceutics. 78: 123-136. DOI: 10.1016/0378-5173(92)90364-8 |
0.34 |
|
| 1992 |
Kim YH, Ghanem AH, Mahmoud H, Higuchi WI. Short chain alkanols as transport enhancers for lipophilic and polar/ionic permeants in hairless mouse skin: Mechanism(s) of action International Journal of Pharmaceutics. 80: 17-31. DOI: 10.1016/0378-5173(92)90258-4 |
0.364 |
|
| 1992 |
Shah VP, Behl CR, Flynn GL, Higuchi WI, Schaefer H, Barry BW, Behl CR, Conners DP, Evans C, Flynn GL, Franz TJ, Gans EH, Higuchi WI, Kail N, Krueger GG, et al. Principles and criteria in the development and optimization of topical therapeutic products International Journal of Pharmaceutics. 82: 21-28. DOI: 10.1016/0378-5173(92)90067-C |
0.533 |
|
| 1992 |
Seta Y, Ghanem AH, Higuchi WI, Borsadia S, Behl CR, Malick AW. Physical model approach to understanding finite dose transport and uptake of hydrocortisone in hairless guinea-pig skin International Journal of Pharmaceutics. 81: 89-99. DOI: 10.1016/0378-5173(92)90046-5 |
0.35 |
|
| 1991 |
Komada F, Imanidis G, Miyajima M, Okano T, Durrani MJ, Higuchi WI, Kim SW, Shannon WM, Baker DC. Design of 9-beta-D-arabinofuranosyladenine (ara-A) transdermal delivery system for animal studies: regulation of drug concentration in vivo. Journal of Pharmaceutical Sciences. 80: 935-41. PMID 1784002 DOI: 10.1002/Jps.2600801007 |
0.306 |
|
| 1991 |
Snah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A, Anderson BD, Andersen KE, Barry BW, Behl CR, Benet LZ, Bronaugh RL, Bucks DAW, ... ... Higuchi WI, et al. In vivo percutaneous penetration/absorption. Sponsored by the American Association of Pharmaceutical Scientist, U.S. Food and Drug Administration, American Academy of Dermatology, Skin Pharmacology Society and the U.S. Army Environmental Hygiene Agency May 1-3, 1989, Washington, DC International Journal of Pharmaceutics. 74: 1-8. DOI: 10.1016/0378-5173(91)90402-A |
0.692 |
|
| 1991 |
Sims SM, Higuchi WI, Srinivasan V. Interaction of electric field and electro-osmotic effects in determining iontophoretic enhancement of anions and cations International Journal of Pharmaceutics. 77: 107-118. DOI: 10.1016/0378-5173(91)90308-B |
0.314 |
|
| 1991 |
Sims SM, Higuchi WI, Srinivasan V. Skin alteration and convective solvent flow effects during iontophoresis: I. Neutral solute transport across human skin International Journal of Pharmaceutics. 69: 109-121. DOI: 10.1016/0378-5173(91)90216-B |
0.317 |
|
| 1990 |
Srinivasan V, Su MH, Higuchi WI, Behl CR. Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin. Journal of Pharmaceutical Sciences. 79: 588-91. PMID 2118954 DOI: 10.1002/Jps.2600790708 |
0.336 |
|
| 1990 |
Sims SM, Higuchi WI. Baseline studies on iontophoretic transport in hairless mouse skin: the effect of applied voltage drop and ph on the iontophoresis of a model weak electrolyte Journal of Membrane Science. 49: 305-320. DOI: 10.1016/S0376-7388(00)80645-6 |
0.356 |
|
| 1990 |
Liu P, Higuchi WI, Ghanem A, Kurihara-Bergstrom T, Good WR. Quantitation of simultaneous diffusion and metabolism of β-estradiol in hairless mouse skin: Enzyme distribution and intrinsic diffusion/metabolism parameters International Journal of Pharmaceutics. 64: 7-25. DOI: 10.1016/0378-5173(90)90174-3 |
0.316 |
|
| 1990 |
Lee PH, Higuchi WI, Mazer NA. Cholesterol monohydrate dissolution rates and solubilities in aqueous taurocholate, taurochenodeoxycholate, and tauroursodeoxycholate solutions: A comparative study Journal of Colloid and Interface Science. 137: 48-65. DOI: 10.1016/0021-9797(90)90042-M |
0.387 |
|
| 1989 |
Chu JS, Fox JL, Higuchi WI. Quantitative Study of Fluoride Transport During Subsurface Dissolution of Dental Enamel Journal of Dental Research. 68: 32-41. PMID 2910957 DOI: 10.1177/00220345890680010501 |
0.342 |
|
| 1989 |
Lambert WJ, Higuchi WI, Knutson K, Krill SL. Dose-Dependent Enhancement Effects of Azone on Skin Permeability Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 798-803. PMID 2813277 DOI: 10.1023/A:1015931715829 |
0.367 |
|
| 1989 |
Srinivasan V, Higuchi WI, Sims SM, Ghanem AH, Behl CR. Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery. Journal of Pharmaceutical Sciences. 78: 370-5. PMID 2664125 DOI: 10.1002/Jps.2600780506 |
0.377 |
|
| 1989 |
Behl CR, Kumar S, Malick AW, DelTerzo S, Higuchi WI, Nash RA. Iontophoretic drug delivery: effects of physicochemical factors on the skin uptake of nonpeptide drugs. Journal of Pharmaceutical Sciences. 78: 355-60. PMID 2664123 DOI: 10.1002/Jps.2600780503 |
0.3 |
|
| 1989 |
Lambert WJ, Higuchi WI, Knutson K, Krill SL. Effects of long-term hydration leading to the development of polar channels in hairless mouse stratum corneum Journal of Pharmaceutical Sciences. 78: 925-928. PMID 2621576 DOI: 10.1002/Jps.2600781109 |
0.321 |
|
| 1989 |
MASADA T, HIGUCHI W, SRINIVASAN V, ROHR U, FOX J, BEHL C, PONS S. Examination of iontophoretic transport of ionic drugs across skin: baseline studies with the four-electrode system International Journal of Pharmaceutics. 49: 57-62. DOI: 10.1016/0378-5173(89)90152-X |
0.345 |
|
| 1989 |
Srinivasan V, Higuchi WI, Su MH. Baseline studies with the four-electrode system: The effect of skin permeability increase and water transport on the flux of a model uncharged solute during iontophoresis Journal of Controlled Release. 10: 157-165. DOI: 10.1016/0168-3659(89)90058-8 |
0.332 |
|
| 1989 |
Fox JL, Dave SC, Higuchi WI. Growth kinetics of fluorapatite deposition on synthetic hydroxyapatite seed crystals Journal of Colloid and Interface Science. 130: 236-253. DOI: 10.1016/0021-9797(89)90096-9 |
0.313 |
|
| 1988 |
Anderson BD, Higuchi WI, Raykar PV. Heterogeneity Effects on Permeability–Partition Coefficient Relationships in Human Stratum Corneum Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 566-573. PMID 3247319 DOI: 10.1023/A:1015989929342 |
0.602 |
|
| 1988 |
Lee PH, Cheng DC, Takayama K, Higuchi WI. Silicone polymer uptake method for determination of cholesterol thermodynamic activity in model bile systems. Journal of Pharmaceutical Sciences. 77: 610-4. PMID 3171948 DOI: 10.1002/Jps.2600770712 |
0.307 |
|
| 1987 |
Kurihara-Bergstrom T, Flynn GL, Higuchi WI. Physicochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: Dimethyl sulfoxide mediation of vidarabine (ara-A) permeation of hairless mouse skin Journal of Investigative Dermatology. 89: 274-280. PMID 3624900 DOI: 10.1111/1523-1747.Ep12471379 |
0.617 |
|
| 1987 |
Patel MV, Fox JL, Higuchi WI. Physical model for non-steady-state dissolution of dental enamel. Journal of Dental Research. 66: 1418-24. PMID 3476613 DOI: 10.1177/00220345870660090201 |
0.343 |
|
| 1987 |
Patel MV, Fox JL, Higuchi WI. Effect of acid type on kinetics and mechanism of dental enamel demineralization. Journal of Dental Research. 66: 1425-30. PMID 3040833 DOI: 10.1177/00220345870660090301 |
0.358 |
|
| 1987 |
Okano T, Miyajima M, Komada F, Imanidis G, Nishiyama S, Kim SW, Higuchi WI. Control of drug concentration-time profiles in vivo by zero-order transdermal delivery systems Journal of Controlled Release. 6: 99-106. DOI: 10.1016/0168-3659(87)90067-8 |
0.344 |
|
| 1987 |
Knutson K, Krill SL, Lambert WJ, Higuchi WI. Physicochemical aspects of transdermal permeation Journal of Controlled Release. 6: 59-74. DOI: 10.1016/0168-3659(87)90064-2 |
0.331 |
|
| 1987 |
Masaharu M, Teruo O, Kim SW, Higuchi WI. Preformulation of an Ara-A transdermal delivery system: Membrane fabrication and characterization Journal of Controlled Release. 5: 179-186. DOI: 10.1016/0168-3659(87)90009-5 |
0.36 |
|
| 1986 |
Kurihara-Bergstrom T, Flynn GL, Higuchi WI. Physicochemical study of percutaneous absorption enhancement by dimethyl sulfoxide: Kinetic and thermodynamic determinants of dimethyl sulfoxide mediated mass transfer of alkanols Journal of Pharmaceutical Sciences. 75: 479-486. PMID 3735087 DOI: 10.1002/Jps.2600750512 |
0.617 |
|
| 1986 |
Sheth NV, Freeman DJ, Higuchi WI, Spruance SL. The influence of Azone, propylene glycol and polyethylene glycol on in vitro skin penetration of trifluorothymidine International Journal of Pharmaceutics. 28: 201-209. DOI: 10.1016/0378-5173(86)90246-2 |
0.334 |
|
| 1986 |
Yasunori M, Kenji S, Ken-ichi H, Higuchi WI. Penetration enhancing effect of Azone on the transport of 5-fluorouracil across the hairless rat skin International Journal of Pharmaceutics. 32: 31-38. DOI: 10.1016/0378-5173(86)90095-5 |
0.339 |
|
| 1986 |
Higuchi WI, Cho PW, Fox JL, Yamamoto K. Unifying criteria for dissolution kinetics of various hydroxyapatite preparations Journal of Colloid and Interface Science. 110: 453-458. DOI: 10.1016/0021-9797(86)90398-X |
0.329 |
|
| 1985 |
Gupta SL, Higuchi WI, Ho NF. Cholesterol monohydrate dissolution rate studies in aqueous micellar sodium chenodeoxycholate solutions. Journal of Pharmaceutical Sciences. 74: 1178-83. PMID 4087177 DOI: 10.1002/Jps.2600741109 |
0.369 |
|
| 1985 |
Shannon WM, Westbrook L, Higuchi WI, Sugibayashi K, Baker DC, Kumar SD, Fox JL, Flynn GL, Ho NF, Vaidyanathan R. Influence of 1-dodecylazacycloheptan-2-one (Azone) on the topical therapy of cutaneous herpes simplex virus type 1 infection in hairless mice with 2',3'-di-O-acetyl-9-beta-D-arabinofuranosyladenine and 5'-O-valeryl-9-beta-D-arabinofuranosyladenine. Journal of Pharmaceutical Sciences. 74: 1157-61. PMID 4087174 DOI: 10.1002/Jps.2600741105 |
0.554 |
|
| 1985 |
Rush BD, Ruwart MJ, Anderson BD, Higuchi WI. Evaluation of lincomycin as a cholesterol gallstone dissolution rate accelerator. Journal of Pharmaceutical Sciences. 74: 621-4. PMID 4020649 DOI: 10.1002/Jps.2600740608 |
0.552 |
|
| 1985 |
Karth MG, Ho NF, Higuchi WI. Quantitative analysis of the interfacial barrier to membrane transport of cholesterol solubilized in a charged micellar system. Journal of Pharmaceutical Sciences. 74: 618-20. PMID 4020648 DOI: 10.1002/Jps.2600740607 |
0.343 |
|
| 1985 |
Karth MG, Higuchi WI, Fox JL. Direct membrane method for the study of interface-controlled transport of cholesterol in aqueous media Journal of Pharmaceutical Sciences. 74: 612-617. PMID 4020647 DOI: 10.1002/Jps.2600740606 |
0.324 |
|
| 1985 |
Gupta SL, Higuchi WI, Ho NF. Cholesterol monohydrate dissolution rate studies in aqueous micellar solutions of alpha-(nonylphenyl)-omega-hydroxydeca(oxyethylene), n-alkylamines, and fatty acids. Journal of Pharmaceutical Sciences. 74: 1172-7. PMID 3003335 DOI: 10.1002/Jps.2600741108 |
0.322 |
|
| 1985 |
Sugibayashi K, Hosoya K‐, Morimoto Y, Higuchi WI. Effect of the absorption enhancer, Azone, on the transport of 5‐fluorouracil across hairless rat skin Journal of Pharmacy and Pharmacology. 37: 578-580. PMID 2864423 DOI: 10.1111/J.2042-7158.1985.Tb03073.X |
0.339 |
|
| 1985 |
Lee PH, Higuchi WI, Noro S. Examination of the Sephadex G10 beads uptake method for determination of bile salt monomer concentration in taurocholate-lecithin solutions Journal of Pharmaceutical Sciences. 74: 880-882. PMID 2411909 DOI: 10.1002/Jps.2600740816 |
0.364 |
|
| 1985 |
Rush BD, Ruwart MJ, Anderson BD, Higuchi WI. Correction to: “Evaluation of Lincomycin as a Cholesterol Gallstone Dissolution Rate Accelerator” Journal of Pharmaceutical Sciences. 74: 1344. DOI: 10.1016/S0022-3549(15)50923-4 |
0.529 |
|
| 1985 |
Knutson K, Potts RO, Guzek DB, Golden GM, McKie JE, Lambert WJ, Higuchi WI. Macro- and molecular physical-chemical considerations in understanding drug transport in the stratum corneum Journal of Controlled Release. 2: 67-87. DOI: 10.1016/0168-3659(85)90034-3 |
0.326 |
|
| 1984 |
Bergstrom DH, Fox JL, Higuchi WI. Quantitative microradiography for studying dental enamel demineralization and remineralization. Journal of Pharmaceutical Sciences. 73: 650-3. PMID 6737239 DOI: 10.1002/Jps.2600730515 |
0.318 |
|
| 1984 |
Higuchi WI, Cesar EY, Cho PW, Fox JL. Powder suspension method for critically re-examining the two-site model for hydroxyapatite dissolution kinetics. Journal of Pharmaceutical Sciences. 73: 146-53. PMID 6707872 DOI: 10.1002/Jps.2600730203 |
0.355 |
|
| 1984 |
Flynn GL, French AB, Ho NFH, Higuchi WI, Ostafin EA, Warbasse LH, Amidon GE, Williams E. Some hydrodynamic boundary layer influences on mass transfer coefficients Journal of Membrane Science. 19: 289-308. DOI: 10.1016/S0376-7388(00)80231-8 |
0.577 |
|
| 1984 |
Muhammad NA, Dave SC, Fox JL, Higuchi WI. The influence of ion activity product on remineralization behavior of carbonate-apatite pellets, hydroxyapatite pellets and hydroxyapatite powder International Journal of Pharmaceutics. 21: 295-306. DOI: 10.1016/0378-5173(84)90188-1 |
0.325 |
|
| 1984 |
Higuchi W, Su C, Daabis N, Wanichsiriroj A, Hofmann A. Mechanism of cholesterol monohydrate dissolution in taurocholate—lecithin media—correlation between equilibrium dialysis results and dissolution rates Journal of Colloid and Interface Science. 98: 9-19. DOI: 10.1016/0021-9797(84)90473-9 |
0.342 |
|
| 1984 |
Ho NFH, Gupta SL, Higuchi WI. Theoretical treatment of cholesterol monohydrate dissolution in Renex-690/ionic surfactant systems based on a physical model approach Journal of Colloid and Interface Science. 101: 544-553. DOI: 10.1016/0021-9797(84)90066-3 |
0.307 |
|
| 1984 |
Bergstrom DH, Fox JL, Higuchi WI. Quantitative microradiography study of simultaneous demineralization/remineralization of dental enamel in weak acid buffers Journal of Pharmaceutical Sciences. 73: 653-656. DOI: 10.1002/Jps.2600730516 |
0.327 |
|
| 1983 |
Behl CR, Linn EE, Flynn GL, Ho NF, Higuchi WI, Pierson CL. Permeation of skin and eschar by antiseptics II: influence of controlled burns on the permeation of phenol. Journal of Pharmaceutical Sciences. 72: 397-400. PMID 6864478 DOI: 10.1002/Jps.2600720419 |
0.586 |
|
| 1983 |
Behl CR, Linn EE, Flynn GL, Pierson CL, Higuchi WI, Ho NF. Permeation of skin and eschar by antiseptics I: baseline studies with phenol. Journal of Pharmaceutical Sciences. 72: 391-7. PMID 6864477 DOI: 10.1002/Jps.2600720418 |
0.593 |
|
| 1983 |
Hsu CC, Park JY, Ho NF, Higuchi WI, Fox JL. Topical vaginal drug delivery I: effect of the estrous cycle on vaginal membrane permeability and diffusivity of vidarabine in mice. Journal of Pharmaceutical Sciences. 72: 674-80. PMID 6683757 DOI: 10.1002/Jps.2600720620 |
0.314 |
|
| 1983 |
Fox JL, Iyer BV, Higuchi WI, Hefferren JJ. Solution activity product (K(FAP)) and simultaneous demineralization-remineralization in bovine tooth enamel and hydroxyapatite pellets Journal of Pharmaceutical Sciences. 72: 1252-1255. PMID 6315916 DOI: 10.1002/Jps.2600721104 |
0.341 |
|
| 1983 |
Ho NFH, Merkle HP, Higuchi WI. Quantitative, mechanistic and physiologically realistic approach to the biopharmaceutical design of oral drug delivery systems Drug Development and Industrial Pharmacy. 9: 1111-1184. DOI: 10.3109/03639048309046315 |
0.304 |
|
| 1983 |
Kanaya Y, Spooner P, Fox JL, Higuchi WI, Muhammad N. Mechanistic studies on the bioavailability of calcium fluoride for remineralization of dental enamel International Journal of Pharmaceutics. 16: 171-179. DOI: 10.1016/0378-5173(83)90054-6 |
0.303 |
|
| 1982 |
Behl CR, Barrett M, Flynn GL, Kurihara T, Walters A, Gatmaitkan OG, Harper N, Higuchi WI, Ho NF, Pierson CL. Hydration and percutaneous absorption III: Influences of stripping and scalding on hydration alteration of the permeability of hairless mouse skin to water and n-alkanols. Journal of Pharmaceutical Sciences. 71: 229-34. PMID 7062251 DOI: 10.1002/Jps.2600710222 |
0.596 |
|
| 1982 |
Feld KM, Higuchi WI, Su C‐. Influence of benzalkonium chloride on the dissolution rate behavior of several solid‐phase preparations of cholesterol in bile acid solutions Journal of Pharmaceutical Sciences. 71: 182-188. PMID 7062241 DOI: 10.1002/Jps.2600710211 |
0.359 |
|
| 1982 |
Flynn GL, Behl CR, Linn E, Higuchi WI, Ho NF, Pierson CL. Permeability of thermally damaged skin v: permeability over the course of maturation of a deep partial-thickness wound. Burns, Including Thermal Injury. 8: 196-202. PMID 7059862 DOI: 10.1016/0305-4179(82)90088-2 |
0.579 |
|
| 1982 |
Amidon GE, Higuchi WI, Ho NF. Theoretical and experimental studies of transport of micelle-solubilized solutes. Journal of Pharmaceutical Sciences. 71: 77-84. PMID 7057387 DOI: 10.1002/Jps.2600710120 |
0.378 |
|
| 1981 |
Amidon GE, Ho NF, French AB, Higuchi WI. Predicted absorption rates with simultaneous bulk fluid flow in the intestinal tract. Journal of Theoretical Biology. 89: 195-210. PMID 7266016 DOI: 10.1016/0022-5193(81)90306-4 |
0.321 |
|
| 1981 |
Feld KM, Higuchi WI. Dissolution rate behavior of solid cholesterol preparations in bile acid solutions Journal of Pharmaceutical Sciences. 70: 717-723. PMID 7264912 DOI: 10.1002/Jps.2600700702 |
0.374 |
|
| 1981 |
Kreuter J, Higuchi WI, Ganesan MG, Weiner ND. Delivery of liposome membrane-associated sterols through silastic membranes. Biochimica Et Biophysica Acta. 676: 118-21. PMID 7260108 DOI: 10.1016/0304-4165(81)90016-7 |
0.318 |
|
| 1981 |
Flynn GL, Durrheim H, Higuchi WI. Permeation of hairless mouse skin II: Membrane sectioning techniques and influence on alkanol permeabilities Journal of Pharmaceutical Sciences. 70: 52-56. PMID 7014828 DOI: 10.1002/Jps.2600700109 |
0.584 |
|
| 1981 |
Behl CR, Flynn GL, Barrett M, Walters KA, Linn EE, Mohamed Z, Kurihara T, Ho NFH, Higuchi WI, Pierson CL. Permeability of thermally damaged skin II: immediate influences of branding at 60°C on hairless mouse skin permeability Burns. 7: 389-399. DOI: 10.1016/0305-4179(81)90125-X |
0.57 |
|
| 1981 |
Flynn GL, Behl CR, Walters KA, Gatmaitan OG, Wittkowsky A, Kurihara T, Ho NFH, Higuchi WI, Pierson CL. Permeability of thermally damaged skin III: Influence of scalding temperature on mass transfer of water and n-alkanols across hairless mouse skin Burns. 8: 47-58. DOI: 10.1016/0305-4179(81)90089-9 |
0.571 |
|
| 1980 |
Behl CR, Flynn GL, Kurihara T, Harper N, Smith W, Higuchi WI, Ho NF, Pierson CL. Hydration and percutaneous absorption: I. Influence of hydration on alkanol permeation through hairless mouse skin. The Journal of Investigative Dermatology. 75: 346-52. PMID 7430699 DOI: 10.1111/1523-1747.Ep12531118 |
0.599 |
|
| 1980 |
Behl CR, Flynn GL, Kurihara T, Smith W, Gatmaitan O, Higuchi WI, Ho NF, Pierson CL. Permeability of thermally damaged skin: I. Immediate influences of 60 degrees C scalding on hairless mouse skin. The Journal of Investigative Dermatology. 75: 340-5. PMID 7430698 DOI: 10.1111/1523-1747.Ep12531096 |
0.583 |
|
| 1980 |
Durrheim H, Flynn GL, Higuchi WI, Behl CR. Permeation of hairless mouse skin I: Experimental methods and comparison with human epidermal permeation by alkanols Journal of Pharmaceutical Sciences. 69: 781-786. PMID 7391939 DOI: 10.1002/Jps.2600690709 |
0.589 |
|
| 1980 |
Yu CD, Gordon NA, Fox JL, Higuchi WI, Ho NF. Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate V: Mechanistic analysis of influence of nonhomogeneous enzyme distributions in hairless mouse skin. Journal of Pharmaceutical Sciences. 69: 775-80. PMID 7391938 DOI: 10.1002/Jps.2600690708 |
0.353 |
|
| 1980 |
Yu CD, Higuchi WI, Ho NF, Fox JL, Flynn GL. Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate III: Permeability differences of vidarabine and n-pentanol in components of hairless mouse skin. Journal of Pharmaceutical Sciences. 69: 770-2. PMID 7391936 DOI: 10.1002/Jps.2600690706 |
0.609 |
|
| 1980 |
Komiya I, Park J, Kamani A, Ho N, Higuchi W. Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes International Journal of Pharmaceutics. 4: 249-262. DOI: 10.1016/0378-5173(80)90140-4 |
0.316 |
|
| 1980 |
Corrigan OI, Farvar MA, Higuchi WI. Drug membrane transport enhancement using high energy drug polyvinylpyrrolidone (PVP) co-precipitates International Journal of Pharmaceutics. 5: 229-238. DOI: 10.1016/0378-5173(80)90130-1 |
0.337 |
|
| 1980 |
Thistle JL, Carlson GL, Hofmann AF, LaRusso NF, MacCarty RL, Flynn GL, Higuchi WI, Babayan VK. Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: Physical properties and clinical application Gastroenterology. 78: 1016-1022. DOI: 10.1016/0016-5085(80)90786-6 |
0.554 |
|
| 1979 |
Yu CD, Fox JL, Ho NF, Higuchi WI. Physical model evaluation of topical prodrug delivery-simultaneous transport and bioconversion of vidarabine-5'-valerate II: Parameter determinations. Journal of Pharmaceutical Sciences. 68: 1347-57. PMID 512881 DOI: 10.1002/Jps.2600681105 |
0.331 |
|
| 1979 |
Yu CD, Fox JL, Ho NF, Higuchi WI. Physical model evaluation of topical prodrug delivery-simultaneous transport and bioconversion of vidarabine-5'-valerate I: Physical model development. Journal of Pharmaceutical Sciences. 68: 1341-6. PMID 512880 DOI: 10.1002/Jps.2600681104 |
0.345 |
|
| 1979 |
Flynn GL, Shah Y, Prakongpan S, Kwan KH, Higuchi WI, Hofmann AF. Cholesterol solubility in organic solvents Journal of Pharmaceutical Sciences. 68: 1090-1097. PMID 501527 DOI: 10.1002/Jps.2600680908 |
0.593 |
|
| 1979 |
Park JY, Langworthy M, Behl CR, Higuchi WI, Flynn GL, Ho NFH. Vaginal drug absorption in the rhesus monkey: Bioavailability method and assessment of estrogens International Journal of Pharmaceutics. 2: 215-238. DOI: 10.1016/0378-5173(79)90022-X |
0.558 |
|
| 1978 |
Ando HY, Ho NF, Higuchi WI, Shipman C. Kinetics of drug transport and concurrent metabolism in human cell cultures I: theory. Journal of Pharmaceutical Sciences. 67: 606-10. PMID 641791 DOI: 10.1002/Jps.2600670508 |
0.301 |
|
| 1977 |
Ando HY, Ho NF, Higuchi WI. Skin as an active metabolizing barrier I: Theoretical analysis of topical bioavailability. Journal of Pharmaceutical Sciences. 66: 1525-8. PMID 915724 DOI: 10.1002/Jps.2600661105 |
0.33 |
|
| 1977 |
Kwan KH, Higuchi WI, Molokhia AM, Hofmann AF. Cholesterol gallstone dissolution rate accelerators I: Exploratory investigations. Journal of Pharmaceutical Sciences. 66: 1105-8. PMID 894495 DOI: 10.1002/Jps.2600660813 |
0.316 |
|
| 1977 |
Kwan KH, Higuchi WI, Molokhia AM, Hofmann AF. Dissolution kinetics of cholesterol in simulated bile I: Influence of bile acid type and concentration, bile acid-lecithin ration, and added electrolyte. Journal of Pharmaceutical Sciences. 66: 1094-101. PMID 894494 DOI: 10.1002/Jps.2600660811 |
0.308 |
|
| 1977 |
Lipper RA, Higuchi WI. Analysis of theoretical behavior of a proposed zero‐order drug delivery system Journal of Pharmaceutical Sciences. 66: 163-164. PMID 839409 DOI: 10.1002/Jps.2600660207 |
0.306 |
|
| 1977 |
Owada E, Behl CR, Hwang SS, Suhardja L, Flynn GL, Ho NFH, Higuchi WI. Vaginal drug absorption in rhesus monkeys I: Development of methodology Journal of Pharmaceutical Sciences. 66: 216-219. PMID 402467 DOI: 10.1002/Jps.2600660221 |
0.564 |
|
| 1977 |
Hwang S, Owada E, Suhardja L, Ho NF, Flynn GL, Higuchi WI. Systems approach to vaginal delivery of drugs V: in situ vaginal absorption of 1-alkanoic acids. Journal of Pharmaceutical Sciences. 66: 781-4. PMID 17717 DOI: 10.1002/Jps.2600660609 |
0.595 |
|
| 1977 |
Hwang S, Owada E, Suhardja L, Ho NF, Flynn GL, Higuchi WI. Systems approach to vaginal delivery of drugs IV: methodology for determination of membrane surface pH. Journal of Pharmaceutical Sciences. 66: 778-81. PMID 17716 DOI: 10.1002/Jps.2600660608 |
0.596 |
|
| 1977 |
Gatmaitan O, Yotsuyanagi T, Higuchi W. Mechanisms for interface-controlled transport of cholesterol in micellar sodium cholate-lecithin and micellar sodium cholate-lecithin-sodium oleate systems Journal of Colloid and Interface Science. 61: 499-515. DOI: 10.1016/0021-9797(77)90468-4 |
0.329 |
|
| 1976 |
Simonelli AP, Mehta SC, Higuchi WI. Dissolution rates of high energy sulfathiazole‐povidone coprecipitates II: Characterization of form of drug controlling its dissolution rate via solubility studies Journal of Pharmaceutical Sciences. 65: 355-361. PMID 1263082 DOI: 10.1002/Jps.2600650310 |
0.691 |
|
| 1976 |
Flynn GL, Ho NF, Higuchi WI, Kent J. Analysis of diffusion through concentric right circular cylinders and concentric spheres. Journal of Pharmaceutical Sciences. 65: 154-8. PMID 1255426 DOI: 10.1002/Jps.2600650143 |
0.503 |
|
| 1976 |
Ho NF, Suhardja L, Hwang S, Owada E, Molokhia A, Flynn GL, Higuchi WI, Park JY. Systems approach to vaginal delivery of drugs III: Simulation studies interfacing steroid release from silicone matrix and vaginal absorption in rabbits. Journal of Pharmaceutical Sciences. 65: 1578-85. PMID 1033272 DOI: 10.1002/Jps.2600651106 |
0.597 |
|
| 1976 |
Ando HY, Ho NF, Higuchi WI, Turi J, Shipman C. Systems approach to the study of drug transport across membranes using suspension culture of mammalian cells. V. Simultaneous poassive transport and biosynthesis. Journal of Theoretical Biology. 62: 211-25. PMID 994520 DOI: 10.1016/0022-5193(76)90057-6 |
0.339 |
|
| 1976 |
Hwang S, Owada E, Yotsuyanagi T, Suhardja L, Ho NF, Flynn GL, Higuchi WI. Systems approach to vaginal delivery of drugs II: In situ vaginal absorption of unbranched aliphatic alcohols. Journal of Pharmaceutical Sciences. 65: 1574-8. PMID 993988 DOI: 10.1002/Jps.2600651105 |
0.596 |
|
| 1976 |
Yeh KC, Higuchi WI. Interpretation of distribution coefficients of p‐alkylpyridines by a modified regular solution theory Journal of Pharmaceutical Sciences. 65: 743-745. PMID 932948 DOI: 10.1002/Jps.2600650531 |
0.304 |
|
| 1976 |
Prakongpan S, Higuchi WI, Kwan KH, Molokhia AM. Dissolution rate studies of cholesterol monohydrate in bile acid–lecithin solutions using the rotating‐disk method Journal of Pharmaceutical Sciences. 65: 685-689. PMID 932935 DOI: 10.1002/Jps.2600650514 |
0.371 |
|
| 1976 |
Ho NF, Park J, Morozowich W, Higuchi WI. A physical model for the simultaneous membrane transport and metabolism of drugs. Journal of Theoretical Biology. 61: 185-93. PMID 10475 DOI: 10.1016/0022-5193(76)90112-0 |
0.333 |
|
| 1975 |
Turi JS, Higuchi WI, Ho NF, Shipman C. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells IV: Uptake and release kinetics of sterols. Journal of Pharmaceutical Sciences. 64: 627-31. PMID 1170314 DOI: 10.1002/Jps.2600640411 |
0.358 |
|
| 1975 |
Turi JS, Ho NF, Higuchi WI, Shipman C. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells V: Uptake and release kinetics of cardiac glycosides by Burkitt lymphoma cells. Journal of Pharmaceutical Sciences. 64: 631-9. PMID 1142073 DOI: 10.1002/Jps.2600640412 |
0.322 |
|
| 1975 |
Turi JS, Ho NF, Higuchi WI, Shipman C. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells III: steady-state diffusion models. Journal of Pharmaceutical Sciences. 64: 622-6. PMID 1142072 DOI: 10.1002/Jps.2600640410 |
0.327 |
|
| 1975 |
Yotsuyanagi T, Molokhia A, Hwang S, Ho NF, Flynn GL, Higuchi WI. Systems approach to vaginal delivery of drugs I: development of in situ vaginal drug absorption procedure. Journal of Pharmaceutical Sciences. 64: 71-6. PMID 237108 DOI: 10.1002/Jps.2600640113 |
0.595 |
|
| 1974 |
Surpuriya V, Higuchi WI. Enhancing effect of calcium ions on transport of cholesterol from aqueous sodium taurocholate‐lecithin micellar phase to oil phase Journal of Pharmaceutical Sciences. 63: 1325-1327. PMID 4851868 DOI: 10.1002/Jps.2600630842 |
0.341 |
|
| 1974 |
Ho NF, Higuchi WI. Theoretical model studies of intestinal drug absorption. IV. Bile acid transport at premicellar concentrations across diffusion layer-membrane barrier. Journal of Pharmaceutical Sciences. 63: 686-90. PMID 4829987 DOI: 10.1002/Jps.2600630508 |
0.375 |
|
| 1974 |
Higuchi WI. Kinetic Factors in the Tooth-Plaque-Saliva Model Systems Journal of Dental Research. 53: 236-238. PMID 4591970 DOI: 10.1177/00220345740530021001 |
0.309 |
|
| 1974 |
Higuchi WI, Valvani SC, Hefferren JJ. The kinetics and mechanisms of reactions of human tooth enamel in buffered solutions of high fluoride concentrations Archives of Oral Biology. 19: 737-746. PMID 4533725 DOI: 10.1016/0003-9969(74)90160-5 |
0.325 |
|
| 1974 |
Chowhan ZT, Higuchi WI. Model transport studies utilizing lecithin spherules IV: Transport of D‐glucose in spherules prepared from lecithin, dicetyl phosphate, and cholesterol Journal of Pharmaceutical Sciences. 63: 1428-1430. PMID 4427266 DOI: 10.1002/Jps.2600630920 |
0.362 |
|
| 1974 |
Dedhiya MG, Young F, Higuchi WI. Mechanism of hydroxyapatite dissolution. The synergistic effects of solution fluoride, strontium, and phosphate Journal of Physical Chemistry. 78: 1273-1279. DOI: 10.1002/Chin.197433042 |
0.325 |
|
| 1973 |
Higuchi WI, Prakongpan S, Young F. Mechanisms of dissolution of human cholesterol gallstones Journal of Pharmaceutical Sciences. 62: 945-948. PMID 4712629 DOI: 10.1002/Jps.2600620618 |
0.348 |
|
| 1973 |
Higuchi WI, Sjuib F, Mufson D, Simonelli AP, Hofmann AF. Dissolution kinetics of gallstones: Physical model approach Journal of Pharmaceutical Sciences. 62: 942-945. PMID 4712628 DOI: 10.1002/Jps.2600620617 |
0.678 |
|
| 1973 |
Chowhan ZT, Higuchi WI. Model transport studies utilizing lecithin spherules III: Transport of taurocholic acid‐[cholic‐3H(G)] in buffered D‐glucose solutions Journal of Pharmaceutical Sciences. 62: 443-448. PMID 4691704 DOI: 10.1002/Jps.2600620318 |
0.36 |
|
| 1973 |
Chowhan ZT, Yotsuyanagi T, Higuchi WI. Model transport studies utilizing lecithin spherules II: Transport of 3‐O‐methyl‐14C‐D‐glucose in D‐glucose solution Journal of Pharmaceutical Sciences. 62: 221-224. PMID 4686393 DOI: 10.1002/Jps.2600620207 |
0.389 |
|
| 1973 |
Yotsuyanagi T, Higuchi WI, Ghanem A‐. Theoretical treatment of diffusional transport into and through an oil‐water emulsion with an interfacial barrier at the oil‐water interface Journal of Pharmaceutical Sciences. 62: 40-43. PMID 4682931 DOI: 10.1002/Jps.2600620106 |
0.317 |
|
| 1973 |
Dedhiya MG, Young F, Higuchi WI. Mechanism for the retardation of the acid dissolution rate of hydroxyapatite by strontium Journal of Dental Research. 52. PMID 4517750 DOI: 10.1177/00220345730520051901 |
0.324 |
|
| 1972 |
Yeh KC, Higuchi WI. Influence of chain length on oil—water ion‐pair partitioning behavior of p‐alkylpyridinium chlorides Journal of Pharmaceutical Sciences. 61: 1648-1650. PMID 5072421 DOI: 10.1002/Jps.2600611027 |
0.309 |
|
| 1972 |
Sjuib F, Simonelli AP, Higuchi WI. Release rates of solid drug mixtures dispersed in inert matrixes IV: Binary mixture of amphoteric drugs released into reactive media Journal of Pharmaceutical Sciences. 61: 1381-1389. PMID 5068942 DOI: 10.1002/Jps.2600610908 |
0.687 |
|
| 1972 |
Sjuib F, Simonelli AP, Higuchi WI. Release rates of solid drug mixtures dispersed in inert matrixes III: Binary mixture of acid drugs released into alkaline media Journal of Pharmaceutical Sciences. 61: 1374-1380. PMID 5068941 DOI: 10.1002/Jps.2600610907 |
0.676 |
|
| 1972 |
Chowhan ZU, Yotsuyanagi T, Higuchi WI. Model transport studies utilizing lecithin spherules. I. Critical evaluations of several physical models in the determination of the permeability coefficient for glucose. Biochimica Et Biophysica Acta. 266: 320-42. PMID 5064533 DOI: 10.1016/0005-2736(72)90091-0 |
0.368 |
|
| 1972 |
Ho NF, Higuchi WI, Turi J. Theoretical model studies of drug absorption and transport in the GI tract. 3. Journal of Pharmaceutical Sciences. 61: 192-7. PMID 5059781 DOI: 10.1002/Jps.2600610210 |
0.37 |
|
| 1972 |
Surpuriya V, Higuchi WI. Interfacially controlled transport of micelle‐solubilized sterols across an oil/water interface in two ionic surfactant systems Journal of Pharmaceutical Sciences. 61: 375-379. PMID 5013372 DOI: 10.1002/Jps.2600610311 |
0.376 |
|
| 1972 |
Turi JS, Higuchi WI, Shipman C, Ho NF. Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells. II. Experimental procedures and uptake studies with cholesterol. Journal of Pharmaceutical Sciences. 61: 1618-24. PMID 4672390 DOI: 10.1002/Jps.2600611016 |
0.363 |
|
| 1972 |
Ho NF, Turi J, Shipman C, Higuchi WI. Systems approach to the study of drug transport across membranes using suspension cultures of mammalian cells. I. Theoretical diffusion models. Journal of Theoretical Biology. 34: 451-67. PMID 4668572 DOI: 10.1016/0022-5193(72)90135-X |
0.352 |
|
| 1972 |
Vora KR, Higuchi WI, Ho NF. Analysis of human buccal absorption of drugs by physical model approach. Journal of Pharmaceutical Sciences. 61: 1785-91. PMID 4652651 DOI: 10.1002/Jps.2600611119 |
0.356 |
|
| 1972 |
Surpuriya V, Higuchi WI. Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface Bba - Biomembranes. 290: 375-383. PMID 4640769 DOI: 10.1016/0005-2736(72)90080-6 |
0.376 |
|
| 1972 |
Stehle RG, Higuchi WI. In vitro model for transport of solutes in three‐phase system II: Experimental considerations Journal of Pharmaceutical Sciences. 61: 1931-1935. PMID 4638099 DOI: 10.1002/Jps.2600611210 |
0.394 |
|
| 1972 |
Stehle RG, Higuchi WI. In vitro model for transport of solutes in three‐phase system I: Theoretical principles Journal of Pharmaceutical Sciences. 61: 1922-1930. PMID 4638098 DOI: 10.1002/Jps.2600611208 |
0.403 |
|
| 1972 |
YOTSUYANAGI T, HIGUCHI WI. A two phase series model for the transport of steroids across the fully hydrated stratum corneum Journal of Pharmacy and Pharmacology. 24: 934-941. PMID 4146524 DOI: 10.1111/J.2042-7158.1972.Tb08923.X |
0.329 |
|
| 1972 |
Higuchi WI, Prakongpan S, Surpuriya V, Young F. Cholesterol dissolution rate in micellar bile acid solutions: Retarding effect of added lecithin Science. 178: 633-634. DOI: 10.1126/Science.178.4061.633 |
0.354 |
|
| 1971 |
Ho NF, Higuchi WI. Quantitative interpretation of in vivo buccal absorption of n-alkanoic acids by the physical model approach. Journal of Pharmaceutical Sciences. 60: 537-41. PMID 5128360 DOI: 10.1002/Jps.2600600404 |
0.387 |
|
| 1971 |
Bernstein DF, Higuchi WI, Ho NF. Kinetics of flocculation and-or coalescence of dilute oil-in-water emulsions. Journal of Pharmaceutical Sciences. 60: 690-4. PMID 5125765 DOI: 10.1002/Jps.2600600506 |
0.326 |
|
| 1971 |
Bikhazi AB, Higuchi WI. Interfacial barriers to the transport of sterols and other organic compounds at the aqueous polysorbate 80-hexadecane interface Bba - Biomembranes. 223: 676-687. PMID 4329757 DOI: 10.1016/0005-2736(71)90167-2 |
0.343 |
|
| 1970 |
Ghanem A‐, Higuchi WI, Simonelli AP. Interfacial barriers in interphase transport III: Transport of cholesterol and other organic solutes into hexadecane—gelatin—water matrices Journal of Pharmaceutical Sciences. 59: 659-665. PMID 5446422 DOI: 10.1002/Jps.2600590516 |
0.692 |
|
| 1970 |
Suzuki A, Higuchi WI, Ho NF. Theoretical model studies of drug absorption and transport in the gastrointestinal tract.i. Journal of Pharmaceutical Sciences. 59: 644-51. PMID 5446420 DOI: 10.1002/Jps.2600590514 |
0.379 |
|
| 1970 |
Mehta SC, Bernardo PD, Higuchi WI, Simonelli AP. Rate of crystal growth of sulfathiazole and methylprednisolone. Journal of Pharmaceutical Sciences. 59: 638-44. PMID 5446419 DOI: 10.1002/Jps.2600590513 |
0.648 |
|
| 1970 |
Simonelli AP, Mehta SC, Higuchi WI. Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone Journal of Pharmaceutical Sciences. 59: 633-638. PMID 5446418 DOI: 10.1002/Jps.2600590512 |
0.646 |
|
| 1970 |
Bikhazi AB, Higuchi WI. Interfacial barrier limited interphase transport of cholesterol in the aqueous polysorbate 80—hexadecane system Journal of Pharmaceutical Sciences. 59: 744-748. PMID 5423072 DOI: 10.1002/Jps.2600590603 |
0.349 |
|
| 1970 |
Roseman TJ, Higuchi WI. Release of medroxyprogesterone acetate from a silicone polymer Journal of Pharmaceutical Sciences. 59: 353-357. PMID 5416178 DOI: 10.1002/Jps.2600590317 |
0.329 |
|
| 1970 |
Ghanem A‐, Higuchi WI, Simonelli AP. Interfacial barriers in interphase transport II: Influence of additives upon the transport of diethylphthalate across the hexadecane‐gelatin‐water interface Journal of Pharmaceutical Sciences. 59: 232-237. PMID 5411345 DOI: 10.1002/Jps.2600590219 |
0.694 |
|
| 1970 |
Nelson KG, Higuchi WI. Mechanism of Fluoride Uptake by Hydroxyapatite from Acidic Fluoride Solutions: I. Theoretical Considerations Journal of Dental Research. 49: 1541-1548. PMID 5274385 DOI: 10.1177/00220345700490066601 |
0.333 |
|
| 1969 |
Simonelli AP, Mehta SC, Higuchi WI. Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)‐Sulfathiazole Coprecipitates Journal of Pharmaceutical Sciences. 58: 538-549. PMID 5796439 DOI: 10.1002/Jps.2600580503 |
0.674 |
|
| 1969 |
Ghanem A‐, Higuchi WI, Simonelli AP. Interfacial barriers in interphase transport: Retardation of the transport of diethylphthalate across the hexadecane‐water interface by an adsorbed gelatin film Journal of Pharmaceutical Sciences. 58: 165-174. PMID 5779852 DOI: 10.1002/Jps.2600580203 |
0.702 |
|
| 1969 |
Goldberg AH, Higuchi WI. Mechanisms of interphase transport II: Theoretical considerations and experimental evaluation of interfacially controlled transport in solubilized systems Journal of Pharmaceutical Sciences. 58: 1341-1352. PMID 5349746 DOI: 10.1002/Jps.2600581109 |
0.354 |
|
| 1969 |
Howard SA, Suzuki A, Farvar MA, Higuchi WI. Two-phase method for the investigation of interphase transport. II. Experimental aspects. Journal of Pharmaceutical Sciences. 58: 1330-5. PMID 5349744 DOI: 10.1002/Jps.2600581107 |
0.329 |
|
| 1969 |
Howard SA, Farvar MA, Suzuki A, Higuchi WI. Two-phase method for the investigation of interphase transport. I. Theoretical aspects. Journal of Pharmaceutical Sciences. 58: 1325-9. PMID 5349743 DOI: 10.1002/Jps.2600581106 |
0.34 |
|
| 1969 |
Mir NA, Higuchi WI, Hefferren JJ. The mechanism of action of solution fluoride upon the demineralization rate of human enamel. Archives of Oral Biology. 14: 901-20. PMID 5257839 DOI: 10.1016/0003-9969(69)90268-4 |
0.364 |
|
| 1969 |
Higuchi WI, Mir NA, Patel PR, Becker JW, Hefferren JJ. Quantitation of Enamel Demineralization Mechanisms: III. A Critical Examination of the Hydroxyapatite Model Journal of Dental Research. 48: 396-409. PMID 5254479 DOI: 10.1177/00220345690480031201 |
0.326 |
|
| 1968 |
Simonelli AP, Flanagan DR, Higuchi WI. Apparent discrepancy between theory and experimental data for dissolution from the rotating disk under stirred and unstirred conditions Journal of Pharmaceutical Sciences. 57: 1629-1631. PMID 5674412 DOI: 10.1002/Jps.2600570940 |
0.639 |
|
| 1968 |
Singh P, Desai SJ, Flanagan DR, Simonelli AP, Higuchi WI. Mechanistic study of the influence of micelle solubilization and hydrodynamic factors on the dissolution rate of solid drugs Journal of Pharmaceutical Sciences. 57: 959-965. PMID 5671343 DOI: 10.1002/Jps.2600570608 |
0.683 |
|
| 1968 |
Koizumi T, Higuchi WI. Analysis of data on drug release from emulsions III. Boundary effect on pyridine release from water‐in‐oil emulsions as a function of pH Journal of Pharmaceutical Sciences. 57: 93-97. PMID 5652141 DOI: 10.1002/Jps.2600570118 |
0.332 |
|
| 1968 |
Koizumi T, Higuchi WI. Analysis of data on drug release from emulsions II. Pyridine release from water‐in‐oil emulsions as a function of pH Journal of Pharmaceutical Sciences. 57: 87-92. PMID 5652140 DOI: 10.1002/Jps.2600570117 |
0.34 |
|
| 1968 |
Schwartz JB, Simonelli AP, Higuchi WI. Drug release from wax matrices II. Application of a mixture theory to the sulfanilamide—wax system Journal of Pharmaceutical Sciences. 57: 278-282. PMID 5641672 DOI: 10.1002/Jps.2600570207 |
0.675 |
|
| 1968 |
Schwartz JB, Simonelli AP, Higuchi WI. Drug release from wax matrices I. Analysis of data with first‐order kinetics and with the diffusion‐controlled model Journal of Pharmaceutical Sciences. 57: 274-277. PMID 5641671 DOI: 10.1002/Jps.2600570206 |
0.669 |
|
| 1968 |
Singh P, Desai SJ, Simonelli AP, Higuchi WI. Role of wetting on the rate of drug release from inert matrices Journal of Pharmaceutical Sciences. 57: 217-226. PMID 5641661 DOI: 10.1002/Jps.2600570202 |
0.672 |
|
| 1967 |
Goldberg AH, Higuchi WI, Ho NF, Zografi G. Mechanisms of interphase transport. I. Theoretical considerations of diffusion and interfacial barriers in transport of solubilized systems. Journal of Pharmaceutical Sciences. 56: 1432-7. PMID 6060587 DOI: 10.1002/Jps.2600561112 |
0.353 |
|
| 1967 |
Singh P, Desai SJ, Simonelli AP, Higuchi WI. Release rates of solid drug mixtures dispersed in inert matrices II. Mutually interacting drug mixtures Journal of Pharmaceutical Sciences. 56: 1548-1555. PMID 5588703 DOI: 10.1002/Jps.2600561204 |
0.673 |
|
| 1967 |
Singh P, Desai SJ, Simonelli AP, Higuchi WI. Release rates of solid drug mixtures dispersed in inert matrices I. Noninteracting drug mixtures Journal of Pharmaceutical Sciences. 56: 1542-1547. PMID 5588702 DOI: 10.1002/Jps.2600561203 |
0.675 |
|
| 1967 |
Higuch T, Finger KF, Higuchi WI. Chapter 33. Pharmaceutics and Biopharmaceutics Annual Reports in Medicinal Chemistry. 2: 340-346. DOI: 10.1016/S0065-7743(08)61531-6 |
0.333 |
|
| 1966 |
Desai SJ, Singh P, Simonelli AP, Higuchi WI. Investigation of factors influencing release of solid drug dispersed in inert matrices IV. Some studies involving the polyvinyl chloride matrix Journal of Pharmaceutical Sciences. 55: 1235-1239. PMID 5969778 DOI: 10.1002/Jps.2600551114 |
0.67 |
|
| 1966 |
Desai SJ, Singh P, Simonelli AP, Higuchi WI. Investigation of factors influencing release of solid drug dispersed in inert matrices III. Quantitative studies involving the polyethylene plastic matrix Journal of Pharmaceutical Sciences. 55: 1230-1234. PMID 5969777 DOI: 10.1002/Jps.2600551113 |
0.686 |
|
| 1966 |
Desai SJ, Singh P, Simonelli AP, Higuchi WI. Investigation of factors influencing release of solid drug dispersed in inert matrices ii quantitation of procedures Journal of Pharmaceutical Sciences. 55: 1224-1229. PMID 5969776 DOI: 10.1002/Jps.2600551112 |
0.677 |
|
| 1965 |
HIGUCHI WI, PARKER AP, HAMLIN WE. DISSOLUTION KINETICS OF A WEAK ACID, 1,1-HEXAMETHYLENE P-TOLYLSULFONYLSEMICARBAZIDE, AND ITS SODIUM SALT. Journal of Pharmaceutical Sciences. 54: 8-11. PMID 14288503 DOI: 10.1002/Jps.2600540103 |
0.33 |
|
| 1965 |
Higuchi WI, Gray JA, Hefferren JJ, Patel PR. Mechanisms of Enamel Dissolution in Acid Buffers Journal of Dental Research. 44: 330-341. PMID 14278188 DOI: 10.1177/00220345650440020501 |
0.375 |
|
| 1965 |
Desai SJ, Simonelli AP, Higuchi WI. Investigation of factors influencing release of solid drug dispersed in inert matrices. Journal of Pharmaceutical Sciences. 54: 1459-64. PMID 5883216 DOI: 10.1002/Jps.2600541012 |
0.324 |
|
| 1965 |
Higuchi WI, Mir NA, Desai SJ. Dissolution rates of polyphase mixtures Journal of Pharmaceutical Sciences. 54: 1405-1410. PMID 5883213 DOI: 10.1002/Jps.2600541003 |
0.325 |
|
| 1965 |
Saad HY, Higuchi WI. Cholesterol particle growth and dissolution rates II. Retardation effects of cholate Journal of Pharmaceutical Sciences. 54: 1303-1307. PMID 5881226 DOI: 10.1002/Jps.2600540917 |
0.312 |
|
| 1965 |
Higuchi WI, Patel PR, Hefferren JJ. Quantitation of enamel demineralization mechanisms. II. Correlation of synthetic hydroxyapatite initial demineralization rates in acetate buffer with powdered enamel Journal of Pharmaceutical Sciences. 54: 587-591. PMID 5842346 DOI: 10.1002/Jps.2600540421 |
0.322 |
|
| 1965 |
Higuchi WI, Rhee TO, Flanagan DR. Kinetics of aggregation in suspensions. Effects of added electrolytes on the aggregation rates of latex particles in aqueous ionic surfactant solutions Journal of Pharmaceutical Sciences. 54: 510-513. PMID 5842331 DOI: 10.1002/Jps.2600540403 |
0.323 |
|
| 1964 |
Higuchi WI. Effects of interacting colloids on transport rates Journal of Pharmaceutical Sciences. 53: 532-535. PMID 14193888 DOI: 10.1002/Jps.2600530516 |
0.336 |
|
| 1964 |
Higuchi WI. Rate of solute transport out of emulsion droplets in micron size range Journal of Pharmaceutical Sciences. 53: 405-408. PMID 14189935 DOI: 10.1002/Jps.2600530413 |
0.357 |
|
| 1964 |
Higuchi WI, Nelson E, Wagner JG. Solubility and dissolution rates in reactive media Journal of Pharmaceutical Sciences. 53: 333-335. PMID 14185027 DOI: 10.1002/Jps.2600530321 |
0.304 |
|
| 1963 |
HIGUCHI WI, HAMLIN WE. Release of drug from a selfcoating surface. Benzphetamine pamoate pellet. Journal of Pharmaceutical Sciences. 52: 575-9. PMID 13954444 DOI: 10.1002/Jps.2600520614 |
0.316 |
|
| 1963 |
HIGUCHI WI, OKADA R, STELTER GA, LEMBERGER AP. Kinetics of rapid aggregation in suspensions. Comparison of experiments with the Smoluchowski theory. Journal of Pharmaceutical Sciences. 52: 49-54. PMID 13954442 DOI: 10.1002/Jps.2600520110 |
0.35 |
|
| 1963 |
HIGUCHI WI, LAU PK, HIGUCHI T, SHELL JW. Polymorphism and drug availability. Solubility relationships in the methylprednisolone system. Journal of Pharmaceutical Sciences. 52: 150-3. PMID 13954440 DOI: 10.1002/Jps.2600520210 |
0.487 |
|
| 1962 |
Higuchi WI. Analysis of data on the medicament release from ointments Journal of Pharmaceutical Sciences. 51: 802-804. PMID 13907274 DOI: 10.1002/Jps.2600510825 |
0.31 |
|
| 1962 |
HIGUCHI WI, MISRA J. Solubilization in nonpolar solvents. Influence of the chain length of solvent on the solubilization of water by dioctyl sodium sulfosuccinate Journal of Pharmaceutical Sciences. 51: 455-458. PMID 13907272 DOI: 10.1002/Jps.2600510513 |
0.318 |
|
| 1960 |
Higuchi WI, Higuchi T. Theoretical analysis of diffusional movement through heterogeneous barriers Journal of the American Pharmaceutical Association. 49: 598-606. DOI: 10.1002/Jps.3030490910 |
0.49 |
|
| 1960 |
Higuchi WI, O'Konski CT. A test of the becker-doering theory of nucleation kinetics Journal of Colloid Science. 15: 14-49. |
0.567 |
|
| 1959 |
Higuchi WI, Schwartz MA, Rippie EG, Higuchi T. A thermometric method for thermodynamics studies and molecular weight determinations in solutions Journal of Physical Chemistry. 63: 996-999. DOI: 10.1021/J150576A602 |
0.504 |
|
| 1958 |
HIGUCHI WI, PARROTT EL, WURSTER DE, HIGUCHI T. Investigation of drug release from solids. II. Theoretical and experimental study of influences of bases and buffers on rates of dissolution of acidic solids. Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 47: 376-83. PMID 13538833 DOI: 10.1002/Jps.3030470522 |
0.566 |
|
| 1956 |
O'Konski CT, Higuchi WI. The kinetics of nucleation in turbulent jets [2] Journal of Physical Chemistry. 60: 1598-1599. |
0.568 |
|
| 1955 |
O'Konski CT, Higuchi WI. Structure and calculation of the binding energy of gaseous alkali halide dimers The Journal of Chemical Physics. 23: 1175-1176. DOI: 10.1063/1.1742225 |
0.596 |
|
| Show low-probability matches. |
