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Javier E. Irazoqui - Publications

Affiliations: 
2008-2017 Massachusetts General Hospital Harvard Medical School, Boston, MA, United States 
 2017- Microbiology and Physiological Systems University of Massachussetts Medical School, Worcester, MA, United States 
Area:
Host-microbe interactions, caenorhabditis elegans, staphylococcus aureus, bacterial pathogenesis
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gonzalez X, Irazoqui JE. Distinct members of the CeMbio reference microbiota exert cryptic virulence and infection protection. Biorxiv : the Preprint Server For Biology. PMID 37961109 DOI: 10.1101/2023.11.02.565327  0.417
2023 Goswamy D, Gonzalez X, Labed SA, Irazoqui JE. orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB. Frontiers in Immunology. 14: 1094145. PMID 36860863 DOI: 10.3389/fimmu.2023.1094145  0.8
2021 Wani KA, Goswamy D, Taubert S, Ratnappan R, Ghazi A, Irazoqui JE. NHR-49/PPAR-α and HLH-30/TFEB cooperate for host defense via a flavin-containing monooxygenase. Elife. 10. PMID 33978570 DOI: 10.7554/eLife.62775  0.821
2021 Najibi M, Honwad HH, Moreau JA, Becker SM, Irazoqui JE. A NOVEL NOX/PHOX-CD38-NAADP-TFEB AXIS IMPORTANT FOR MACROPHAGE ACTIVATION DURING BACTERIAL PHAGOCYTOSIS. Autophagy. 1-18. PMID 33818279 DOI: 10.1080/15548627.2021.1911548  0.757
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Irazoqui JE, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  0.769
2020 Goswamy D, Irazoqui JE. A unifying hypothesis on the central role of reactive oxygen species in bacterial pathogenesis and host defense in C. elegans. Current Opinion in Immunology. 68: 9-20. PMID 32898751 DOI: 10.1016/J.Coi.2020.08.002  0.813
2020 Irazoqui JE. Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation. Trends in Immunology. 41: 157-171. PMID 31959514 DOI: 10.1016/J.It.2019.12.003  0.536
2019 Wani KA, Goswamy D, Irazoqui JE. Nervous system control of intestinal host defense in C. elegans. Current Opinion in Neurobiology. 62: 1-9. PMID 31790812 DOI: 10.1016/J.Conb.2019.11.007  0.814
2019 Wani KA, Goswamy D, Irazoqui JE. A Nutrition-Longevity Tradeoff Enforced by Innate Immunity. Molecular Cell. 74: 864-865. PMID 31173721 DOI: 10.1016/J.Molcel.2019.05.012  0.785
2019 Labed SA, Wani KA, Jagadeesan S, Hakkim A, Najibi M, Irazoqui JE. Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection. Immunity. 48: 963-978.e3. PMID 29768179 DOI: 10.1016/J.Immuni.2018.04.017  0.794
2017 Murano T, Najibi M, Paulus GLC, Adiliaghdam F, Valencia-Guerrero A, Selig M, Wang X, Jeffrey K, Xavier RJ, Lassen KG, Irazoqui JE. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Scientific Reports. 7: 13938. PMID 29066772 DOI: 10.1038/S41598-017-14370-4  0.781
2016 Najibi M, Labed SA, Visvikis O, Irazoqui JE. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Reports. 15: 1728-42. PMID 27184844 DOI: 10.1016/J.Celrep.2016.04.052  0.792
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Irazoqui JE, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.655
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Irazoqui JE, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.764
2015 Irazoqui JE. Why worms watch their hemidesmosomes and why you should, too. Immunity. 42: 206-8. PMID 25692695 DOI: 10.1016/J.Immuni.2015.01.021  0.409
2014 Irazoqui JE. DAF-tly depart stinky situations with elegans. Cell Host & Microbe. 16: 553-5. PMID 25525785 DOI: 10.1016/J.Chom.2014.10.017  0.341
2014 Visvikis O, Ihuegbu N, Labed SA, Luhachack LG, Alves AM, Wollenberg AC, Stuart LM, Stormo GD, Irazoqui JE. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 40: 896-909. PMID 24882217 DOI: 10.1016/J.Immuni.2014.05.002  0.79
2013 Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nature Communications. 4: 2267. PMID 23925298 DOI: 10.1038/Ncomms3267  0.782
2013 Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Klisch TJ, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nature Cell Biology. 15: 647-58. PMID 23604321 DOI: 10.1038/Ncb2718  0.775
2012 Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE. EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways. Plos Pathogens. 8: e1002798. PMID 22792069 DOI: 10.1371/Journal.Ppat.1002798  0.825
2012 Wählby C, Kamentsky L, Liu ZH, Riklin-Raviv T, Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O, Ljosa V, Irazoqui JE, Golland P, Ruvkun G, Ausubel FM, Carpenter AE. An image analysis toolbox for high-throughput C. elegans assays. Nature Methods. 9: 714-6. PMID 22522656 DOI: 10.1038/Nmeth.1984  0.744
2011 Irazoqui JE. Transparent worms help survey the fortress of innate immunity. Virulence. 2: 83-5. PMID 21460640 DOI: 10.4161/Viru.2.2.15665  0.503
2010 Irazoqui JE, Troemel ER, Feinbaum RL, Luhachack LG, Cezairliyan BO, Ausubel FM. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Plos Pathogens. 6: e1000982. PMID 20617181 DOI: 10.1371/Journal.Ppat.1000982  0.651
2010 Irazoqui JE, Ausubel FM. 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis. Clinical and Experimental Immunology. 160: 48-57. PMID 20415851 DOI: 10.1111/J.1365-2249.2010.04122.X  0.657
2010 Irazoqui JE, Urbach JM, Ausubel FM. Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nature Reviews. Immunology. 10: 47-58. PMID 20029447 DOI: 10.1038/Nri2689  0.671
2008 Irazoqui JE, Ng A, Xavier RJ, Ausubel FM. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 17469-74. PMID 18981407 DOI: 10.1073/Pnas.0809527105  0.656
2005 Irazoqui JE, Howell AS, Theesfeld CL, Lew DJ. Opposing roles for actin in Cdc42p polarization. Molecular Biology of the Cell. 16: 1296-304. PMID 15616194 DOI: 10.1091/Mbc.E04-05-0430  0.753
2004 Irazoqui JE, Gladfelter AS, Lew DJ. Cdc42p, GTP hydrolysis, and the cell's sense of direction. Cell Cycle (Georgetown, Tex.). 3: 861-4. PMID 15190213 DOI: 10.4161/Cc.3.7.993  0.668
2004 Irazoqui JE, Lew DJ. Polarity establishment in yeast. Journal of Cell Science. 117: 2169-71. PMID 15126618 DOI: 10.1242/Jcs.00953  0.494
2003 Irazoqui JE, Gladfelter AS, Lew DJ. Scaffold-mediated symmetry breaking by Cdc42p. Nature Cell Biology. 5: 1062-70. PMID 14625559 DOI: 10.1038/Ncb1068  0.657
2001 Bose I, Irazoqui JE, Moskow JJ, Bardes ES, Zyla TR, Lew DJ. Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. The Journal of Biological Chemistry. 276: 7176-86. PMID 11113154 DOI: 10.1074/Jbc.M010546200  0.66
1999 Theesfeld CL, Irazoqui JE, Bloom K, Lew DJ. The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. The Journal of Cell Biology. 146: 1019-32. PMID 10477756 DOI: 10.1083/Jcb.146.5.1019  0.706
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