☰

Phang-Lang Chen - Publications

Affiliations: 
Biomedical Sciences University of California, Irvine, Irvine, CA 
Area:
Biochemistry, General Biology, Genetics
Tree Info Similar researchers PubMed Report error

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Wang DD, Guo XE, Modrek AS, Chen CF, Chen PL, Lee WH. Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes. The Journal of Biological Chemistry. 289: 16727-35. PMID 24770417 DOI: 10.1074/Jbc.M113.536540  0.342
2013 Chen PL, Chen CF, Chen Y, Guo XE, Huang CK, Shew JY, Reddick RL, Wallace DC, Lee WH. Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Oncogene. 32: 1193-201. PMID 22562243 DOI: 10.1038/Onc.2012.120  0.326
2011 Guo XE, Chen CF, Wang DD, Modrek AS, Phan VH, Lee WH, Chen PL. Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. The Journal of Biological Chemistry. 286: 38783-94. PMID 21911497 DOI: 10.1074/Jbc.M111.257956  0.357
2011 Chen Y, Chen CF, Riley DJ, Chen PL. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR Cell Cycle. 10: 655-663. PMID 21301226 DOI: 10.4161/cc.10.4.14814  0.314
2011 Chen Y, Chen CF, Chiang HC, Pena M, Polci R, Wei RL, Edwards RA, Hansel DE, Chen PL, Riley DJ. Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Molecular Cancer. 10: 5. PMID 21214959 DOI: 10.1186/1476-4598-10-5  0.308
2009 Wang DD, Shu Z, Lieser SA, Chen PL, Lee WH. Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. The Journal of Biological Chemistry. 284: 20812-21. PMID 19509288 DOI: 10.1074/Jbc.M109.009605  0.319
2009 Gu B, Chen PL. Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle (Georgetown, Tex.). 8: 1409-20. PMID 19342888 DOI: 10.4161/cc.8.9.8322  0.392
2009 Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. Journal of Medicinal Chemistry. 52: 1757-67. PMID 19243176 DOI: 10.1021/Jm8015969  0.348
2008 Wu G, Qiu XL, Zhou L, Zhu J, Chamberlin R, Lau J, Chen PL, Lee WH. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Research. 68: 8393-9. PMID 18922912 DOI: 10.1158/0008-5472.Can-08-1915  0.372
2008 Fang L, Wang X, Yamoah K, Chen PL, Pan ZQ, Huang L. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Journal of Proteome Research. 7: 4914-25. PMID 18850735 DOI: 10.1021/Pr800574C  0.367
2008 Wu G, Zhou L, Khidr L, Guo XE, Kim W, Lee YM, Krasieva T, Chen PL. A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle (Georgetown, Tex.). 7: 2013-20. PMID 18604178 DOI: 10.4161/Cc.7.13.6130  0.424
2008 Wu G, Chen PL. Structural requirements of chromokinesin Kif4A for its proper function in mitosis. Biochemical and Biophysical Research Communications. 372: 454-8. PMID 18502200 DOI: 10.1016/J.Bbrc.2008.05.065  0.392
2007 Wang X, Chen CF, Baker PR, Chen PL, Kaiser P, Huang L. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Biochemistry. 46: 3553-65. PMID 17323924 DOI: 10.1021/Bi061994U  0.376
2007 Zhou L, Zhu J, Konig H, Lin X, Bhatia R, Chamberlin AR, Chen P, Lee W. Small Molecules Targeting Rad51 Recombinase Synergize with Imatinib and Overcome Imatinib-Resistance in CML. Blood. 110: 466-466. DOI: 10.1182/Blood.V110.11.466.466  0.35
2005 Furuta S, Jiang X, Gu B, Cheng E, Chen PL, Lee WH. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 9176-81. PMID 15967981 DOI: 10.1073/Pnas.0503793102  0.324
2005 Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A. STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage Journal of Cell Science. 118: 1629-1639. PMID 15784679 DOI: 10.1242/Jcs.01728  0.317
2004 Utomo A, Jiang X, Furuta S, Yun J, Levin DS, Wang YC, Desai KV, Green JE, Chen PL, Lee WH. Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. The Journal of Biological Chemistry. 279: 43522-9. PMID 15294905 DOI: 10.1074/Jbc.M407141200  0.351
2004 Shu Z, Vijayakumar S, Chen CF, Chen PL, Lee WH. Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry. 43: 4781-90. PMID 15096047 DOI: 10.1021/Bi0356449  0.379
2003 Wu G, Jiang X, Lee WH, Chen PL. Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1. Cancer Research. 63: 2589-95. PMID 12750284  0.37
2003 Peng A, Chen PL. NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. The Journal of Biological Chemistry. 278: 8873-6. PMID 12551934 DOI: 10.1074/jbc.C300001200  0.351
2003 Shang YL, Bodero AJ, Chen PL. NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. The Journal of Biological Chemistry. 278: 6323-9. PMID 12475977 DOI: 10.1074/Jbc.M210749200  0.4
2002 Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH. Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation Journal of Biological Chemistry. 277: 49408-49416. PMID 12386167 DOI: 10.1074/jbc.M207069200  0.308
2002 Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thomä NH, Zheng N, Chen PL, Lee WH, Pavletich NP. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure Science. 297: 1837-1848. PMID 12228710 DOI: 10.1126/Science.297.5588.1837  0.306
2002 Zhong Q, Boyer TG, Chen PL, Lee WH. Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Research. 62: 3966-70. PMID 12124328  0.302
2002 Zhong Q, Chen CF, Chen PL, Lee WH. BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. The Journal of Biological Chemistry. 277: 28641-7. PMID 12039951 DOI: 10.1074/jbc.M200748200  0.322
2001 Xiao J, Liu C, Chen P, Lee W. RINT-1, a Novel Rad50-interacting Protein, Participates in Radiation-induced G2/M Checkpoint Control Journal of Biological Chemistry. 276: 6105-6111. PMID 11096100 DOI: 10.1074/Jbc.M008893200  0.471
2001 Li S, Ting NSY, Zheng L, Chen P, Lee W. Effect of DNA damage on a BRCA1 complex Nature. 414: 36-36. DOI: 10.1038/35102121  0.364
2000 Wu G, Lee W, Chen P. NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. Journal of Biological Chemistry. 275: 30618-30622. PMID 10913111 DOI: 10.1074/Jbc.C000390200  0.411
2000 Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature. 406: 210-5. PMID 10910365 DOI: 10.1038/35018134  0.334
2000 Zheng L, Chen Y, Riley DJ, Chen PL, Lee WH. Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p Molecular and Cellular Biology. 20: 3529-3537. PMID 10779342 DOI: 10.1128/MCB.20.10.3529-3537.2000  0.34
1997 Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 9040-5. PMID 9256431 DOI: 10.1073/Pnas.94.17.9040  0.367
1995 Johnson EM, Chen PL, Krachmarov CP, Barr SM, Kanovsky M, Ma ZW, Lee WH. Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element. The Journal of Biological Chemistry. 270: 24352-60. PMID 7592647 DOI: 10.1074/Jbc.270.41.24352  0.342
1994 Chen Y, Chen P, Lee W. Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle. Molecular and Cellular Biology. 14: 6764-6772. PMID 7935394 DOI: 10.1128/Mcb.14.10.6764  0.391
1993 Hollingsworth RE, Chen P, Lee W. Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein. Current Opinion in Cell Biology. 5: 194-200. PMID 8507491 DOI: 10.1016/0955-0674(93)90102-V  0.373
1993 Durfee T, Becherer K, Chen P, Yeh S, Yang Y, Kilburn AE, Lee W, Elledge SJ. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes & Development. 7: 555-569. PMID 8384581 DOI: 10.1101/Gad.7.4.555  0.409
1990 Bookstein R, Shew J, Chen P, Scully P, Lee W. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene Science. 247: 712-715. PMID 2300823 DOI: 10.1126/Science.2300823  0.39
1990 Shew J, Lin BTY, Chen P, Tseng BY, Yang-Feng TL, Lee W. C-terminal truncation of the retinoblastoma gene product leads to functional inactivation Proceedings of the National Academy of Sciences of the United States of America. 87: 6-10. PMID 1688660 DOI: 10.1073/Pnas.87.1.6  0.432
1989 Chen P, Scully P, Shew J, Wang JYJ, Lee W. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell. 58: 1193-1198. PMID 2673546 DOI: 10.1016/0092-8674(89)90517-5  0.311
1988 Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedmann T, Lee EY, Lee WH. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science (New York, N.Y.). 242: 1563-6. PMID 3201247 DOI: 10.1126/Science.3201247  0.322
Show low-probability matches.