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Diego Varela, PhD - Publications

Affiliations: 
Pathophysiology Universidad de Chile, Santiago, Región Metropolitana, Chile 
Area:
Cardiac Calcium channels
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F. Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Biological Research. 56: 24. PMID 37165417 DOI: 10.1186/s40659-023-00433-6  0.457
2023 Jiménez-Dinamarca I, Prado Y, Tapia P, Gatica S, Alt C, Lin CP, Reyes-Martínez C, Feijóo CG, Aravena C, González-Canacer A, Correa S, Varela D, Cabello-Verrugio C, Simon F. Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis. Biological Research. 56: 8. PMID 36869357 DOI: 10.1186/s40659-023-00419-4  0.505
2022 Echeverría C, Martin A, Simon F, Salas CO, Nazal M, Varela D, Pérez-Castro RA, Santibanez JF, Valdés-Valdés RO, Forero-Doria O, Echeverría J. and antitumor activity of tomatine in hepatocellular carcinoma. Frontiers in Pharmacology. 13: 1003264. PMID 36160442 DOI: 10.3389/fphar.2022.1003264  0.404
2020 Moreno C, Hermosilla T, Hardy P, Aballai V, Rojas P, Varela D. Ca1.2 Activity and Downstream Signaling Pathways in the Hippocampus of An Animal Model of Depression. Cells. 9. PMID 33291797 DOI: 10.3390/cells9122609  0.303
2020 Díaz-García A, Varela D. Voltage-Gated K/Na Channels and Scorpion Venom Toxins in Cancer. Frontiers in Pharmacology. 11: 913. PMID 32655396 DOI: 10.3389/Fphar.2020.00913  0.5
2020 Rivas J, Díaz N, Silva I, Morales D, Lavanderos B, Álvarez A, Saldías MP, Pulgar E, Cruz P, Maureira D, Flores G, Colombo A, Blanco C, Contreras HR, Jaña F, ... ... Varela D, et al. KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32301552 DOI: 10.1096/Fj.201901195Rrr  0.736
2020 Pérez L, Vallejos A, Echeverria C, Varela D, Cabello-Verrugio C, Simon F. Correction: OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 31942005 DOI: 10.1038/S41374-020-0375-X  0.449
2019 Gatica S, Villegas V, Vallejos A, Olivares P, Aballai V, Lagos-Meza F, Echeverria C, Cabello-Verrugio C, Varela D, Simon F. TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 31444399 DOI: 10.1038/S41374-019-0304-Z  0.49
2019 Gatica S, Eltit F, Santibanez JF, Varela D, Cabello-Verrugio C, Simon F. Expression suppression and activity inhibition of TRPM7 regulates cytokine production and multiple organ dysfunction syndrome during endotoxemia: A new target for sepsis. Current Molecular Medicine. PMID 31288723 DOI: 10.2174/1566524019666190709181726  0.487
2019 Blanco C, Morales D, Mogollones I, Vergara-Jaque A, Vargas C, Álvarez A, Riquelme D, Leiva-Salcedo E, González W, Morales D, Maureira D, Aldunate I, Cáceres M, Varela D, Cerda O. EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900136R. PMID 31112396 DOI: 10.1096/Fj.201900136R  0.792
2019 Morales D, Hermosilla T, Varela D. Calcium-dependent inactivation controls cardiac L-type Ca currents under β-adrenergic stimulation. The Journal of General Physiology. PMID 30814137 DOI: 10.1085/Jgp.201812236  0.324
2019 Pérez L, Vallejos A, Echeverria C, Varela D, Cabello-Verrugio C, Simon F. OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30664710 DOI: 10.1038/S41374-018-0151-3  0.478
2018 Vallejos A, Olivares P, Varela D, Echeverria C, Cabello-Verrugio C, Pérez-Leighton C, Simon F. Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival. Frontiers in Physiology. 9: 1800. PMID 30618812 DOI: 10.3389/Fphys.2018.01800  0.396
2018 Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, et al. FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway. Scientific Reports. 8: 13190. PMID 30181620 DOI: 10.1038/S41598-018-31367-9  0.369
2018 Hernández H, Parra A, Tobar N, Molina J, Kallens V, Hidalgo M, Varela D, Martínez J, Porras O. Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity. Redox Biology. 16: 199-208. PMID 29524842 DOI: 10.1016/J.Redox.2018.02.023  0.714
2017 Hermosilla T, Encina M, Morales D, Moreno C, Conejeros C, Alfaro-Valdés HM, Lagos-Meza F, Simon F, Altier C, Varela D. Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes. Scientific Reports. 7: 10131. PMID 28860469 DOI: 10.1038/S41598-017-10474-Z  0.552
2016 Hermosilla T, Encina M, Moreno C, Morales D, Salamanca E, Hidalgo N, Alfaro H, Varela D. CaV1.2 Interaction with AT1R Reduces Receptor Internalization Biophysical Journal. 110: 441a. DOI: 10.1016/J.Bpj.2015.11.2376  0.431
2015 Moreno C, Hermosilla T, Morales D, Encina M, Torres-Díaz L, Díaz P, Sarmiento D, Simon F, Varela D. Cavβ 2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes. Pflugers Archiv : European Journal of Physiology. PMID 26265381 DOI: 10.1007/S00424-015-1723-3  0.495
2015 Cáceres M, Ortiz L, Recabarren T, Romero A, Colombo A, Leiva-Salcedo E, Varela D, Rivas J, Silva I, Morales D, Campusano C, Almarza O, Simon F, Toledo H, Park KS, et al. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. Plos One. 10: e0130540. PMID 26110647 DOI: 10.1371/Journal.Pone.0130540  0.795
2015 Echeverría C, Montorfano I, Cabello-Verrugio C, Armisén R, Varela D, Simon F. Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway. Journal of Hypertension. 33: 981-92. PMID 25909699 DOI: 10.1097/Hjh.0000000000000496  0.429
2015 Cerda O, Cáceres M, Park KS, Leiva-Salcedo E, Romero A, Varela D, Trimmer JS, Stutzin A. Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca(2+)-activated non-selective cation channel TRPM4. PflüGers Archiv : European Journal of Physiology. 467: 1723-32. PMID 25231975 DOI: 10.1007/S00424-014-1610-3  0.782
2015 Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F. Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Microvascular Research. 98: 187-96. PMID 24518820 DOI: 10.1016/J.Mvr.2014.02.001  0.751
2014 Flynn R, Chapman K, Iftinca M, Aboushousha R, Varela D, Altier C. Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity. The Journal of Biological Chemistry. 289: 16675-87. PMID 24808184 DOI: 10.1074/Jbc.M114.558668  0.437
2014 Echeverría C, Montorfano I, Hermosilla T, Armisén R, Velásquez LA, Cabello-Verrugio C, Varela D, Simon F. Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. Plos One. 9: e94146. PMID 24710004 DOI: 10.1371/Journal.Pone.0094146  0.576
2014 Simon F, Echeverria C, Montorfano I, Becerra A, Varela D, Hermosilla T, Cabello-Verrugio C, Armisen R. P173Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives Cardiovascular Research. 103: S30.4-S30. DOI: 10.1093/Cvr/Cvu082.109  0.541
2013 Simon F, Varela D, Cabello-Verrugio C. Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans. Cellular Signalling. 25: 1614-24. PMID 23602937 DOI: 10.1016/J.Cellsig.2013.03.023  0.536
2011 Becerra A, Echeverría C, Varela D, Sarmiento D, Armisén R, Nuñez-Villena F, Montecinos M, Simon F. Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death. Cardiovascular Research. 91: 677-84. PMID 21565835 DOI: 10.1093/Cvr/Cvr135  0.505
2011 Nuñez-Villena F, Becerra A, Echeverría C, Briceño N, Porras O, Armisén R, Varela D, Montorfano I, Sarmiento D, Simon F. Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death. Antioxidants & Redox Signaling. 15: 2425-38. PMID 21539414 DOI: 10.1089/Ars.2010.3825  0.732
2011 Hermosilla T, Moreno C, Itfinca M, Altier C, Armisén R, Stutzin A, Zamponi GW, Varela D. L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes. Channels (Austin, Tex.). 5: 280-6. PMID 21525790 DOI: 10.4161/Chan.5.3.15833  0.71
2011 Hermosilla T, Moreno C, Itfinca M, Altier C, Armisén R, Stutzin A, Zamponi GW, Varela D. L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes Channels. 5.  0.641
2010 Simon F, Leiva-Salcedo E, Armisén R, Riveros A, Cerda O, Varela D, Eguiguren AL, Olivero P, Stutzin A. Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death. The Journal of Biological Chemistry. 285: 37150-8. PMID 20884614 DOI: 10.1074/Jbc.M110.155390  0.735
2010 Varela D, Penna A, Simon F, Eguiguren AL, Leiva-Salcedo E, Cerda O, Sala F, Stutzin A. P2X4 activation modulates volume-sensitive outwardly rectifying chloride channels in rat hepatoma cells. The Journal of Biological Chemistry. 285: 7566-74. PMID 20056605 DOI: 10.1074/Jbc.M109.063693  0.79
2008 Sun H, Varela D, Chartier D, Ruben PC, Nattel S, Zamponi GW, Leblanc N. Differential interactions of Na+ channel toxins with T-type Ca2+ channels. The Journal of General Physiology. 132: 101-13. PMID 18591418 DOI: 10.1085/Jgp.200709883  0.354
2008 Varela DL, Hermosilla T, Zamponi GW. Making the T-type even tinier: corticotropin-releasing factor-mediated inhibition of low-voltage-activated calcium channel activity. Molecular Pharmacology. 73: 1589-91. PMID 18326584 DOI: 10.1124/Mol.108.046961  0.313
2007 Varela D, Simon F, Olivero P, Armisén R, Leiva-Salcedo E, Jørgensen F, Sala F, Stutzin A. Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 20: 773-80. PMID 17982259 DOI: 10.1159/000110437  0.802
2007 Iftinca M, Hamid J, Chen L, Varela D, Tadayonnejad R, Altier C, Turner RW, Zamponi GW. Regulation of T-type calcium channels by Rho-associated kinase. Nature Neuroscience. 10: 854-60. PMID 17558400 DOI: 10.1038/Nn1921  0.399
2004 Varela D, Simon F, Riveros A, Jørgensen F, Stutzin A. The volume-activated chloride current depends on phospholipase C activation and intracellular calcium mobilization. Advances in Experimental Medicine and Biology. 559: 141-5. PMID 18727235 DOI: 10.1007/0-387-23752-6_13  0.735
2004 Simon F, Varela D, Eguiguren AL, Díaz LF, Sala F, Stutzin A. Hydroxyl radical activation of a Ca(2+)-sensitive nonselective cation channel involved in epithelial cell necrosis. American Journal of Physiology. Cell Physiology. 287: C963-70. PMID 15163619 DOI: 10.1152/Ajpcell.00041.2004  0.78
2004 Varela D, Simon F, Riveros A, Jørgensen F, Stutzin A. NAD(P)H oxidase-derived H(2)O(2) signals chloride channel activation in cell volume regulation and cell proliferation. The Journal of Biological Chemistry. 279: 13301-4. PMID 14761962 DOI: 10.1074/Jbc.C400020200  0.798
2004 Zúñiga L, Niemeyer MI, Varela D, Catalán M, Cid LP, Sepúlveda FV. The voltage-dependent ClC-2 chloride channel has a dual gating mechanism. The Journal of Physiology. 555: 671-82. PMID 14724195 DOI: 10.1113/jphysiol.2003.060046  0.374
2002 Simon F, Varela D, Riveros A, Eguiguren AL, Stutzin A. Non-selective cation channels and oxidative stress-induced cell swelling. Biological Research. 35: 215-22. PMID 12415739 DOI: 10.4067/S0716-97602002000200013  0.793
2002 Varela D, Niemeyer MI, Cid LP, Sepúlveda FV. Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel. The Journal of Physiology. 544: 363-72. PMID 12381811 DOI: 10.1113/jphysiol.2002.026096  0.335
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