| Year |
Citation |
Score |
| 2023 |
Qiang L, Zhao B, Ming M, Wang N, He TC, Hwang S, Thorburn A, He YY. Autophagy regulates tumor growth and metastasis. Biorxiv : the Preprint Server For Biology. PMID 37961427 DOI: 10.1101/2023.10.31.564991 |
0.314 |
|
| 2021 |
Miller DR, Thorburn A. Autophagy and organelle homeostasis in cancer. Developmental Cell. 56: 906-918. PMID 33689692 DOI: 10.1016/j.devcel.2021.02.010 |
0.402 |
|
| 2021 |
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Thorburn A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280 |
0.304 |
|
| 2020 |
Atwood DJ, Brown CN, Holditch SJ, Pokhrel D, Thorburn A, Hopp K, Edelstein CL. The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cellular Signalling. 109760. PMID 32866627 DOI: 10.1016/J.Cellsig.2020.109760 |
0.329 |
|
| 2020 |
Thorburn A. A new mechanism for autophagy regulation of anti-tumor immune responses. Autophagy. 16: 2282-2284. PMID 32866428 DOI: 10.1080/15548627.2020.1817286 |
0.394 |
|
| 2020 |
Atwood DJ, Pokhrel D, Brown CN, Holditch SJ, Bachu DM, Thorburn A, Hopp K, Edelstein CL. Increased mTOR and suppressed autophagic flux in the heart of a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cellular Signalling. 109730. PMID 32730856 DOI: 10.1016/J.Cellsig.2020.109730 |
0.325 |
|
| 2020 |
Thorburn A. Crosstalk between autophagy and apoptosis: Mechanisms and therapeutic implications. Progress in Molecular Biology and Translational Science. 172: 55-65. PMID 32620250 DOI: 10.1016/Bs.Pmbts.2020.04.023 |
0.477 |
|
| 2020 |
Miller DR, Cramer SD, Thorburn A. The interplay of autophagy and non-apoptotic cell death pathways. International Review of Cell and Molecular Biology. 352: 159-187. PMID 32334815 DOI: 10.1016/Bs.Ircmb.2019.12.004 |
0.495 |
|
| 2020 |
Towers CG, Wodetzki D, Thorburn A. Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms. Autophagy. 16: 1332-1340. PMID 32160093 DOI: 10.1080/15548627.2020.1741204 |
0.42 |
|
| 2020 |
Towers CG, Wodetzki D, Thorburn A. Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms. Autophagy. 16: 1332-1340. PMID 32160093 DOI: 10.1080/15548627.2020.1741204 |
0.42 |
|
| 2019 |
Tompkins KD, Thorburn A. Regulation of Apoptosis by Autophagy to Enhance Cancer Therapy. The Yale Journal of Biology and Medicine. 92: 707-718. PMID 31866785 |
0.342 |
|
| 2019 |
Mulcahy Levy JM, Thorburn A. Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients. Cell Death and Differentiation. PMID 31836831 DOI: 10.1038/S41418-019-0474-7 |
0.507 |
|
| 2019 |
Towers CG, Wodetzki D, Thorburn A. Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations. The Journal of Cell Biology. PMID 31753861 DOI: 10.1083/Jcb.201909033 |
0.543 |
|
| 2019 |
Towers CG, Thorburn A. Circumventing autophagy inhibition Cell Cycle. 18: 3421-3431. PMID 31736401 DOI: 10.1080/15384101.2019.1692483 |
0.386 |
|
| 2019 |
Towers CG, Fitzwalter BE, Regan D, Goodspeed A, Morgan MJ, Liu CW, Gustafson DL, Thorburn A. Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition. Developmental Cell. PMID 31378590 DOI: 10.1016/J.Devcel.2019.07.010 |
0.505 |
|
| 2019 |
Tompkins K, Towers C, Kar A, Zhang Y, Kiseljak-Vassiliades K, Thorburn A, Wierman M. SAT-LB064 Mitotane Induces Autophagy: A Mechanism to Promote Chemoresistance in Adrenocortical Carcinoma Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Sat-Lb064 |
0.353 |
|
| 2018 |
Morgan MJ, Fitzwalter BE, Owens CR, Powers RK, Sottnik JL, Gamez G, Costello JC, Theodorescu D, Thorburn A. Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127018 DOI: 10.1073/Pnas.1706526115 |
0.452 |
|
| 2018 |
Scott AJ, Arcaroli JJ, Bagby SM, Yahn R, Huber KM, Serkova NJ, Nguyen A, Kim J, Thorburn A, Vogel J, Quackenbush KS, Capasso A, Schreiber A, Blatchford P, Klauck PJ, et al. Cabozantinib exhibits potent antitumor activity in colorectal cancer patient-derived tumor xenograft models via autophagy and signaling mechanisms. Molecular Cancer Therapeutics. PMID 30026382 DOI: 10.1158/1535-7163.Mct-17-0131 |
0.451 |
|
| 2018 |
Fitzwalter BE, Thorburn A. FOXO3 links autophagy to apoptosis. Autophagy. 14: 1467-1468. PMID 29938591 DOI: 10.1080/15548627.2018.1475819 |
0.507 |
|
| 2018 |
Fitzwalter BE, Thorburn A. Autophagy inhibition improves anti-cancer drugs FOXO3a activation. Oncotarget. 9: 25384-25385. PMID 29875995 DOI: 10.18632/Oncotarget.25366 |
0.366 |
|
| 2018 |
Bamberg A, Redente EF, Groshong SD, Tuder RM, Cool CD, Keith RC, Edelman BL, Black BP, Cosgrove GP, Wynes MW, Curran-Everett D, De Langhe S, Ortiz LA, Thorburn A, Riches DWH. Protein Tyrosine Phosphatase-N13 (PTPN13) Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. PMID 29727583 DOI: 10.1164/Rccm.201707-1497Oc |
0.309 |
|
| 2018 |
Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A. Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Developmental Cell. 44: 555-565.e3. PMID 29533771 DOI: 10.1016/J.Devcel.2018.02.014 |
0.544 |
|
| 2018 |
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Thorburn A, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4 |
0.458 |
|
| 2017 |
Thorburn A. Autophagy and disease Journal of Biological Chemistry. 293: 5425-5430. PMID 29191833 DOI: 10.1074/Jbc.R117.810739 |
0.369 |
|
| 2017 |
Towers CG, Thorburn A. Targeting the Lysosome for Cancer Therapy. Cancer Discovery. 7: 1218-1220. PMID 29097619 DOI: 10.1158/2159-8290.Cd-17-0996 |
0.435 |
|
| 2017 |
Fitzwalter BE, Thorburn A. A caspase-independent way to kill cancer cells. Nature Cell Biology. 19: 1014-1015. PMID 28855734 DOI: 10.1038/Ncb3604 |
0.477 |
|
| 2017 |
Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nature Reviews. Cancer. PMID 28751651 DOI: 10.1038/Nrc.2017.53 |
0.442 |
|
| 2017 |
Dimberg L, Towers CG, Behbakht K, Hotz T, Kim J, Fosmire SP, Porter CC, Tan AC, Thorburn A, Ford HL. A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance. Molecular Cancer Research : McR. PMID 28108622 DOI: 10.1158/1541-7786.Mcr-16-0234 |
0.494 |
|
| 2017 |
Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, ... ... Thorburn A, et al. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 6. PMID 28094001 DOI: 10.7554/Elife.19671 |
0.412 |
|
| 2017 |
Thorburn J, Staskiewicz L, Goodall ML, Dimberg L, Frankel AE, Ford HL, Thorburn A. Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells. Molecular Pharmacology. 91: 58-64. PMID 27974637 DOI: 10.1124/Mol.116.106070 |
0.486 |
|
| 2016 |
Towers CG, Thorburn A. Therapeutic Targeting of Autophagy. Ebiomedicine. PMID 28029600 DOI: 10.1016/J.Ebiom.2016.10.034 |
0.442 |
|
| 2016 |
Goodall ML, Cramer SD, Thorburn A. Autophagy RIPs into cell death. Cell Cycle (Georgetown, Tex.). 15: 3014-3015. PMID 27574850 DOI: 10.1080/15384101.2016.1216923 |
0.461 |
|
| 2016 |
Goodall ML, Cramer SD, Thorburn A. Autophagy complexes cell death by necroptosis. Oncotarget. 7: 50818-50819. PMID 27449298 DOI: 10.18632/Oncotarget.10640 |
0.509 |
|
| 2016 |
Morgan MJ, Thorburn A. Measuring Autophagy in the Context of Cancer. Advances in Experimental Medicine and Biology. 899: 121-43. PMID 27325265 DOI: 10.1007/978-3-319-26666-4_8 |
0.449 |
|
| 2016 |
Barnard RA, Regan DP, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL. Autophagy inhibition delays early but not late stage metastatic disease. The Journal of Pharmacology and Experimental Therapeutics. PMID 27231155 DOI: 10.1124/Jpet.116.233908 |
0.464 |
|
| 2016 |
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A. The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis. Developmental Cell. 37: 337-349. PMID 27219062 DOI: 10.1016/J.Devcel.2016.04.018 |
0.502 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Thorburn A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.398 |
|
| 2016 |
Levy JMM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters B, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, ... ... Thorburn A, et al. Author response: Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors Elife. DOI: 10.7554/Elife.19671.032 |
0.37 |
|
| 2015 |
Fitzwalter BE, Thorburn A. Recent insights into cell death and autophagy. The Febs Journal. 282: 4279-88. PMID 26367268 DOI: 10.1111/Febs.13515 |
0.471 |
|
| 2015 |
Koo GB, Morgan MJ, Lee DG, Kim WJ, Yoon JH, Koo JS, Kim SI, Kim SJ, Son MK, Hong SS, Levy JM, Pollyea DA, Jordan CT, Yan P, Frankhouser D, ... ... Thorburn A, et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell Research. 25: 707-25. PMID 25952668 DOI: 10.1038/Cr.2015.56 |
0.422 |
|
| 2015 |
Yonekawa T, Gamez G, Kim J, Tan AC, Thorburn J, Gump J, Thorburn A, Morgan MJ. RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis. Embo Reports. 16: 700-8. PMID 25908842 DOI: 10.15252/Embr.201439496 |
0.434 |
|
| 2015 |
Thorburn A, Morgan MJ. Targeting Autophagy in BRAF-Mutant Tumors. Cancer Discovery. 5: 353-4. PMID 25847956 DOI: 10.1158/2159-8290.Cd-15-0222 |
0.413 |
|
| 2015 |
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, ... ... Thorburn AM, et al. Autophagy in malignant transformation and cancer progression. The Embo Journal. 34: 856-80. PMID 25712477 DOI: 10.15252/Embj.201490784 |
0.393 |
|
| 2015 |
Maycotte P, Jones KL, Goodall ML, Thorburn J, Thorburn A. Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion. Molecular Cancer Research : McR. 13: 651-8. PMID 25573951 DOI: 10.1158/1541-7786.Mcr-14-0487 |
0.431 |
|
| 2015 |
Zahedi S, Griesinger AM, Hankinson TC, Handler MH, Foreman NK, Thorburn A, Levy JMM. Abstract A25: Autophagy inhibition reverses resistance to targeted BRAF therapy in CNS tumors Brain. 75. DOI: 10.1158/1538-7445.Brain15-A25 |
0.462 |
|
| 2015 |
Barnard RA, Regan D, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL. Abstract 4121: Autophagy influences the development of the pre-metastatic niche Cancer Research. 75: 4121-4121. DOI: 10.1158/1538-7445.Am2015-4121 |
0.46 |
|
| 2015 |
Zahedi S, Griesinger A, Handler M, Foreman N, Thorburn A, Levy JM. Tr-10Autophagy Inhibition Reverses Resistance To Targeted Braf Therapy In Pediatric Cns Tumors. Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov061.155 |
0.454 |
|
| 2014 |
Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, ... ... Thorburn A, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 3: e955691. PMID 25941621 DOI: 10.4161/21624011.2014.955691 |
0.428 |
|
| 2014 |
Mulcahy Levy JM, Foreman NK, Thorburn A. Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors. Autophagy. 10: 2077-8. PMID 25484091 DOI: 10.4161/Auto.36138 |
0.477 |
|
| 2014 |
Thorburn A. Autophagy and its effects: making sense of double-edged swords. Plos Biology. 12: e1001967. PMID 25313680 DOI: 10.1371/Journal.Pbio.1001967 |
0.343 |
|
| 2014 |
Morgan MJ, Gamez G, Menke C, Hernandez A, Thorburn J, Gidan F, Staskiewicz L, Morgan S, Cummings C, Maycotte P, Thorburn A. Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy. 10: 1814-26. PMID 25136801 DOI: 10.4161/Auto.32135 |
0.367 |
|
| 2014 |
Maycotte P, Thorburn A. Targeting autophagy in breast cancer. World Journal of Clinical Oncology. 5: 224-40. PMID 25114840 DOI: 10.5306/Wjco.V5.I3.224 |
0.398 |
|
| 2014 |
Klionsky DJ, Thorburn A. Clinical research and Autophagy. Autophagy. 10: 1357-8. PMID 24991837 DOI: 10.4161/Auto.29159 |
0.316 |
|
| 2014 |
Barnard RA, Wittenburg LA, Amaravadi RK, Gustafson DL, Thorburn A, Thamm DH. Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma. Autophagy. 10: 1415-25. PMID 24991836 DOI: 10.4161/Auto.29165 |
0.342 |
|
| 2014 |
Qiang L, Zhao B, Ming M, Wang N, He TC, Hwang S, Thorburn A, He YY. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proceedings of the National Academy of Sciences of the United States of America. 111: 9241-6. PMID 24927592 DOI: 10.1073/Pnas.1322913111 |
0.42 |
|
| 2014 |
Gump JM, Thorburn A. Sorting cells for basal and induced autophagic flux by quantitative ratiometric flow cytometry. Autophagy. 10: 1327-34. PMID 24915460 DOI: 10.4161/Auto.29394 |
0.345 |
|
| 2014 |
Levy JM, Thompson JC, Griesinger AM, Amani V, Donson AM, Birks DK, Morgan MJ, Mirsky DM, Handler MH, Foreman NK, Thorburn A. Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. Cancer Discovery. 4: 773-80. PMID 24823863 DOI: 10.1158/2159-8290.Cd-14-0049 |
0.464 |
|
| 2014 |
Goodall M, Thorburn A. Identifying specific receptors for cargo-mediated autophagy. Cell Research. 24: 783-4. PMID 24797431 DOI: 10.1038/Cr.2014.56 |
0.325 |
|
| 2014 |
Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, Green DR, Espinosa JM, Thorburn A. Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Reports. 7: 45-52. PMID 24685133 DOI: 10.1016/J.Celrep.2014.02.036 |
0.487 |
|
| 2014 |
Maycotte P, Gearheart CM, Barnard R, Aryal S, Mulcahy Levy JM, Fosmire SP, Hansen RJ, Morgan MJ, Porter CC, Gustafson DL, Thorburn A. STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. Cancer Research. 74: 2579-90. PMID 24590058 DOI: 10.1158/0008-5472.Can-13-3470 |
0.529 |
|
| 2014 |
Thorburn A, Thamm DH, Gustafson DL. Autophagy and cancer therapy. Molecular Pharmacology. 85: 830-8. PMID 24574520 DOI: 10.1124/mol.114.091850 |
0.397 |
|
| 2014 |
Kulbe JR, Mulcahy Levy JM, Coultrap SJ, Thorburn A, Bayer KU. Excitotoxic glutamate insults block autophagic flux in hippocampal neurons. Brain Research. 1542: 12-9. PMID 24505621 DOI: 10.1016/J.Brainres.2013.10.032 |
0.427 |
|
| 2014 |
Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A. Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nature Cell Biology. 16: 47-54. PMID 24316673 DOI: 10.1038/Ncb2886 |
0.489 |
|
| 2014 |
Barnard R, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL. Abstract A37: Role of autophagy inhibition in metastatic disease utilizing mouse models Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-A37 |
0.456 |
|
| 2014 |
Barnard RA, Wittenburg LA, Gustafson DL, Thorburn A, Thamm DH. Abstract A04: Measuring autophagy inhibition as a pharmacodynamic response to hydroxychloroquine in a spontaneous canine lymphoma clinical trial Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-A04 |
0.398 |
|
| 2013 |
Yonekawa T, Thorburn A. Autophagy and cell death. Essays in Biochemistry. 55: 105-17. PMID 24070475 DOI: 10.1042/Bse0550105 |
0.507 |
|
| 2013 |
Staskiewicz L, Thorburn J, Morgan MJ, Thorburn A. Inhibiting autophagy by shRNA knockdown: cautions and recommendations. Autophagy. 9: 1449-50. PMID 23800703 DOI: 10.4161/Auto.24895 |
0.434 |
|
| 2013 |
Keysar SB, Le PN, Anderson RT, Morton JJ, Bowles DW, Paylor JJ, Vogler BW, Thorburn J, Fernandez P, Glogowska MJ, Takimoto SM, Sehrt DB, Gan GN, Eagles-Soukup JR, Serracino H, ... ... Thorburn A, et al. Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer. Cancer Research. 73: 3381-92. PMID 23576557 DOI: 10.1158/0008-5472.Can-12-4047 |
0.403 |
|
| 2013 |
Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? The Journal of Pharmacology and Experimental Therapeutics. 344: 544-52. PMID 23291713 DOI: 10.1124/Jpet.112.199802 |
0.444 |
|
| 2013 |
Yang X, Kessler E, Su LJ, Thorburn A, Frankel AE, Li Y, La Rosa FG, Shen J, Li CY, Varella-Garcia M, Glodé LM, Flaig TW. Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 148-57. PMID 23172881 DOI: 10.1158/1078-0432.Ccr-12-1258 |
0.375 |
|
| 2013 |
Dimberg LY, Anderson CK, Camidge R, Behbakht K, Thorburn A, Ford HL. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene. 32: 1341-50. PMID 22580613 DOI: 10.1038/Onc.2012.164 |
0.457 |
|
| 2013 |
Barnard RA, Maycotte P, Hansen RJ, Gustafson DL, Thorburn A. Abstract C19: The effect of autophagy inhibition on anchorage-independent cell growth Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C19 |
0.506 |
|
| 2013 |
Barnard RA, Maycotte P, Hansen RJ, Gustafson DL, Thorburn A. Abstract 1863: Differing sensitivity to stage-specific autophagy inhibition. Cancer Research. 73: 1863-1863. DOI: 10.1158/1538-7445.Am2013-1863 |
0.502 |
|
| 2013 |
Maycotte P, Morgan MJ, Thorburn A. Abstract 1681: Autophagy-regulation of STAT3 phosphorylation determines subtype differences in autophagy addiction and breast cancer cell survival. Cancer Research. 73: 1681-1681. DOI: 10.1158/1538-7445.Am2013-1681 |
0.461 |
|
| 2013 |
Dimberg LY, Cabrera J, Menke C, Kim J, Porter CC, Tan A, Behbakht K, Thorburn A, Ford HL. Abstract B115: Use of a genome-wide loss-of-function screen to identify novel mechanisms of resistance to TRAIL induced apoptosis. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B115 |
0.472 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Thorburn A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.366 |
|
| 2012 |
Li Y, Hahn T, Garrison K, Cui ZH, Thorburn A, Thorburn J, Hu HM, Akporiaye ET. The vitamin E analogue α-TEA stimulates tumor autophagy and enhances antigen cross-presentation. Cancer Research. 72: 3535-45. PMID 22745370 DOI: 10.1158/0008-5472.Can-11-3103 |
0.433 |
|
| 2012 |
Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM. Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle (Georgetown, Tex.). 11: 2022-9. PMID 22580450 DOI: 10.4161/Cc.20424 |
0.496 |
|
| 2012 |
LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. The Journal of Physiology. 590: 3305-16. PMID 22570377 DOI: 10.1113/Jphysiol.2012.229690 |
0.316 |
|
| 2012 |
Qamar L, Deitsch E, Patrick AN, Post MD, Spillman MA, Iwanaga R, Thorburn A, Ford HL, Behbakht K. Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer. Gynecologic Oncology. 125: 451-7. PMID 22333994 DOI: 10.1016/J.Ygyno.2012.02.007 |
0.345 |
|
| 2012 |
Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy. 8: 200-12. PMID 22252008 DOI: 10.4161/Auto.8.2.18554 |
0.443 |
|
| 2012 |
Levy JM, Thorburn A. Modulation of pediatric brain tumor autophagy and chemosensitivity. Journal of Neuro-Oncology. 106: 281-90. PMID 21842312 DOI: 10.1007/S11060-011-0684-4 |
0.49 |
|
| 2012 |
Thorburn J, Morgan M, Thorburn A. Abstract 4846: Manipulation of autophagy during tumor cell killing regulates the growth of neighboring tumor cells Cancer Research. 72: 4846-4846. DOI: 10.1158/1538-7445.Am2012-4846 |
0.543 |
|
| 2011 |
Flaig TW, Su L, Thorburn A, Frankel AE, Li Y, Woo JH, Varella-Garcia M, La Rosa FG, Li C, Yang X. DAB389 EGF for the treatment of superficial urothelial cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 255. PMID 27968507 DOI: 10.1200/Jco.2011.29.7_Suppl.255 |
0.336 |
|
| 2011 |
Thorburn A, Debnath J. Targeting chaperone-mediated autophagy in cancer. Science Translational Medicine. 3: 109ps45. PMID 22089450 DOI: 10.1126/Scitranslmed.3003390 |
0.465 |
|
| 2011 |
Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, ... ... Thorburn A, et al. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 7: 1273-94. PMID 21997368 DOI: 10.4161/Auto.7.11.17661 |
0.403 |
|
| 2011 |
Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O'Sullivan B, He Z, Peng Y, Tan AC, Zhou L, Shen J, Han G, Wang XJ, Thorburn J, ... Thorburn A, et al. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nature Medicine. 17: 860-6. PMID 21725296 DOI: 10.1038/Nm.2385 |
0.487 |
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| 2011 |
Gump JM, Thorburn A. Autophagy and apoptosis: what is the connection? Trends in Cell Biology. 21: 387-92. PMID 21561772 DOI: 10.1016/J.Tcb.2011.03.007 |
0.433 |
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| 2011 |
Levy JM, Thorburn A. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacology & Therapeutics. 131: 130-41. PMID 21440002 DOI: 10.1016/J.Pharmthera.2011.03.009 |
0.418 |
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| 2011 |
Menke C, Bin L, Thorburn J, Behbakht K, Ford HL, Thorburn A. Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Research. 71: 1883-92. PMID 21363923 DOI: 10.1158/0008-5472.Can-10-2252 |
0.407 |
|
| 2011 |
Thorburn A. I think autophagy controls the death of my cells: what do I do to get my paper published? Autophagy. 7: 455-6. PMID 21270514 DOI: 10.4161/Auto.7.5.14797 |
0.478 |
|
| 2011 |
Menke C, Goncharov T, Qamar L, Korch C, Ford HL, Behbakht K, Thorburn A. TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. Plos One. 6: e14527. PMID 21264287 DOI: 10.1371/Journal.Pone.0014527 |
0.46 |
|
| 2011 |
Maycotte P, Thorburn A. Autophagy and cancer therapy. Cancer Biology & Therapy. 11: 127-37. PMID 21178393 DOI: 10.4161/Cbt.11.2.14627 |
0.526 |
|
| 2010 |
Flanigan SA, Pitts TM, Eckhardt SG, Tentler JJ, Tan AC, Thorburn A, Leong S. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5436-46. PMID 20943761 DOI: 10.1158/1078-0432.Ccr-10-2054 |
0.387 |
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| 2010 |
Clark PE, Polosukhina DA, Gyabaah K, Moses HL, Thorburn A, Zent R. TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis. The Journal of Urology. 184: 1166-74. PMID 20663526 DOI: 10.1016/J.Juro.2010.04.064 |
0.386 |
|
| 2010 |
Zhang L, Kavanagh BD, Thorburn AM, Camidge DR. Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4478-89. PMID 20630997 DOI: 10.1158/1078-0432.CCR-10-0859 |
0.328 |
|
| 2010 |
Keating AK, Kim GK, Jones AE, Donson AM, Ware K, Mulcahy JM, Salzberg DB, Foreman NK, Liang X, Thorburn A, Graham DK. Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. Molecular Cancer Therapeutics. 9: 1298-307. PMID 20423999 DOI: 10.1158/1535-7163.Mct-09-0707 |
0.451 |
|
| 2010 |
Kenific CM, Thorburn A, Debnath J. Autophagy and metastasis: another double-edged sword. Current Opinion in Cell Biology. 22: 241-5. PMID 19945838 DOI: 10.1016/J.Ceb.2009.10.008 |
0.419 |
|
| 2010 |
Maycotte P, Thorburn J, Thorburn A. Abstract 4849: Role of autophagy in breast cancer metastasis and treatment Cancer Research. 70: 4849-4849. DOI: 10.1158/1538-7445.Am10-4849 |
0.432 |
|
| 2010 |
Menke CR, Bin L, Thorburn J, Behbakht K, Ford H, Thorburn A. Abstract 207: Distinct TRAIL resistance mechanisms can be overcome by proteosome inhibition Cancer Research. 70: 207-207. DOI: 10.1158/1538-7445.Am10-207 |
0.406 |
|
| 2009 |
Martin AP, Park MA, Mitchell C, Walker T, Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S, Dent P. BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing. Molecular Pharmacology. 76: 327-41. PMID 19483105 DOI: 10.1124/Mol.109.056309 |
0.422 |
|
| 2009 |
Horita H, Thorburn J, Frankel AE, Thorburn A. EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins. Journal of Neuro-Oncology. 95: 175-84. PMID 19449148 DOI: 10.1007/S11060-009-9914-4 |
0.501 |
|
| 2009 |
Thorburn J, Frankel AE, Thorburn A. Regulation of HMGB1 release by autophagy. Autophagy. 5: 247-9. PMID 19098461 DOI: 10.4161/Auto.5.2.7552 |
0.525 |
|
| 2009 |
Thorburn J, Horita H, Redzic J, Hansen K, Frankel AE, Thorburn A. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death and Differentiation. 16: 175-83. PMID 18846108 DOI: 10.1038/Cdd.2008.143 |
0.505 |
|
| 2009 |
Kavanagh B, Chen C, Thorburn A, Zhang L, Frederick B, Camidge DR. Serum Cell Death Marker Increases after IMRT for Glioblastoma or SBRT for Epithelial Tumors: A Clinical Measure of Apoptosis as Therapeutic Mechanism International Journal of Radiation Oncology Biology Physics. 75. DOI: 10.1016/J.Ijrobp.2009.07.535 |
0.456 |
|
| 2008 |
Horita H, Frankel AE, Thorburn A. Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms. Plos One. 3: e3909. PMID 19079542 DOI: 10.1371/Journal.Pone.0003909 |
0.417 |
|
| 2008 |
Thorburn A, Behbakht K, Ford H. TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 11: 17-24. PMID 18374623 DOI: 10.1016/J.Drup.2008.02.001 |
0.426 |
|
| 2008 |
Thorburn A. Studying autophagy's relationship to cell death. Autophagy. 4: 391-4. PMID 18253085 DOI: 10.4161/Auto.5661 |
0.416 |
|
| 2008 |
Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis : An International Journal On Programmed Cell Death. 13: 1-9. PMID 17990121 DOI: 10.1007/S10495-007-0154-9 |
0.467 |
|
| 2008 |
Horita H, Frankel AE, Thorburn A. Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death. Leukemia. 22: 652-5. PMID 17882279 DOI: 10.1038/Sj.Leu.2404956 |
0.433 |
|
| 2007 |
Bin L, Thorburn J, Thomas LR, Clark PE, Humphreys R, Thorburn A. Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. The Journal of Biological Chemistry. 282: 28189-94. PMID 17666396 DOI: 10.1074/Jbc.M704210200 |
0.416 |
|
| 2007 |
Thorburn A. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway signaling. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 2: 461-5. PMID 17545839 DOI: 10.1097/Jto.0B013E31805Fea64 |
0.485 |
|
| 2007 |
Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK. Regulation of the Pro-apoptotic scaffolding protein POSH by Akt. The Journal of Biological Chemistry. 282: 21987-97. PMID 17535800 DOI: 10.1074/Jbc.M704321200 |
0.437 |
|
| 2007 |
Behbakht K, Qamar L, Aldridge CS, Coletta RD, Davidson SA, Thorburn A, Ford HL. Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Research. 67: 3036-42. PMID 17409410 DOI: 10.1158/0008-5472.Can-06-3755 |
0.404 |
|
| 2006 |
Hippert MM, O'Toole PS, Thorburn A. Autophagy in cancer: good, bad, or both? Cancer Research. 66: 9349-51. PMID 17018585 DOI: 10.1158/0008-5472.Can-06-1597 |
0.471 |
|
| 2006 |
Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M. Fatty acid synthase: a novel target for antiglioma therapy. British Journal of Cancer. 95: 869-78. PMID 16969344 DOI: 10.1038/Sj.Bjc.6603350 |
0.437 |
|
| 2006 |
Thorburn A, Frankel AE. Apoptosis and anthracycline cardiotoxicity. Molecular Cancer Therapeutics. 5: 197-9. PMID 16505091 DOI: 10.1158/1535-7163.Mct-06-Co1 |
0.372 |
|
| 2006 |
Thomas LR, Bender LM, Morgan MJ, Thorburn A. Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5. Cell Death and Differentiation. 13: 160-2. PMID 16003390 DOI: 10.1038/Sj.Cdd.4401714 |
0.304 |
|
| 2005 |
Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE, Thorburn A, Kidd VJ, Slaughter CA, Osborn SL, Winoto A, Tang WJ, Peter ME. Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Molecular Cell. 19: 321-32. PMID 16061179 DOI: 10.1016/J.Molcel.2005.06.024 |
0.384 |
|
| 2005 |
Iordanov MS, Kirsch JD, Ryabinina OP, Wong J, Spitz PN, Korcheva VB, Thorburn A, Magun BE. Recruitment of TRADD, FADD, and caspase 8 to double-stranded RNA-triggered death inducing signaling complexes (dsRNA-DISCs). Apoptosis : An International Journal On Programmed Cell Death. 10: 167-76. PMID 15711932 DOI: 10.1007/S10495-005-6071-X |
0.448 |
|
| 2005 |
Thorburn J, Moore F, Rao A, Barclay WW, Thomas LR, Grant KW, Cramer SD, Thorburn A. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Molecular Biology of the Cell. 16: 1189-99. PMID 15635090 DOI: 10.1091/Mbc.E04-10-0906 |
0.544 |
|
| 2005 |
Bender ML, Thorburn A. Death Domain Interactions in Death Receptor Signaling Journal of Biological Sciences. 5: 33-37. DOI: 10.3923/Jbs.2005.33.37 |
0.323 |
|
| 2004 |
Thomas LR, Johnson RL, Reed JC, Thorburn A. The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation. The Journal of Biological Chemistry. 279: 52479-86. PMID 15452120 DOI: 10.1074/Jbc.M409578200 |
0.413 |
|
| 2004 |
Thomas LR, Henson A, Reed JC, Salsbury FR, Thorburn A. Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. The Journal of Biological Chemistry. 279: 32780-5. PMID 15173180 DOI: 10.1074/Jbc.M401680200 |
0.403 |
|
| 2004 |
Thorburn A, Thorburn J, Frankel AE. Induction of apoptosis by tumor cell-targeted toxins. Apoptosis. 9: 19-25. PMID 14739595 DOI: 10.1023/B:Appt.0000012118.95548.88 |
0.428 |
|
| 2004 |
Bharadwaj S, Hitchcock-DeGregori S, Thorburn A, Prasad GL. N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1. The Journal of Biological Chemistry. 279: 14039-48. PMID 14722123 DOI: 10.1074/Jbc.M310934200 |
0.309 |
|
| 2004 |
Thorburn A. Death receptor-induced cell killing. Cellular Signalling. 16: 139-44. PMID 14636884 DOI: 10.1016/J.Cellsig.2003.08.007 |
0.452 |
|
| 2003 |
Thorburn J, Bender LM, Morgan MJ, Thorburn A. Caspase- and serine protease-dependent apoptosis by the death domain of FADD in normal epithelial cells. Molecular Biology of the Cell. 14: 67-77. PMID 12529427 DOI: 10.1091/Mbc.E02-04-0207 |
0.5 |
|
| 2002 |
Frankel AE, Beran M, Hogge DE, Powell BL, Thorburn A, Chen YQ, Vallera DA. Malignant progenitors from patients with CD87+ acute myelogenous leukemia are sensitive to a diphtheria toxin-urokinase fusion protein. Experimental Hematology. 30: 1316-23. PMID 12423685 DOI: 10.1016/S0301-472X(02)00925-6 |
0.327 |
|
| 2002 |
Thomas LR, Stillman DJ, Thorburn A. Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen. The Journal of Biological Chemistry. 277: 34343-8. PMID 12107169 DOI: 10.1074/Jbc.M204169200 |
0.362 |
|
| 2002 |
Morgan M, Thorburn J, Pandolfi PP, Thorburn A. Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. The Journal of Cell Biology. 157: 975-84. PMID 12045187 DOI: 10.1083/Jcb.200204039 |
0.47 |
|
| 2002 |
Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley RL, Chen YQ. Mediation of the DCC apoptotic signal by DIP13 alpha. The Journal of Biological Chemistry. 277: 26281-5. PMID 12011067 DOI: 10.1074/Jbc.M204679200 |
0.45 |
|
| 2002 |
Greene BT, Thorburn J, Willingham MC, Thorburn A, Planalp RP, Brechbiel MW, Jennings-Gee J, Wilkinson J, Torti FM, Torti SV. Activation of caspase pathways during iron chelator-mediated apoptosis. The Journal of Biological Chemistry. 277: 25568-75. PMID 11980894 DOI: 10.1074/Jbc.M110345200 |
0.457 |
|
| 2001 |
Morgan MJ, Thorburn J, Thomas L, Maxwell T, Brothman AR, Thorburn A. An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells. Cell Death and Differentiation. 8: 696-705. PMID 11464214 DOI: 10.1038/Sj.Cdd.4400866 |
0.488 |
|
| 2001 |
Morgan MJ, Thorburn A. Measurement of caspase activity in individual cells reveals differences in the kinetics of caspase activation between cells. Cell Death and Differentiation. 8: 38-43. PMID 11313701 DOI: 10.1038/Sj.Cdd.4400800 |
0.437 |
|
| 2000 |
Singleton JR, Baker BL, Thorburn A. Dexamethasone inhibits insulin-like growth factor signaling and potentiates myoblast apoptosis. Endocrinology. 141: 2945-50. PMID 10919283 DOI: 10.1210/Endo.141.8.7621 |
0.419 |
|
| 2000 |
Jette C, Thorburn A. A Raf-induced, MEK-independent signaling pathway regulates atrial natriuretic factor gene expression in cardiac muscle cells. Febs Letters. 467: 1-6. PMID 10664445 DOI: 10.1016/S0014-5793(00)01114-5 |
0.339 |
|
| 1999 |
Hines WA, Thorburn J, Thorburn A. Cell density and contraction regulate p38 MAP kinasedependent responses in neonatal rat cardiac myocytes American Journal of Physiology-Heart and Circulatory Physiology. 277. PMID 10409213 DOI: 10.1152/Ajpheart.1999.277.1.H331 |
0.337 |
|
| 1998 |
Hines WA, Thorburn A. Ras and Rho are Required for Gαq-Induced Hypertrophic Gene Expression in Neonatal Rat Cardiac Myocytes☆ Journal of Molecular and Cellular Cardiology. 30: 485-494. PMID 9515026 DOI: 10.1006/Jmcc.1997.0613 |
0.335 |
|
| 1997 |
Thorburn J, Xu S, Thorburn A. MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells The Embo Journal. 16: 1888-1900. PMID 9155015 DOI: 10.1093/Emboj/16.8.1888 |
0.331 |
|
| 1996 |
Thorburn J, Carlson M, Mansour SJ, Chien KR, Ahn NG, Thorburn A. Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Molecular Biology of the Cell. 6: 1479-90. PMID 8589450 DOI: 10.1091/Mbc.6.11.1479 |
0.321 |
|
| 1994 |
Thorburn J, Frost JA, Thorburn A. Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy. Journal of Cell Biology. 126: 1565-1572. PMID 8089186 DOI: 10.1083/Jcb.126.6.1565 |
0.314 |
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