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Kwong W. Lai, Ph.D. - Publications

Affiliations: 
2004 Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 
Area:
Organic Chemistry, Pharmaceutical Chemistry
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9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorganic & Medicinal Chemistry Letters. PMID 31307887 DOI: 10.1016/J.Bmcl.2019.06.021  0.334
2019 McKerrall SJ, Nguyen T, Lai KW, Bergeron P, Deng L, DiPasquale A, Chang JH, Chen J, Chernov-Rogan T, Hackos DH, Maher J, Ortwine DF, Pang J, Payandeh J, Proctor WR, et al. Structure- and ligand-based discovery of chromane arylsulfonamide Na1.7 inhibitors for the treatment of chronic pain. Journal of Medicinal Chemistry. PMID 30943032 DOI: 10.1021/Acs.Jmedchem.9B00141  0.373
2017 Lai KW, Romero FA, Tsui V, Beresini MH, de Leon Boenig G, Bronner SM, Chen K, Chen Z, Choo EF, Crawford TD, Cyr P, Kaufman S, Li Y, Liao J, Liu W, et al. Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. Bioorganic & Medicinal Chemistry Letters. PMID 29169673 DOI: 10.1016/J.Bmcl.2017.11.025  0.399
2017 Bronner SM, Murray JM, Romero FA, Lai KW, Tsui V, Cyr P, Beresini MH, de Leon Boenig G, Chen Z, Choo EF, Clark KR, Crawford TD, Jayaram H, Kaufman S, Li R, et al. A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors. Journal of Medicinal Chemistry. PMID 29155580 DOI: 10.1021/acs.jmedchem.7b01372  0.381
2017 Romero FA, Murray JM, Lai KW, Tsui V, Albrecht BK, An L, Beresini MH, de Leon Boenig G, Bronner SM, Chan EW, Chen KX, Chen Z, Choo EF, Clagg K, Clark K, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). Journal of Medicinal Chemistry. PMID 28892380 DOI: 10.1021/Acs.Jmedchem.7B00796  0.418
2016 Purkey HE, Robarge K, Chen J, Chen Z, Corson LB, Ding CZ, DiPasquale AG, Dragovich PS, Eigenbrot C, Evangelista M, Fauber BP, Gao Z, Ge H, Hitz A, Ho Q, ... ... Lai KW, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Medicinal Chemistry Letters. 7: 896-901. PMID 27774125 DOI: 10.1021/Acsmedchemlett.6B00190  0.372
2016 Crawford TD, Romero FA, Lai KW, Tsui V, Taylor AM, de Leon Boenig G, Noland CL, Murray J, Ly J, Choo EF, Hunsaker TL, Chan EW, Merchant M, Kharbanda S, Gascoigne KE, et al. Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry. PMID 27682507 DOI: 10.1021/Acs.Jmedchem.6B01022  0.397
2015 Labadie S, Dragovich PS, Chen J, Fauber BP, Boggs J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Ho Q, Lai KW, Ma S, Malek S, Peterson D, Purkey HE, et al. Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorganic & Medicinal Chemistry Letters. 25: 75-82. PMID 25466195 DOI: 10.1016/J.Bmcl.2014.11.008  0.363
2002 Dai WM, Lai KW, Wu A, Hamaguchi W, Lee MY, Zhou L, Ishii A, Nishimoto S. DNA cleavage potency, cytotoxicity, and mechanism of action of a novel class of enediyne prodrugs. Journal of Medicinal Chemistry. 45: 758-61. PMID 11831888 DOI: 10.1021/Jm015588E  0.355
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