| Year |
Citation |
Score |
| 2024 |
Wu V, Swider M, Sumaroka A, Dufour VL, Vance JE, Aleman TS, Aguirre GD, Beltran WA, Cideciyan AV. Retinal response to light exposure in BEST1-mutant dogs evaluated with ultra-high resolution OCT. Vision Research. 218: 108379. PMID 38460402 DOI: 10.1016/j.visres.2024.108379 |
0.427 |
|
| 2024 |
Taskin HO, Wivel J, Aguirre GD, Beltran WA, Aguirre GK. Cone-Driven, Geniculocortical Responses in Canine Models of Outer Retinal Disease. Translational Vision Science & Technology. 13: 18. PMID 38241039 DOI: 10.1167/tvst.13.1.18 |
0.497 |
|
| 2023 |
Taskin HO, Wivel J, Aguirre GD, Beltran WA, Aguirre GK. Cone-driven, geniculo-cortical responses in canine models of outer retinal disease. Biorxiv : the Preprint Server For Biology. PMID 38168165 DOI: 10.1101/2023.12.13.571523 |
0.775 |
|
| 2023 |
Takahashi K, Kwok JC, Sato Y, Aguirre GD, Miyadera K. Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine -associated cone-rod dystrophy. Frontiers in Cellular Neuroscience. 17: 1226603. PMID 37650070 DOI: 10.3389/fncel.2023.1226603 |
0.445 |
|
| 2023 |
Takahashi K, Kwok JC, Sato Y, Aguirre GD, Miyadera K. Extended functional rescue following AAV gene therapy in a canine model of LRIT3-congenital stationary night blindness. Vision Research. 209: 108260. PMID 37220680 DOI: 10.1016/j.visres.2023.108260 |
0.429 |
|
| 2023 |
Ripolles-Garcia A, Murgiano L, Ziolkowska N, Marinho FP, Roszak K, Iffrig S, Aguirre GD, Miyadera K. Natural disease history of a canine model of oligogenic RPGRIP1-cone-rod dystrophy establishes variable effects of previously and newly mapped modifier loci. Human Molecular Genetics. PMID 36951959 DOI: 10.1093/hmg/ddad046 |
0.334 |
|
| 2023 |
Appelbaum T, Aguirre GD, Beltran WA. Identification of circular RNAs hosted by the ORF15 genomic locus. Rna Biology. 20: 31-47. PMID 36593651 DOI: 10.1080/15476286.2022.2159165 |
0.67 |
|
| 2022 |
Nikonov S, Dolgova N, Sudharsan R, Tochitsky I, Iwabe S, Guzman JM, Van Gelder RN, Kramer RH, Aguirre GD, Beltran WA. Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina. Pharmaceutics. 14. PMID 36559205 DOI: 10.3390/pharmaceutics14122711 |
0.715 |
|
| 2022 |
Cideciyan AV, Jacobson SG, Swider M, Sumaroka A, Sheplock R, Krishnan AK, Garafalo AV, Guziewicz KE, Aguirre GD, Beltran WA, Heon E. Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations. Investigative Ophthalmology & Visual Science. 63: 12. PMID 36512348 DOI: 10.1167/iovs.63.13.12 |
0.716 |
|
| 2022 |
Cideciyan AV, Jacobson SG, Sumaroka A, Swider M, Krishnan AK, Sheplock R, Garafalo AV, Guziewicz KE, Aguirre GD, Beltran WA, Matsui Y, Kondo M, Heon E. Photoreceptor function and structure in retinal degenerations caused by biallelic BEST1 mutations. Vision Research. 203: 108157. PMID 36450205 DOI: 10.1016/j.visres.2022.108157 |
0.787 |
|
| 2022 |
Ripolles-Garcia A, Chen Y, Sato Y, Gray A, Ying GS, Aguirre GD, Beltran WA. Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations. Investigative Ophthalmology & Visual Science. 63: 22. PMID 36378130 DOI: 10.1167/iovs.63.12.22 |
0.763 |
|
| 2022 |
Ripolles-Garcia A, Dolgova N, Phillips MJ, Savina S, Ludwig AL, Stuedemann SA, Nlebedum U, Wolfe JH, Garden OA, Maminishkis A, Amaral J, Bharti K, Gamm DM, Aguirre GD, Beltran WA. Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs. Stem Cell Reports. PMID 35905738 DOI: 10.1016/j.stemcr.2022.06.009 |
0.714 |
|
| 2022 |
Miyadera K, Santana E, Roszak K, Iffrig S, Visel M, Iwabe S, Boyd RF, Bartoe JT, Sato Y, Gray A, Ripolles-Garcia A, Dufour VL, Byrne LC, Flannery JG, Beltran WA, ... Aguirre GD, et al. Targeting ON-bipolar cells by AAV gene therapy stably reverses -congenital stationary night blindness. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117038119. PMID 35316139 DOI: 10.1073/pnas.2117038119 |
0.701 |
|
| 2021 |
Ripolles-Garcia A, Ruthel G, Ying GS, Chen Y, Cuenca N, Aguirre GD, Beltran WA. Characterization of the Canine Retinal Vasculature With Optical Coherence Tomography Angiography: Comparisons With Histology and Fluorescein Angiography. Frontiers in Neuroanatomy. 15: 785249. PMID 34966262 DOI: 10.3389/fnana.2021.785249 |
0.735 |
|
| 2021 |
Badiei A, Beltran WA, Aguirre GD. Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases. Experimental Eye Research. 215: 108902. PMID 34954206 DOI: 10.1016/j.exer.2021.108902 |
0.706 |
|
| 2021 |
Aguirre GD, Kazacos KR. Is it canine DUSN?: Another view of retinopathies, some acquired, and others possibly "inherited": Another view of retinopathies, some acquired, and others possibly "inherited". Veterinary Ophthalmology. 25: 96-108. PMID 34894198 DOI: 10.1111/vop.12951 |
0.484 |
|
| 2021 |
Sato Y, Gray A, Takahashi K, Dufour V, Lutty G, Miyadera K, Aguirre G. Monocular retinopathy of prematurity-like retinal vasculopathy in a dog. Veterinary Ophthalmology. PMID 34861080 DOI: 10.1111/vop.12959 |
0.389 |
|
| 2021 |
Ripolles-Garcia A, Holle DM, Cohen JA, Beltran WA, Aguirre GD. Retinal structural and microvascular abnormalities in retinal dysplasia imaged by OCT and OCT angiography. Veterinary Ophthalmology. PMID 34808028 DOI: 10.1111/vop.12952 |
0.714 |
|
| 2021 |
Aguirre GD, Cideciyan AV, Dufour VL, Ripolles-García A, Sudharsan R, Swider M, Nikonov R, Iwabe S, Boye SL, Hauswirth WW, Jacobson SG, Beltran WA. Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 34715016 DOI: 10.1016/j.ymthe.2021.10.021 |
0.67 |
|
| 2021 |
Öztürk BE, Johnson ME, Kleyman M, Turunç S, He J, Jabalameli S, Xi Z, Visel M, Dufour VL, Iwabe S, Pompeo Marinho F, Aguirre GD, Sahel JA, Schaffer DV, Pfenning AR, et al. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Elife. 10. PMID 34664552 DOI: 10.7554/eLife.64175 |
0.629 |
|
| 2021 |
Aguirre GD, Cideciyan AV, Dufour VL, Ripolles-García A, Sudharsan R, Swider M, Nikonov R, Iwabe S, Boye SL, Hauswirth WW, Jacobson SG, Beltran WA. Gene Therapy Reforms Photoreceptor Structure and Restores Vision in NPHP5-associated Leber Congenital Amaurosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33781914 DOI: 10.1016/j.ymthe.2021.03.021 |
0.764 |
|
| 2021 |
Sudharsan R, Murgiano L, Tang HY, Olsen TW, Chavali VRM, Aguirre GD, Beltran WA. Short prolactin isoforms are expressed in photoreceptors of canine retinas undergoing retinal degeneration. Scientific Reports. 11: 460. PMID 33432105 DOI: 10.1038/s41598-020-80691-6 |
0.761 |
|
| 2020 |
Appelbaum T, Murgiano L, Becker D, Santana E, Aguirre GD. Candidate Genetic Modifiers for RPGR Retinal Degeneration. Investigative Ophthalmology & Visual Science. 61: 20. PMID 33326016 DOI: 10.1167/iovs.61.14.20 |
0.413 |
|
| 2020 |
Murgiano L, Becker D, Spector C, Carlin K, Santana E, Niggel JK, Jagannathan V, Leeb T, Pearce-Kelling S, Aguirre GD, Miyadera K. CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs. Scientific Reports. 10: 21162. PMID 33273526 DOI: 10.1038/s41598-020-77980-5 |
0.424 |
|
| 2020 |
Cideciyan AV, Jacobson SG, Roman AJ, Sumaroka A, Wu V, Charng J, Lisi B, Swider M, Aguirre GD, Beltran WA. Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations. Scientific Reports. 10: 12552. PMID 32724127 DOI: 10.1038/S41598-020-69456-3 |
0.744 |
|
| 2020 |
Song C, Dufour VLL, Cideciyan AV, Ye GJ, Swider M, Newmark J, Timmers A, Robinson P, Knop DR, Chulay JD, Jacobson S, Aguirre G, Beltran W, Shearman MS. Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy. Human Gene Therapy. PMID 32414297 DOI: 10.1089/Hum.2019.337 |
0.685 |
|
| 2020 |
Appelbaum T, Santana E, Aguirre GD. Critical Decrease in the Level of Axon Guidance Receptor ROBO1 in Rod Synaptic Terminals Is Followed by Axon Retraction. Investigative Ophthalmology & Visual Science. 61: 11. PMID 32176262 DOI: 10.1167/iovs.61.3.11 |
0.324 |
|
| 2020 |
Dufour VL, Yu Y, Pan W, Ying GS, Aguirre GD, Beltran WA. In-vivo longitudinal changes in thickness of the canine postnatal retina. Experimental Eye Research. 107926. PMID 31931002 DOI: 10.1016/J.Exer.2020.107926 |
0.745 |
|
| 2020 |
Dufour VLL, Cideciyan AV, Ye GJ, Song C, Timmers A, Habecker P, Pan W, Weinstein N, Swider M, Durham A, Ying GS, Robinson P, Jacobson S, Knop DR, Chulay JD, ... ... Aguirre G, et al. Toxicity and Efficacy Evaluation of an AAV Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa. Human Gene Therapy. PMID 31910043 DOI: 10.1089/Hum.2019.297 |
0.726 |
|
| 2019 |
Garafalo AV, Cideciyan AV, Heon E, Sheplock R, Pearson A, WeiYang Yu C, Sumaroka A, Aguirre GD, Jacobson SG. Progress in treating inherited retinal diseases: Early subretinal gene therapy clinical trials and candidates for future initiatives. Progress in Retinal and Eye Research. 100827. PMID 31899291 DOI: 10.1016/J.Preteyeres.2019.100827 |
0.352 |
|
| 2019 |
Iwabe S, Dufour VL, Guzmán JM, Holle DM, Cohen JA, Beltran WA, Aguirre GD. Focal/multifocal and geographic retinal dysplasia in the dog-In vivo retinal microanatomy analyses. Veterinary Ophthalmology. PMID 31746146 DOI: 10.1111/Vop.12725 |
0.764 |
|
| 2019 |
Gardiner KL, Cideciyan AV, Swider M, Dufour VL, Sumaroka A, Komáromy AM, Hauswirth WW, Iwabe S, Jacobson SG, Beltran WA, Aguirre GD. Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31604676 DOI: 10.1016/J.Ymthe.2019.08.013 |
0.711 |
|
| 2019 |
Krishnan H, Diehl K, Stefanovski D, Aguirre GD. Vitreous degeneration and associated ocular abnormalities in the dog. Veterinary Ophthalmology. PMID 31464365 DOI: 10.1111/Vop.12707 |
0.424 |
|
| 2019 |
Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD. Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. Experimental Eye Research. PMID 30653965 DOI: 10.1016/j.exer.2019.01.007 |
0.448 |
|
| 2018 |
Murgiano L, Becker D, Torjman D, Niggel JK, Milano A, Cullen C, Feng R, Wang F, Jagannathan V, Pearce-Kelling S, Katz ML, Leeb T, Aguirre GD. Complex Structural Variant Associated with Non-syndromic Canine Retinal Degeneration. G3 (Bethesda, Md.). PMID 30541930 DOI: 10.1534/G3.118.200859 |
0.451 |
|
| 2018 |
Sudharsan R, Beiting DP, Aguirre GD, Beltran WA. Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Scientific Reports. 8: 17041. PMID 30429513 DOI: 10.1038/S41598-018-35520-2 |
0.59 |
|
| 2018 |
Hardcastle AJ, Sieving PA, Sahel JA, Jacobson SG, Cideciyan AV, Flannery JG, Beltran WA, Aguirre GD. Translational Retinal Research and Therapies. Translational Vision Science & Technology. 7: 8. PMID 30225158 DOI: 10.1167/Tvst.7.5.8 |
0.706 |
|
| 2018 |
Das RG, Marinho FP, Iwabe S, Santana E, McDaid KS, Aguirre GD, Miyadera K. Author Correction: Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. Scientific Reports. 8: 13058. PMID 30139995 DOI: 10.1038/s41598-018-31337-1 |
0.333 |
|
| 2018 |
Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC. Ndr kinases regulate retinal interneuron proliferation and homeostasis. Scientific Reports. 8: 12544. PMID 30135513 DOI: 10.1038/S41598-018-30492-9 |
0.733 |
|
| 2018 |
Cideciyan AV, Sudharsan R, Dufour VL, Massengill MT, Iwabe S, Swider M, Lisi B, Sumaroka A, Marinho LF, Appelbaum T, Rossmiller B, Hauswirth WW, Jacobson SG, Lewin AS, Aguirre GD, et al. Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127005 DOI: 10.1073/Pnas.1805055115 |
0.784 |
|
| 2018 |
Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA. Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Advances in Experimental Medicine and Biology. 1074: 593-601. PMID 29721992 DOI: 10.1007/978-3-319-75402-4_72 |
0.749 |
|
| 2018 |
Guziewicz KE, Cideciyan AV, Beltran WA, Komáromy AM, Dufour VL, Swider M, Iwabe S, Sumaroka A, Kendrick BT, Ruthel G, Chiodo VA, Héon E, Hauswirth WW, Jacobson SG, Aguirre GD.
gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507198 DOI: 10.1073/Pnas.1720662115 |
0.775 |
|
| 2017 |
Sudharsan R, Beiting DP, Aguirre GD, Beltran WA. Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Scientific Reports. 7: 17897. PMID 29263354 DOI: 10.1038/S41598-017-18236-7 |
0.772 |
|
| 2017 |
Aguirre GD. Concepts and Strategies in Retinal Gene Therapy. Investigative Ophthalmology & Visual Science. 58: 5399-5411. PMID 29053763 DOI: 10.1167/iovs.17-22978 |
0.45 |
|
| 2017 |
Ye GJ, Komaromy AM, Zeiss CJ, Calcedo R, Harman CD, Koehl KL, Stewart G, Iwabe S, Chiodo V, Hauswirth WW, Aguirre G, Chulay JD. Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in CNGB3-mutant Dogs. Human Gene Therapy. Clinical Development. PMID 29020838 DOI: 10.1089/Humc.2017.125 |
0.377 |
|
| 2017 |
Das RG, Marinho FP, Iwabe S, Santana E, McDaid KS, Aguirre GD, Miyadera K. Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. Scientific Reports. 7: 12823. PMID 28993665 DOI: 10.1038/s41598-017-13112-w |
0.5 |
|
| 2017 |
Beltran WA, Cideciyan AV, Boye SE, Ye GJ, Iwabe S, Dufour VL, Marinho LF, Swider M, Kosyk MS, Sha J, Boye SL, Peterson JJ, Witherspoon CD, Alexander JJ, Ying GS, ... ... Aguirre GD, et al. Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28566226 DOI: 10.1016/J.Ymthe.2017.05.004 |
0.743 |
|
| 2017 |
Appelbaum T, Santana E, Aguirre GD. Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration. Plos One. 12: e0177224. PMID 28486508 DOI: 10.1371/journal.pone.0177224 |
0.337 |
|
| 2017 |
Sudharsan R, Simone KM, Anderson NP, Aguirre GD, Beltran WA. Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 58: 270-281. PMID 28114588 DOI: 10.1167/Iovs.16-20749 |
0.761 |
|
| 2017 |
Guziewicz KE, Sinha D, Gómez NM, Zorych K, Dutrow EV, Dhingra A, Mullins RF, Stone EM, Gamm DM, Boesze-Battaglia K, Aguirre GD. Bestrophinopathy: An RPE-photoreceptor interface disease. Progress in Retinal and Eye Research. PMID 28111324 DOI: 10.1016/J.Preteyeres.2017.01.005 |
0.46 |
|
| 2016 |
Downs LM, Scott EM, Cideciyan AV, Iwabe S, Dufour V, Gardiner KL, Genini S, Marinho LF, Sumaroka A, Kosyk MS, Swider M, Aguirre GK, Jacobson SG, Beltran WA, Aguirre GD. Overlap of Abnormal Photoreceptor Development and Progressive Degeneration in Leber Congenital Amaurosis Caused by NPHP5 Mutation. Human Molecular Genetics. PMID 27506978 DOI: 10.1093/Hmg/Ddw254 |
0.776 |
|
| 2016 |
Appelbaum T, Becker D, Santana E, Aguirre GD. Molecular studies of phenotype variation in canine RPGR-XLPRA1. Molecular Vision. 22: 319-31. PMID 27122963 |
0.48 |
|
| 2016 |
Iwabe S, Ying GS, Aguirre GD, Beltran WA. Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog. Experimental Eye Research. 146: 341-353. PMID 27085210 DOI: 10.1016/J.Exer.2016.04.006 |
0.715 |
|
| 2016 |
Gardiner KL, Downs L, Berta-Antalics AI, Santana E, Aguirre GD, Genini S. Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations. Bmc Genomics. 17: 221. PMID 26969498 DOI: 10.1186/s12864-016-2477-9 |
0.562 |
|
| 2016 |
Downs LM, Aguirre GD. FAM161A and TTC8 are Differentially Expressed in Non-Allelelic Early Onset Retinal Degeneration. Advances in Experimental Medicine and Biology. 854: 201-7. PMID 26427412 DOI: 10.1007/978-3-319-17121-0_27 |
0.486 |
|
| 2016 |
Byrne LC, Visel M, Dufour V, Marinho FP, Aguirre GD, Beltran WA, Flannery JG, Schaffer DV. 617. Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery Molecular Therapy. 24: S244-S245. DOI: 10.1016/S1525-0016(16)33425-6 |
0.745 |
|
| 2015 |
Beltran WA, Cideciyan AV, Iwabe S, Swider M, Kosyk MS, McDaid K, Martynyuk I, Ying GS, Shaffer J, Deng WT, Boye SL, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease. Proceedings of the National Academy of Sciences of the United States of America. 112: E5844-53. PMID 26460017 DOI: 10.1073/Pnas.1509914112 |
0.772 |
|
| 2015 |
Tanaka N, Dutrow EV, Miyadera K, Delemotte L, MacDermaid CM, Reinstein SL, Crumley WR, Dixon CJ, Casal ML, Klein ML, Aguirre GD, Tanaka JC, Guziewicz KE. Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment. Plos One. 10: e0138943. PMID 26407004 DOI: 10.1371/Journal.Pone.0138943 |
0.306 |
|
| 2015 |
Kondo M, Das G, Imai R, Santana E, Nakashita T, Imawaka M, Ueda K, Ohtsuka H, Sakai K, Aihara T, Kato K, Sugimoto M, Ueno S, Nishizawa Y, Aguirre GD, et al. A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. Plos One. 10: e0137072. PMID 26368928 DOI: 10.1371/journal.pone.0137072 |
0.45 |
|
| 2015 |
Singh R, Kuai D, Guziewicz KE, Meyer J, Wilson M, Lu J, Smith M, Clark E, Verhoeven A, Aguirre GD, Gamm DM. TAPharmacological modulation of photoreceptor outer segment degradation in a human iPS cell model of inherited macular degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26300224 DOI: 10.1038/Mt.2015.141 |
0.385 |
|
| 2015 |
Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opinion On Orphan Drugs. 3: 563-575. PMID 26246977 DOI: 10.1517/21678707.2015.1030393 |
0.493 |
|
| 2015 |
Marsili S, Genini S, Sudharsan R, Gingrich J, Aguirre GD, Beltran WA. Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. Plos One. 10: e0115723. PMID 25695253 DOI: 10.1371/Journal.Pone.0115723 |
0.711 |
|
| 2015 |
Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. Cold Spring Harbor Perspectives in Medicine. 5: a017392. PMID 25301933 DOI: 10.1101/Cshperspect.A017392 |
0.764 |
|
| 2014 |
Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5574-83. PMID 25489083 DOI: 10.1073/Pnas.1414162111 |
0.749 |
|
| 2014 |
Genini S, Beltran WA, Stein VM, Aguirre GD. Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina. Advances in Experimental Medicine and Biology. 801: 339-45. PMID 24664716 DOI: 10.1007/978-1-4614-3209-8_43 |
0.631 |
|
| 2014 |
Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD. Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations. Plos One. 9: e90390. PMID 24599007 DOI: 10.1371/Journal.Pone.0090390 |
0.778 |
|
| 2014 |
Genini S, Guziewicz KE, Beltran WA, Aguirre GD. Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration. Bmc Genomics. 15: 172. PMID 24581223 DOI: 10.1186/1471-2164-15-172 |
0.707 |
|
| 2013 |
Genini S, Beltran WA, Aguirre GD. Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration. Plos One. 8: e85408. PMID 24367709 DOI: 10.1371/Journal.Pone.0085408 |
0.755 |
|
| 2013 |
Guziewicz KE, Zangerl B, Komáromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD. Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects. Plos One. 8: e75666. PMID 24143172 DOI: 10.1371/Journal.Pone.0075666 |
0.762 |
|
| 2013 |
Goldstein O, Mezey JG, Schweitzer PA, Boyko AR, Gao C, Bustamante CD, Jordan JA, Aguirre GD, Acland GM. IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds. Investigative Ophthalmology & Visual Science. 54: 7005-19. PMID 24045995 DOI: 10.1167/Iovs.13-12915 |
0.479 |
|
| 2013 |
Goldstein O, Jordan JA, Aguirre GD, Acland GM. A non-stop S-antigen gene mutation is associated with late onset hereditary retinal degeneration in dogs. Molecular Vision. 19: 1871-84. PMID 24019744 |
0.439 |
|
| 2013 |
Cideciyan AV, Jacobson SG, Beltran WA, Hauswirth WW, Aguirre GD. Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 110: E1706. PMID 23789127 DOI: 10.1073/Pnas.1304296110 |
0.771 |
|
| 2013 |
Komáromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD. Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1131-41. PMID 23568263 DOI: 10.1038/Mt.2013.50 |
0.749 |
|
| 2013 |
Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komáromy AM, Hauswirth WW, Aguirre GD. Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proceedings of the National Academy of Sciences of the United States of America. 110: E517-25. PMID 23341635 DOI: 10.1073/Pnas.1218933110 |
0.778 |
|
| 2013 |
De Vera Mudry MC, Kronenberg S, Komatsu S, Aguirre GD. Blinded by the light: retinal phototoxicity in the context of safety studies. Toxicologic Pathology. 41: 813-25. PMID 23271306 DOI: 10.1177/0192623312469308 |
0.413 |
|
| 2012 |
Hoffmann I, Guziewicz KE, Zangerl B, Aguirre GD, Mardin CY. Canine multifocal retinopathy in the Australian Shepherd: a case report. Veterinary Ophthalmology. 15: 134-8. PMID 22432598 DOI: 10.1111/j.1463-5224.2012.01005.x |
0.347 |
|
| 2012 |
Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Alemán TS, Boye SL, Genini S, Swaroop A, ... ... Aguirre GD, et al. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 109: 2132-7. PMID 22308428 DOI: 10.1073/Pnas.1118847109 |
0.797 |
|
| 2012 |
Genini S, Beltran WA, Aguirre GD. Development and validation of a canine-specific profiling array to examine expression of pro-apoptotic and pro-survival genes in retinal degenerative diseases. Advances in Experimental Medicine and Biology. 723: 353-63. PMID 22183353 DOI: 10.1007/978-1-4614-0631-0_46 |
0.693 |
|
| 2012 |
Kuznetsova T, Zangerl B, Aguirre GD. RPGRIP1 and cone-rod dystrophy in dogs. Advances in Experimental Medicine and Biology. 723: 321-8. PMID 22183349 DOI: 10.1007/978-1-4614-0631-0_42 |
0.386 |
|
| 2012 |
Miyadera K, Acland GM, Aguirre GD. Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 40-61. PMID 22065099 DOI: 10.1007/s00335-011-9361-3 |
0.473 |
|
| 2012 |
Walker K, Komaromy AM, Aguirre GD, Aguirre GK. Staged gene therapy of canine retinal blindness does not produce cortical amblyopia for the later treated eye Journal of Vision. 12: 1360-1360. DOI: 10.1167/12.9.1360 |
0.415 |
|
| 2011 |
Berta ÁI, Boesze-Battaglia K, Genini S, Goldstein O, O'Brien PJ, Szél Á, Acland GM, Beltran WA, Aguirre GD. Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina. Plos One. 6: e24074. PMID 21980341 DOI: 10.1371/Journal.Pone.0024074 |
0.74 |
|
| 2011 |
Kuznetsova T, Zangerl B, Goldstein O, Acland GM, Aguirre GD. Structural organization and expression pattern of the canine RPGRIP1 isoforms in retinal tissue. Investigative Ophthalmology & Visual Science. 52: 2989-98. PMID 21282582 DOI: 10.1167/iovs.10-6094 |
0.345 |
|
| 2011 |
Komáromy AM, Alexander JJ, Cooper AE, Chiodo VA, Acland GM, Hauswirth WW, Aguirre GD. Erratum: Targeting gene expression to cones with human cone opsin promoters in recombinant AAV Gene Therapy. 18: 1179-1179. DOI: 10.1038/gt.2011.156 |
0.329 |
|
| 2010 |
Goldstein O, Kukekova AV, Aguirre GD, Acland GM. Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd). Genomics. 96: 362-8. PMID 20887780 DOI: 10.1016/j.ygeno.2010.09.003 |
0.475 |
|
| 2010 |
Goldstein O, Mezey JG, Boyko AR, Gao C, Wang W, Bustamante CD, Anguish LJ, Jordan JA, Pearce-Kelling SE, Aguirre GD, Acland GM. An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. Molecular Vision. 16: 1549-69. PMID 20806078 |
0.452 |
|
| 2010 |
Goldstein O, Guyon R, Kukekova A, Kuznetsova TN, Pearce-Kelling SE, Johnson J, Aguirre GD, Acland GM. COL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 398-408. PMID 20686772 DOI: 10.1007/s00335-010-9276-4 |
0.32 |
|
| 2010 |
Hernández M, Pearce-Kelling SE, Rodriguez FD, Aguirre GD, Vecino E. Altered expression of retinal molecular markers in the canine RPE65 model of Leber congenital amaurosis. Investigative Ophthalmology & Visual Science. 51: 6793-802. PMID 20671290 DOI: 10.1167/iovs.10-5213 |
0.577 |
|
| 2010 |
Genini S, Zangerl B, Slavik J, Acland GM, Beltran WA, Aguirre GD. Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration. Investigative Ophthalmology & Visual Science. 51: 6038-50. PMID 20574030 DOI: 10.1167/Iovs.10-5443 |
0.745 |
|
| 2010 |
Beltran WA, Boye SL, Boye SE, Chiodo VA, Lewin AS, Hauswirth WW, Aguirre GD. rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters. Gene Therapy. 17: 1162-74. PMID 20428215 DOI: 10.1038/Gt.2010.56 |
0.742 |
|
| 2010 |
Komáromy AM, Alexander JJ, Rowlan JS, Garcia MM, Chiodo VA, Kaya A, Tanaka JC, Acland GM, Hauswirth WW, Aguirre GD. Gene therapy rescues cone function in congenital achromatopsia. Human Molecular Genetics. 19: 2581-93. PMID 20378608 DOI: 10.1093/Hmg/Ddq136 |
0.519 |
|
| 2009 |
Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ. CREB1/ATF1 activation in photoreceptor degeneration and protection. Investigative Ophthalmology & Visual Science. 50: 5355-63. PMID 19643965 DOI: 10.1167/Iovs.09-3741 |
0.6 |
|
| 2009 |
Beltran WA, Acland GM, Aguirre GD. Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations. Investigative Ophthalmology & Visual Science. 50: 3985-95. PMID 19255154 DOI: 10.1167/Iovs.08-3364 |
0.759 |
|
| 2009 |
Gu D, Beltran WA, Pearce-Kelling S, Li Z, Acland GM, Aguirre GD. Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition. Investigative Ophthalmology & Visual Science. 50: 3482-94. PMID 19234347 DOI: 10.1167/Iovs.08-3111 |
0.683 |
|
| 2008 |
Komáromy AM, Acland GM, Aguirre GD. Operating in the dark: a night-vision system for surgery in retinas susceptible to light damage. Archives of Ophthalmology (Chicago, Ill. : 1960). 126: 714-7. PMID 18474785 DOI: 10.1001/archopht.126.5.714 |
0.455 |
|
| 2008 |
Komáromy AM, Alexander JJ, Cooper AE, Chiodo VA, Glushakova LG, Acland GM, Hauswirth WW, Aguirre GD. Targeting gene expression to cones with human cone opsin promoters in recombinant AAV. Gene Therapy. 15: 1049-55. PMID 18337838 DOI: 10.1038/Gt.2008.32 |
0.438 |
|
| 2008 |
Paez GL, Zangerl B, Sellers K, Acland GM, Aguirre GD. Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray Advances in Experimental Medicine and Biology. 613: 179-184. PMID 18188943 DOI: 10.1007/978-0-387-74904-4_20 |
0.353 |
|
| 2008 |
Komáromy AM, Alexander JJ, Cooper AE, Chiodo VA, Glushakova LG, Acland GM, Hauswirth WW, Aguirre GD. Erratum: Targeting gene expression to cones with human cone opsin promoters in recombinant AAV Gene Therapy. 15: 1073-1073. DOI: 10.1038/Gt.2008.107 |
0.329 |
|
| 2007 |
Gu D, Beltran WA, Li Z, Acland GM, Aguirre GD. Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina? Investigative Ophthalmology & Visual Science. 48: 4907-18. PMID 17962438 DOI: 10.1167/Iovs.07-0428 |
0.718 |
|
| 2007 |
Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Human cone photoreceptor dependence on RPE65 isomerase. Proceedings of the National Academy of Sciences of the United States of America. 104: 15123-8. PMID 17848510 DOI: 10.1073/Pnas.0706367104 |
0.768 |
|
| 2007 |
Guyon R, Pearce-Kelling SE, Zeiss CJ, Acland GM, Aguirre GD. Analysis of six candidate genes as potential modifiers of disease expression in canine XLPRA1, a model for human X-linked retinitis pigmentosa 3. Molecular Vision. 13: 1094-105. PMID 17653054 |
0.486 |
|
| 2007 |
Zangerl B, Johnson JL, Acland GM, Aguirre GD. Independent origin and restricted distribution of RPGR deletions causing XLPRA. The Journal of Heredity. 98: 526-30. PMID 17646274 DOI: 10.1093/jhered/esm060 |
0.413 |
|
| 2007 |
Aguirre GK, Komáromy AM, Cideciyan AV, Brainard DH, Aleman TS, Roman AJ, Avants BB, Gee JC, Korczykowski M, Hauswirth WW, Acland GM, Aguirre GD, Jacobson SG. Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation. Plos Medicine. 4: e230. PMID 17594175 DOI: 10.1371/Journal.Pmed.0040230 |
0.466 |
|
| 2007 |
Guziewicz KE, Zangerl B, Lindauer SJ, Mullins RF, Sandmeyer LS, Grahn BH, Stone EM, Acland GM, Aguirre GD. Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease. Investigative Ophthalmology & Visual Science. 48: 1959-67. PMID 17460247 DOI: 10.1167/Iovs.06-1374 |
0.353 |
|
| 2007 |
Beltran WA, Wen R, Acland GM, Aguirre GD. Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. Experimental Eye Research. 84: 753-71. PMID 17320077 DOI: 10.1016/J.Exer.2006.12.019 |
0.756 |
|
| 2006 |
Paez GL, Sellers KF, Band M, Acland GM, Zangerl B, Aguirre GD. Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray. Molecular Vision. 12: 1048-56. PMID 17093389 |
0.426 |
|
| 2006 |
Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, et al. Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy. 17: 845-58. PMID 16942444 DOI: 10.1089/Hum.2006.17.845 |
0.492 |
|
| 2006 |
Zangerl B, Goldstein O, Philp AR, Lindauer SJ, Pearce-Kelling SE, Mullins RF, Graphodatsky AS, Ripoll D, Felix JS, Stone EM, Acland GM, Aguirre GD. Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans. Genomics. 88: 551-63. PMID 16938425 DOI: 10.1016/J.Ygeno.2006.07.007 |
0.539 |
|
| 2006 |
Zangerl B, Sun Q, Pillardy J, Johnson JL, Schweitzer PA, Hernandez AG, Liu L, Acland GM, Aguirre GD. Development and characterization of a normalized canine retinal cDNA library for genomic and expression studies. Investigative Ophthalmology & Visual Science. 47: 2632-8. PMID 16723480 DOI: 10.1167/iovs.05-1463 |
0.47 |
|
| 2006 |
Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Kaushal S, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Chiodo VA, et al. Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1074-84. PMID 16644289 DOI: 10.1016/J.Ymthe.2006.03.005 |
0.358 |
|
| 2006 |
Beltran WA, Hammond P, Acland GM, Aguirre GD. A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa. Investigative Ophthalmology & Visual Science. 47: 1669-81. PMID 16565408 DOI: 10.1167/Iovs.05-0845 |
0.765 |
|
| 2006 |
Kukekova AV, Nelson J, Kuchtey RW, Lowe JK, Johnson JL, Ostrander EA, Aguirre GD, Acland GM. Linkage mapping of canine rod cone dysplasia type 2 (rcd2) to CFA7, the canine orthologue of human 1q32. Investigative Ophthalmology & Visual Science. 47: 1210-5. PMID 16505060 DOI: 10.1167/Iovs.05-0861 |
0.498 |
|
| 2006 |
Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Boye SL, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Li Q, et al. 881. Safety, Efficacy and Biodistribution of Recombinant AAV2-RPE65 Vector Delivered by Ocular Subretinal Injection Molecular Therapy. 13: S339. DOI: 10.1016/J.Ymthe.2006.08.970 |
0.326 |
|
| 2005 |
Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 1072-82. PMID 16226919 DOI: 10.1016/J.Ymthe.2005.08.008 |
0.572 |
|
| 2005 |
Beltran WA, Rohrer H, Aguirre GD. Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. Molecular Vision. 11: 232-44. PMID 15827545 |
0.687 |
|
| 2005 |
Cideciyan AV, Jacobson SG, Aleman TS, Gu D, Pearce-Kelling SE, Sumaroka A, Acland GM, Aguirre GD. In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 102: 5233-8. PMID 15784735 DOI: 10.1073/pnas.0408892102 |
0.462 |
|
| 2004 |
Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. The Journal of Biological Chemistry. 279: 53828-39. PMID 15459196 DOI: 10.1074/Jbc.M408472200 |
0.453 |
|
| 2004 |
Kijas JW, Zangerl B, Miller B, Nelson J, Kirkness EF, Aguirre GD, Acland GM. Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies. Molecular Vision. 10: 223-32. PMID 15064680 |
0.515 |
|
| 2004 |
Haskins M, O'Malley T, Ellinwood NM, O'Donnell P, Cullen K, Cullen K, Sleeper M, Aguirre G, Xu L, Wang P, Ponder K. 855. Stable Transduction of Hepatocytes Following Intravenous Retroviral Gene Therapy in Seven-Week-Old Dogs with Mucopolysaccharidosis (MPS) VII|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.763 |
0.315 |
|
| 2003 |
Zhang Q, Beltran WA, Mao Z, Li K, Johnson JL, Acland GM, Aguirre GD. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. Investigative Ophthalmology & Visual Science. 44: 4542-9. PMID 14507903 DOI: 10.1167/Iovs.02-1202 |
0.698 |
|
| 2003 |
Kukekova AV, Aguirre GD, Acland GM. Cloning and characterization of canine SHARP1 and its evaluation as a positional candidate for canine early retinal degeneration (erd). Gene. 312: 335-43. PMID 12909371 DOI: 10.1016/S0378-1119(03)00630-9 |
0.49 |
|
| 2003 |
Beltran WA, Zhang Q, Kijas JW, Gu D, Rohrer H, Jordan JA, Aguirre GD. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Investigative Ophthalmology & Visual Science. 44: 3642-9. PMID 12882818 DOI: 10.1167/Iovs.02-0763 |
0.699 |
|
| 2003 |
Lowe JK, Kukekova AV, Kirkness EF, Langlois MC, Aguirre GD, Acland GM, Ostrander EA. Linkage mapping of the primary disease locus for collie eye anomaly. Genomics. 82: 86-95. PMID 12809679 DOI: 10.1016/S0888-7543(03)00078-8 |
0.301 |
|
| 2003 |
Kijas JW, Miller BJ, Pearce-Kelling SE, Aguirre GD, Acland GM. Canine models of ocular disease: outcross breedings define a dominant disorder present in the English mastiff and bull mastiff dog breeds. The Journal of Heredity. 94: 27-30. PMID 12692159 DOI: 10.1093/jhered/esg007 |
0.391 |
|
| 2003 |
Sidjanin DJ, Miller B, Kijas J, McElwee J, Pillardy J, Malek J, Pai G, Feldblyum T, Fraser C, Acland G, Aguirre G. Radiation hybrid map, physical map, and low-pass genomic sequence of the canine prcd region on CFA9 and comparative mapping with the syntenic region on human chromosome 17. Genomics. 81: 138-48. PMID 12620391 DOI: 10.1016/S0888-7543(02)00028-9 |
0.318 |
|
| 2002 |
Ho TT, Maguire AM, Aguirre GD, Surace EM, Anand V, Zeng Y, Salvetti A, Hopwood JJ, Haskins ME, Bennett J. Phenotypic rescue after adeno-associated virus-mediated delivery of 4-sulfatase to the retinal pigment epithelium of feline mucopolysaccharidosis VI. The Journal of Gene Medicine. 4: 613-21. PMID 12439853 DOI: 10.1002/Jgm.302 |
0.454 |
|
| 2002 |
Aguirre GD, Yashar BM, John SK, Smith JE, Breuer DK, Hiriyanna S, Swaroop A, Milam AH. Retinal histopathology of an XLRP carrier with a mutation in the RPGR exon ORF15. Experimental Eye Research. 75: 431-43. PMID 12387791 DOI: 10.1006/Exer.2002.2037 |
0.487 |
|
| 2002 |
Tao W, Wen R, Goddard MB, Sherman SD, O'Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM, Aguirre GD. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Investigative Ophthalmology & Visual Science. 43: 3292-8. PMID 12356837 |
0.389 |
|
| 2002 |
Zangerl B, Zhang Q, Pearce-Kelling SE, Aguirre GD. Molecular cloning, characterization and mapping of the canine glucocorticoid receptor DNA binding factor 1 (GRLF1). Gene. 294: 167-76. PMID 12234678 DOI: 10.1016/S0378-1119(02)00765-5 |
0.396 |
|
| 2002 |
Zangerl B, Zhang Q, Acland GM, Aguirre GD. Characterization of three microsatellite loci linked to the canine RP3 interval. The Journal of Heredity. 93: 70-3. PMID 12011183 DOI: 10.1093/Jhered/93.1.70 |
0.355 |
|
| 2002 |
Zhang Q, Acland GM, Wu WX, Johnson JL, Pearce-Kelling S, Tulloch B, Vervoort R, Wright AF, Aguirre GD. Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration. Human Molecular Genetics. 11: 993-1003. PMID 11978759 DOI: 10.1093/Hmg/11.9.993 |
0.411 |
|
| 2002 |
Kijas JW, Cideciyan AV, Aleman TS, Pianta MJ, Pearce-Kelling SE, Miller BJ, Jacobson SG, Aguirre GD, Acland GM. Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 99: 6328-33. PMID 11972042 DOI: 10.1073/pnas.082714499 |
0.544 |
|
| 2002 |
Akhmedov NB, Baldwin VJ, Zangerl B, Kijas JW, Hunter L, Minoofar KD, Mellersh C, Ostrander EA, Acland GM, Farber DB, Aguirre GD. Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog. Molecular Vision. 8: 79-84. PMID 11951083 |
0.424 |
|
| 2001 |
Verdugo ME, Alling J, Lazar ES, Del Cerro M, Ray J, Aguirre G. Posterior Segment Approach for Subretinal Transplantation or Injection in the Canine Model. Cell Transplantation. 10: 317-327. PMID 28866944 DOI: 10.3727/000000001783986710 |
0.399 |
|
| 2001 |
Milam AH, De Castro EB, Smith JE, Tang WX, John SK, Gorin MB, Stone EM, Aguirre GD, Jacobson SG. Concentric retinitis pigmentosa: clinicopathologic correlations. Experimental Eye Research. 73: 493-508. PMID 11825021 DOI: 10.1006/Exer.2001.1059 |
0.519 |
|
| 2001 |
Aguirre G. Genes and diseases in man and models. Progress in Brain Research. 131: 663-78. PMID 11420979 DOI: 10.1016/S0079-6123(01)31052-X |
0.336 |
|
| 2001 |
Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, Cideciyan AV, Pearce-Kelling SE, Anand V, Zeng Y, Maguire AM, Jacobson SG, Hauswirth WW, Bennett J. Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics. 28: 92-5. PMID 11326284 DOI: 10.1038/Ng0501-92 |
0.545 |
|
| 2001 |
Syed N, Smith JE, John SK, Seabra MC, Aguirre GD, Milam AH. Evaluation of retinal photoreceptors and pigment epithelium in a female carrier of choroideremia. Ophthalmology. 108: 711-20. PMID 11297488 DOI: 10.1016/S0161-6420(00)00643-6 |
0.452 |
|
| 2000 |
Zeiss CJ, Ray K, Acland GM, Aguirre GD. Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3). Human Molecular Genetics. 9: 531-7. PMID 10699176 DOI: 10.1093/hmg/9.4.531 |
0.472 |
|
| 2000 |
Zhang Q, Ray K, Acland GM, Czarnecki JM, Aguirre GD. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. Gene. 243: 151-60. PMID 10675623 DOI: 10.1016/S0378-1119(99)00542-9 |
0.408 |
|
| 1999 |
Wang W, Acland GM, Ray K, Aguirre GD. Evaluation of cGMP-phosphodiesterase (PDE) subunits for causal association with rod-cone dysplasia 2 (rcd2), a canine model of abnormal retinal cGMP metabolism. Experimental Eye Research. 69: 445-53. PMID 10504278 DOI: 10.1006/exer.1999.0720 |
0.409 |
|
| 1999 |
Wang W, Zhang Q, Acland GM, Mellersh C, Ostrander EA, Ray K, Aguirre GD. Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D). Gene. 236: 325-32. PMID 10452952 DOI: 10.1016/S0378-1119(99)00246-2 |
0.355 |
|
| 1999 |
Acland GM, Ray K, Mellersh CS, Langston AA, Rine J, Ostrander EA, Aguirre GD. A novel retinal degeneration locus identified by linkage and comparative mapping of canine early retinal degeneration. Genomics. 59: 134-42. PMID 10409424 DOI: 10.1006/Geno.1999.5842 |
0.47 |
|
| 1999 |
Aguirre GD, Baldwin V, Weeks KM, Acland GM, Ray K. Frequency of the codon 807 mutation in the cGMP phosphodiesterase beta-subunit gene in Irish setters and other dog breeds with hereditary retinal degeneration. The Journal of Heredity. 90: 143-7. PMID 9987922 DOI: 10.1093/Jhered/90.1.143 |
0.409 |
|
| 1999 |
Ray K, Wang W, Czarnecki J, Zhang Q, Acland GM, Aguirre GD. Strategies for identification of mutations causing hereditary retinal diseases in dogs: evaluation of opsin as a candidate gene. The Journal of Heredity. 90: 133-7. PMID 9987920 DOI: 10.1093/Jhered/90.1.133 |
0.492 |
|
| 1999 |
Zhang Q, Baldwin VJ, Acland GM, Parshall CJ, Haskel J, Aguirre GD, Ray K. Photoreceptor dysplasia (pd) in miniature schnauzer dogs: evaluation of candidate genes by molecular genetic analysis. The Journal of Heredity. 90: 57-61. PMID 9987905 DOI: 10.1093/Jhered/90.1.57 |
0.394 |
|
| 1998 |
Zeiss CJ, Acland GM, Aguirre GD, RayK. TIMP-1 expression is increased in X-linked progressive retinal atrophy despite its exclusion as a candidate gene. Gene. 225: 67-75. PMID 9931441 DOI: 10.1016/S0378-1119(98)00521-6 |
0.433 |
|
| 1998 |
Zhang Q, Acland GM, Parshall CJ, Haskell J, Ray K, Aguirre GD. Characterization of canine photoreceptor phosducin cDNA and identification of a sequence variant in dogs with photoreceptor dysplasia. Gene. 215: 231-9. PMID 9714819 DOI: 10.1016/S0378-1119(98)00310-2 |
0.392 |
|
| 1998 |
Acland GM, Ray K, Mellersh CS, Gu W, Langston AA, Rine J, Ostrander EA, Aguirre GD. Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans. Proceedings of the National Academy of Sciences of the United States of America. 95: 3048-53. PMID 9501213 DOI: 10.1073/Pnas.95.6.3048 |
0.362 |
|
| 1997 |
Gropp KE, Huang JC, Aguirre GD. Differential expression of photoreceptor-specific proteins during disease and degeneration in the progressive rod-cone degeneration (prcd) retina. Experimental Eye Research. 64: 875-86. PMID 9301468 DOI: 10.1006/exer.1996.0257 |
0.425 |
|
| 1997 |
Zhang Q, Pearce-kelling S, Acland GM, Aguirre GD, Ray K. Canine rod photoreceptor cGMP-gated channel protein alpha-subunit: studies on the expression of the gene and characterization of the cDNA. Experimental Eye Research. 65: 301-9. PMID 9268598 DOI: 10.1006/Exer.1997.0342 |
0.391 |
|
| 1997 |
Ray J, Wu Y, Aguirre GD. Characterization of beta-glucuronidase in the retinal pigment epithelium. Current Eye Research. 16: 131-43. PMID 9068944 DOI: 10.1076/Ceyr.16.2.131.5087 |
0.345 |
|
| 1997 |
Ray K, Baldwin VJ, Zeiss C, Acland GM, Aguirre GD. Canine rod transducin alpha-1: cloning of the cDNA and evaluation of the gene as a candidate for progressive retinal atrophy. Current Eye Research. 16: 71-7. PMID 9043826 DOI: 10.1076/ceyr.16.1.71.5122 |
0.521 |
|
| 1996 |
Gropp KE, Szél A, Huang JC, Acland GM, Farber DB, Aguirre GD. Selective absence of cone outer segment beta 3-transducin immunoreactivity in hereditary cone degeneration (cd). Experimental Eye Research. 63: 285-96. PMID 8943701 DOI: 10.1006/Exer.1996.0117 |
0.373 |
|
| 1995 |
Ray K, Baldwin VJ, Acland GM, Aguirre GD. Molecular diagnostic tests for ascertainment of genotype at the rod cone dysplasia 1 (rcd1) locus in Irish setters. Current Eye Research. 14: 243-7. PMID 7796608 DOI: 10.3109/02713689509033521 |
0.366 |
|
| 1994 |
Huang JC, Mieziewska K, Philp N, van Veen T, Aguirre GD. Diethylene glycol distearate (DGD): a versatile embedding medium for retinal cytochemistry. Journal of Neuroscience Methods. 47: 227-34. PMID 8271821 DOI: 10.1016/0165-0270(93)90085-6 |
0.469 |
|
| 1994 |
Acland GM, Blanton SH, Hershfield B, Aguirre GD. XLPRA: a canine retinal degeneration inherited as an X-linked trait. American Journal of Medical Genetics. 52: 27-33. PMID 7977457 DOI: 10.1002/ajmg.1320520106 |
0.464 |
|
| 1993 |
Szél A, Röhlich P, Mieziewska K, Aguirre G, van Veen T. Spatial and temporal differences between the expression of short- and middle-wave sensitive cone pigments in the mouse retina: a developmental study. The Journal of Comparative Neurology. 331: 564-77. PMID 8509512 DOI: 10.1002/Cne.903310411 |
0.53 |
|
| 1993 |
Mieziewska K, Van Veen T, Aguirre GD. Development and fate of interphotoreceptor matrix components during dysplastic photoreceptor differentiation: a lectin cytochemical study of rod-cone dysplasia 1. Experimental Eye Research. 56: 429-41. PMID 8500556 DOI: 10.1006/exer.1993.1056 |
0.364 |
|
| 1992 |
Szel A, Rohlich P, Caffe AR, Juliusson B, Aguirre G, Veen TV. Unique topographic separation of two spectral classes of cones in the mouse retina The Journal of Comparative Neurology. 325: 327-342. PMID 1447405 DOI: 10.1002/Cne.903250302 |
0.479 |
|
| 1992 |
Farber DB, Danciger JS, Aguirre G. The β subunit of cyclic GMP phosphodiesterase mRNA is deficient in canine rod-cone dysplasia 1 Neuron. 9: 349-356. PMID 1323314 DOI: 10.1016/0896-6273(92)90173-B |
0.475 |
|
| 1992 |
Maude MB, Aguirre G, Acland GM, Anderson RE. The role of docosahexaenoic acid in retinal degenerations Experimental Eye Research. 55: 248. DOI: 10.1016/0014-4835(92)91082-9 |
0.516 |
|
| 1991 |
Jansen HG, Aguirre GD, van Veen T, Sanyal S. Development and degeneration of retina in rds mutant mice: ultraimmunohistochemical localization of S-antigen. Current Eye Research. 9: 903-11. PMID 2147137 DOI: 10.3109/02713689008999562 |
0.381 |
|
| 1991 |
Wiggert B, Kutty G, Long KO, Inouye L, Gery I, Chader GJ, Aguirre GD. Interphotoreceptor retinoid-binding protein (IRBP) in progressive rod-cone degeneration (prcd)--biochemical, immunocytochemical and immunologic studies. Experimental Eye Research. 53: 389-98. PMID 1936175 DOI: 10.1016/0014-4835(91)90245-A |
0.474 |
|
| 1991 |
Long KO, Aguirre GD. The cone matrix sheath in the normal and diseased retina: cytochemical and biochemical studies of peanut agglutinin-binding proteins in cone and rod-cone degeneration. Experimental Eye Research. 52: 699-713. PMID 1855544 DOI: 10.1016/0014-4835(91)90022-7 |
0.457 |
|
| 1990 |
Acland GM, Fletcher RT, Gentleman S, Chader GJ, Aguirre GD. Non-allelism of three genes (rcd1, rcd2 and erd) for early-onset hereditary retinal degeneration. Experimental Eye Research. 49: 983-98. PMID 2558906 DOI: 10.1016/S0014-4835(89)80021-1 |
0.535 |
|
| 1990 |
Acland GM, Halloran-Blanton S, Boughman JA, Aguirre GD. Segregation distortion in inheritance of progressive rod cone degeneration (prcd) in miniature poodle dogs. American Journal of Medical Genetics. 35: 354-9. PMID 2309782 DOI: 10.1002/ajmg.1320350309 |
0.301 |
|
| 1990 |
Stramm LE, Wolfe JH, Schuchman EH, Haskins ME, Patterson DF, Aguirre GD. β-Glucuronidase mediated pathway essential for retinal pigment epithelial degradation of glycosaminoglycans. Disease expression and in vitro disease correction using retroviral mediated cDNA transfer Experimental Eye Research. 50: 521-532. PMID 2164946 DOI: 10.1016/0014-4835(90)90041-R |
0.391 |
|
| 1990 |
Acland GM, Fletcher RT, Chader GJ, Aguirre GD. Retinal cyclic GMP and AMP in rod-cone dysplasia: comparison of assays in fixed and unfixed retinal tissues. Ophthalmic Research. 22: 117-22. PMID 2160633 DOI: 10.1159/000267010 |
0.459 |
|
| 1989 |
Wetzel MG, Fahlman C, Alligood JP, O'Brien PJ, Aguirre GD. Metabolic labeling of normal canine rod outer segment phospholipids in vivo and in vitro. Experimental Eye Research. 48: 149-60. PMID 2522054 DOI: 10.1016/0014-4835(89)90028-6 |
0.304 |
|
| 1988 |
Burns MS, Bellhorn RW, Impellizzeri CW, Aguirre GD, Laties AM. Development of hereditary tapetal degeneration in the beagle dog. Current Eye Research. 7: 103-14. PMID 3371063 DOI: 10.3109/02713688808995739 |
0.354 |
|
| 1988 |
Aguirre GD, Acland GM. Variation in retinal degeneration phenotype inherited at the prcd locus. Experimental Eye Research. 46: 663-87. PMID 3164273 DOI: 10.1016/S0014-4835(88)80055-1 |
0.479 |
|
| 1988 |
Barbehenn E, Gagnon C, Noelker D, Aguirre G, Chader G. Inherited rod-cone dysplasia: abnormal distribution of cyclic GMP in visual cells of affected Irish setters Experimental Eye Research. 46: 149-159. PMID 2895011 DOI: 10.1016/S0014-4835(88)80073-3 |
0.471 |
|
| 1987 |
Acland GM, Aguirre GD. Retinal degenerations in the dog: IV. Early retinal degeneration (erd) in Norwegian elkhounds. Experimental Eye Research. 44: 491-521. PMID 3496233 DOI: 10.1016/S0014-4835(87)80160-4 |
0.44 |
|
| 1986 |
Fletcher RT, Sanyal S, Krishna G, Aguirre G, Chader GJ. Genetic expression of cyclic GMP phosphodiesterase activity defines abnormal photoreceptor differentiation in neurological mutants of inherited retinal degeneration. Journal of Neurochemistry. 46: 1240-5. PMID 3005510 DOI: 10.1111/j.1471-4159.1986.tb00644.x |
0.451 |
|
| 1984 |
Sanyal S, Fletcher R, Liu YP, Aguirre G, Chader G. Cyclic nucleotide content and phosphodiesterase activity in the rds mouse (020/A) retina. Experimental Eye Research. 38: 247-56. PMID 6327341 DOI: 10.1016/0014-4835(84)90163-5 |
0.557 |
|
| 1983 |
Marmor MF, Aguirre G, Arden G, Berson E, Birch DG, Boughman JA, Carr R, Chatrian GE, Del Monte M, Dowling J, Enoch J, Fishman GA, Fulton AB, Garcia CA, Gouras P, et al. Retinitis Pigmentosa Ophthalmology. 90: 126-131. DOI: 10.1016/S0161-6420(83)34587-5 |
0.518 |
|
| 1981 |
Chader GJ, Liu YP, Fletcher RT, Aguirre G, Santos-Anderson R, Tso MOM. Chapter 8 Cyclic-GMP Phosphodiesterase and Calmodulin in Early-Onset Inherited Retinal Degenerations Current Topics in Membranes and Transport. 15: 133-156. DOI: 10.1016/S0070-2161(08)60499-2 |
0.42 |
|
| 1980 |
Chader G, Liu Y, O'Brien P, Fletcher R, Krishna G, Aguirre G, Farber D, Lolley R. Cyclic GMP phosphodiesterase activator: Involvement in a hereditary retinal degeneration. Neurochemistry International. 1: 441-458. PMID 20487753 DOI: 10.1016/0197-0186(80)90078-9 |
0.565 |
|
| 1980 |
Buyukmihci N, Aguirre G, Marshall J. Retinal degenerations in the dog. II. Development of the retina in rod-cone dysplasia. Experimental Eye Research. 30: 575-91. PMID 7409013 DOI: 10.1016/0014-4835(80)90041-X |
0.52 |
|
| 1978 |
Aguirre G. Retinal degenerations in the dog. I. Rod dysplasia. Experimental Eye Research. 26: 233-253. PMID 639877 DOI: 10.1016/0014-4835(78)90072-6 |
0.565 |
|
| 1978 |
Siakotos AN, Aguirre G, Schuster L. Two methods for the rapid purification of the retinal pigment epithelium: Adsorption and filtration Experimental Eye Research. 26: 13-23. PMID 624323 DOI: 10.1016/0014-4835(78)90148-3 |
0.405 |
|
| 1975 |
Aguirre G, Carmichael L, Bistner S. Corneal endothelium in viral induced anterior uveitis. Ultrastructural changes following canine adenovirus type 1 infection. Archives of Ophthalmology. 93: 219-24. PMID 1138688 DOI: 10.1001/Archopht.1975.01010020227012 |
0.304 |
|
| 1973 |
Aguirre G. Hereditary retinal diseases in small animals. Veterinary Clinics of North America - Large Animal Practice. 3: 515-528. PMID 4599339 DOI: 10.1016/S0091-0279(73)50065-0 |
0.548 |
|
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