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Reuben Lotan - Publications

Affiliations: 
The University of Texas Graduate School of Biomedical Sciences at Houston 
Area:
Oncology, Molecular Biology, Biomedical Engineering
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Year Citation  Score
2012 Fujimoto J, Kadara H, Garcia MM, Kabbout M, Behrens C, Liu DD, Lee JJ, Solis LM, Kim ES, Kalhor N, Moran C, Sharafkhaneh A, Lotan R, Wistuba II. G-protein coupled receptor family C, group 5, member A (GPRC5A) expression is decreased in the adjacent field and normal bronchial epithelia of patients with chronic obstructive pulmonary disease and non-small-cell lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 7: 1747-54. PMID 23154545 DOI: 10.1097/Jto.0B013E31826Bb1Ff  0.631
2012 Hildebrandt MA, Lippman SM, Etzel CJ, Kim E, Lee JJ, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X. Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3705-13. PMID 22577058 DOI: 10.1158/1078-0432.Ccr-11-3271  0.354
2012 Barta P, Van Pelt C, Men T, Dickey BF, Lotan R, Moghaddam SJ. Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation. Molecular Cancer. 11: 4. PMID 22239913 DOI: 10.1186/1476-4598-11-4  0.331
2012 Oridate N, Lotan D, Mitchell M, Hong W, Lotan R. Induction of apoptosis by retinoids in human cervical-carcinoma cell-lines. International Journal of Oncology. 7: 433-41. PMID 21552857 DOI: 10.3892/ijo.7.3.433  0.313
2011 Gold KA, Lee JJ, Ping Y, Behrens C, Liu D, Lee H, Koo JS, Lotan R, Solis L, Rinsurongkawong W, Stewart DJ, Hofstetter WL, Swisher S, Lippman SM, Wistuba II, et al. Biologic risk model for recurrence in resected early-stage non-small cell lung cancer (ES NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 7053. PMID 28020037 DOI: 10.1200/Jco.2011.29.15_Suppl.7053  0.307
2011 Moussalli MJ, Wu Y, Zuo X, Yang XL, Wistuba II, Raso MG, Morris JS, Bowser JL, Minna JD, Lotan R, Shureiqi I. Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion. Cancer Prevention Research (Philadelphia, Pa.). 4: 1961-72. PMID 21881028 DOI: 10.1158/1940-6207.Capr-10-0280  0.479
2011 Zhao M, Sano D, Pickering CR, Jasser SA, Henderson YC, Clayman GL, Sturgis EM, Ow TJ, Lotan R, Carey TE, Sacks PG, Grandis JR, Sidransky D, Heldin NE, Myers JN. Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 7248-64. PMID 21868764 DOI: 10.1158/1078-0432.Ccr-11-0690  0.388
2011 Kadara H, Behrens C, Yuan P, Solis L, Liu D, Gu X, Minna JD, Lee JJ, Kim E, Hong WK, Wistuba II, Lotan R. A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1490-501. PMID 21163870 DOI: 10.1158/1078-0432.Ccr-10-2703  0.624
2011 Kadara H, Lotan R. Effects of natural and synthetic retinoids on the differentiation and growth of squamous cancers Signaling Pathways in Squamous Cancer. 261-282. DOI: 10.1007/978-1-4419-7203-3_13  0.624
2010 Chen Y, Deng J, Fujimoto J, Kadara H, Men T, Lotan D, Lotan R. Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor. Cancer Research. 70: 8917-26. PMID 20959490 DOI: 10.1158/0008-5472.Can-10-0518  0.67
2010 Fujimoto J, Kadara H, Men T, van Pelt C, Lotan D, Lotan R. Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice. Plos One. 5: e11847. PMID 20686609 DOI: 10.1371/Journal.Pone.0011847  0.601
2010 Fujimoto J, Kong M, Lee JJ, Hong WK, Lotan R. Validation of a novel statistical model for assessing the synergy of combined-agent cancer chemoprevention. Cancer Prevention Research (Philadelphia, Pa.). 3: 917-28. PMID 20663979 DOI: 10.1158/1940-6207.Capr-10-0129  0.41
2010 Wang J, Lippman SM, Lee JJ, Yang H, Khuri FR, Kim E, Lin J, Chang DW, Lotan R, Hong WK, Wu X. Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. Carcinogenesis. 31: 1755-61. PMID 20627871 DOI: 10.1093/Carcin/Bgq138  0.312
2010 Kadara H, Fujimoto J, Men T, Ye X, Lotan D, Lee JS, Lotan R. A Gprc5a tumor suppressor loss of expression signature is conserved, prevalent, and associated with survival in human lung adenocarcinomas. Neoplasia (New York, N.Y.). 12: 499-505. PMID 20563252 DOI: 10.1593/Neo.10390  0.644
2010 Lee JJ, Feng L, Reshef DS, Sabichi AL, Williams B, Rinsurongkawong W, Wistuba II, Lotan R, Lippman SM. Mortality in the randomized, controlled lung intergroup trial of isotretinoin. Cancer Prevention Research (Philadelphia, Pa.). 3: 738-44. PMID 20501862 DOI: 10.1158/1940-6207.Capr-09-0124  0.326
2010 Deng J, Fujimoto J, Ye XF, Men TY, Van Pelt CS, Chen YL, Lin XF, Kadara H, Tao Q, Lotan D, Lotan R. Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis. Cancer Prevention Research (Philadelphia, Pa.). 3: 424-37. PMID 20354164 DOI: 10.1158/1940-6207.Capr-10-0032  0.626
2010 Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prevention Research (Philadelphia, Pa.). 3: 331-8. PMID 20145189 DOI: 10.1158/1940-6207.Capr-09-0076  0.648
2010 Kim ES, Hong WK, Lee JJ, Mao L, Morice RC, Liu DD, Jimenez CA, Eapen GA, Lotan R, Tang X, Newman RA, Wistuba II, Kurie JM. Biological activity of celecoxib in the bronchial epithelium of current and former smokers. Cancer Prevention Research (Philadelphia, Pa.). 3: 148-59. PMID 20103722 DOI: 10.1158/1940-6207.Capr-09-0233  0.317
2010 Behrens C, Feng L, Kadara H, Kim HJ, Lee JJ, Mehran R, Hong WK, Lotan R, Wistuba II. Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 34-44. PMID 20028769 DOI: 10.1158/1078-0432.Ccr-09-0650  0.622
2010 Kim SJ, Choi IJ, Cheong TC, Lee SJ, Lotan R, Park SH, Chun KH. Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression. Gastroenterology. 138: 1035-45.e1-2. PMID 19818782 DOI: 10.1053/J.Gastro.2009.09.061  0.388
2010 Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X. Abstract PR-03: Genetic variations in microRNA biogenesis genes as predictors for risk of second primary tumor (SPT) and/or recurrence in patients with early‐stage head and neck cancer Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-Pr-03  0.302
2010 Lotan R. Abstract PL02-03: Insights from a new mouse model into the role of inflammation at early stages of lung carcinogenesis Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-Pl02-03  0.475
2010 Hildebrandt MAT, Lippman SM, Kim E, Lee JJ, Khuri F, Spitz MR, Lotan R, Hong WK, Wu X. Abstract B94: Pharmacogenetics of retinoid chemoprevention in head and neck cancer patients: Modulation of response by common genetic variation in the mTOR signaling pathway Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-B94  0.315
2010 Chen Y, Deng J, Fujimoto J, Kadara H, Ye X, Men T, Lotan D, Lotan R. Abstract 4995: Loss of the lung-specific tumor suppressor Gprc5a causes persistent activation of Stat3 leading to increased survival signaling in normal and malignant lung epithelial cells Cancer Research. 70: 4995-4995. DOI: 10.1158/1538-7445.Am10-4995  0.675
2010 Kadara HN, Hong WK, Wistuba II, Lotan R. Abstract 4817: A five-gene signature predictive of survival in lung adenocarcinoma but not in squamous cell carcinoma Cancer Research. 70: 4817-4817. DOI: 10.1158/1538-7445.Am10-4817  0.388
2010 Fujimoto J, Kadara HN, Tao Q, Men T, Pelt Cv, Lotan D, Lotan R. Abstract 2466: Tobacco carcinogen-enhanced lung tumorigenesis in Gprc5a knockout mice recapitulates human lung cancer development Cancer Research. 70: 2466-2466. DOI: 10.1158/1538-7445.Am10-2466  0.444
2009 Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis. 30: 1949-56. PMID 19793800 DOI: 10.1093/Carcin/Bgp229  0.422
2009 Kadara H, Lacroix L, Behrens C, Solis L, Gu X, Lee JJ, Tahara E, Lotan D, Hong WK, Wistuba II, Lotan R. Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system. Cancer Prevention Research (Philadelphia, Pa.). 2: 702-11. PMID 19638491 DOI: 10.1158/1940-6207.Capr-09-0084  0.639
2009 Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. Cancer Prevention Research (Philadelphia, Pa.). 2: 617-24. PMID 19584075 DOI: 10.1158/1940-6207.Capr-09-0025  0.312
2009 Brannan JM, Dong W, Prudkin L, Behrens C, Lotan R, Bekele BN, Wistuba I, Johnson FM. Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4423-30. PMID 19531623 DOI: 10.1158/1078-0432.Ccr-09-0473  0.428
2009 Tahara E, Kadara H, Lacroix L, Lotan D, Lotan R. Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction. Cancer Biology & Therapy. 8: 801-7. PMID 19333010 DOI: 10.4161/Cbt.8.9.8186  0.681
2009 Ye X, Tao Q, Wang Y, Cheng Y, Lotan R. Mechanisms underlying the induction of the putative human tumor suppressor GPRC5A by retinoic acid. Cancer Biology & Therapy. 8: 951-62. PMID 19279407 DOI: 10.4161/Cbt.8.10.8244  0.376
2009 Song S, Guan B, Men T, Hoque A, Lotan R, Xu XC. Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. Cancer Prevention Research (Philadelphia, Pa.). 2: 274-80. PMID 19258542 DOI: 10.1158/1940-6207.Capr-08-0180  0.383
2009 Hail N, Lotan R. Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state. Molecular Nutrition & Food Research. 53: 49-67. PMID 19051186 DOI: 10.1002/Mnfr.200700527  0.376
2008 Behrens C, Lin HY, Lee JJ, Raso MG, Hong WK, Wistuba II, Lotan R. Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6014-22. PMID 18829480 DOI: 10.1158/1078-0432.Ccr-08-0167  0.442
2008 Kadara H, Tahara E, Kim HJ, Lotan D, Myers J, Lotan R. Involvement of Rac in fenretinide-induced apoptosis. Cancer Research. 68: 4416-23. PMID 18519704 DOI: 10.1158/0008-5472.Can-08-0031  0.678
2008 Ye X, Lotan R. Potential misinterpretation of data on differential gene expression in normal and malignant cells in vitro. Briefings in Functional Genomics & Proteomics. 7: 322-6. PMID 18467351 DOI: 10.1093/bfgp/eln021  0.307
2007 Gillenwater AM, Zhong M, Lotan R. Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells. Molecular Cancer Therapeutics. 6: 2967-75. PMID 18025281 DOI: 10.1158/1535-7163.Mct-04-0344  0.426
2007 Tao Q, Fujimoto J, Men T, Ye X, Deng J, Lacroix L, Clifford JL, Mao L, Van Pelt CS, Lee JJ, Lotan D, Lotan R. Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene. Journal of the National Cancer Institute. 99: 1668-82. PMID 18000218 DOI: 10.1093/Jnci/Djm208  0.443
2007 Chakravarti N, Lotan R, Diwan AH, Warneke CL, Johnson MM, Prieto VG. Decreased expression of retinoid receptors in melanoma: entailment in tumorigenesis and prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 4817-24. PMID 17699860 DOI: 10.1158/1078-0432.Ccr-06-3026  0.393
2007 Kim SW, Cheon K, Kim CH, Yoon JH, Hawke DH, Kobayashi R, Prudkin L, Wistuba II, Lotan R, Hong WK, Koo JS. Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method. Cancer Research. 67: 6565-73. PMID 17638865 DOI: 10.1158/0008-5472.Can-06-2783  0.44
2007 Schroeder CP, Yang P, Newman RA, Lotan R. Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines. Journal of Experimental Therapeutics & Oncology. 6: 183-92. PMID 17552358  0.337
2007 Kadara H, Lacroix L, Lotan D, Lotan R. Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells. Cancer Biology & Therapy. 6: 705-11. PMID 17404501 DOI: 10.4161/Cbt.6.5.3963  0.598
2006 Williams MD, Chakravarti N, Kies MS, Maruya S, Myers JN, Haviland JC, Weber RS, Lotan R, El-Naggar AK. Implications of methylation patterns of cancer genes in salivary gland tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 7353-8. PMID 17189407 DOI: 10.1158/1078-0432.Ccr-06-1272  0.325
2006 Shen J, Behrens C, Wistuba II, Feng L, Lee JJ, Hong WK, Lotan R. Identification and validation of differences in protein levels in normal, premalignant, and malignant lung cells and tissues using high-throughput Western Array and immunohistochemistry. Cancer Research. 66: 11194-206. PMID 17145864 DOI: 10.1158/0008-5472.Can-04-1444  0.48
2006 Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacological Reviews. 58: 760-72. PMID 17132853 DOI: 10.1124/Pr.58.4.7  0.302
2006 Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacological Reviews. 58: 712-25. PMID 17132850 DOI: 10.1124/Pr.58.4.4  0.332
2006 Schroeder CP, Kadara H, Lotan D, Woo JK, Lee HY, Hong WK, Lotan R. Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells. Cancer Research. 66: 9762-70. PMID 17018636 DOI: 10.1158/0008-5472.Can-05-4124  0.635
2006 Liang ZD, Lippman SM, Wu TT, Lotan R, Xu XC. RRIG1 mediates effects of retinoic acid receptor beta2 on tumor cell growth and gene expression through binding to and inhibition of RhoA. Cancer Research. 66: 7111-8. PMID 16849557 DOI: 10.1158/0008-5472.Can-06-0812  0.441
2006 Lacroix L, Feng G, Lotan R. Identification of genes expressed differentially in an in vitro human lung carcinogenesis model. Cancer Biology & Therapy. 5: 665-73. PMID 16775421 DOI: 10.4161/Cbt.5.6.2870  0.488
2006 Kadara H, Schroeder CP, Lotan D, Pisano C, Lotan R. Induction of GDF-15/NAG-1/MIC-1 in human lung carcinoma cells by retinoid-related molecules and assessment of its role in apoptosis. Cancer Biology & Therapy. 5: 518-22. PMID 16582595 DOI: 10.4161/Cbt.5.5.2602  0.624
2006 Fukumori T, Oka N, Takenaka Y, Nangia-Makker P, Elsamman E, Kasai T, Shono M, Kanayama HO, Ellerhorst J, Lotan R, Raz A. Galectin-3 regulates mitochondrial stability and antiapoptotic function in response to anticancer drug in prostate cancer. Cancer Research. 66: 3114-9. PMID 16540661 DOI: 10.1158/0008-5472.Can-05-3750  0.416
2006 Chakravarti N, El-Naggar AK, Lotan R, Anderson J, Diwan AH, Saadati HG, Diba R, Prieto VG, Esmaeli B. Expression of retinoid receptors in sebaceous cell carcinoma. Journal of Cutaneous Pathology. 33: 10-7. PMID 16441406 DOI: 10.1111/J.0303-6987.2006.00396.X  0.346
2006 Kim HJ, Chakravarti N, Oridate N, Choe C, Claret FX, Lotan R. N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells Oncogene. 25: 2785-2794. PMID 16407847 DOI: 10.1038/Sj.Onc.1209303  0.342
2005 Zelent A, Petrie K, Lotan R, Waxman S, Gore SD. Clinical translation of epigenetics in cancer: eN-CORe--a report on the second workshop. Molecular Cancer Therapeutics. 4: 1810-9. PMID 16276003 DOI: 10.1158/1535-7163.Mct-05-0230  0.335
2005 Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer Research. 65: 9555-65. PMID 16230421 DOI: 10.1158/0008-5472.Can-05-1585  0.342
2005 Kim HJ, Oridate N, Lotan R. Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells. International Journal of Oncology. 27: 787-90. PMID 16077929 DOI: 10.3892/Ijo.27.3.787  0.454
2005 Chakravarti N, Saadati HG, El-Naggar AK, Lotan R, Diba RE, Esmaeli B. Retinoid receptor subtypes in sebaceous cell carcinoma of the eyelid. Ophthalmic Plastic and Reconstructive Surgery. 21: 292-7. PMID 16052143 DOI: 10.1097/01.Iop.0000172180.94824.79  0.372
2005 Ju Z, Kapoor M, Newton K, Cheon K, Ramaswamy A, Lotan R, Strong LC, Koo JS. Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells Molecular Genetics and Genomics. 274: 141-154. PMID 16049682 DOI: 10.1007/S00438-005-0014-7  0.464
2005 Jin F, Liu X, Zhou Z, Yue P, Lotan R, Khuri FR, Chung LW, Sun SY. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Research. 65: 6354-63. PMID 16024638 DOI: 10.1158/0008-5472.Can-04-4061  0.354
2005 Lee HY, Chang YS, Han JY, Liu DD, Lee JJ, Lotan R, Spitz MR, Hong WK. Effects of 9-cis-retinoic acid on the insulin-like growth factor axis in former smokers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 4439-49. PMID 15994153 DOI: 10.1200/Jco.2005.04.572  0.344
2005 Maruya SI, Myers JN, Weber RS, Rosenthal DI, Lotan R, El-Naggar AK. ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion! Oral Oncology. 41: 580-588. PMID 15975520 DOI: 10.1016/J.Oraloncology.2005.01.002  0.407
2005 Sun SY, Schroeder CP, Yue P, Lotan D, Hong WK, Lotan R. Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations. Cancer Biology & Therapy. 4: 407-13. PMID 15846100 DOI: 10.4161/Cbt.4.4.1618  0.454
2005 Oridate N, Kim HJ, Xu X, Lotan R. Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin. Cancer Biology & Therapy. 4: 318-23. PMID 15846092 DOI: 10.4161/Cbt.4.3.1504  0.417
2005 Chun KH, Pfahl M, Lotan R. Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells. Oncogene. 24: 3669-77. PMID 15782141 DOI: 10.1038/Sj.Onc.1208339  0.408
2005 Zelent A, Petrie K, Chen Z, Lotan R, Lübbert M, Tallman MS, Ohno R, Degos L, Waxman S. Molecular target-based treatment of human cancer: summary of the 10th international conference on differentiation therapy. Cancer Research. 65: 1117-23. PMID 15734991 DOI: 10.1158/0008-5472.Can-04-3603  0.301
2005 Oridate N, Lotan R. Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21. International Journal of Oncology. 26: 757-61. PMID 15703834 DOI: 10.3892/Ijo.26.3.757  0.443
2005 Kim HJ, Lotan R. Identification of protein modulation by the synthetic retinoid CD437 in lung carcinoma cells using high throughput immunoblotting. International Journal of Oncology. 26: 483-91. PMID 15645134 DOI: 10.3892/Ijo.26.2.483  0.414
2005 Lotan R. A crucial role for cellular retinol-binding protein I in retinoid signaling. Journal of the National Cancer Institute. 97: 3-4. PMID 15632368 DOI: 10.1093/Jnci/Dji031  0.354
2005 Zou C, Ramakumar S, Qian L, Zou C, Zang R, Wang J, Grossman HB, Lotan R, Liebert M. Effect of retinoic acid and interferon alpha-2a on transitional cell carcinoma of bladder. The Journal of Urology. 173: 247-51. PMID 15592090 DOI: 10.1097/01.Ju.0000141584.50650.26  0.408
2005 Meric-Bernstam F, Zhang H, Lotan R, Lotan D, Sahin A, Babiera GV, Kopelovich L, Crowell JA, Strong LC. Feasibility of the use of primary breast epithelial cell cultures to identify genotype-specific preventive agents Journal of Clinical Oncology. 23: 3140-3140. DOI: 10.1200/Jco.2005.23.16_Suppl.3140  0.316
2005 Lotan R, Men T, Fujimoto J, Tao Q. P-081 Gpcr5a-knockout mouse: A novel model for spontaneous and tobacco carcinogen-enhanced lung adenocarcinoma Lung Cancer. 49: S135. DOI: 10.1016/S0169-5002(05)80575-6  0.335
2004 Hsi LC, Xi X, Lotan R, Shureiqi I, Lippman SM. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells. Cancer Research. 64: 8778-81. PMID 15574791 DOI: 10.1158/0008-5472.Can-04-1867  0.441
2004 Lu C, Soria JC, Tang X, Xu XC, Wang L, Mao L, Lotan R, Kemp B, Bekele BN, Feng L, Hong WK, Khuri FR. Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 4575-83. PMID 15542809 DOI: 10.1200/Jco.2004.01.091  0.419
2004 Lee HY, Moon H, Chun KH, Chang YS, Hassan K, Ji L, Lotan R, Khuri FR, Hong WK. Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells. Journal of the National Cancer Institute. 96: 1536-48. PMID 15494604 DOI: 10.1093/Jnci/Djh286  0.474
2004 Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Research. 64: 7570-8. PMID 15492284 DOI: 10.1158/0008-5472.Can-04-1238  0.403
2004 Youssef EM, Issa JP, Lotan R. Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling. Cancer Biology & Therapy. 3: 1002-6. PMID 15467435 DOI: 10.4161/Cbt.3.10.1139  0.418
2004 Choi JH, Chun KH, Raz A, Lotan R. Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3. Cancer Biology & Therapy. 3: 447-52. PMID 15326375 DOI: 10.4161/Cbt.3.5.808  0.44
2004 Khuri FR, Lotan R. Retinoids in lung cancer: friend, foe, or fellow traveler? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3435-7. PMID 15277536 DOI: 10.1200/Jco.2004.05.947  0.388
2004 Schroeder CP, Yang P, Newman RA, Lotan R. Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib. Cancer Biology & Therapy. 3: 847-52. PMID 15254428 DOI: 10.4161/Cbt.3.9.1037  0.432
2004 Lotan R, Lotan Y. Retinoic acid receptor beta2 hypermethylation: implications for prostate cancer detection, prevention, and therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3935-6. PMID 15217922 DOI: 10.1158/1078-0432.Ccr-04-0536  0.392
2004 Maruya S, Issa JP, Weber RS, Rosenthal DI, Haviland JC, Lotan R, El-Naggar AK. Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3825-30. PMID 15173091 DOI: 10.1158/1078-0432.Ccr-03-0370  0.316
2004 Sun SY, Hail N, Lotan R. Apoptosis as a novel target for cancer chemoprevention. Journal of the National Cancer Institute. 96: 662-72. PMID 15126603 DOI: 10.1093/Jnci/Djh123  0.436
2004 Kim HJ, Lotan R. Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting. Cancer Research. 64: 2439-48. PMID 15059897 DOI: 10.1158/0008-5472.Can-03-2643  0.417
2004 Youssef EM, Chen XQ, Higuchi E, Kondo Y, Garcia-Manero G, Lotan R, Issa JP. Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. Cancer Research. 64: 2411-7. PMID 15059893 DOI: 10.1158/0008-5472.Can-03-0164  0.446
2004 Youssef EM, Lotan D, Issa JP, Wakasa K, Fan YH, Mao L, Hassan K, Feng L, Lee JJ, Lippman SM, Hong WK, Lotan R. Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1733-42. PMID 15014026 DOI: 10.1158/1078-0432.Ccr-0989-3  0.333
2004 Yang Z, Bagheri-Yarmand R, Wang RA, Adam L, Papadimitrakopoulou VV, Clayman GL, El-Naggar A, Lotan R, Barnes CJ, Hong WK, Kumar R. The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 658-67. PMID 14760089 DOI: 10.1158/1078-0432.Ccr-0382-03  0.419
2004 Hail N, Konopleva M, Sporn M, Lotan R, Andreeff M. Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO). The Journal of Biological Chemistry. 279: 11179-87. PMID 14711815 DOI: 10.1074/Jbc.M312758200  0.39
2004 Tao Q, Cheng Y, Clifford J, Lotan R. Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid. Genomics. 83: 270-80. PMID 14706456 DOI: 10.1016/S0888-7543(03)00237-4  0.306
2004 Appierto V, Villani MG, Cavadini E, Lotan R, Vinson C, Formelli F. Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells Cell Death and Differentiation. 11: 270-279. PMID 14647238 DOI: 10.1038/sj.cdd.4401349  0.305
2003 Sudbø J, Bryne M, Mao L, Lotan R, Reith A, Kildal W, Davidson B, Søland TM, Lippman SM. Molecular based treatment of oral cancer. Oral Oncology. 39: 749-58. PMID 13679198 DOI: 10.1016/S1368-8375(03)00098-8  0.362
2003 Higuchi E, Chandraratna RA, Hong WK, Lotan R. Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype. Oncogene. 22: 4627-35. PMID 12879006 DOI: 10.1038/Sj.Onc.1206235  0.499
2003 Chun KH, Benbrook DM, Berlin KD, Hong WK, Lotan R. The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway. Cancer Research. 63: 3826-32. PMID 12839980  0.346
2003 Huh JJ, Wolf JK, Fightmaster DL, Lotan R, Follen M. Transduction of adenovirus-mediated wild-type p53 after radiotherapy in human cervical cancer cells. Gynecologic Oncology. 89: 243-50. PMID 12713987 DOI: 10.1016/S0090-8258(03)00054-4  0.353
2003 Chun KH, Kosmeder JW, Sun S, Pezzuto JM, Lotan R, Hong WK, Lee HY. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. Journal of the National Cancer Institute. 95: 291-302. PMID 12591985 DOI: 10.1093/Jnci/95.4.291  0.418
2003 Hayashi K, Goodison S, Urquidi V, Tarin D, Lotan R, Tahara E. Differential effects of retinoic acid on the growth of isogenic metastatic and non-metastatic breast cancer cell lines and their association with distinct expression of retinoic acid receptor beta isoforms 2 and 4. International Journal of Oncology. 22: 623-9. PMID 12579317  0.312
2003 Kurie JM, Lotan R, Lee JJ, Lee JS, Morice RC, Liu DD, Xu XC, Khuri FR, Ro JY, Hittelman WN, Walsh GL, Roth JA, Minna JD, Hong WK. Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: results from a randomized placebo-controlled trial. Journal of the National Cancer Institute. 95: 206-14. PMID 12569142 DOI: 10.1093/Jnci/95.3.206  0.316
2003 Faderl S, Lotan R, Kantarjian HM, Harris D, Van Q, Estrov Z. N-(4-Hydroxylphenyl)retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL). Leukemia Research. 27: 259-66. PMID 12537979 DOI: 10.1016/S0145-2126(02)00162-5  0.381
2003 Soria JC, Xu X, Liu DD, Lee JJ, Kurie J, Morice RC, Khuri F, Mao L, Hong WK, Lotan R. Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers. Journal of the National Cancer Institute. 95: 165-8. PMID 12529350 DOI: 10.1093/Jnci/95.2.165  0.343
2003 Lotan R, Feng G. P-268 Application of an in vitro cell model and cDNA array for the identification of genes expressed differentially early during lung carcinogenesis Lung Cancer. 41: S159-S160. DOI: 10.1016/S0169-5002(03)92236-7  0.39
2002 Kim KB, Lotan R, Yue P, Sporn MB, Suh N, Gribble GW, Honda T, Wu GS, Hong WK, Sun SY. Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells. Molecular Cancer Therapeutics. 1: 177-84. PMID 12467212  0.37
2002 Wu W, Tang X, Hu W, Lotan R, Hong WK, Mao L. Identification and validation of metastasis-associated proteins in head and neck cancer cell lines by two-dimensional electrophoresis and mass spectrometry. Clinical & Experimental Metastasis. 19: 319-26. PMID 12090472 DOI: 10.1023/A:1015515119300  0.367
2002 Guan B, Yue P, Lotan R, Sun SY. Evidence that the human death receptor 4 is regulated by activator protein 1. Oncogene. 21: 3121-9. PMID 12082627 DOI: 10.1038/Sj.Onc.1205430  0.357
2002 Sun SY, Yue P, Chen X, Hong WK, Lotan R. The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Cancer Research. 62: 2430-6. PMID 11956107  0.374
2002 Shureiqi I, Jiang W, Fischer SM, Xu X, Chen D, Lee JJ, Lotan R, Lippman SM. GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells. Cancer Research. 62: 1178-83. PMID 11861401  0.329
2002 Li M, Song S, Lippman SM, Zhang XK, Liu X, Lotan R, Xu XC. Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene. 21: 411-8. PMID 11821953 DOI: 10.1038/Sj.Onc.1205106  0.364
2002 Sun SY, Lotan R. Retinoids and their receptors in cancer development and chemoprevention. Critical Reviews in Oncology/Hematology. 41: 41-55. PMID 11796231 DOI: 10.1016/S1040-8428(01)00144-5  0.449
2002 Shin DM, Glisson BS, Khuri FR, Clifford JL, Clayman G, Benner SE, Forastiere AA, Ginsberg L, Liu D, Lee JJ, Myers J, Goepfert H, Lotan R, Hong WK, Lippman SM. Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 364-70. PMID 11786562 DOI: 10.1200/Jco.20.2.364  0.347
2002 Hayashi K, Yokozaki H, Goodison S, Oue N, Suzuki T, Lotan R, Yasui W, Tahara E. Inactivation of retinoic acid receptor beta by promoter CpG hypermethylation in gastric cancer. Differentiation; Research in Biological Diversity. 68: 13-21. PMID 11683489 DOI: 10.1046/J.1432-0436.2001.068001013.X  0.383
2002 Hail N, Lotan R. Mitochondrial respiration is uniquely associated with the prooxidant and apoptotic effects of N-(4-hydroxyphenyl)retinamide. The Journal of Biological Chemistry. 276: 45614-21. PMID 11546781 DOI: 10.1074/Jbc.M106559200  0.328
2001 Zou CP, Youssef EM, Zou CC, Carey TE, Lotan R. Differential effects of chromosome 3p deletion on the expression of the putative tumor suppressor RAR beta and on retinoid resistance in human squamous carcinoma cells. Oncogene. 20: 6820-7. PMID 11687961 DOI: 10.1038/Sj.Onc.1204846  0.418
2001 Nakashima T, Sun SY, Lotan R, Fujiwara T, Yasumatsu R, Komiyama S, Clayman GL. All-trans-retinoic acid enhances the effect of adenovirus-mediated wild-type p53 gene transfer in head and neck squamous cell carcinoma. The Laryngoscope. 111: 1459-64. PMID 11568584 DOI: 10.1097/00005537-200108000-00024  0.408
2001 Lippman SM, Lee JJ, Karp DD, Vokes EE, Benner SE, Goodman GE, Khuri FR, Marks R, Winn RJ, Fry W, Graziano SL, Gandara DR, Okawara G, Woodhouse CL, Williams B, ... ... Lotan R, et al. Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer. Journal of the National Cancer Institute. 93: 605-18. PMID 11309437 DOI: 10.1093/Jnci/93.8.605  0.413
2001 Hayashi K, Yokozaki H, Naka K, Yasui W, Lotan R, Tahara E. Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines. Japanese Journal of Cancer Research : Gann. 92: 42-50. PMID 11173543 DOI: 10.1111/J.1349-7006.2001.Tb01046.X  0.464
2001 Sun SY, Yue P, Zhou JY, Wang Y, Choi Kim HR, Lotan R, Wu GS. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochemical and Biophysical Research Communications. 280: 788-97. PMID 11162590 DOI: 10.1006/Bbrc.2000.4218  0.392
2001 Hail N, Lotan R. Synthetic retinoid CD437 promotes rapid apoptosis in malignant human epidermal keratinocytes and G1 arrest in their normal counterparts. Journal of Cellular Physiology. 186: 24-34. PMID 11147811 DOI: 10.1002/1097-4652(200101)186:1<24::Aid-Jcp1006>3.0.Co;2-S  0.384
2001 ZOU C, LIEBERT M, ZOU C, GROSSMAN HB, LOTAN R. IDENTIFICATION OF EFFECTIVE RETINOIDS FOR INHIBITING GROWTH AND INDUCING APOPTOSIS IN BLADDER CANCER CELLS Journal of Urology. 165: 986-992. DOI: 10.1016/S0022-5347(05)66589-5  0.48
2000 Sun SY, Yue P, Lotan R. Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells. Oncogene. 19: 4513-22. PMID 11002424 DOI: 10.1038/Sj.Onc.1203810  0.37
2000 Sun SY, Yue P, Chandraratna RA, Tesfaigzi Y, Hong WK, Lotan R. Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells. Molecular Pharmacology. 58: 508-14. PMID 10953043 DOI: 10.1124/Mol.58.3.508  0.381
2000 Khuri FR, Lotan R, Kemp BL, Lippman SM, Wu H, Feng L, Lee JJ, Cooksley CS, Parr B, Chang E, Walsh GL, Lee JS, Hong WK, Xu XC. Retinoic acid receptor-beta as a prognostic indicator in stage I non-small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 2798-804. PMID 10920126 DOI: 10.1200/Jco.2000.18.15.2798  0.409
2000 Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, Brenner DE, Lotan R, Fischer SM, Lippman SM. 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells Journal of the National Cancer Institute. 92: 1136-1142. PMID 10904086 DOI: 10.1093/Jnci/92.14.1136  0.439
2000 Xu XC, Sola Gallego JJ, Lotan R, El-Naggar AK. Differential expression of galectin-1 and galectin-3 in benign and malignant salivary gland neoplasms. International Journal of Oncology. 17: 271-6. PMID 10891535 DOI: 10.3892/Ijo.17.2.271  0.396
2000 Qiu H, Lotan R, Lippman SM, Xu XC. Lack of correlation between expression of retinoic acid receptor-beta and loss of heterozygosity on chromosome band 3p24 in esophageal cancer. Genes, Chromosomes & Cancer. 28: 196-202. PMID 10825004 DOI: 10.1002/(Sici)1098-2264(200006)28:2<196::Aid-Gcc8>3.0.Co;2-L  0.359
2000 Lu Y, Lotan D, Lotan R. Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells. Biochimica Et Biophysica Acta. 1491: 13-9. PMID 10760565 DOI: 10.1016/S0167-4781(00)00055-5  0.378
2000 Gillenwater A, Zou CP, Zhong M, Lotan R. Effects of sodium butyrate on growth, differentiation, and apoptosis in head and neck squamous carcinoma cell lines. Head & Neck. 22: 247-56. PMID 10748448 DOI: 10.1002/(Sici)1097-0347(200005)22:3<247::Aid-Hed7>3.0.Co;2-O  0.431
2000 Sun SY, Wan H, Yue P, Hong WK, Lotan R. Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition. The Journal of Biological Chemistry. 275: 17149-53. PMID 10747926 DOI: 10.1074/Jbc.M000527200  0.473
2000 Hayashi K, Yokozaki H, Naka K, Yasui W, Yajin K, Lotan R, Tahara E. Effect of 9-cis-retinoic acid on oral squamous cell carcinoma cell lines. Cancer Letters. 151: 199-208. PMID 10738115 DOI: 10.1016/S0304-3835(99)00422-X  0.428
2000 Lippman SM, Lotan R. Advances in the development of retinoids as chemopreventive agents. The Journal of Nutrition. 130: 479S-482S. PMID 10721933 DOI: 10.1093/Jn/130.2.479S  0.337
2000 Lotan Y, Xu XC, Shalev M, Lotan R, Williams R, Wheeler TM, Thompson TC, Kadmon D. Differential expression of nuclear retinoid receptors in normal and malignant prostates. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 116-21. PMID 10623701 DOI: 10.1200/Jco.2000.18.1.116  0.328
2000 Suzuki S, Higuchi M, Proske RJ, Oridate N, Hong WK, Lotan R. Implication of mitochondria-derived reactive oxygen species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. Oncogene. 18: 6380-7. PMID 10597238 DOI: 10.1038/Sj.Onc.1203024  0.354
2000 Heintzelman DL, Lotan R, Richards-Kortum RR. Characterization of the Autofluorescence of Polymorphonuclear Leukocytes, Mononuclear Leukocytes and Cervical Epithelial Cancer Cells for Improved Spectroscopic Discrimination of Inflammation from Dysplasia Photochemistry and Photobiology. 71: 327-332. DOI: 10.1562/0031-8655(2000)0710327Cotaop2.0.Co2  0.356
1999 Qiu H, Zhang W, El-Naggar AK, Lippman SM, Lin P, Lotan R, Xu XC. Loss of Retinoic Acid Receptor-β Expression Is an Early Event during Esophageal Carcinogenesis American Journal of Pathology. 155: 1519-1523. PMID 10550308 DOI: 10.1016/S0002-9440(10)65467-3  0.349
1999 Sun SY, Yue P, Shroot B, Hong WK, Lotan R. Implication of c-Myc in apoptosis induced by the retinoid CD437 in human lung carcinoma cells. Oncogene. 18: 3894-901. PMID 10445853 DOI: 10.1038/Sj.Onc.1202771  0.405
1999 Xu XC, Lee JS, Lee JJ, Morice RC, Liu X, Lippman SM, Hong WK, Lotan R. Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention. Journal of the National Cancer Institute. 91: 1317-21. PMID 10433621 DOI: 10.1093/Jnci/91.15.1317  0.376
1999 Lotan R. Aberrant expression of retinoid receptors and lung carcinogenesis. Journal of the National Cancer Institute. 91: 989-91. PMID 10379957 DOI: 10.1093/Jnci/91.12.989  0.49
1999 Sun SY, Yue P, Wu GS, El-Deiry WS, Shroot B, Hong WK, Lotan R. Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. Oncogene. 18: 2357-65. PMID 10327056 DOI: 10.1038/Sj.Onc.1202543  0.41
1999 Zou CP, Hong WK, Lotan R. Expression of retinoic acid receptor β is associated with inhibition of keratinization in human head and neck squamous carcinoma cells Differentiation. 64: 123-132. PMID 10234809 DOI: 10.1046/J.1432-0436.1999.6420123.X  0.421
1999 Lu Y, Lotan R. Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochimica Et Biophysica Acta. 1444: 85-91. PMID 9931450 DOI: 10.1016/S0167-4781(98)00257-7  0.337
1999 Ellerhorst J, Nguyen T, Cooper DN, Estrov Y, Lotan D, Lotan R. Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1. International Journal of Oncology. 14: 225-32. PMID 9917496 DOI: 10.3892/Ijo.14.2.225  0.434
1999 Lotan R. Lung cancer promotion by beta-carotene and tobacco smoke: relationship to suppression of retinoic acid receptor-beta and increased activator protein-1? Journal of the National Cancer Institute. 91: 7-9. PMID 9890162 DOI: 10.1093/Jnci/91.1.7  0.353
1999 Cheng Y, Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. The Journal of Biological Chemistry. 273: 35008-15. PMID 9857033 DOI: 10.1074/Jbc.273.52.35008  0.455
1999 Ellerhorst J, Nguyen T, Cooper DNW, Lotan D, Lotan R. Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype. International Journal of Oncology. 14: 217-241. DOI: 10.3892/Ijo.14.2.217  0.39
1999 Yazdi Y, Ramanujam N, Lotan R, Mitchell MF, Hittelman WN, Richards-Kortum R. Resonance Raman Spectroscopy at 257 nm Excitation of Normal and Malignant Cultured Breast and Cervical Cells Applied Spectroscopy. 53: 82-85. DOI: 10.1366/0003702991945254  0.347
1998 Lu Y, Amos B, Cruise E, Lotan D, Lotan R. A parallel association between differentiation and induction of galectin-1, and inhibition of galectin-3 by retinoic acid in mouse embryonal carcinoma F9 cells. Biological Chemistry. 379: 1323-31. PMID 9865605 DOI: 10.1515/Bchm.1998.379.11.1323  0.361
1998 Zou C, Wang L, Liebert M, Grossman HB, Lotan R, Wei Q. Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines. International Journal of Oncology. 13: 1037-41. PMID 9772297 DOI: 10.3892/Ijo.13.5.1037  0.417
1998 Wan H, Dawson MI, Hong WK, Lotan R. Overexpressed activated retinoid X receptors can mediate growth inhibitory effects of retinoids in human carcinoma cells Journal of Biological Chemistry. 273: 26915-26922. PMID 9756939 DOI: 10.1074/Jbc.273.41.26915  0.387
1998 Bernacki SH, Medvedev A, Holloway G, Dawson M, Lotan R, Jetten AM. Suppression Of Relaxin Gene Expression By Retinoids In Squamous Differentiated Rabbit Tracheal Epithelial Cells Molecular and Cellular Endocrinology. 138: 115-125. PMID 9685220 DOI: 10.1016/S0303-7207(98)00013-6  0.401
1998 Biesalski HK, Bueno de Mesquita B, Chesson A, Chytil F, Grimble R, Hermus RJ, Köhrle J, Lotan R, Norpoth K, Pastorino U, Thurnham D. European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel. Ca: a Cancer Journal For Clinicians. 48: 167-76; discussion 1. PMID 9594919 DOI: 10.3322/Canjclin.48.3.167  0.367
1998 Gillenwater A, Xu XC, Estrov Y, Sacks PG, Lotan D, Lotan R. Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate. International Journal of Cancer. Journal International Du Cancer. 75: 217-24. PMID 9462711 DOI: 10.1002/(Sici)1097-0215(19980119)75:2<217::Aid-Ijc9>3.0.Co;2-X  0.444
1998 Lotan R. Retinoids and chemoprevention of aerodigestive tract cancers. Cancer Metastasis Reviews. 16: 349-56. PMID 9433644 DOI: 10.1023/A:1005808429176  0.454
1997 Biesalski HK, Bueno de Mesquita B, Chesson A, Chytil F, Grinble R, Hermus RI, Köhrle J, Lotan R, Norpoth K, Pastorino U, Thurnham D. Consensus statement on lung cancer. Lung Cancer Panel. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 6: 316-22. PMID 9370093 DOI: 10.1097/00008469-199708000-00002  0.379
1997 Wan H, Dawson MI, Hong WK, Lotan R. Enhancement of Calu-1 human lung carcinoma cell growth in serum-free medium by retinoids: Dependence on AP-1 activation, but not on retinoid response element activation Oncogene. 15: 2109-2118. PMID 9366527 DOI: 10.1038/Sj.Onc.1201381  0.44
1997 Sun SY, Yue P, Shroot B, Hong WK, Lotan R. Induction of apoptosis in human non-small cell lung carcinoma cells by the novel synthetic retinoid CD437. Journal of Cellular Physiology. 173: 279-84. PMID 9365537 DOI: 10.1002/(Sici)1097-4652(199711)173:2<279::Aid-Jcp36>3.0.Co;2-8  0.45
1997 Naka K, Yokozaki H, Domen T, Hayashi K, Kuniyasu H, Yasui W, Lotan R, Tahara E. Growth inhibition of cultured human gastric cancer cells by 9-cis-retinoic acid with induction of cdk inhibitor Waf1/Cip1/Sdi1/p21 protein. Differentiation; Research in Biological Diversity. 61: 313-20. PMID 9342842 DOI: 10.1046/J.1432-0436.1997.6150313.X  0.431
1997 Oridate N, Suzuki S, Higuchi M, Mitchell MF, Hong WK, Lotan R. Involvement of Reactive Oxygen Species in N-(4-Hydroxyphenyl)retinamide-Induced Apoptosis in Cervical Carcinoma Cells Journal of the National Cancer Institute. 89: 1191-1198. PMID 9274913 DOI: 10.1093/Jnci/89.16.1191  0.388
1997 Lotan R. Roles of retinoids and their nuclear receptors in the development and prevention of upper aerodigestive tract cancers. Environmental Health Perspectives. 985-8. PMID 9255592 DOI: 10.1289/Ehp.97105S4985  0.453
1997 Papadimitrakopoulou V, Izzo J, Lippman SM, Lee JS, Fan YH, Clayman G, Ro JY, Hittelman WN, Lotan R, Hong WK, Mao L. Frequent inactivation of p16INK4a in oral premalignant lesions. Oncogene. 14: 1799-803. PMID 9150385 DOI: 10.1038/Sj.Onc.1201010  0.302
1997 Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R. Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development. Journal of the National Cancer Institute. 89: 624-9. PMID 9150186 DOI: 10.1093/Jnci/89.9.624  0.502
1997 Oridate N, Higuchi M, Suzuki S, Shroot B, Hong WK, Lotan R. Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6-[3-(1-adamantyl)hydroxyphenyl]-2-naphtalene carboxylic acid (CD437). International Journal of Cancer. 70: 484-7. PMID 9033662 DOI: 10.1002/(Sici)1097-0215(19970207)70:4<484::Aid-Ijc21>3.0.Co;2-E  0.338
1997 Khuri FR, Lippman SM, Spitz MR, Lotan R, Hong WK. Molecular epidemiology and retinoid chemoprevention of head and neck cancer Journal of the National Cancer Institute. 89: 199-211. PMID 9017000 DOI: 10.1093/Jnci/89.3.199  0.376
1997 Eicher SA, Lotan R. Differential effects of retinoic acid and N-(4-hydroxyphenyl)retinamide on head and neck squamous cell carcinoma cells. The Laryngoscope. 106: 1471-5. PMID 8948605 DOI: 10.1097/00005537-199612000-00005  0.442
1997 Gillenwater A, Xu XC, el-Naggar AK, Clayman GL, Lotan R. Expression of galectins in head and neck squamous cell carcinoma. Head & Neck. 18: 422-32. PMID 8864733 DOI: 10.1002/(Sici)1097-0347(199609/10)18:5<422::Aid-Hed5>3.0.Co;2-7  0.399
1997 ORIDATE N, FUKUDA S, INUYAMA Y, LOTAN R. Reconstituted basement membrane (Matrigel) as a useful semisolid medium for growth of head and neck squamous carcinoma cell colonies. Japanese Jornal of Head and Neck Cancer. 23: 137-139. DOI: 10.5981/Jjhnc1974.23.137  0.326
1997 Lotan R. Retinoids and their nuclear receptors in the development, prevention, and treatment of upper airways epithelial cancers Lung Cancer. 18: 12-13. DOI: 10.1016/S0169-5002(97)83861-5  0.516
1997 Mitchell MF, Tortolero-Luna G, Lee JJ, Hittelman WK, Lotan R, Wharton JT, Hong WK, Nishioka K. Polyamine measurements in the uterine cervix Journal of Cellular Biochemistry. 67: 125-132. DOI: 10.1002/(Sici)1097-4644(1997)28/29+<125::Aid-Jcb14>3.0.Co;2-G  0.315
1996 Sacks PG, Amos B, Lotan R. Enhancement of glycosylation of cellular glycoconjugates in the squamous carcinoma cell line MDA886Ln by beta-all-trans retinoic acid. Glycoconjugate Journal. 13: 791-6. PMID 8910006 DOI: 10.1007/Bf00702343  0.358
1996 Lotan R. Retinoids in cancer chemoprevention. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 1031-9. PMID 8801164 DOI: 10.1096/Fasebj.10.9.8801164  0.448
1996 Oridate N, Lotan R, Lotan D. Reconstituted basement membrane (Matrigel): a useful semisolid medium for growth of tumor cell colonies. In Vitro Cellular & Developmental Biology. Animal. 32: 192-3. PMID 8727041 DOI: 10.1007/Bf02722944  0.306
1996 Mitchell MF, Hittelman WK, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Wharton JT, Hong WK. Chemoprevention trials and surrogate end point biomarkers in the cervix. Cancer. 76: 1956-77. PMID 8634987 DOI: 10.1002/1097-0142(19951115)76:10+<1956::Aid-Cncr2820761312>3.0.Co;2-V  0.313
1995 Lotan R, Xu XC, Lippman SM, Ro JY, Lee JS, Lee JJ, Hong WK. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. The New England Journal of Medicine. 332: 1405-10. PMID 7723796 DOI: 10.1056/Nejm199505253322103  0.354
1995 Lotan R, Belloni PN, Tressler RJ, Lotan D, Xu XC, Nicolson GL. Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion. Glycoconjugate Journal. 11: 462-8. PMID 7696849 DOI: 10.1007/Bf00731282  0.391
1995 Lotan R. Retinoids and apoptosis: implications for cancer chemoprevention and therapy. Journal of the National Cancer Institute. 87: 1655-7. PMID 7473809 DOI: 10.1093/Jnci/87.22.1655  0.439
1994 Lippman SM, Glisson BS, Kavanagh JJ, Lotan R, Hong WK, Paredes-Espinoza M, Hittelman WN, Holdener EE, Krakoff IH. Retinoic acid and interferon combination studies in human cancer. European Journal of Cancer (Oxford, England : 1990). S9-13. PMID 8260265 DOI: 10.1016/0959-8049(93)90618-P  0.415
1994 Lotan R, Ito H, Yasui W, Yokozaki H, Lotan D, Tahara E. Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomas. International Journal of Cancer. 56: 474-80. PMID 8112883 DOI: 10.1002/Ijc.2910560404  0.315
1994 Xu XC, Clifford JL, Hong WK, Lotan R. Detection of nuclear retinoic acid receptor mRNA in histological tissue sections using nonradioactive in situ hybridization histochemistry Diagnostic Molecular Pathology. 3: 122-131. PMID 7520332 DOI: 10.1097/00019606-199406000-00009  0.39
1993 Lotan R. Squamous cell differentiation markers in normal, premalignant, and malignant epithelium: effects of retinoids. Journal of Cellular Biochemistry. Supplement. 167-74. PMID 8412188 DOI: 10.1002/Jcb.240531024  0.443
1993 Lee JS, Lippman SM, Hong WK, Ro JY, Lotan R, Hittelman WN. Biomarkers in aerodigestive tract chemoprevention trials Lung Cancer. 9: 361-367. DOI: 10.1016/0169-5002(93)90692-Q  0.372
1993 Lotan R, Ellerhorst J, Gillenwater A, Amos B, Lotan D, Ohannesian D. S4.6 Expression of lactoside-binding lectins and their cognate glycoconjugates during induced differentiation of cancer cells Glycoconjugate Journal. 10: 246-246. DOI: 10.1007/Bf01209885  0.404
1992 Lotan R, Pieniazek J, George MD, Jetten AM. Identification of a new squamous cell differentiation marker and its suppression by retinoids. Journal of Cellular Physiology. 151: 94-102. PMID 1348511 DOI: 10.1002/Jcp.1041510114  0.418
1991 Clifford JL, Petkovich M, Chambon P, Lotan R. Modulation by retinoids of mRNA levels for nuclear retinoic acid receptors in murine melanoma cells. Molecular Endocrinology (Baltimore, Md.). 4: 1546-55. PMID 2178220 DOI: 10.1210/Mend-4-10-1546  0.351
1991 Lotan R, Matsushita Y, Ohannesian D, Carralero D, Ota DM, Cleary KR, Nicolson GL, Irimura T. Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression. Carbohydrate Research. 213: 47-57. PMID 1933952 DOI: 10.1016/S0008-6215(00)90597-4  0.327
1991 Poddar S, Hong WK, Thacher SM, Lotan R. Retinoic acid suppression of squamous differentiation in human head-and-neck squamous carcinoma cells International Journal of Cancer. 48: 239-247. PMID 1708365 DOI: 10.1002/Ijc.2910480215  0.417
1991 Lotan R, Clifford J. Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells Biomedicine and Pharmacotherapy. 45: 145-156. PMID 1657236 DOI: 10.1016/0753-3322(91)90102-Y  0.413
1990 Lotan R, Lotan D, Carralero DM. Modulation of galactoside-binding lectins in tumor cells by differentiation-inducing agents. Cancer Letters. 48: 115-22. PMID 2555043 DOI: 10.1016/0304-3835(89)90046-3  0.423
1990 Lippman SM, Lee JS, Lotan R, Hong WK. Chemoprevention of upper aerodigestive tract cancers: A report of the third upper Aerodigestive Cancer Task Force workshop Head and Neck. 12: 5-20. PMID 2404905 DOI: 10.1002/Hed.2880120103  0.328
1990 Steck PA, Hadi A, Lotan R, Yung WKA. Inhibition of epidermal growth factor receptor activity by retinoic acid in glioma cells Journal of Cellular Biochemistry. 42: 83-94. PMID 2307713 DOI: 10.1002/Jcb.240420204  0.389
1990 Hong WK, Lippman SM, Itri LM, Karp DD, Lee JS, Byers RM, Schantz SP, Kramer AM, Lotan R, Peters LJ. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. The New England Journal of Medicine. 323: 795-801. PMID 2202902 DOI: 10.1056/Nejm199009203231205  0.359
1990 Amos B, Lotan D, Lotan R. Increased fucosylation of high-molecular-weight glycoproteins accompanies retinoic-acid-induced differentiation of F-9 embryonal carcinoma cells. International Journal of Cancer. 46: 86-94. PMID 2163993 DOI: 10.1002/Ijc.2910460117  0.353
1990 Amos B, Lotan R. Retinoid-sensitive cells and cell lines. Methods in Enzymology. 190: 217-25. PMID 2087173 DOI: 10.1016/0076-6879(90)90026-W  0.362
1990 Lotan R, Lotan D, Sacks PG. Inhibition of tumor cell growth by retinoids. Methods in Enzymology. 190: 100-10. PMID 2087165 DOI: 10.1016/0076-6879(90)90014-R  0.366
1990 Jetten AM, Kim JS, Sacks PG, Rearick JI, Lotan D, Hong WK, Lotan R. Inhibition of growth and squamous-cell differentiation markers in cultured human head and neck squamous carcinoma cells by beta-all-trans retinoic acid. International Journal of Cancer. Journal International Du Cancer. 45: 195-202. PMID 1967595 DOI: 10.1002/Ijc.2910450135  0.408
1989 Sacks PG, Oke V, Vasey T, Lotan R. Retinoic acid inhibition of a head and neck multicellular tumor spheroid model. Head & Neck. 11: 219-25. PMID 2722497 DOI: 10.1002/Hed.2880110305  0.35
1989 Sacks PG, Oke V, Amos B, Vasey T, Lotan R. Modulation of growth, differentiation and glycoprotein synthesis by beta-all-trans retinoic acid in a multicellular tumor spheroid model for squamous carcinoma of the head and neck. International Journal of Cancer. Journal International Du Cancer. 44: 926-33. PMID 2479609 DOI: 10.1002/Ijc.2910440530  0.369
1988 Lotan R, Raz A. Lectins in cancer cells Annals of the New York Academy of Sciences. 551: 385-398. PMID 3072905 DOI: 10.1111/J.1749-6632.1988.Tb22372.X  0.394
1984 Meromsky L, Lotan R. Modulation by Retinoic Acid of Cellular, Surface-Exposed, and Secreted Glycoconjugates in Cultured Human Sarcoma Cells Journal of the National Cancer Institute. 72: 203-215. DOI: 10.1093/Jnci/72.2.203  0.366
1980 Lotan R, Ong DE, Chytil F. Comparison of the level of cellular retinoid-binding proteins and susceptibility to retinoid-induced growth inhibition of various neoplastic cell lines. Journal of the National Cancer Institute. 64: 1259-62. PMID 6929023 DOI: 10.1093/Jnci/64.5.1259  0.392
1979 Dennert G, Crowley C, Kouba J, Lotan R. Retinoic acid stimulation of the induction of mouse killer t-cells in allogeneic and syngeneic systems Journal of the National Cancer Institute. 62: 89-94. PMID 309967 DOI: 10.1093/Jnci/62.1.89  0.334
1978 Lotan R, Nicolson GL. Inhibitory effects of retinoic acid or retinyl acetate on the growth of untransformed, transformed, and tumor cells in vitro. Journal of the National Cancer Institute. 59: 1717-22. PMID 562945 DOI: 10.1093/Jnci/59.6.1717  0.346
1978 Lotan R, Giotta G, Nork E, Nicolson GL. Characterization of the inhibitory effects of retinoids on the in vitro growth of two malignant murine melanomas. Journal of the National Cancer Institute. 60: 1035-41. PMID 205660 DOI: 10.1093/Jnci/60.5.1035  0.371
Low-probability matches (unlikely to be authored by this person)
2002 Hail N, Lotan R. Examining the role of mitochondrial respiration in vanilloid-induced apoptosis. Journal of the National Cancer Institute. 94: 1281-92. PMID 12208893 DOI: 10.1093/Jnci/94.17.1281  0.297
2000 Ellerhorst J, Troncoso P, Xu XC, Lee J, Lotan R. Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer. Urological Research. 27: 362-7. PMID 10550525 DOI: 10.1007/S002400050164  0.295
2011 Lee JJ, Wu X, Hildebrandt MA, Yang H, Khuri FR, Kim E, Gu J, Ye Y, Lotan R, Spitz MR, Hong WK. Global assessment of genetic variation influencing response to retinoid chemoprevention in head and neck cancer patients. Cancer Prevention Research (Philadelphia, Pa.). 4: 185-93. PMID 21292633 DOI: 10.1158/1940-6207.Capr-10-0125  0.293
2006 Hail N, Kim HJ, Lotan R. Mechanisms of fenretinide-induced apoptosis Apoptosis. 11: 1677-1694. PMID 16850162 DOI: 10.1007/s10495-006-9289-3  0.292
2002 Zuluaga AF, Drezek R, Collier T, Lotan R, Follen M, Richards-Kortum R. Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspension. Journal of Biomedical Optics. 7: 398-403. PMID 12175289 DOI: 10.1117/1.1481047  0.292
2003 Chun KH, Lee HY, Hassan K, Khuri F, Hong WK, Lotan R. Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells. Cancer Research. 63: 4796-800. PMID 12941797  0.29
2009 Zinner RG, Barrett BL, Popova E, Damien P, Volgin AY, Gelovani JG, Lotan R, Tran HT, Pisano C, Mills GB, Mao L, Hong WK, Lippman SM, Miller JH. Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells. Molecular Cancer Therapeutics. 8: 521-32. PMID 19276160 DOI: 10.1158/1535-7163.Mct-08-0937  0.289
2007 Hittelman WN, Liu DD, Kurie JM, Lotan R, Lee JS, Khuri F, Ibarguen H, Morice RC, Walsh G, Roth JA, Minna J, Ro JY, Broxson A, Hong WK, Lee JJ. Proliferative changes in the bronchial epithelium of former smokers treated with retinoids. Journal of the National Cancer Institute. 99: 1603-12. PMID 17971525 DOI: 10.1093/Jnci/Djm205  0.288
2006 Chun KH, Lotan R. Higher potency of the synthetic retinoid MX3350-1 compared to the natural all-trans-retinoic acid in modulation of cell cycle and induction of apoptosis in head and neck squamous carcinoma cells [2] Cell Death and Differentiation. 13: 1830-1832. PMID 16601752 DOI: 10.1038/sj.cdd.4401917  0.288
2002 Lotan R. Is TIG1 a new tumor suppressor in prostate cancer? Journal of the National Cancer Institute. 94: 469-70. PMID 11929940 DOI: 10.1093/Jnci/94.7.469  0.286
2009 William WN, Lee JJ, Lippman SM, Martin JW, Chakravarti N, Tran HT, Sabichi AL, Kim ES, Feng L, Lotan R, Papadimitrakopoulou VA. High-dose fenretinide in oral leukoplakia. Cancer Prevention Research (Philadelphia, Pa.). 2: 22-6. PMID 19139014 DOI: 10.1158/1940-6207.Capr-08-0100  0.286
2006 Lippman SM, Lee JJ, Martin JW, El-Naggar AK, Xu X, Shin DM, Thomas M, Mao L, Fritsche HA, Zhou X, Papadimitrakopoulou V, Khuri FR, Tran H, Clayman GL, Hittelman WN, ... ... Lotan R, et al. Fenretinide activity in retinoid-resistant oral leukoplakia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 3109-14. PMID 16707609 DOI: 10.1158/1078-0432.Ccr-05-2636  0.284
2010 Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. Carcinogenesis. 31: 2118-23. PMID 20819778 DOI: 10.1093/Carcin/Bgq177  0.283
2004 Alberts D, Ranger-Moore J, Einspahr J, Saboda K, Bozzo P, Liu Y, Xu XC, Lotan R, Warneke J, Salasche S, Stratton S, Levine N, Goldman R, Islas M, Duckett L, et al. Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1875-80. PMID 15041701 DOI: 10.1158/1078-0432.Ccr-03-0188  0.283
1981 Lotan R, Neumann G, Lotan D. Characterization of retinoic acid-induced alterations in the proliferation and differentiation of a murine and a human melanoma cell line in culture. Annals of the New York Academy of Sciences. 359: 150-70. PMID 6942672 DOI: 10.1111/j.1749-6632.1981.tb12744.x  0.282
2007 Sudbø J, Bryne M, Mao L, Lotan R, Reith A, Kildal W, Davidson B, Soland TM, Lippman SM. Retraction notice to 'Molecular based treatment of oral cancer' [Oral Oncol. 39 (2003) 749-758] (DOI:10.1016/S1368-8375(03)00098-8) Oral Oncology. 43: 421. PMID 17457996 DOI: 10.1016/J.Oraloncology.2007.01.004  0.282
1980 Lotan R, Kramer RH, Neumann G, Lotan D, Nicolson GL. Retinoic acid-induced modifications in the growth and cell surface components of a human carcinoma (HeLa) cell line. Experimental Cell Research. 130: 401-14. PMID 6256189 DOI: 10.1016/0014-4827(80)90018-X  0.27
2003 Sabichi AL, Xu H, Fischer S, Zou C, Yang X, Steele VE, Kelloff GJ, Lotan R, Clifford JL. Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 4606-13. PMID 14555536  0.269
2000 Drezek RA, Collier T, Brookner CK, Malpica A, Lotan R, Richards-Kortum RR, Follen M. Laser scanning confocal microscopy of cervical tissue before and after application of acetic acid. American Journal of Obstetrics and Gynecology. 182: 1135-9. PMID 10819847 DOI: 10.1067/Mob.2000.104844  0.268
2003 Lotan R. Receptor-independent induction of apoptosis by synthetic retinoids Journal of Biological Regulators and Homeostatic Agents. 17: 13-28. PMID 12757019  0.267
2012 Xu X, Stier U, Rosewicz S, Elnaggar A, Lotan R. Selective suppression of nuclear retinoic acid receptor beta gene expression in human pancreatic carcinomas. International Journal of Oncology. 8: 445-51. PMID 21544381 DOI: 10.3892/ijo.8.3.445  0.266
1999 Stiegler P, Lotan R, Giordano A. From cell cycle regulation to angiogenesis: dialogue between the basic and clinical sciences. Journal of Cellular Physiology. 179: 233-6. PMID 10199563 DOI: 10.1002/(Sici)1097-4652(199905)179:2<233::Aid-Jcp14>3.0.Co;2-N  0.263
1988 Lotan R, Lotan D, Amos B. Enhancement of sialyltransferase in two melanoma cell lines that are growth-inhibited by retinoic acid results in increased sialylation of different cell-surface glycoproteins. Experimental Cell Research. 177: 284-94. PMID 3391245 DOI: 10.1016/0014-4827(88)90462-4  0.261
2006 Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ, Szabo E, Jordan VC, Spitz MR, Mills GB, Papadimitrakopoulou VA, Lotan R, Aggarwal BB, Bresalier RS, Kim J, et al. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 3661-97. PMID 16778094 DOI: 10.1158/1078-0432.Ccr-06-1104  0.261
1993 Dhingra K, Papadopoulos N, Lippman S, Lotan R, Legha SS. Phase II study of alpha-interferon and 13-cis-retinoic acid in metastatic melanoma. Investigational New Drugs. 11: 39-43. PMID 8349434 DOI: 10.1007/Bf00873908  0.261
2005 Han JY, Liu DD, Lee JJ, Kurie J, Lotan R, Hong WK, Lee HY. 9-cis-retinoic acid treatment increases serum concentrations of alpha-tocopherol in former smokers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 2305-11. PMID 15788681 DOI: 10.1158/1078-0432.Ccr-04-2074  0.261
1984 Lotan R, Stolarsky T, Lotan D, Ben-Ze'ev A. Retinoic acid restores shape-dependent growth control in neoplastic cells cultured on poly(2-hydroxyethyl methacrylate)-coated substrate. International Journal of Cancer. 33: 115-21. PMID 6693189 DOI: 10.1002/ijc.2910330118  0.255
2000 Brookner CK, Follen M, Boiko I, Galvan J, Thomsen S, Malpica A, Suzuki S, Lotan R, Richards-Kortum R. Autofluorescence patterns in short-term cultures of normal cervical tissue. Photochemistry and Photobiology. 71: 730-6. PMID 10857369 DOI: 10.1562/0031-8655(2000)071<0730:Apistc>2.0.Co;2  0.254
1987 Lotan R, Sacks PG, Lotan D, Hong WK. Differential effects of retinoic acid on the in vitro growth and cell-surface glycoconjugates of 2 human head and neck squamous-cell carcinomas. International Journal of Cancer. Journal International Du Cancer. 40: 224-9. PMID 3610390 DOI: 10.1002/ijc.2910400217  0.254
1992 Lotan R, Clifford J, Hong W, Zou C. 179. Modulation of differentiation and growth of squamous carcinoma cells in vitro by retinoids Biomedicine & Pharmacotherapy. 46: 330. DOI: 10.1016/0753-3322(92)90264-8  0.249
1984 Feingold C, Mirelman D, Lotan D, Lotan R. Enhancement by retinoic acid of the sensitivity of different tumor cell lines to the sialic acid-specific toxin of Entamoeba histolytica. Cancer Letters. 24: 263-71. PMID 6093993 DOI: 10.1016/0304-3835(84)90022-3  0.248
1987 Nicolson GL, Lotan R. Preventing diversification of malignant tumor cells during therapy. Clinical & Experimental Metastasis. 4: 231-5. PMID 3791725 DOI: 10.1007/BF00133588  0.248
1982 Lotan R, Fischer I, Meromsky L, Moldave K. Effects of retinoic acid on protein synthesis in cultured melanoma cells Journal of Cellular Physiology. 113: 47-55. PMID 7130290 DOI: 10.1002/jcp.1041130110  0.242
1984 Deutsch V, Lotan R. Stimulation of sialyltransferase activity of melanoma cells by retinoic acid. Experimental Cell Research. 149: 237-45. PMID 6641795 DOI: 10.1016/0014-4827(83)90395-6  0.24
1987 Raz A, Meromsky L, Zvibel I, Lotan R. Transformation-related changes in the expression of endogenous cell lectins. International Journal of Cancer. 39: 353-60. PMID 3818125 DOI: 10.1002/ijc.2910390314  0.24
1977 Lotan R, Beattie G, Hubbell W, Nicolson GL. Activities of lectins and their immobilized derivatives in detergent solutions. Implications on the use of lectin affinity chromatography for the purification of membrane glycoproteins. Biochemistry. 16: 1787-94. PMID 66931 DOI: 10.1021/Bi00628A004  0.238
2001 Drezek R, Brookner C, Pavlova I, Boiko I, Malpica A, Lotan R, Follen M, Richards-Kortum R. Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with dysplasia. Photochemistry and Photobiology. 73: 636-41. PMID 11421069 DOI: 10.1562/0031-8655(2001)0730636Amofct2.0.Co2  0.236
2004 Hail N, Lotan R. Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics Apoptosis. 9: 437-447. PMID 15192326 DOI: 10.1023/B:APPT.0000031449.57551.e1  0.236
1997 Lippman SM, Lotan R, Schleuniger U. Retinoid-interferon therapy of solid tumors. International Journal of Cancer. 70: 481-3. PMID 9033661 DOI: 10.1002/(Sici)1097-0215(19970207)70:4<481::Aid-Ijc20>3.0.Co;2-H  0.235
1992 Lotan R, Bemacki S, Pieniazek J, Floyd E, George M, Jetten A. 12. Discovery of new secreted protein marker of squamous differentiation (SqD), establishment of its relation to preprorelaxin and its regulation by retinoids in rabbit tracheal epithelial (RbTE) cells Biomedicine & Pharmacotherapy. 46: 244. DOI: 10.1016/0753-3322(92)90097-Q  0.233
1985 Lotan R, Meromsky L, Marikovsky Y. Prevention by retinoic acid of anionic site redistribution on the surface of cultured human sarcoma cells. Biology of the Cell. 51: 147-56. PMID 6151408 DOI: 10.1111/j.1768-322X.1984.tb00293.x  0.229
2004 Gottfried Y, Rotem A, Lotan R, Steller H, Larisch S. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. The Embo Journal. 23: 1627-35. PMID 15029247 DOI: 10.1038/sj.emboj.7600155  0.228
2012 Li X, Yoshida M, Beppu T, Lotan R. Modulation of growth and differentiation of human colon carcinoma cells by histone deacetylase inhibitory trichostatins. International Journal of Oncology. 8: 431-7. PMID 21544379 DOI: 10.3892/ijo.8.3.431  0.225
1999 Yazdi Y, Ramanujam N, Lotan R, Mitchell MF, Hittelman W, Richards-Kortum R. Resonance Raman spectroscopy at 257 nm excitation of normal and malignant cultured breast and cervical cells Applied Spectroscopy. 53: 82-85.  0.224
1981 Lotan R, Lotan D. Enhancement of melanotic expression in cultured mouse melanoma cells by retinoids. Journal of Cellular Physiology. 106: 179-89. PMID 6260817 DOI: 10.1002/jcp.1041060203  0.222
1980 Giotta GJ, Brunson KW, Lotan R. The effects of 5-bromodeoxyuridine on cyclic AMP levels and cytoskeletal organization in malignant melanoma cells. Cell Biology International Reports. 4: 105-16. PMID 6248251 DOI: 10.1016/0309-1651(80)90015-6  0.221
2001 Appierto V, Cavadini E, Pergolizzi R, Cleris L, Lotan R, Canevari S, Formelli F. Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarian tumour cell line. British Journal of Cancer. 84: 1528-34. PMID 11384104 DOI: 10.1054/bjoc.2001.1826  0.219
1988 Lotan R, Raz A. Endogenous lectins as mediators of tumor cell adhesion Journal of Cellular Biochemistry. 37: 107-117. PMID 3292544 DOI: 10.1002/jcb.240370110  0.214
2006 Lotan R. What is the relevance of in-vitro-studies for human cancer prevention? European Journal of Cancer Supplements. 4: 10. DOI: 10.1016/S1359-6349(06)80481-7  0.209
1978 Dennert G, Lotan R. Effects of retinoic acid on the immune system: stimulation of T killer cell induction European Journal of Immunology. 8: 23-29. PMID 346357 DOI: 10.1002/eji.1830080106  0.208
2005 Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S. Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation. The Journal of Biological Chemistry. 280: 25802-10. PMID 15837787 DOI: 10.1074/Jbc.M501955200  0.208
2004 Lee HY, Han JY, Chang YS, Tran H, Kurie JM, Lotan R, Liu DD, Lee JJ, Lee JS, Hong WK. Implication of insulin-like growth factor (IGF)/IGF binding protein-3 and alpha-tocopherol in the chemopreventive activity of 9-cis retinoic acid in lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 1005. PMID 28014639 DOI: 10.1200/jco.2004.22.14_suppl.1005  0.207
1982 Lotan R, Lotan D, Kadouri A. Comparison of retinoic acid effects on anchorage-dependent growth, anchorage-independent growth and fibrinolytic activity of neoplastic cells. Experimental Cell Research. 141: 79-86. PMID 6956516 DOI: 10.1016/0014-4827(82)90070-2  0.206
1996 Oridate N, Lotan D, Mitchell MF, Hong WK, Lotan R. Inhibition of proliferation and induction of apoptosis in cervical carcinoma cells by retinoids: implications for chemoprevention. Journal of Cellular Biochemistry. Supplement. 23: 80-6. PMID 8747381 DOI: 10.1002/jcb.240590911  0.206
1990 Lippman SM, Lee JS, Lotan R, Hittelman W, Wargovich MJ, Hong WK. Biomarkers as intermediate end points in chemoprevention trials Journal of the National Cancer Institute. 82: 555-560. PMID 2179569 DOI: 10.1093/Jnci/82.7.555  0.203
1988 Lotan R, Nicolson GL. Can anticancer therapy be improved by sequential use of cytotoxic and cytostatic (differentiating or immunomodulating) agents to suppress tumor cell phenotypic diversification? Biochemical Pharmacology. 37: 149-54. PMID 3277636 DOI: 10.1016/0006-2952(88)90711-3  0.199
1987 Marikovsky Y, Weinstein GD, Lotan D, Lotan R. Modulation of polycation-induced redistribution of melanoma cell surface anionic macromolecules by retinoic acid. Cancer Letters. 34: 345-52. PMID 3828986 DOI: 10.1016/0304-3835(87)90186-8  0.193
1981 Lotan R, Kramer RH, Nicolson GL. Changes in HeLa cell proliferation rate and cell surface components. Annals of the New York Academy of Sciences. 359: 407-9. PMID 6942690 DOI: 10.1111/j.1749-6632.1981.tb12773.x  0.193
1978 Lotan R, Sharon N. [41] Peanut (Arachis hypogaea) agglutinin Methods in Enzymology. 50: 361-367. DOI: 10.1016/0076-6879(78)50043-8  0.193
1980 Lotan R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochimica Et Biophysica Acta. 605: 33-91. PMID 6989400 DOI: 10.1016/0304-419X(80)90021-9  0.189
1984 Sklan D, Lotan R. Retinoid binding lipoprotein in neoplastic cells. Cancer Letters. 22: 41-7. PMID 6582999 DOI: 10.1016/0304-3835(84)90041-7  0.188
2008 Lotan Y, Lotan R. Prevention of bladder cancer recurrence by retinoic acid-ketoconazole: a promising strategy? Cancer Biology & Therapy. 7: 101-2. PMID 18347420  0.186
1977 Skutelsky E, Lotan R, Sharon N, Danon D. Distribution of the T-antigen on erythroid cell surfaces. Studies with peanut agglutinin, an anti-T specific lectin. Biochimica Et Biophysica Acta. 467: 165-74. PMID 560204 DOI: 10.1016/0005-2736(77)90193-6  0.186
1996 Kavanagh J, Liffman S, Paredes-Espinoza M, Erikson A, Delgadillo-Madrueno F, Paredes-Casillas P, Kudelka A, Hong WK, Lotan R, Hittelman W, Ahn W, Holdener E, Schleuniger U, Silva E, Tornos C, et al. The combination of 13-cis-retinoic acid and interferon alpha2a with radiation therapy in squamous cell carcinoma of the cervix International Journal of Gynecological Cancer. 6: 439-444. DOI: 10.1046/j.1525-1438.1996.06060439.x  0.183
2003 Lam S, Xu X, Parker-Klein H, Le Riche JC, Macaulay C, Guillaud M, Coldman A, Gazdar A, Lotan R. Surrogate end-point biomarker analysis in a retinol chemoprevention trial in current and former smokers with bronchial dysplasia. International Journal of Oncology. 23: 1607-13. PMID 14612933  0.183
2002 Clifford JL, Walch E, Yang X, Xu X, Alberts DS, Clayman GL, El-Naggar AK, Lotan R, Lippman SM. Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2067-72. PMID 12114405  0.18
1986 Marikovsky Y, Shlomai Z, Asher O, Lotan R, Ben-Bassat H. Distribution and modulation of surface charges of cells from human leukemia-lymphoma lines at various stages of differentiation. Cancer. 58: 2218-23. PMID 3756771 DOI: 10.1002/1097-0142(19861115)58:10<2218::AID-CNCR2820581010>3.0.CO;2-W  0.176
1976 Goldman R, Sharon N, Lotan R. A differential response elicited in macrophages on interaction with lectins Experimental Cell Research. 99: 408-422. PMID 944636 DOI: 10.1016/0014-4827(76)90598-X  0.173
1997 Bresalier RS, Yan PS, Byrd JC, Lotan R, Raz A. Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous system. Cancer. 80: 776-87. PMID 9264362 DOI: 10.1002/(SICI)1097-0142(19970815)80:4<776::AID-CNCR17>3.0.CO;2-Q  0.171
1992 Lippman S, Kavanagh J, Paredes M, Hong W, Lotan R, Hua H, Hittelman W, Holdener E, Krakoff I. 178. Phase-II trial of 13-cis retinoic acid (13cRA) plus interferon-α (IFN) in locally-advanced squamous cell carcinoma (SCC) of the cervix Biomedicine & Pharmacotherapy. 46: 329. DOI: 10.1016/0753-3322(92)90263-7  0.166
1995 Lotan RM. Squamous differentiation and retinoids. Cancer Treatment and Research. 74: 43-72. PMID 7779622 DOI: 10.1007/978-1-4615-2023-8_3  0.16
2002 Yaniv G, Shilkrut M, Lotan R, Berke G, Larisch S, Binah O. Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes. Cardiovascular Research. 54: 611-23. PMID 12031707 DOI: 10.1016/S0008-6363(02)00264-X  0.157
1976 Lotan R, Sharon N, Mirelman D. Interaction of wheat-germ agglutinin with bacterial cells and cell-wall polymers. European Journal of Biochemistry. 55: 257-62. PMID 809273 DOI: 10.1111/J.1432-1033.1975.Tb02158.X  0.157
2003 Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A, Lotan R, Richards-Kortum R. Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Research. 63: 1999-2004. PMID 12727808  0.151
1975 Mirelman D, Galun E, Sharon N, Lotan R. Inhibition of fungal growth by wheat germ agglutinin. Nature. 256: 414-6. PMID 1170502 DOI: 10.1038/256414A0  0.148
1977 Schechter B, Lis H, Lotan R, Novogrodsky A, Sharon N. The requirement for tetravalency of soybean agglutinin for induction of mitogenic stimulation of lymphocytes. European Journal of Immunology. 6: 145-9. PMID 1033064 DOI: 10.1002/Eji.1830060302  0.13
2002 Singletary SE, Atkinson EN, Hoque A, Sneige N, Sahin AA, Fritsche HA, Lotan R, Lu T, Hittelman WN, Bevers TB, Stelling CB, Lippman SM. Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2835-42. PMID 12231524  0.128
1980 Lotan R, Nicolson GL. Purification of cell membrane glycoproteins by lectin affinity chromatography. Biochimica Et Biophysica Acta. 559: 329-76. PMID 391282 DOI: 10.1016/0304-4157(79)90010-8  0.126
1991 Amit T, Hertz P, Ish-Shalom S, Lotan R, Luboshitzki R, Youdim MB, Hochberg Z. Effects of hypo or hyper-thyroidism on growth hormone-binding protein. Clinical Endocrinology. 35: 159-62. PMID 1934532 DOI: 10.1111/j.1365-2265.1991.tb03515.x  0.124
1983 Nicolson G, Lotan R, Rios A. Heterogeneous in Vitro Sensitivities of Metastatic B16 Melanoma Sublines and Clones to Retinoic Acid or BCNU Journal of Urology. 129: 1284-1284. DOI: 10.1016/S0022-5347(17)52699-3  0.119
2002 Sokolov K, Aaron J, Pavlova I, Lotan R, Malpica A, Follen M, Richards-Kortum R. Molecular specific contrast agents to enhance optical imaging of pre-cancers Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2327-2328.  0.116
1976 Lotan R, Berdicevsky I, Merzbach D, Grossowicz N. Effect of calcium ions on growth and metabolism of Saccharomyces carlsbergensis. Journal of General Microbiology. 92: 76-80. PMID 812953 DOI: 10.1099/00221287-92-1-76  0.114
1976 E.A. Pereira M, Kabat EA, Lotan R, Sharon N. Immunochemical studies on the specificity of the peanut (Arachis hypogaea) Agglutinin Carbohydrate Research. 51: 107-118. PMID 1033785 DOI: 10.1016/S0008-6215(00)84040-9  0.11
1983 Hofmann CA, Lotan RM, Rath GD, Oeltmann TN. Insulin-ricin B hybrid molecules: receptor binding and biological activity in a minimal-deviation hepatoma cell line. Archives of Biochemistry and Biophysics. 227: 448-56. PMID 6364983 DOI: 10.1016/0003-9861(83)90475-7  0.108
2002 Abd-El-Barr MM, Hsu ER, Anslyn EV, Descour MR, Lotan R, Gillenwater AM, Richards-Kortum RR. Optical sectioning wide-field microscopy for imaging oral cancer Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2306-2307.  0.104
1976 Marikovsky Y, Lotan R, Lis H, Sharon N, Danon D. Agglutination and labeling density of soybean agglutinin on young and old human red blood cells. Experimental Cell Research. 99: 453-6. PMID 1269537 DOI: 10.1016/0014-4827(76)90607-8  0.101
2007 Smorgick Y, Mirovsky Y, Shalmon E, Lotan R, Dotan A, Anekstein Y. Diagnosis and treatment of spine metastases Harefuah. 146: 358-363. PMID 17674553  0.101
1998 Xu X, Lotan R. Nonisotopic in situ hybridization for the detection of nuclear retinoid receptor transcripts in tissue sections. Methods in Molecular Biology (Clifton, N.J.). 89: 233-46. PMID 9664332 DOI: 10.1385/0-89603-438-0:233  0.1
2002 Sokolov K, Galvan J, Myakov A, Lacy A, Lotan R, Richards-Kortum R. Realistic three-dimensional epithelial tissue phantoms for biomedical optics. Journal of Biomedical Optics. 7: 148-56. PMID 11818022 DOI: 10.1117/1.1427052  0.098
1981 Baldwin D, Prince M, Tsai P, Johnson C, Lotan R, Rubenstein AH, Olefsky JM. Insulin binding, internalization, and receptor regulation in cultured human fibroblasts. The American Journal of Physiology. 241: E251-60. PMID 7025657 DOI: 10.1152/Ajpendo.1981.241.3.E251  0.098
2010 Srouji S, Ben-David D, Lotan R, Riminucci M, Livne E, Bianco P. The innate osteogenic potential of the maxillary sinus (Schneiderian) membrane: An ectopic tissue transplant model simulating sinus lifting International Journal of Oral and Maxillofacial Surgery. 39: 793-801. PMID 20417057 DOI: 10.1016/j.ijom.2010.03.009  0.092
2006 Selitrennik M, Duek L, Lotan R, Choder M. Nucleocytoplasmic shuttling of the Rpb4p and Rpb7p subunits of Saccharomyces cerevisiae RNA polymerase II by two pathways Eukaryotic Cell. 5: 2092-2103. PMID 17056745 DOI: 10.1128/EC.00288-06  0.091
1998 Sun S, Lotan R. Retinoids as chemopreventive and therapeutic agents Drugs of the Future. 23: 621. DOI: 10.1358/dof.1998.023.06.858360  0.088
1977 Lotan R, Sharon N. Modification of the biological properties of plant lectins by chemical crosslinking Advances in Experimental Medicine and Biology. 86: 149-168. PMID 411349 DOI: 10.1007/978-1-4684-3282-4_8  0.086
2005 Lotan R, Bar-On VG, Harel-Sharvit L, Duek L, Melamed D, Choder M. The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs Genes and Development. 19: 3004-3016. PMID 16357218 DOI: 10.1101/gad.353205  0.084
1975 Lis H, Lotan R, Sharon N. Isolation of wheat germ agglutinin by affinity chromatography. Methods in Enzymology. 34: 341-6. PMID 4449458 DOI: 10.1016/S0076-6879(74)34035-9  0.082
2017 Reinstein E, Drasinover V, Lotan R, Gal-Tanamy M, Bolocan Nachman I, Eyal E, Jaber L, Magal N, Shohat M. Mutations in ERGIC1 cause Arthrogryposis multiplex congenita, neuropathic type. Clinical Genetics. 93: 160-163. PMID 28317099 DOI: 10.1111/cge.13018  0.082
2007 Lotan R, Goler-Baron V, Duek L, Haimovich G, Choder M. The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms Journal of Cell Biology. 178: 1133-1143. PMID 17875743 DOI: 10.1083/jcb.200701165  0.079
1976 Privat JP, Lotan R, Bouchard P, Sharon N, Monsigny M. Chemical modification of the tryptophan residues of wheat-germ agglutinin. Effect on fluorescence and saccharide-binding properties. European Journal of Biochemistry. 68: 563-72. PMID 976273 DOI: 10.1111/J.1432-1033.1976.Tb10844.X  0.077
1974 Lotan R, Lis H, Rosenwasser A, Novogrodsky A, Sharon N. Enhancement of the biological activities of soybean agglutinin by cross-linking with glutaraldehyde. Biochemical and Biophysical Research Communications. 55: 1347-55. PMID 4203906 DOI: 10.1016/S0006-291X(73)80042-7  0.069
2004 Levy AP, Friedenberg P, Lotan R, Ouyang P, Tripputi M, Higginson L, Cobb FR, Tardif JC, Bittner V, Howard BV. The Effect of Vitamin Therapy on the Progression of Corona Artery Atherosclerosis Varies by Haptoglobin Type in Postmenopausal Women Diabetes Care. 27: 925-930. PMID 15047650 DOI: 10.2337/Diacare.27.4.925  0.064
1973 Lotan R, Gussin AE, Lis H, Sharon N. Purification of wheat germ agglutinin by affinity chromatography on a sepharose-bound N-acetylglucosamine derivative. Biochemical and Biophysical Research Communications. 52: 656-62. PMID 4711179 DOI: 10.1016/0006-291X(73)90763-8  0.063
2011 Srouji S, Ben-David D, Lotan R, Livne E, Avrahami R, Zussman E. Slow-release human recombinant bone morphogenetic protein-2 embedded within electrospun scaffolds for regeneration of bone defect: In vitro and in vivo evaluation Tissue Engineering - Part A. 17: 269-277. PMID 20799887 DOI: 10.1089/ten.tea.2010.0250  0.063
2008 Goler-Baron V, Selitrennik M, Barkai O, Haimovich G, Lotan R, Choder M. Transcription in the nucleus and mRNA decay in the cytoplasm are coupled processes. Genes & Development. 22: 2022-7. PMID 18676807 DOI: 10.1101/gad.473608  0.062
2010 Finkelstein JA, Lotan R. Less invasive surgical approaches for spine metastases Journal of Pain Management. 4: 73-81.  0.061
2001 Drezek R, Brookner C, Pavlova I, Boiko I, Malpica A, Lotan R, Follen M, Richards-Kortum R. Autofluorescence Microscopy of Fresh Cervical-Tissue Sections Reveals Alterations in Tissue Biochemistry with Dysplasia¶ Photochemistry and Photobiology. 73: 636-641. DOI: 10.1562/0031-8655(2001)0730636AMOFCT2.0.CO2  0.059
2010 Lotan R, Finkelstein JA. Minimally invasive surgical approaches for spine metastases Bone and Brain Metastases: Advances in Research and Treatment. 97-109.  0.059
1975 Lotan R, Lis H, Sharon N. Aggregation and fragmentation of soybean agglutinin. Biochemical and Biophysical Research Communications. 62: 144-50. PMID 1167449 DOI: 10.1016/S0006-291X(75)80416-5  0.058
2007 Lee JJ, Kong M, Ayers GD, Lotan R. Interaction index and different methods for determining drug interaction in combination therapy Journal of Biopharmaceutical Statistics. 17: 461-480. PMID 17479394 DOI: 10.1080/10543400701199593  0.058
1973 Lotan R, Sharon N. The fluorescence of wheat germ agglutinin and of its complexes with saccharides Biochemical and Biophysical Research Communications. 55: 1340-1346. PMID 4771999 DOI: 10.1016/S0006-291X(73)80041-5  0.054
2014 Zelber-Sagi S, Salomone F, Yeshua H, Lotan R, Webb M, Halpern Z, Santo E, Oren R, Shibolet O. Non-high-density lipoprotein cholesterol independently predicts new onset of non-alcoholic fatty liver disease Liver International. 34. PMID 24118857 DOI: 10.1111/liv.12318  0.052
2007 Efrati S, Berman S, Siman-Tov Y, Lotan R, Averbukh Z, Weissgarten J, Golik A. N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis Nephrology Dialysis Transplantation. 22: 1873-1881. PMID 17400565 DOI: 10.1093/ndt/gfm113  0.047
2013 Zelber-Sagi S, Lotan R, Shibolet O, Webb M, Buch A, Nitzan-Kaluski D, Halpern Z, Santo E, Oren R. Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up Liver International. 33: 1406-1412. PMID 23656177 DOI: 10.1111/liv.12200  0.047
2010 Lotan R, Al-Rashdi A, Yee A, Finkelstein J. Clinical features of conjoined lumbosacral nerve roots versus lumbar intervertebral disc herniations. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 19: 1094-8. PMID 20602242 DOI: 10.1007/s00586-010-1329-6  0.045
2005 Suleiman M, Aronson D, Asleh R, Kapeliovich MR, Roguin A, Meisel SR, Shochat M, Sulieman A, Reisner SA, Markiewicz W, Hammerman H, Lotan R, Levy NS, Levy AP. Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction. Diabetes. 54: 2802-6. PMID 16123372 DOI: 10.2337/diabetes.54.9.2802  0.039
2004 Levy AP, Larson MG, Corey D, Lotan R, Vita JA, Benjamin EJ. Haptoglobin phenotype and prevalent coronary heart disease in the Framingham offspring cohort. Atherosclerosis. 172: 361-5. PMID 15019547 DOI: 10.1016/j.atherosclerosis.2003.10.014  0.035
2012 Zelber-Sagi S, Lotan R, Shlomai A, Webb M, Harrari G, Buch A, Nitzan Kaluski D, Halpern Z, Oren R. Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. Journal of Hepatology. 56: 1145-51. PMID 22245895 DOI: 10.1016/J.Jhep.2011.12.011  0.035
2015 Barzilay Y, Segal G, Lotan R, Regev G, Beer Y, Lonner BS, Mor A, Elbaz A. Patients with chronic non-specific low back pain who reported reduction in pain and improvement in function also demonstrated an improvement in gait pattern. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. PMID 25981205 DOI: 10.1007/s00586-015-4004-0  0.034
2016 Mlynarsky L, Schlesinger D, Lotan R, Webb M, Halpern Z, Santo E, Shibolet O, Zelber-Sagi S. Non-alcoholic fatty liver disease is not associated with a lower health perception. World Journal of Gastroenterology. 22: 4362-72. PMID 27158205 DOI: 10.3748/wjg.v22.i17.4362  0.029
1975 Lotan R, Cacan R, Cacan M, Debray H, Carter WG, Sharon N. On the presence of two types of subunit in soybean agglutinin. Febs Letters. 57: 100-3. PMID 1236809 DOI: 10.1016/0014-5793(75)80161-X  0.028
2003 Lavie L, Lotan R, Hochberg I, Herer P, Lavie P, Levy AP. Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome Sleep. 26: 592-595. PMID 12938813  0.028
2002 Cohen EG, Lotan RA, Abram PL, Scarloss BA, Schultz SE. Can groups learn? Teachers College Record. 104: 1045-1068.  0.027
2004 Lotan RA. Stepping into groupwork Teaching Cooperative Learning: the Challenge For Teacher Education. 167-182.  0.024
2015 Zelber-Sagi S, Salomone F, Webb M, Lotan R, Yeshua H, Halpern Z, Santo E, Oren R, Shibolet O. Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population. Translational Research : the Journal of Laboratory and Clinical Medicine. 165: 428-36. PMID 25468486 DOI: 10.1016/j.trsl.2014.10.008  0.021
2014 Holthuis N, Lotan R, Saltzman J, Mastrandrea M, Wild A. Supporting and understanding students’ epistemological discourse about climate change Journal of Geoscience Education. 62: 374-387. DOI: 10.5408/13-036.1  0.019
1974 Lis H, Lotan R, Sharon N. Synthesis and use of affinity chromatography columns for the purification of plant lectins. Annals of the New York Academy of Sciences. 234: 232-8. PMID 4528754 DOI: 10.1111/J.1749-6632.1974.Tb53036.X  0.019
2010 Anekstein Y, Smorgick Y, Lotan R, Agar G, Shalmon E, Floman Y, Mirovsky Y. Diabetes mellitus as a risk factor for the development of lumbar spinal stenosis Israel Medical Association Journal. 12: 16-20. PMID 20450123  0.018
2006 Lotan R. Teaching teachers to build equitable classrooms Theory Into Practice. 45: 32-39. DOI: 10.1207/s15430421tip4501_5  0.014
2003 Suleiman M, Kapeliovich MR, Roguin A, Aronson D, Meisel SR, Shochat M, Reisner SA, Hammerman H, Lotan R, Levy NS, Levy AP. Haptoglobin type and 30-day mortality in diabetic individuals presenting with acute myocardial infarction. Diabetes Care. 26: 2699-700. PMID 12941748 DOI: 10.2337/diacare.26.9.2699  0.01
2010 Ben-peretz M, Lotan R. Social and cultural influences on teacher education International Encyclopedia of Education. 525-531. DOI: 10.1016/B978-0-08-044894-7.00648-5  0.01
2008 Lotan R, Oron A, Anekstein Y, Shalmon E, Mirovsky Y. Lumbar stenosis and systemic diseases: is there any relevance? Journal of Spinal Disorders & Techniques. 21: 247-51. PMID 18525484 DOI: 10.1097/BSD.0b013e31813707af  0.01
2003 Lotan RA. Group-worthy tasks Educational Leadership. 60: 72-75.  0.01
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