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Brian M. Button, Ph.D. - Publications

Affiliations: 
2000 University of Texas Medical Branch, Galveston, TX 
Area:
Animal Physiology Biology, Medical Biophysics, Molecular Biology
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mikami Y, Grubb BR, Rogers TD, Dang H, Asakura T, Kota P, Gilmore RC, Okuda K, Morton LC, Sun L, Chen G, Wykoff JA, Ehre C, Vilar J, van Heusden C, ... Button B, et al. Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration. Science Translational Medicine. 15: eabo7728. PMID 37285404 DOI: 10.1126/scitranslmed.abo7728  0.312
2022 Kato T, Radicioni G, Papanikolas MJ, Stoychev GV, Markovetz MR, Aoki K, Porterfield M, Okuda K, Barbosa Cardenas SM, Gilmore RC, Morrison CB, Ehre C, Burns KA, White KK, Brennan TA, ... ... Button B, et al. Mucus concentration-dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis. Science Advances. 8: eabm9718. PMID 35363522 DOI: 10.1126/sciadv.abm9718  0.361
2022 Hill DB, Button B, Rubinstein M, Boucher RC. Physiology and Pathophysiology of Human Airway Mucus. Physiological Reviews. PMID 35001665 DOI: 10.1152/physrev.00004.2021  0.315
2021 van Heusden C, Grubb BR, Button B, Lazarowski ER. Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance. Life (Basel, Switzerland). 11. PMID 34064654 DOI: 10.3390/life11050430  0.334
2020 Bennett WD, Henderson AG, Ceppe A, Zeman KL, Wu J, Gladman C, Fuller F, Gazda S, Button B, Boucher RC, Donaldson SH. Effect of hypertonic saline on mucociliary clearance and clinical outcomes in chronic bronchitis. Erj Open Research. 6. PMID 32802823 DOI: 10.1183/23120541.00269-2020  0.357
2020 Danahay HL, Lilley S, Fox R, Charlton H, Sabater J, Button B, McCarthy C, Collingwood SP, Gosling M. TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine. PMID 31898911 DOI: 10.1164/Rccm.201908-1641Oc  0.469
2019 van Heusden C, Button B, Anderson WH, Ceppe A, Morton LC, O'Neal WK, Dang H, Alexis NE, Donaldson SH, Stephan H, Boucher RC, Lazarowski ER. Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 31800264 DOI: 10.1152/Ajplung.00449.2019  0.473
2019 Ramsey KA, Chen ACH, Radicioni G, Lourie R, Martin M, Broomfield A, Sheng YH, Hasnain SZ, Radford-Smith G, Simms LA, Burr L, Thornton DJ, Bowler SD, Livengood S, Ceppe A, ... ... Button B, et al. Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis. American Journal of Respiratory and Critical Care Medicine. PMID 31765597 DOI: 10.1164/Rccm.201906-1219Oc  0.397
2019 Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, et al. IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis. The Journal of Clinical Investigation. PMID 31524632 DOI: 10.1172/Jci125669  0.314
2019 Brinks V, Lipinska K, de Jager M, Beumer W, Button B, Livraghi-Butrico A, Henig N, Matthee B. The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32: 303-316. PMID 31120356 DOI: 10.1089/Jamp.2018.1502  0.432
2019 Danahay H, Lilley S, Charlton H, Fox R, Button B, Gosling M. WS03-6 TMEM16A potentiators: a new therapeutic opportunity for treating Cystic Fibrosis-Related Lung Disease Journal of Cystic Fibrosis. 18. DOI: 10.1016/S1569-1993(19)30135-3  0.36
2018 Button B, Goodell HP, Atieh E, Chen YC, Williams R, Shenoy S, Lackey E, Shenkute NT, Cai LH, Dennis RG, Boucher RC, Rubinstein M. Roles of mucus adhesion and cohesion in cough clearance. Proceedings of the National Academy of Sciences of the United States of America. PMID 30420506 DOI: 10.1073/Pnas.1811787115  0.377
2018 Hill DB, Long RF, Kissner WJ, Atieh E, Garbarine IC, Markovetz MR, Fontana NC, Christy M, Habibpour M, Tarran R, Gregory Forest M, Boucher RC, Button B. Pathological Mucus and Impaired Mucus Clearance in Cystic Fibrosis Patients Results from Increased Concentration, not altered pH. The European Respiratory Journal. PMID 30361244 DOI: 10.1183/13993003.01297-2018  0.435
2018 Rogers TD, Ostrowski LE, Livraghi-Butrico A, Button B, Grubb BR. Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads. Scientific Reports. 8: 14744. PMID 30282981 DOI: 10.1038/S41598-018-33053-2  0.3
2018 Goralski JL, Wu D, Thelin WR, Boucher RC, Button B. TheEffect of Nebulised Hypertonic Saline on Human Bronchial Epithelium. The European Respiratory Journal. PMID 29599187 DOI: 10.1183/13993003.02652-2017  0.357
2018 Ramsey K, Radicioni G, Hill D, Ehre C, Button B, Alexis NE, Knowles M, Donaldson S, Kesimer M, Mcguckin M, Boucher R. Airways mucus pathogenesis in patients with non-cystic fibrosis bronchiectasis European Respiratory Journal. 52. DOI: 10.1183/13993003.Congress-2018.Pa5049  0.352
2017 Wu D, Boucher RC, Button B, Elston T, Lin CL. An Integrated Mathematical Epithelial Cell Model for Airway Surface Liquid Regulation by Mechanical Forces. Journal of Theoretical Biology. PMID 29154907 DOI: 10.1016/J.Jtbi.2017.11.010  0.473
2017 Schultz A, Puvvadi R, Borisov SM, Shaw NC, Klimant I, Berry LJ, Montgomery ST, Nguyen T, Kreda SM, Kicic A, Noble PB, Button B, Stick SM. Airway surface liquid pH is not acidic in children with cystic fibrosis. Nature Communications. 8: 1409. PMID 29123085 DOI: 10.1038/S41467-017-00532-5  0.335
2017 Esther CR, Hill DB, Button B, Shi S, Jania CM, Duncan EA, Doerschuk CM, Chen G, Ranganathan S, Stick SM, Boucher RC. The sialic acid to urea ratio as a measure of airway surface hydration. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00398.2016. PMID 28062483 DOI: 10.1152/Ajplung.00398.2016  0.36
2016 Button B, Anderson WH, Boucher RC. Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype. Annals of the American Thoracic Society. 13: S156-62. PMID 27115951 DOI: 10.1513/Annalsats.201507-455Kv  0.387
2016 Brinks V, Lipinska K, Koppelaar M, Matthee B, Button BM, Livraghi-Butrico A, Henig N. WS18.6 QR-010 penetrates the CF-like mucus barrier in vitro and in vivo Journal of Cystic Fibrosis. 15. DOI: 10.1016/S1569-1993(16)30168-0  0.343
2014 Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. The Journal of Clinical Investigation. 124: 3047-60. PMID 24892808 DOI: 10.1172/Jci73469  0.424
2014 Henderson A, Button B, Boucher R, Kesimer M. WS12.2 Mucins are abnormally concentrated in CF respiratory secretions: role in disease pathogenesis Journal of Cystic Fibrosis. 13: S25. DOI: 10.1016/S1569-1993(14)60077-1  0.37
2013 Button B, Okada SF, Frederick CB, Thelin WR, Boucher RC. Mechanosensitive ATP release maintains proper mucus hydration of airways. Science Signaling. 6: ra46. PMID 23757023 DOI: 10.1126/Scisignal.2003755  0.456
2013 Button BM, Button B. Structure and function of the mucus clearance system of the lung. Cold Spring Harbor Perspectives in Medicine. 3. PMID 23751214 DOI: 10.1101/Cshperspect.A009720  0.44
2013 Herschlag G, Garcia GJ, Button B, Tarran R, Lindley B, Reinhardt B, Elston TC, Forest MG. A mechanochemical model for auto-regulation of lung airway surface layer volume. Journal of Theoretical Biology. 325: 42-51. PMID 23415939 DOI: 10.1016/J.Jtbi.2013.01.023  0.361
2013 Button B, VanHook AM. Science Signaling Podcast: 11 June 2013 Science Signaling. 6. DOI: 10.1126/Scisignal.2004351  0.33
2012 Oldenburg AL, Chhetri RK, Hill DB, Button B. Monitoring airway mucus flow and ciliary activity with optical coherence tomography. Biomedical Optics Express. 3: 1978-92. PMID 23024894 DOI: 10.1364/Boe.3.001978  0.365
2012 Hill DB, Button B. Establishment of respiratory air-liquid interface cultures and their use in studying mucin production, secretion, and function Methods in Molecular Biology. 842: 245-258. PMID 22259141 DOI: 10.1007/978-1-61779-513-8_15  0.353
2012 Grubb BR, O'Neal WK, Ostrowski LE, Kreda SM, Button B, Boucher RC. Transgenic hCFTR expression fails to correct β -ENaC mouse lung disease American Journal of Physiology - Lung Cellular and Molecular Physiology. 302: 238-247. PMID 22003093 DOI: 10.1152/Ajplung.00083.2011  0.386
2012 Oldenburg AL, Chhetri RK, Button BM, Hill DB, Boucher RC. Dynamic imaging of in vitro human airway epithelium using optical coherence tomography Biomedical Optics, Biomed 2012. DOI: 10.1364/Biomed.2012.Btu4B.6  0.347
2011 Garcia GJ, Picher M, Zuo P, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. Sub-Cellular Biochemistry. 55: 51-74. PMID 21560044 DOI: 10.1007/978-94-007-1217-1_3  0.419
2010 Mall MA, Button B, Johannesson B, Zhou Z, Livraghi A, Caldwell RA, Schubert SC, Schultz C, O'Neal WK, Pradervand S, Hummler E, Rossier BC, Grubb BR, Boucher RC. Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. The Journal of Biological Chemistry. 285: 26945-55. PMID 20566636 DOI: 10.1074/Jbc.M110.151803  0.423
2010 Goralski JL, Boucher RC, Button B. Osmolytes and ion transport modulators: new strategies for airway surface rehydration. Current Opinion in Pharmacology. 10: 294-9. PMID 20439165 DOI: 10.1016/J.Coph.2010.04.003  0.408
2009 Zhang L, Button B, Gabriel SE, Burkett S, Yan Y, Skiadopoulos MH, Dang YL, Vogel LN, McKay T, Mengos A, Boucher RC, Collins PL, Pickles RJ. CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. Plos Biology. 7: e1000155. PMID 19621064 DOI: 10.1371/Journal.Pbio.1000155  0.429
2008 Zuo P, Picher M, Okada SF, Lazarowski ER, Button B, Boucher RC, Elston TC. Mathematical model of nucleotide regulation on airway epithelia. Implications for airway homeostasis. The Journal of Biological Chemistry. 283: 26805-19. PMID 18662982 DOI: 10.1074/Jbc.M801516200  0.395
2008 Button B, Boucher RC. Role of mechanical stress in regulating airway surface hydration and mucus clearance rates. Respiratory Physiology & Neurobiology. 163: 189-201. PMID 18585484 DOI: 10.1016/J.Resp.2008.04.020  0.455
2007 Button B, Picher M, Boucher RC. Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. The Journal of Physiology. 580: 577-92. PMID 17317749 DOI: 10.1113/Jphysiol.2006.126086  0.483
2006 Matsui H, Wagner VE, Hill DB, Schwab UE, Rogers TD, Button B, Taylor RM, Superfine R, Rubinstein M, Iglewski BH, Boucher RC. A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proceedings of the National Academy of Sciences of the United States of America. 103: 18131-6. PMID 17116883 DOI: 10.1073/Pnas.0606428103  0.376
2006 Tarran R, Button B, Boucher RC. Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress. Annual Review of Physiology. 68: 543-61. PMID 16460283 DOI: 10.1146/Annurev.Physiol.68.072304.112754  0.461
2006 Muhlebach M, Button B, Leigh M, Boucher R. 205 Serum biomarkers in CF lung disease Journal of Cystic Fibrosis. 5: S48. DOI: 10.1016/S1569-1993(06)80187-6  0.352
2005 Koukoulis G, Caldwell R, Inokawa H, Button B, Sevala M, Lyles JD, Takashima S, Blackwell J, Randell SH, Egan TM. Trends in lung pH and po2 after circulatory arrest: Implications for non-heart-beating donors and cell culture models of lung ischemia-reperfusion injury Journal of Heart and Lung Transplantation. 24: 2218-2225. PMID 16364874 DOI: 10.1016/J.Healun.2005.06.009  0.308
2005 Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC. Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. The Journal of Biological Chemistry. 280: 35751-9. PMID 16087672 DOI: 10.1074/Jbc.M505832200  0.444
2004 Roomans GM, Kozlova I, Nilsson H, Vanthanouvong V, Button B, Tarran R. Measurements of airway surface liquid height and mucus transport by fluorescence microscopy, and of ion composition by X-ray microanalysis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 135-9. PMID 15463946 DOI: 10.1016/J.Jcf.2004.05.029  0.323
2004 Chen Y, Button B, Altenberg GA, Reuss L. Potentiation of effect of PKA stimulation of Xenopus CFTR by activation of PKC: role of NBD2. American Journal of Physiology. Cell Physiology. 287: C1436-44. PMID 15282191 DOI: 10.1152/Ajpcell.00045.2004  0.602
2001 Button B, Reuss L, Altenberg GA. PKC-mediated stimulation of amphibian CFTR depends on a single phosphorylation consensus site. Insertion of this site confers PKC sensitivity to human CFTR Journal of General Physiology. 117: 457-467. PMID 11331356 DOI: 10.1085/Jgp.117.5.457  0.665
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